메뉴 건너뛰기




Volumn 20, Issue 22, 2014, Pages 3595-3606

Pharmacological prevention of eNOS uncoupling

Author keywords

Endothelial NO synthase; eNOS uncoupling; NADPH oxidase; Nitric oxide; Oxidative stress

Indexed keywords

ALISKIREN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPLERENONE; FOLIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NEBIVOLOL; NITRIC OXIDE; PENTAERYTHRITYL TETRANITRATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SEPIAPTERIN; TETRAHYDROBIOPTERIN; UNCOUPLING PROTEIN;

EID: 84907779838     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113196660749     Document Type: Article
Times cited : (50)

References (191)
  • 1
    • 70449431340 scopus 로고    scopus 로고
    • Prevention of atherosclerosis by interference with the vascular nitric oxide system
    • Li H, Forstermann U. Prevention of atherosclerosis by interference with the vascular nitric oxide system. Curr Pharm Des 2009, 15: 3133-45.
    • (2009) Curr Pharm Des , vol.15 , pp. 3133-3145
    • Li, H.1    Forstermann, U.2
  • 2
    • 84859487532 scopus 로고    scopus 로고
    • Nitric oxide synthases: Regulation and function
    • Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J 2012, 33: 829-37, 837a-837d.
    • (2012) Eur Heart J , vol.33
    • Forstermann, U.1    Sessa, W.C.2
  • 3
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006, 113: 1708-14.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 4
    • 34447536457 scopus 로고    scopus 로고
    • Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
    • Schmidt TS, Alp NJ. Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin Sci (Lond) 2007, 113: 47-63.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 47-63
    • Schmidt, T.S.1    Alp, N.J.2
  • 5
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin
    • Laursen JB, Somers M, Kurz S, et al. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 2001, 103: 1282-8.
    • (2001) Circulation , vol.103 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3
  • 6
    • 70350496588 scopus 로고    scopus 로고
    • Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: Relative importance of the de novo biopterin synthesis versus salvage pathways
    • Crabtree MJ, Tatham AL, Hale AB, Alp NJ, Channon KM. Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathways. J Biol Chem 2009, 284: 28128-36.
    • (2009) J Biol Chem , vol.284 , pp. 28128-28136
    • Crabtree, M.J.1    Tatham, A.L.2    Hale, A.B.3    Alp, N.J.4    Channon, K.M.5
  • 7
    • 67649781721 scopus 로고    scopus 로고
    • Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells
    • Sugiyama T, Levy BD, Michel T. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells. J Biol Chem 2009, 284: 12691-700.
    • (2009) J Biol Chem , vol.284 , pp. 12691-12700
    • Sugiyama, T.1    Levy, B.D.2    Michel, T.3
  • 8
    • 79955613244 scopus 로고    scopus 로고
    • Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
    • Crabtree MJ, Hale AB, Channon KM. Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency. Free Radic Biol Med 2011, 50: 1639-46.
    • (2011) Free Radic Biol Med , vol.50 , pp. 1639-1646
    • Crabtree, M.J.1    Hale, A.B.2    Channon, K.M.3
  • 9
    • 80051549032 scopus 로고    scopus 로고
    • Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
    • Crabtree MJ, Channon KM. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide 2011, 25: 81-8.
    • (2011) Nitric Oxide , vol.25 , pp. 81-88
    • Crabtree, M.J.1    Channon, K.M.2
  • 10
    • 52049114150 scopus 로고    scopus 로고
    • Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure
    • Wang S, Xu J, Song P, et al. Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure. Hypertension 2008, 52: 484-90.
