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Volumn 5, Issue 1, 2012, Pages 94-113

DNA methylation as clinically useful biomarkers - Light at the end of the tunnel

Author keywords

Biomarker; Cancer; cfcDNA; DNA methylation; MethDet; Therapy

Indexed keywords

BETA1A INTERFERON; CELL FREE CIRCULATING DNA; DNA; GENOMIC DNA; GLATIRAMER; HYDRALAZINE; NATALIZUMAB; PROCAINAMIDE; UNCLASSIFIED DRUG;

EID: 84856269241     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph5010094     Document Type: Review
Times cited : (47)

References (142)
  • 6
    • 84855204022 scopus 로고    scopus 로고
    • TNFSFR1A R92Q mutation, autoinflammatory symptoms and multiple sclerosis in a cohort from Argentina
    • Kauffman, M.A.; Gonzalez-Moron, D.; Garcea, O.; Villa, A.M. TNFSFR1A R92Q mutation, autoinflammatory symptoms and multiple sclerosis in a cohort from Argentina. Mol. Biol. Rep. 2011, 39, 117-121.
    • (2011) Mol. Biol. Rep , vol.39 , pp. 117-121
    • Kauffman, M.A.1    Gonzalez-Moron, D.2    Garcea, O.3    Villa, A.M.4
  • 8
    • 79952018056 scopus 로고    scopus 로고
    • Arylsulfatase a gene polymorphisms in relapsing remitting multiple sclerosis: Genotype-phenotype correlation and estimation of disease progression
    • Baronica, K.B.; Mlinac, K.; Ozretic, D.; Vladic, A.; Bognar, S.K. Arylsulfatase a gene polymorphisms in relapsing remitting multiple sclerosis: Genotype-phenotype correlation and estimation of disease progression. Coll. Antropol. 2011, 35, S11-S16.
    • (2011) Coll. Antropol , vol.35
    • Baronica, K.B.1    Mlinac, K.2    Ozretic, D.3    Vladic, A.4    Bognar, S.K.5
  • 12
    • 73949106115 scopus 로고    scopus 로고
    • Epigenetic therapies for chemoresensitization of epithelial ovarian cancer
    • Matei, D.E.; Nephew, K.P. Epigenetic therapies for chemoresensitization of epithelial ovarian cancer. Gynecol. Oncol. 2010, 116, 195-201.
    • (2010) Gynecol. Oncol , vol.116 , pp. 195-201
    • Matei, D.E.1    Nephew, K.P.2
  • 13
    • 78649622045 scopus 로고    scopus 로고
    • Methylation patterns in cell-free plasma DNA reflect removal of the primary tumor and drug treatment of breast cancer patients
    • Liggett, T.E.; Melnikov, A.A.; Marks, J.R.; Levenson, V.V. Methylation patterns in cell-free plasma DNA reflect removal of the primary tumor and drug treatment of breast cancer patients. Int. J. Cancer 2011, 128, 492-499.
    • (2011) Int. J. Cancer , vol.128 , pp. 492-499
    • Liggett, T.E.1    Melnikov, A.A.2    Marks, J.R.3    Levenson, V.V.4
  • 14
    • 77951039961 scopus 로고    scopus 로고
    • DNA methylation based biomarkers in non-invasive cancer screening
    • Shivapurkar, N.; Gazdar, A.F. DNA methylation based biomarkers in non-invasive cancer screening. Curr. Mol. Med. 2010, 10, 123-132.
    • (2010) Curr. Mol. Med , vol.10 , pp. 123-132
    • Shivapurkar, N.1    Gazdar, A.F.2
  • 15
    • 52249117895 scopus 로고    scopus 로고
    • Circulating nucleic acids in plasma and serum. Recent developments
    • Gahan, P.B.; Swaminathan, R. Circulating nucleic acids in plasma and serum. Recent developments. Ann. NY Acad. Sci. 2008, 1137, 1-6.
    • (2008) Ann. NY Acad. Sci , vol.1137 , pp. 1-6
    • Gahan, P.B.1    Swaminathan, R.2
  • 16
    • 78049329829 scopus 로고    scopus 로고
    • Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise
    • Atamaniuk, J.; Vidotto, C.; Kinzlbauer, M.; Bachl, N.; Tiran, B.; Tschan, H. Cell-free plasma DNA and purine nucleotide degradation markers following weightlifting exercise. Eur. J. Appl. Physiol. 2010, 110, 695-701.
    • (2010) Eur. J. Appl. Physiol , vol.110 , pp. 695-701
    • Atamaniuk, J.1    Vidotto, C.2    Kinzlbauer, M.3    Bachl, N.4    Tiran, B.5    Tschan, H.6
  • 17
    • 52249095547 scopus 로고    scopus 로고
    • Metabolic DNA as the origin of spontaneously released DNA?
    • Gahan, P.B.; Anker, P.; Stroun, M. Metabolic DNA as the origin of spontaneously released DNA? Ann. NY Acad. Sci. 2008, 1137, 7-17.
    • (2008) Ann. NY Acad. Sci , vol.1137 , pp. 7-17
    • Gahan, P.B.1    Anker, P.2    Stroun, M.3
  • 19
    • 0016764251 scopus 로고
    • Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system
    • Anker, P.; Stroun, M.; Maurice, P.A. Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system. Cancer Res. 1975, 35, 2375-2382.