    • (2008) Hypertension , vol.52 , pp. 484-490
    • Wang, S.1    Xu, J.2    Song, P.3
  • 11
    • 21144435142 scopus 로고    scopus 로고
    • Endothelial dihydrofolate reductase: Critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase
    • Chalupsky K, Cai H. Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. Proc Natl Acad Sci USA 2005, 102: 9056-61.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 9056-9061
    • Chalupsky, K.1    Cai, H.2
  • 13
    • 80052169339 scopus 로고    scopus 로고
    • Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial nitric oxide synthase uncoupling by angiotensin II in endothelial cells
    • Lobysheva I, Rath G, Sekkali B, et al. Moderate caveolin-1 downregulation prevents NADPH oxidase-dependent endothelial nitric oxide synthase uncoupling by angiotensin II in endothelial cells. Arterioscler Thromb Vasc Biol 2011, 31: 2098-105.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2098-2105
    • Lobysheva, I.1    Rath, G.2    Sekkali, B.3
  • 14
    • 0036199685 scopus 로고    scopus 로고
    • Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
    • Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 2002, 109: 817-26.
    • (2002) J Clin Invest , vol.109 , pp. 817-826
    • Zou, M.H.1    Shi, C.2    Cohen, R.A.3
  • 15
    • 33751178591 scopus 로고    scopus 로고
    • Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: Role of NAD(P)H oxidase-derived superoxide and peroxynitrite
    • Xu J, Xie Z, Reece R, Pimental D, Zou MH. Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite. Arterioscler Thromb Vasc Biol 2006, 26: 2688-95.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2688-2695
    • Xu, J.1    Xie, Z.2    Reece, R.3    Pimental, D.4    Zou, M.H.5
  • 16
    • 79955070997 scopus 로고    scopus 로고
    • Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin IIinfused hypertensive rats
    • Kang KT, Sullivan JC, Spradley FT, d'Uscio LV, Katusic ZS, Pollock JS. Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin IIinfused hypertensive rats. Am J Physiol Heart Circ Physiol 2011, 300: H718-24.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Kang, K.T.1    Sullivan, J.C.2    Spradley, F.T.3    D'uscio, L.V.4    Katusic, Z.S.5    Pollock, J.S.6
  • 18
    • 37349021748 scopus 로고    scopus 로고
    • Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation
    • Antoniades C, Shirodaria C, Crabtree M, et al. Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation. Circulation 2007, 116: 2851-9.
    • (2007) Circulation , vol.116 , pp. 2851-2859
    • Antoniades, C.1    Shirodaria, C.2    Crabtree, M.3
  • 20
    • 84878525986 scopus 로고    scopus 로고
    • Oxidative stress in vascular disease and its pharmacological prevention
    • Li H, Horke S, Forstermann U. Oxidative stress in vascular disease and its pharmacological prevention. Trends in pharmacological sciences 2013, 34: 313-9.
    • (2013) Trends in Pharmacological Sciences , vol.34 , pp. 313-319
    • Li, H.1    Horke, S.2    Forstermann, U.3
  • 21
    • 0033021938 scopus 로고    scopus 로고
    • Superoxide anion production is increased in a model of genetic hypertension: Role of the endothelium
    • Kerr S, Brosnan MJ, McIntyre M, Reid JL, Dominiczak AF, Hamilton CA. Superoxide anion production is increased in a model of genetic hypertension: role of the endothelium. Hypertension 1999, 33: 1353-8.
    • (1999) Hypertension , vol.33 , pp. 1353-1358
    • Kerr, S.1    Brosnan, M.J.2    McIntyre, M.3    Reid, J.L.4    Dominiczak, A.F.5    Hamilton, C.A.6
  • 22
    • 33745009958 scopus 로고    scopus 로고
    • Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats
    • Li H, Witte K, August M, et al. Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. J Am Coll Cardiol 2006, 47: 2536-44.
    • (2006) J am Coll Cardiol , vol.47 , pp. 2536-2544
    • Li, H.1    Witte, K.2    August, M.3
  • 23
    • 0037040947 scopus 로고    scopus 로고
    • Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling
    • Mollnau H, Wendt M, Szocs K, et al. Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res 2002, 90: E58-65.
    • (2002) Circ Res , vol.90
    • Mollnau, H.1    Wendt, M.2    Szocs, K.3
  • 24
    • 0037399439 scopus 로고    scopus 로고
    • Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    • Landmesser U, Dikalov S, Price SR, et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 2003, 111: 1201-9.
    • (2003) J Clin Invest , vol.111 , pp. 1201-1209
    • Landmesser, U.1    Dikalov, S.2    Price, S.R.3
  • 25
    • 0041915626 scopus 로고    scopus 로고
    • Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension
    • Zheng JS, Yang XQ, Lookingland KJ, et al. Gene transfer of human guanosine 5'-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension. Circulation 2003, 108: 1238-45.
    • (2003) Circulation , vol.108 , pp. 1238-1245
    • Zheng, J.S.1    Yang, X.Q.2    Lookingland, K.J.3
  • 26
    • 84861783891 scopus 로고    scopus 로고
    • Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension
    • Youn JY, Wang T, Blair J, et al. Endothelium-specific sepiapterin reductase deficiency in DOCA-salt hypertension. Am J Physiol Heart Circ Physiol 2012, 302: H2243-9.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302
    • Youn, J.Y.1    Wang, T.2    Blair, J.3
  • 27
    • 67650088296 scopus 로고    scopus 로고
    • Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability
    • Gao L, Pung YF, Zhang J, et al. Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability. Am J Physiol Heart Circ Physiol 2009, 297: H331-9.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Gao, L.1    Pung, Y.F.2    Zhang, J.3
  • 28
    • 0034085114 scopus 로고    scopus 로고
    • Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats
    • Zalba G, Beaumont FJ, San Jose G, et al. Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension 2000, 35: 1055-61.
    • (2000) Hypertension , vol.35 , pp. 1055-1061
    • Zalba, G.1    Beaumont, F.J.2    San Jose, G.3
  • 29
    • 29144446282 scopus 로고    scopus 로고
    • Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats
    • Sanchez M, Galisteo M, Vera R, et al. Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 2006, 24: 75-84.
    • (2006) J Hypertens , vol.24 , pp. 75-84
    • Sanchez, M.1    Galisteo, M.2    Vera, R.3
  • 30
    • 77955980491 scopus 로고    scopus 로고
    • Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition
    • Wind S, Beuerlein K, Armitage ME, et al. Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition. Hypertension 2010, 56: 490-7.
    • (2010) Hypertension , vol.56 , pp. 490-497
    • Wind, S.1    Beuerlein, K.2    Armitage, M.E.3
  • 31
    • 54049123809 scopus 로고    scopus 로고
    • NAD(P)H oxidasederived peroxide mediates elevated basal and impaired flowinduced NO production in SHR mesenteric arteries in vivo
    • Zhou X, Bohlen HG, Miller SJ, Unthank JL. NAD(P)H oxidasederived peroxide mediates elevated basal and impaired flowinduced NO production in SHR mesenteric arteries in vivo. Am J Physiol Heart Circ Physiol 2008, 295: H1008-H1016.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Zhou, X.1    Bohlen, H.G.2    Miller, S.J.3    Unthank, J.L.4
  • 32
    • 80052037390 scopus 로고    scopus 로고
    • Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats
    • Bhatt SR, Lokhandwala MF, Banday AA. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol 2011, 667: 258-64.
    • (2011) Eur J Pharmacol , vol.667 , pp. 258-264
    • Bhatt, S.R.1    Lokhandwala, M.F.2    Banday, A.A.3
  • 33
    • 0036100972 scopus 로고    scopus 로고
    • Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    • Higashi Y, Sasaki S, Nakagawa K, et al. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am J Hypertens 2002, 15: 326-32.
    • (2002) Am J Hypertens , vol.15 , pp. 326-332
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3
  • 34
    • 77950508168 scopus 로고    scopus 로고
    • Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1
    • Schuhmacher S, Wenzel P, Schulz E, et al. Pentaerythritol tetranitrate improves angiotensin II-induced vascular dysfunction via induction of heme oxygenase-1. Hypertension 2010, 55: 897-904.