    • (1975) Cancer Res , vol.35 , pp. 2375-2382
    • Anker, P.1    Stroun, M.2    Maurice, P.A.3
  • 20
    • 51049091006 scopus 로고    scopus 로고
    • Quantitative analysis of the transrenal excretion of circulating EBV DNA in nasopharyngeal carcinoma patients
    • Chan, K.C.; Leung, S.F.; Yeung, S.W.; Chan, A.T.; Lo, Y.M. Quantitative analysis of the transrenal excretion of circulating EBV DNA in nasopharyngeal carcinoma patients. Clin. Cancer Res. 2008, 14, 4809-4813.
    • (2008) Clin. Cancer Res , vol.14 , pp. 4809-4813
    • Chan, K.C.1    Leung, S.F.2    Yeung, S.W.3    Chan, A.T.4    Lo, Y.M.5
  • 22
    • 0031815875 scopus 로고    scopus 로고
    • Cell-free DNA in human blood plasma: Length measurements in patients with pancreatic cancer and healthy controls
    • Giacona, M.B.; Ruben, G.C.; Iczkowski, K.A.; Roos, T.B.; Porter, D.M.; Sorenson, G.D. Cell-free DNA in human blood plasma: Length measurements in patients with pancreatic cancer and healthy controls. Pancreas 1998, 17, 89-97.
    • (1998) Pancreas , vol.17 , pp. 89-97
    • Giacona, M.B.1    Ruben, G.C.2    Iczkowski, K.A.3    Roos, T.B.4    Porter, D.M.5    Sorenson, G.D.6
  • 23
    • 77950211367 scopus 로고    scopus 로고
    • Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis
    • Liggett, T.; Melnikov, A.; Yi, Q.L.; Replogle, C.; Brand, R.; Kaul, K.; Talamonti, M.; Abrams, R.A.; Levenson, V. Differential methylation of cell-free circulating DNA among patients with pancreatic cancer versus chronic pancreatitis. Cancer 2010, 116, 1674-1680.
    • (2010) Cancer , vol.116 , pp. 1674-1680
    • Liggett, T.1    Melnikov, A.2    Yi, Q.L.3    Replogle, C.4    Brand, R.5    Kaul, K.6    Talamonti, M.7    Abrams, R.A.8    Levenson, V.9
  • 24
    • 0037381516 scopus 로고    scopus 로고
    • Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke
    • Rainer, T.H.; Wong, L.K.; Lam, W.; Yuen, E.; Lam, N.Y.; Metreweli, C.; Lo, Y.M. Prognostic use of circulating plasma nucleic acid concentrations in patients with acute stroke. Clin. Chem 2003, 49, 562-569.
    • (2003) Clin. Chem , vol.49 , pp. 562-569
    • Rainer, T.H.1    Wong, L.K.2    Lam, W.3    Yuen, E.4    Lam, N.Y.5    Metreweli, C.6    Lo, Y.M.7
  • 25
    • 27644597171 scopus 로고    scopus 로고
    • Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias
    • Goebel, G.; Zitt, M.; Zitt, M.; Muller, H.M. Circulating nucleic acids in plasma or serum (CNAPS) as prognostic and predictive markers in patients with solid neoplasias. Dis. Markers 2005, 21, 105-120.
    • (2005) Dis. Markers , vol.21 , pp. 105-120
    • Goebel, G.1    Zitt, M.2    Zitt, M.3    Muller, H.M.4
  • 27
    • 0035103448 scopus 로고    scopus 로고
    • Quantitation of genomic DNA in plasma and serum samples: Higher concentrations of genomic DNA found in serum than in plasma
    • Lee, T.H.; Montalvo, L.; Chrebtow, V.; Busch, M.P. Quantitation of genomic DNA in plasma and serum samples: Higher concentrations of genomic DNA found in serum than in plasma. Transfusion 2001, 41, 276-282.
    • (2001) Transfusion , vol.41 , pp. 276-282
    • Lee, T.H.1    Montalvo, L.2    Chrebtow, V.3    Busch, M.P.4
  • 28
    • 0036254964 scopus 로고    scopus 로고
    • Difference between free circulating plasma and serum DNA in patients with colorectal liver metastases
    • Thijssen, M.A.; Swinkels, D.W.; Ruers, T.J.; de Kok, J.B. Difference between free circulating plasma and serum DNA in patients with colorectal liver metastases. Anticancer Res. 2002, 22, 421-425.
    • (2002) Anticancer Res , vol.22 , pp. 421-425
    • Thijssen, M.A.1    Swinkels, D.W.2    Ruers, T.J.3    de Kok, J.B.4
  • 30
    • 33845686977 scopus 로고    scopus 로고
    • Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender, age and frequency of blood donations?
    • Zhong, X.Y.; Hahn, S.; Kiefer, V.; Holzgreve, W. Is the quantity of circulatory cell-free DNA in human plasma and serum samples associated with gender, age and frequency of blood donations? Ann. Hematol. 2007, 86, 139-143.
    • (2007) Ann. Hematol , vol.86 , pp. 139-143
    • Zhong, X.Y.1    Hahn, S.2    Kiefer, V.3    Holzgreve, W.4
  • 31
    • 52249085870 scopus 로고    scopus 로고
    • DNA integrity in plasma and serum of patients with malignant and benign diseases
    • Holdenrieder, S.; Burges, A.; Reich, O.; Spelsberg, F.W.; Stieber, P. DNA integrity in plasma and serum of patients with malignant and benign diseases. Ann. NY Acad. Sci. 2008, 1137, 162-170.