    • (2010) Hypertension , vol.55 , pp. 897-904
    • Schuhmacher, S.1    Wenzel, P.2    Schulz, E.3
  • 35
    • 11144338749 scopus 로고    scopus 로고
    • Vascular NADPH oxidases: Molecular mechanisms of activation
    • Brandes RP, Kreuzer J. Vascular NADPH oxidases: molecular mechanisms of activation. Cardiovasc Res 2005, 65: 16-27.
    • (2005) Cardiovasc Res , vol.65 , pp. 16-27
    • Brandes, R.P.1    Kreuzer, J.2
  • 36
    • 27444441677 scopus 로고    scopus 로고
    • Nox1 is involved in angiotensin II-mediated hypertension: A study in Nox1-deficient mice
    • Matsuno K, Yamada H, Iwata K, et al. Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice. Circulation 2005, 112: 2677-85.
    • (2005) Circulation , vol.112 , pp. 2677-2685
    • Matsuno, K.1    Yamada, H.2    Iwata, K.3
  • 37
    • 0036792751 scopus 로고    scopus 로고
    • Role of p47(Phox) in vascular oxidative stress and hypertension caused by angiotensin II
    • Landmesser U, Cai H, Dikalov S, et al. Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II. Hypertension 2002, 40: 511-5.
    • (2002) Hypertension , vol.40 , pp. 511-515
    • Landmesser, U.1    Cai, H.2    Dikalov, S.3
  • 38
    • 27444447834 scopus 로고    scopus 로고
    • Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice
    • Dikalova A, Clempus R, Lassegue B, et al. Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation 2005, 112: 2668-76.
    • (2005) Circulation , vol.112 , pp. 2668-2676
    • Dikalova, A.1    Clempus, R.2    Lassegue, B.3
  • 39
    • 77953807521 scopus 로고    scopus 로고
    • Redox signaling (Cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
    • Daiber A. Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species. Biochimica et biophysica acta 2010, 1797: 897-906.
    • (2010) Biochimica Et Biophysica Acta , vol.1797 , pp. 897-906
    • Daiber, A.1
  • 41
    • 27844580204 scopus 로고    scopus 로고
    • Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure
    • Daiber A, Oelze M, Coldewey M, et al. Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure. Biochemical and biophysical research communications 2005, 338: 1865-74.
    • (2005) Biochemical and Biophysical Research Communications , vol.338 , pp. 1865-1874
    • Daiber, A.1    Oelze, M.2    Coldewey, M.3
  • 42
    • 0029133481 scopus 로고
    • Native lowdensity lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion
    • Pritchard KA, Jr., Groszek L, Smalley DM, et al. Native lowdensity lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res 1995, 77: 510-8.
    • (1995) Circ Res , vol.77 , pp. 510-518
    • Pritchard, K.A.1    Groszek, L.2    Smalley, D.M.3
  • 43
    • 0031018510 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
    • Stroes E, Kastelein J, Cosentino F, et al. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 1997, 99: 41-6.
    • (1997) J Clin Invest , vol.99 , pp. 41-46
    • Stroes, E.1    Kastelein, J.2    Cosentino, F.3
  • 44
    • 33751166173 scopus 로고    scopus 로고
    • Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia
    • Umeji K, Umemoto S, Itoh S, et al. Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia. Am J Physiol Heart Circ Physiol 2006, 291: H2522-32.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Umeji, K.1    Umemoto, S.2    Itoh, S.3
  • 45
    • 0033779395 scopus 로고    scopus 로고
    • Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells
    • Heinloth A, Heermeier K, Raff U, Wanner C, Galle J. Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells. J Am Soc Nephrol 2000, 11: 1819-25.
    • (2000) J am Soc Nephrol , vol.11 , pp. 1819-1825
    • Heinloth, A.1    Heermeier, K.2    Raff, U.3    Wanner, C.4    Galle, J.5
  • 47
    • 46749092639 scopus 로고    scopus 로고
    • Synergistic effect of amlodipine and atorvastatin in reversing LDL-induced endothelial dysfunction
    • Mason RP, Kubant R, Heeba G, et al. Synergistic effect of amlodipine and atorvastatin in reversing LDL-induced endothelial dysfunction. Pharm Res 2008, 25: 1798-806.
    • (2008) Pharm Res , vol.25 , pp. 1798-1806
    • Mason, R.P.1    Kubant, R.2    Heeba, G.3
  • 48
    • 1542344000 scopus 로고    scopus 로고
    • Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
    • Alp NJ, McAteer MA, Khoo J, Choudhury RP, Channon KM. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 2004, 24: 445-50.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 445-450
    • Alp, N.J.1    McAteer, M.A.2    Khoo, J.3    Choudhury, R.P.4    Channon, K.M.5
  • 49
    • 42449083767 scopus 로고    scopus 로고
    • Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitricoxide synthase (ENOS) expression and preventing eNOS uncoupling
    • Wohlfart P, Xu H, Endlich A, et al. Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitricoxide synthase (eNOS) expression and preventing eNOS uncoupling. J Pharmacol Exp Ther 2008, 325: 370-9.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 370-379
    • Wohlfart, P.1    Xu, H.2    Endlich, A.3
  • 50
    • 77957220423 scopus 로고    scopus 로고
    • C et al. Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein
    • Xia N, Daiber A, Habermeier A, C et al. Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 2010, 335: 149-54.
    • (2010) E Knockout Mice. J Pharmacol Exp Ther , vol.335 , pp. 149-154
    • Xia, N.1    Daiber, A.2    Habermeier, A.3
  • 51
    • 80051978810 scopus 로고    scopus 로고
    • Therapeutic effect of enhancing endothelial nitric oxide synthase (ENOS) expression and preventing eNOS uncoupling
    • Forstermann U, Li H. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. Br J Pharmacol 2011, 164: 213-23.
    • (2011) Br J Pharmacol , vol.164 , pp. 213-223
    • Forstermann, U.1    Li, H.2
  • 52
    • 0344541709 scopus 로고    scopus 로고
    • Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men
    • Nickenig G, Baumer AT, Temur Y, Kebben D, Jockenhovel F, Bohm M. Statin-sensitive dysregulated AT1 receptor function and density in hypercholesterolemic men. Circulation 1999, 100: 2131-4.
    • (1999) Circulation , vol.100 , pp. 2131-2134
    • Nickenig, G.1    Baumer, A.T.2    Temur, Y.3    Kebben, D.4    Jockenhovel, F.5    Bohm, M.6
  • 53
    • 0030872917 scopus 로고    scopus 로고
    • Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression
    • Nickenig G, Jung O, Strehlow K, et al. Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression. Am J Physiol 1997, 272: H2701-7.
    • (1997) Am J Physiol , vol.272
    • Nickenig, G.1    Jung, O.2    Strehlow, K.3
  • 54
    • 0031713366 scopus 로고    scopus 로고
    • Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits
    • Yang BC, Phillips MI, Mohuczy D, et al. Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol 1998, 18: 1433-9.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1433-1439
    • Yang, B.C.1    Phillips, M.I.2    Mohuczy, D.3
  • 55
    • 0034602878 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : Evidence for a dysfunctional nitric oxide synthase
    • Heitzer T, Brockhoff C, Mayer B, et al. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase. Circ Res 2000, 86: E36-41.