    • (2008) Ann. NY Acad. Sci , vol.1137 , pp. 162-170
    • Holdenrieder, S.1    Burges, A.2    Reich, O.3    Spelsberg, F.W.4    Stieber, P.5
  • 33
    • 74149094792 scopus 로고    scopus 로고
    • The prevalence of human endogenous retroviruses in cerebrospinal fluids from patients with sporadic Creutzfeldt-Jakob disease
    • Jeong, B.H.; Lee, Y.J.; Carp, R.I.; Kim, Y.S. The prevalence of human endogenous retroviruses in cerebrospinal fluids from patients with sporadic Creutzfeldt-Jakob disease. J. Clin. Virol. 2010, 47, 136-142.
    • (2010) J. Clin. Virol , vol.47 , pp. 136-142
    • Jeong, B.H.1    Lee, Y.J.2    Carp, R.I.3    Kim, Y.S.4
  • 34
    • 0034988757 scopus 로고    scopus 로고
    • Detection of Y chromosome-specific DNA in the plasma and urine of pregnant women using nested polymerase chain reaction
    • Al-Yatama, M.K.; Mustafa, A.S.; Ali, S.; Abraham, S.; Khan, Z.; Khaja, N. Detection of Y chromosome-specific DNA in the plasma and urine of pregnant women using nested polymerase chain reaction. Prenat. Diagn. 2001, 21, 399-402.
    • (2001) Prenat. Diagn , vol.21 , pp. 399-402
    • Al-Yatama, M.K.1    Mustafa, A.S.2    Ali, S.3    Abraham, S.4    Khan, Z.5    Khaja, N.6
  • 35
    • 37349058851 scopus 로고    scopus 로고
    • Maternal urine for prenatal diagnosis-An analysis of cell-free fetal DNA in maternal urine and plasma in the third trimester
    • Majer, S.; Bauer, M.; Magnet, E.; Strele, A.; Giegerl, E.; Eder, M.; Lang, U.; Pertl, B. Maternal urine for prenatal diagnosis-An analysis of cell-free fetal DNA in maternal urine and plasma in the third trimester. Prenat. Diagn. 2007, 27, 1219-1223.
    • (2007) Prenat. Diagn , vol.27 , pp. 1219-1223
    • Majer, S.1    Bauer, M.2    Magnet, E.3    Strele, A.4    Giegerl, E.5    Eder, M.6    Lang, U.7    Pertl, B.8
  • 38
    • 34848911647 scopus 로고    scopus 로고
    • DNA methylation: The nuts and bolts of repression
    • Miranda, T.B.; Jones, P.A. DNA methylation: The nuts and bolts of repression. J. Cell. Physiol. 2007, 213, 384-390.
    • (2007) J. Cell. Physiol , vol.213 , pp. 384-390
    • Miranda, T.B.1    Jones, P.A.2
  • 39
    • 34547792388 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer: The DNA hypermethylome
    • Esteller, M. Epigenetic gene silencing in cancer: The DNA hypermethylome. Hum. Mol. Genet. 2007, 16, R50-R59.
    • (2007) Hum. Mol. Genet , vol.16
    • Esteller, M.1
  • 41
    • 33746063711 scopus 로고    scopus 로고
    • CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    • Kurukuti, S.; Tiwari, V.K.; Tavoosidana, G.; Pugacheva, E.; Murrell, A.; Zhao, Z.; Lobanenkov, V.; Reik, W.; Ohlsson, R. CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc. Natl. Acad. Sci. USA 2006, 103, 10684-10689.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 10684-10689
    • Kurukuti, S.1    Tiwari, V.K.2    Tavoosidana, G.3    Pugacheva, E.4    Murrell, A.5    Zhao, Z.6    Lobanenkov, V.7    Reik, W.8    Ohlsson, R.9
  • 43
    • 80054769799 scopus 로고    scopus 로고
    • Disturbed methylation at multiple imprinted loci: An increasing observation in imprinting disorders
    • Eggermann, T.; Leisten, I.; Binder, G.; Begemann, M.; Spengler, S. Disturbed methylation at multiple imprinted loci: An increasing observation in imprinting disorders. Epigenomics 2011, 3, 625-637.
    • (2011) Epigenomics , vol.3 , pp. 625-637
    • Eggermann, T.1    Leisten, I.2    Binder, G.3    Begemann, M.4    Spengler, S.5
  • 47
    • 55549102967 scopus 로고    scopus 로고
    • Keeping active endogenous retroviral-like elements in heck: The epigenetic perspective
    • Maksakova, I.A.; Mager, D.L.; Reiss, D. Keeping active endogenous retroviral-like elements in heck: The epigenetic perspective. Cell. Mol. Life Sci. 2008, 65, 3329-3347.
    • (2008) Cell. Mol. Life Sci , vol.65 , pp. 3329-3347
    • Maksakova, I.A.1    Mager, D.L.2    Reiss, D.3
  • 48
    • 77952519089 scopus 로고    scopus 로고
    • DNA methylation as a universal biomarker
    • Levenson, V.V. DNA methylation as a universal biomarker. Expert Rev. Mol. Diagn. 2010, 10, 481-488.