    • (2000) Circ Res , vol.86
    • Heitzer, T.1    Brockhoff, C.2    Mayer, B.3
  • 57
    • 2942541144 scopus 로고    scopus 로고
    • Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation
    • Jaimes EA, DeMaster EG, Tian RX, Raij L. Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation. Arterioscler Thromb Vasc Biol 2004, 24: 1031-6.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1031-1036
    • Jaimes, E.A.1    Demaster, E.G.2    Tian, R.X.3    Raij, L.4
  • 58
    • 84864418766 scopus 로고    scopus 로고
    • Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase
    • Steffen Y, Vuillaume G, Stolle K, et al. Cigarette smoke and LDL cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both eNOS and NADPH oxidase. Nitric Oxide 2012, 27: 176-84.
    • (2012) Nitric Oxide , vol.27 , pp. 176-184
    • Steffen, Y.1    Vuillaume, G.2    Stolle, K.3
  • 59
    • 0028798319 scopus 로고
    • Inhibition of endothelial nitric oxide synthase activity by protein kinase C
    • Hirata K, Kuroda R, Sakoda T, et al. Inhibition of endothelial nitric oxide synthase activity by protein kinase C. Hypertension 1995, 25: 180-5.
    • (1995) Hypertension , vol.25 , pp. 180-185
    • Hirata, K.1    Kuroda, R.2    Sakoda, T.3
  • 60
    • 79961038726 scopus 로고    scopus 로고
    • Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice
    • Taguchi K, Kobayashi T, Matsumoto T, Kamata K. Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice. Am J Physiol Heart Circ Physiol 2011, 301: H571-83.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Taguchi, K.1    Kobayashi, T.2    Matsumoto, T.3    Kamata, K.4
  • 61
    • 0035180299 scopus 로고    scopus 로고
    • Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
    • Du XL, Edelstein D, Dimmeler S, Ju Q, Sui C, Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 2001, 108: 1341-8.
    • (2001) J Clin Invest , vol.108 , pp. 1341-1348
    • Du, X.L.1    Edelstein, D.2    Dimmeler, S.3    Ju, Q.4    Sui, C.5    Brownlee, M.6
  • 62
    • 33645509709 scopus 로고    scopus 로고
    • Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
    • Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest 2006, 116: 1071-80.
    • (2006) J Clin Invest , vol.116 , pp. 1071-1080
    • Du, X.1    Edelstein, D.2    Obici, S.3    Higham, N.4    Zou, M.H.5    Brownlee, M.6
  • 63
    • 0035793616 scopus 로고    scopus 로고
    • Mechanisms underlying endothelial dysfunction in diabetes mellitus
    • Hink U, Li H, Mollnau H, et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001, 88: E14-22.
    • (2001) Circ Res , vol.88
    • Hink, U.1    Li, H.2    Mollnau, H.3
  • 64
    • 85047690420 scopus 로고    scopus 로고
    • Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression
    • Alp NJ, Mussa S, Khoo J, et al. Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest 2003, 112: 725-35.
    • (2003) J Clin Invest , vol.112 , pp. 725-735
    • Alp, N.J.1    Mussa, S.2    Khoo, J.3
  • 65
    • 84863219375 scopus 로고    scopus 로고
    • Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by reestablishing tetrahydrobiopterin levels
    • Faria AM, Papadimitriou A, Silva KC, Lopes de Faria JM, Lopes de Faria JB. Uncoupling endothelial nitric oxide synthase is ameliorated by green tea in experimental diabetes by reestablishing tetrahydrobiopterin levels. Diabetes 2012, 61: 1838-47.
    • (2012) Diabetes , vol.61 , pp. 1838-1847
    • Faria, A.M.1    Papadimitriou, A.2    Silva, K.C.3    De Lopes Faria, J.M.4    De Lopes Faria, J.B.5
  • 66
    • 34548134851 scopus 로고    scopus 로고
    • Proteasomedependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    • Xu J, Wu Y, Song P, Zhang M, Wang S, Zou MH. Proteasomedependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus. Circulation 2007, 116: 944-53.