    • (2010) Expert Rev. Mol. Diagn , vol.10 , pp. 481-488
    • Levenson, V.V.1
  • 49
    • 79952532412 scopus 로고    scopus 로고
    • Cancer epigenetics: Linking basic biology to clinical medicine
    • Tsai, H.C.; Baylin, S.B. Cancer epigenetics: Linking basic biology to clinical medicine. Cell Res. 2011, 21, 502-517.
    • (2011) Cell Res , vol.21 , pp. 502-517
    • Tsai, H.C.1    Baylin, S.B.2
  • 50
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes, M.; Esteller, M. Cancer epigenetics reaches mainstream oncology. Nat. Med. 2011, 17, 330-339.
    • (2011) Nat. Med , vol.17 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 52
    • 0038561216 scopus 로고    scopus 로고
    • Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: A marker of malignancy and a cause of gene silencing
    • Xing, M.; Usadel, H.; Cohen, Y.; Tokumaru, Y.; Guo, Z.; Westra, W.B.; Tong, B.C.; Tallini, G.; Udelsman, R.; Califano, J.A.; et al. Methylation of the thyroid-stimulating hormone receptor gene in epithelial thyroid tumors: A marker of malignancy and a cause of gene silencing. Cancer Res. 2003, 63, 2316-2321.
    • (2003) Cancer Res , vol.63 , pp. 2316-2321
    • Xing, M.1    Usadel, H.2    Cohen, Y.3    Tokumaru, Y.4    Guo, Z.5    Westra, W.B.6    Tong, B.C.7    Tallini, G.8    Udelsman, R.9    Califano, J.A.10
  • 55
    • 32644467225 scopus 로고    scopus 로고
    • Methylated tumor-specific DNA as a plasma biomarker in patients with glioma
    • Weaver, K.D.; Grossman, S.A.; Herman, J.G. Methylated tumor-specific DNA as a plasma biomarker in patients with glioma. Cancer Invest. 2006, 24, 35-40.
    • (2006) Cancer Invest , vol.24 , pp. 35-40
    • Weaver, K.D.1    Grossman, S.A.2    Herman, J.G.3
  • 56
    • 0033047813 scopus 로고    scopus 로고
    • Methylation profiling of CpG islands in human breast cancer cells
    • Huang, T.H.; Perry, M.R.; Laux, D.E. Methylation profiling of CpG islands in human breast cancer cells. Hum. Mol. Genet. 1999, 8, 459-470.
    • (1999) Hum. Mol. Genet , vol.8 , pp. 459-470
    • Huang, T.H.1    Perry, M.R.2    Laux, D.E.3
  • 61
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry, R.A.; Ladd-Acosta, C.; Wen, B.; Wu, Z.; Montano, C.; Onyango, P.; Cui, H.; Gabo, K.; Rongione, M.; Webster, M.; et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat. Genet. 2009, 41, 178-186.
    • (2009) Nat. Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5    Onyango, P.6    Cui, H.7    Gabo, K.8    Rongione, M.9    Webster, M.10
  • 65
    • 33744932953 scopus 로고    scopus 로고
    • Identification of novel target genes by an epigenetic reactivation screen of renal cancer
    • Ibanez de Caceres, I.; Dulaimi, E.; Hoffman, A.M.; Al-Saleem, T.; Uzzo, R.G.; Cairns, P. Identification of novel target genes by an epigenetic reactivation screen of renal cancer. Cancer Res. 2006, 66, 5021-5028.
    • (2006) Cancer Res , vol.66 , pp. 5021-5028
    • de Caceres, I.I.1    Dulaimi, E.2    Hoffman, A.M.3    Al-Saleem, T.4    Uzzo, R.G.5    Cairns, P.6
  • 67
    • 0036322489 scopus 로고    scopus 로고
    • Applications of CpG island microarrays for high-throughput analysis of DNA methylation
    • Yan, P.S.; Chen, C.M.; Shi, H.; Rahmatpanah, F.; Wei, S.H.; Huang, T.H. Applications of CpG island microarrays for high-throughput analysis of DNA methylation. J. Nutr. 2002, 132, 2430S-2434S.
    • (2002) J. Nutr , vol.132
    • Yan, P.S.1    Chen, C.M.2    Shi, H.3    Rahmatpanah, F.4    Wei, S.H.5    Huang, T.H.6
  • 68
    • 33745700202 scopus 로고    scopus 로고
    • Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia
    • Gebhard, C.; Schwarzfischer, L.; Pham, T.H.; Schilling, E.; Klug, M.; Andreesen, R.; Rehli, M. Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia. Cancer Res. 2006, 66, 6118-6128.
    • (2006) Cancer Res , vol.66 , pp. 6118-6128
    • Gebhard, C.1    Schwarzfischer, L.2    Pham, T.H.3    Schilling, E.4    Klug, M.5    Andreesen, R.6    Rehli, M.7
  • 69
    • 74949087173 scopus 로고    scopus 로고
    • Methylated DNA immunoprecipitation and microarray-based analysis: Detection of DNA methylation in breast cancer cell lines
    • Weng, Y.I.; Huang, T.H.; Yan, P.S. Methylated DNA immunoprecipitation and microarray-based analysis: Detection of DNA methylation in breast cancer cell lines. Methods Mol. Biol. 2009, 590, 165-176.
    • (2009) Methods Mol. Biol , vol.590 , pp. 165-176
    • Weng, Y.I.1    Huang, T.H.2    Yan, P.S.3
  • 74
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genomewide DNA methylation analysis
    • Laird, P.W. Principles and challenges of genomewide DNA methylation analysis. Nat. Rev. Genet. 2010, 11, 191-203.
    • (2010) Nat. Rev. Genet , vol.11 , pp. 191-203
    • Laird, P.W.1
  • 75
    • 0035821727 scopus 로고    scopus 로고
    • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer
    • Umbricht, C.B.; Evron, E.; Gabrielson, E.; Ferguson, A.; Marks, J.; Sukumar, S. Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. Oncogene 2001, 20, 3348-3353.
    • (2001) Oncogene , vol.20 , pp. 3348-3353
    • Umbricht, C.B.1    Evron, E.2    Gabrielson, E.3    Ferguson, A.4    Marks, J.5    Sukumar, S.6
  • 76
    • 0035328527 scopus 로고    scopus 로고
    • Accelerated age-related CpG island methylation in ulcerative colitis
    • Issa, J.P.; Ahuja, N.; Toyota, M.; Bronner, M.P.; Brentnall, T.A. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res. 2001, 61, 3573-3577.
    • (2001) Cancer Res , vol.61 , pp. 3573-3577
    • Issa, J.P.1    Ahuja, N.2    Toyota, M.3    Bronner, M.P.4    Brentnall, T.A.5
  • 78
    • 78049282338 scopus 로고    scopus 로고
    • Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue
    • Wolff, E.M.; Chihara, Y.; Pan, F.; Weisenberger, D.J.; Siegmund, K.D.; Sugano, K.; Kawashima, K.; Laird, P.W.; Jones, P.A.; Liang, G. Unique DNA methylation patterns distinguish noninvasive and invasive urothelial cancers and establish an epigenetic field defect in premalignant tissue. Cancer Res. 2010, 70, 8169-8178.
    • (2010) Cancer Res , vol.70 , pp. 8169-8178
    • Wolff, E.M.1    Chihara, Y.2    Pan, F.3    Weisenberger, D.J.4    Siegmund, K.D.5    Sugano, K.6    Kawashima, K.7    Laird, P.W.8    Jones, P.A.9    Liang, G.10
  • 81
    • 80053180338 scopus 로고    scopus 로고
    • Insulin-like growth factor-2 (IGF2) loss of imprinting marks a field defect within human prostates containing cancer
    • Bhusari, S.; Yang, B.; Kueck, J.; Huang, W.; Jarrard, D.F. Insulin-like growth factor-2 (IGF2) loss of imprinting marks a field defect within human prostates containing cancer. Prostate 2011, 71, 1621-1630.
    • (2011) Prostate , vol.71 , pp. 1621-1630
    • Bhusari, S.1    Yang, B.2    Kueck, J.3    Huang, W.4    Jarrard, D.F.5
  • 82
    • 51649117107 scopus 로고    scopus 로고
    • Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • Hegi, M.E.; Liu, L.; Herman, J.G.; Stupp, R.; Wick, W.; Weller, M.; Mehta, M.P.; Gilbert, M.R. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J. Clin. Oncol. 2008, 26, 4189-4199.
    • (2008) J. Clin. Oncol , vol.26 , pp. 4189-4199
    • Hegi, M.E.1    Liu, L.2    Herman, J.G.3    Stupp, R.4    Wick, W.5    Weller, M.6    Mehta, M.P.7    Gilbert, M.R.8
  • 83
    • 79955397102 scopus 로고    scopus 로고
    • DNA methylation predicts recurrence from resected stage III proximal colon cancer
    • Ahn, J.B.; Chung, W.B.; Maeda, O.; Shin, S.J.; Kim, H.S.; Chung, H.C.; Kim, N.K.; Issa, J.P. DNA methylation predicts recurrence from resected stage III proximal colon cancer. Cancer 2011, 117, 1847-1854.
    • (2011) Cancer , vol.117 , pp. 1847-1854
    • Ahn, J.B.1    Chung, W.B.2    Maeda, O.3    Shin, S.J.4    Kim, H.S.5    Chung, H.C.6    Kim, N.K.7    Issa, J.P.8
  • 84
    • 79959218200 scopus 로고    scopus 로고
    • Systematic CpG islands methylation profiling of genes in the Wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival
    • Dai, W.; Teodoridis, J.M.; Zeller, C.; Graham, J.; Hersey, J.; Flanagan, J.M.; Stronach, E.; Millan, D.W.; Siddiqui, N.; Paul, J.; et al. Systematic CpG islands methylation profiling of genes in the Wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival. Clin. Cancer Res. 2011, 17, 4052-4062.
    • (2011) Clin. Cancer Res , vol.17 , pp. 4052-4062
    • Dai, W.1    Teodoridis, J.M.2    Zeller, C.3    Graham, J.4    Hersey, J.5    Flanagan, J.M.6    Stronach, E.7    Millan, D.W.8    Siddiqui, N.9    Paul, J.10
  • 85
    • 80054765897 scopus 로고    scopus 로고
    • Assays for hypermethylation of the BRCA1 gene promoter in tumor cells to predict sensitivity to PARP-inhibitor therapy
    • Ibragimova, I.; Cairns, P. Assays for hypermethylation of the BRCA1 gene promoter in tumor cells to predict sensitivity to PARP-inhibitor therapy. Methods Mol. Biol. 2011, 780, 277-291.
    • (2011) Methods Mol. Biol , vol.780 , pp. 277-291
    • Ibragimova, I.1    Cairns, P.2
  • 89
    • 77955787215 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients
    • Cho, Y.H.; Yazici, H.; Wu, H.C.; Terry, M.B.; Gonzalez, K.; Qu, M.; Dalay, N.; Santella, R.M. Aberrant promoter hypermethylation and genomic hypomethylation in tumor, adjacent normal tissues and blood from breast cancer patients. Anticancer Res. 2010, 30, 2489-2496.
    • (2010) Anticancer Res , vol.30 , pp. 2489-2496
    • Cho, Y.H.1    Yazici, H.2    Wu, H.C.3    Terry, M.B.4    Gonzalez, K.5    Qu, M.6    Dalay, N.7    Santella, R.M.8
  • 91
    • 78651247591 scopus 로고    scopus 로고
    • DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy
    • Sapienza, C.; Lee, J.; Powell, J.; Erinle, O.; Yafai, F.; Reichert, J.; Siraj, E.S.; Madaio, M. DNA methylation profiling identifies epigenetic differences between diabetes patients with ESRD and diabetes patients without nephropathy. Epigenetics 2011, 6, 20-28.
    • (2011) Epigenetics , vol.6 , pp. 20-28
    • Sapienza, C.1    Lee, J.2    Powell, J.3    Erinle, O.4    Yafai, F.5    Reichert, J.6    Siraj, E.S.7    Madaio, M.8
  • 93
    • 80054924531 scopus 로고    scopus 로고
    • Epithelial-specific methylation marker: A potential plasma biomarker in advanced non-small cell lung cancer
    • Vinayanuwattikun, C.; Sriuranpong, V.; Tanasanvimon, S.; Chantranuwat, P.; Mutirangura, A. Epithelial-specific methylation marker: A potential plasma biomarker in advanced non-small cell lung cancer. J. Thorac. Oncol. 2011, 6, 1818-1825.
    • (2011) J. Thorac. Oncol , vol.6 , pp. 1818-1825
    • Vinayanuwattikun, C.1    Sriuranpong, V.2    Tanasanvimon, S.3    Chantranuwat, P.4    Mutirangura, A.5
  • 99
    • 0033563165 scopus 로고    scopus 로고
    • Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
    • Toyota, M.; Ho, C.; Ahuja, N.; Jair, K.W.; Li, Q.; Ohe-Toyota, M.; Baylin, S.B.; Issa, J.P. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res. 1999, 59, 2307-2312.
    • (1999) Cancer Res , vol.59 , pp. 2307-2312
    • Toyota, M.1    Ho, C.2    Ahuja, N.3    Jair, K.W.4    Li, Q.5    Ohe-Toyota, M.6    Baylin, S.B.7    Issa, J.P.8
  • 101
    • 79960231910 scopus 로고    scopus 로고
    • Prospective clinical validation of an assay for methylated SEPT9 DNA in human plasma as a colorectal cancer screening tool in average risk men and women ≥50 years
    • Church, T.R.; Wandell, M.; Lofton-Day, C.; Mongin, S.; Blumenstein, B.A.; Allen, J.I.; Roesch, T.; Snover, D.; Day, R.; Ransohoff, D.F. Prospective clinical validation of an assay for methylated SEPT9 DNA in human plasma as a colorectal cancer screening tool in average risk men and women ≥50 years. Gastroenterology 2010, 139, e18.
    • (2010) Gastroenterology , vol.139
    • Church, T.R.1    Wandell, M.2    Lofton-Day, C.3    Mongin, S.4    Blumenstein, B.A.5    Allen, J.I.6    Roesch, T.7    Snover, D.8    Day, R.9    Ransohoff, D.F.10
  • 102
    • 0038066467 scopus 로고    scopus 로고
    • The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines
    • Montagna, C.; Lyu, M.S.; Hunter, K.; Lukes, L.; Lowther, W.; Reppert, T.; Hissong, B.; Weaver, Z.; Ried, T. The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines. Cancer Res. 2003, 63, 2179-2187.
    • (2003) Cancer Res , vol.63 , pp. 2179-2187
    • Montagna, C.1    Lyu, M.S.2    Hunter, K.3    Lukes, L.4    Lowther, W.5    Reppert, T.6    Hissong, B.7    Weaver, Z.8    Ried, T.9
  • 105
    • 31844454774 scopus 로고    scopus 로고
    • Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis
    • Scott, M.; McCluggage, W.G.; Hillan, K.J.; Hall, P.A.; Russell, S.E. Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis. Int. J. Cancer 2006, 118, 1325-1329.
    • (2006) Int. J. Cancer , vol.118 , pp. 1325-1329
    • Scott, M.1    McCluggage, W.G.2    Hillan, K.J.3    Hall, P.A.4    Russell, S.E.5
  • 107
    • 77949377722 scopus 로고    scopus 로고
    • HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas
    • Bennett, K.L.; Lee, W.; Lamarre, E.; Zhang, X.; Seth, R.; Scharpf, J.; Hunt, J.; Eng, C. HPV status-independent association of alcohol and tobacco exposure or prior radiation therapy with promoter methylation of FUSSEL18, EBF3, IRX1, and SEPT9, but not SLC5A8, in head and neck squamous cell carcinomas. Genes Chromosomes Cancer 2010, 49, 319-326.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 319-326
    • Bennett, K.L.1    Lee, W.2    Lamarre, E.3    Zhang, X.4    Seth, R.5    Scharpf, J.6    Hunt, J.7    Eng, C.8
  • 108
    • 21344444056 scopus 로고    scopus 로고
    • Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours
    • Scott, M.; Hyland, P.L.; McGregor, G.; Hillan, K.J.; Russell, S.E.; Hall, P.A. Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours. Oncogene 2005, 24, 4688-4700.
    • (2005) Oncogene , vol.24 , pp. 4688-4700
    • Scott, M.1    Hyland, P.L.2    McGregor, G.3    Hillan, K.J.4    Russell, S.E.5    Hall, P.A.6
  • 109
    • 58849140824 scopus 로고    scopus 로고
    • Differential methylation profile of ovarian cancer in tissues and plasma
    • Melnikov, A.; Scholtens, D.; Godwin, A.; Levenson, V. Differential methylation profile of ovarian cancer in tissues and plasma. J. Mol. Diagn. 2009, 11, 60-65.
    • (2009) J. Mol. Diagn , vol.11 , pp. 60-65
    • Melnikov, A.1    Scholtens, D.2    Godwin, A.3    Levenson, V.4
  • 110
    • 52149102033 scopus 로고    scopus 로고
    • Methylation of tumor associated genes in tissue and plasma samples from liver disease patients
    • Chang, H.; Yi, B.; Li, L.; Zhang, H.Y.; Sun, F.; Dong, S.Q.; Cao, Y. Methylation of tumor associated genes in tissue and plasma samples from liver disease patients. Exp. Mol. Pathol. 2008, 85, 96-100.
    • (2008) Exp. Mol. Pathol , vol.85 , pp. 96-100
    • Chang, H.1    Yi, B.2    Li, L.3    Zhang, H.Y.4    Sun, F.5    Dong, S.Q.6    Cao, Y.7
  • 113
    • 80054942534 scopus 로고    scopus 로고
    • The MethDet: A technology for biomarker development
    • Levenson, V.V.; Melnikov, A.A. The MethDet: A technology for biomarker development. Expert Rev. Mol. Diagn. 2011, 11, 807-812.
    • (2011) Expert Rev. Mol. Diagn , vol.11 , pp. 807-812
    • Levenson, V.V.1    Melnikov, A.A.2
  • 117
  • 120
    • 79960332723 scopus 로고    scopus 로고
    • Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder
    • Carrard, A.; Salzmann, A.; Malafosse, A.; Karege, F. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. J. Affect. Disord. 2011, 132, 450-453.
    • (2011) J. Affect. Disord , vol.132 , pp. 450-453
    • Carrard, A.1    Salzmann, A.2    Malafosse, A.3    Karege, F.4
  • 123
  • 125
    • 77955693084 scopus 로고    scopus 로고
    • DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection
    • Kaur, P.; Paliwal, A.; Durantel, D.; Hainaut, P.; Scoazec, J.Y.; Zoulim, F.; Chemin, I.; Herceg, Z. DNA methylation of hepatitis B virus (HBV) genome associated with the development of hepatocellular carcinoma and occult HBV infection. J. Infect. Dis. 2010, 202, 700-704.
    • (2010) J. Infect. Dis , vol.202 , pp. 700-704
    • Kaur, P.1    Paliwal, A.2    Durantel, D.3    Hainaut, P.4    Scoazec, J.Y.5    Zoulim, F.6    Chemin, I.7    Herceg, Z.8
  • 126
    • 78149490635 scopus 로고    scopus 로고
    • IL-32: A host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection
    • Li, W.; Sun, W.; Liu, L.; Yang, F.; Li, Y.; Chen, Y.; Fang, J.; Zhang, W.; Wu, J.; Zhu, Y. IL-32: A host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection. J. Immunol. 2010, 185, 5056-5065.
    • (2010) J. Immunol , vol.185 , pp. 5056-5065
    • Li, W.1    Sun, W.2    Liu, L.3    Yang, F.4    Li, Y.5    Chen, Y.6    Fang, J.7    Zhang, W.8    Wu, J.9    Zhu, Y.10
  • 127
    • 80052476882 scopus 로고    scopus 로고
    • Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of Hodgkin's lymphoma
    • Leonard, S.; Wei, W.; Anderton, J.; Vockerodt, M.; Rowe, M.; Murray, P.G.; Woodman, C.B. Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of Hodgkin's lymphoma. J. Virol. 2011, 85, 9568-9577.
    • (2011) J. Virol , vol.85 , pp. 9568-9577
    • Leonard, S.1    Wei, W.2    Anderton, J.3    Vockerodt, M.4    Rowe, M.5    Murray, P.G.6    Woodman, C.B.7
  • 128
    • 79958795069 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation in pediatric gastric mucosa in association with Helicobacter pylori infection
    • Shin, S.H.; Park, S.Y.; Ko, J.S.; Kim, N.; Kang, G.H. Aberrant CpG island hypermethylation in pediatric gastric mucosa in association with Helicobacter pylori infection. Arch. Pathol. Lab. Med. 2011, 135, 759-765.
    • (2011) Arch. Pathol. Lab. Med , vol.135 , pp. 759-765
    • Shin, S.H.1    Park, S.Y.2    Ko, J.S.3    Kim, N.4    Kang, G.H.5
  • 130
    • 84856250741 scopus 로고    scopus 로고
    • Associations between DNA methylation of a glucocorticoid receptor promoter and acute stress responses in a large healthy adult population are largely explained by lifestyle and educational differences
    • in press
    • de Rooij, S.R.; Costello, P.M.; Veenendaal, M.V.; Lillycrop, K.A.; Gluckman, P.D.; Hanson, M.A.; Painter, R.C.; Roseboom, T.J. Associations between DNA methylation of a glucocorticoid receptor promoter and acute stress responses in a large healthy adult population are largely explained by lifestyle and educational differences. Psychoneuroendocrinology 2011, in press.
    • (2011) Psychoneuroendocrinology
    • de Rooij, S.R.1    Costello, P.M.2    Veenendaal, M.V.3    Lillycrop, K.A.4    Gluckman, P.D.5    Hanson, M.A.6    Painter, R.C.7    Roseboom, T.J.8
  • 131
    • 79954726811 scopus 로고    scopus 로고
    • Lead exposure suppressed ALAD transcription by increasing methylation level of the promoter CpG islands
    • Li, C.; Xu, M.; Wang, S.; Yang, X.; Zhou, S.; Zhang, J.; Liu, Q.; Sun, Y. Lead exposure suppressed ALAD transcription by increasing methylation level of the promoter CpG islands. Toxicol. Lett. 2011, 203, 48-53.
    • (2011) Toxicol. Lett , vol.203 , pp. 48-53
    • Li, C.1    Xu, M.2    Wang, S.3    Yang, X.4    Zhou, S.5    Zhang, J.6    Liu, Q.7    Sun, Y.8
  • 133
    • 77957333258 scopus 로고    scopus 로고
    • Induction of epigenetic alterations by dietary and other environmental factors
    • Mathers, J.C.; Strathdee, G.; Relton, C.L. Induction of epigenetic alterations by dietary and other environmental factors. Adv. Genet. 2010, 71, 3-39.
    • (2010) Adv. Genet , vol.71 , pp. 3-39
    • Mathers, J.C.1    Strathdee, G.2    Relton, C.L.3
  • 136
    • 77954121574 scopus 로고    scopus 로고
    • A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer
    • Fang, F.; Balch, C.; Schilder, J.; Breen, T.; Zhang, S.; Shen, C.; Li, L.; Kulesavage, C.; Snyder, A.J.; Nephew, K.P.; et al. A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer. Cancer 2010, 116, 4043-4053.
    • (2010) Cancer , vol.116 , pp. 4043-4053
    • Fang, F.1    Balch, C.2    Schilder, J.3    Breen, T.4    Zhang, S.5    Shen, C.6    Li, L.7    Kulesavage, C.8    Snyder, A.J.9    Nephew, K.P.10
  • 138
    • 27644597195 scopus 로고    scopus 로고
    • Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine
    • Chuang, J.C.; Yoo, C.B.; Kwan, J.M.; Li, T.W.; Liang, G.; Yang, A.S.; Jones, P.A. Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine. Mol. Cancer Ther. 2005, 4, 1515-1520.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1515-1520
    • Chuang, J.C.1    Yoo, C.B.2    Kwan, J.M.3    Li, T.W.4    Liang, G.5    Yang, A.S.6    Jones, P.A.7
  • 139
    • 65549165786 scopus 로고    scopus 로고
    • The transferome of metabolic genes explored: Analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes
    • Whitaker, J.W.; McConkey, G.A.; Westhead, D.R. The transferome of metabolic genes explored: Analysis of the horizontal transfer of enzyme encoding genes in unicellular eukaryotes. Genome Biol. 2009, 10, R36.
    • (2009) Genome Biol , vol.10
    • Whitaker, J.W.1    McConkey, G.A.2    Westhead, D.R.3
  • 140
    • 77955658052 scopus 로고    scopus 로고
    • Horizontal transfer of transposable elements and why it matters for eukaryotic evolution
    • Schaack, S.; Gilbert, C.; Feschotte, C. Promiscuous DNA: Horizontal transfer of transposable elements and why it matters for eukaryotic evolution. Trends Ecol. Evol. 2010, 25, 537-546.
    • (2010) Trends Ecol. Evol , vol.25 , pp. 537-546
    • Schaack, S.1    Gilbert, C.2    Feschotte, C.3    Promiscuous, D.N.A.4
  • 141
    • 79953063688 scopus 로고    scopus 로고
    • Horizontal gene transfer between bacteria and animals
    • Dunning Hotopp, J.C. Horizontal gene transfer between bacteria and animals. Trends Genet. 2011, 27, 157-163.
    • (2011) Trends Genet , vol.27 , pp. 157-163
    • Dunning, H.J.C.1
  • 142
    • 76549132066 scopus 로고    scopus 로고
    • Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells
    • Garcia-Olmo, D.C.; Dominguez, C.; Garcia-Arranz, M.; Anker, P.; Stroun, M.; Garcia-Verdugo, J.M.; Garcia-Olmo, D. Cell-free nucleic acids circulating in the plasma of colorectal cancer patients induce the oncogenic transformation of susceptible cultured cells. Cancer Res. 2010, 70, 560-567.
    • (2010) Cancer Res , vol.70 , pp. 560-567
    • Garcia-Olmo, D.C.1    Dominguez, C.2    Garcia-Arranz, M.3    Anker, P.4    Stroun, M.5    Garcia-Verdugo, J.M.6    Garcia-Olmo, D.7


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