    • (2007) Circulation , vol.116 , pp. 944-953
    • Xu, J.1    Wu, Y.2    Song, P.3    Zhang, M.4    Wang, S.5    Zou, M.H.6
  • 67
    • 80053425581 scopus 로고    scopus 로고
    • Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy
    • Schuhmacher S, Oelze M, Bollmann F, et al. Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy. Diabetes 2011, 60: 2608-16.
    • (2011) Diabetes , vol.60 , pp. 2608-2616
    • Schuhmacher, S.1    Oelze, M.2    Bollmann, F.3
  • 68
    • 48449093231 scopus 로고    scopus 로고
    • AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats
    • Wenzel P, Schulz E, Oelze M, et al. AT1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats. Free Radic Biol Med 2008, 45: 619-26.
    • (2008) Free Radic Biol Med , vol.45 , pp. 619-626
    • Wenzel, P.1    Schulz, E.2    Oelze, M.3
  • 69
    • 79151484305 scopus 로고    scopus 로고
    • Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency
    • Oelze M, Knorr M, Schuhmacher S, et al. Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency. Journal of vascular research 2011, 48: 275-84.
    • (2011) Journal of Vascular Research , vol.48 , pp. 275-284
    • Oelze, M.1    Knorr, M.2    Schuhmacher, S.3
  • 70
    • 0242409173 scopus 로고    scopus 로고
    • Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (Db/db) mice
    • Pannirselvam M, Simon V, Verma S, Anderson T, Triggle CR. Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. Br J Pharmacol 2003, 140: 701-6.
    • (2003) Br J Pharmacol , vol.140 , pp. 701-706
    • Pannirselvam, M.1    Simon, V.2    Verma, S.3    Erson, T.4    Triggle, C.R.5
  • 71
    • 0036271495 scopus 로고    scopus 로고
    • Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (Db/db-/-) mice: role of decreased tetrahydrobiopterin bioavailability
    • Pannirselvam M, Verma S, Anderson TJ, Triggle CR. Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db-/-) mice: role of decreased tetrahydrobiopterin bioavailability. Br J Pharmacol 2002, 136: 255-63.
    • (2002) Br J Pharmacol , vol.136 , pp. 255-263
    • Pannirselvam, M.1    Verma, S.2    Erson, T.J.3    Triggle, C.R.4
  • 72
    • 0033512422 scopus 로고    scopus 로고
    • Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta
    • Shinozaki K, Kashiwagi A, Nishio Y, et al. Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2-imbalance in insulin-resistant rat aorta. Diabetes 1999, 48: 2437-45.
    • (1999) Diabetes , vol.48 , pp. 2437-2445
    • Shinozaki, K.1    Kashiwagi, A.2    Nishio, Y.3
  • 73
    • 0034730795 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats
    • Shinozaki K, Nishio Y, Okamura T, et al. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ Res 2000, 87: 566-73.
    • (2000) Circ Res , vol.87 , pp. 566-573
    • Shinozaki, K.1    Nishio, Y.2    Okamura, T.3
  • 74
    • 84879411196 scopus 로고    scopus 로고
    • Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease
    • Li H, Forstermann U. Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease. Current opinion in pharmacology 2013, 13: 161-7.
    • (2013) Current Opinion in Pharmacology , vol.13 , pp. 161-167
    • Li, H.1    Forstermann, U.2
  • 75
    • 39749139508 scopus 로고    scopus 로고
    • Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability
    • Imanishi T, Ikejima H, Tsujioka H, et al. Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability. Hypertension 2008, 51: 734-41.
    • (2008) Hypertension , vol.51 , pp. 734-741
    • Imanishi, T.1    Ikejima, H.2    Tsujioka, H.3
  • 76
    • 77952668483 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptordependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice
    • Wong WT, Tian XY, Xu A, et al. Angiotensin II type 1 receptordependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice. Antioxid Redox Signal 2010, 13: 757-68.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 757-768
    • Wong, W.T.1    Tian, X.Y.2    Xu, A.3
  • 77
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: Role in cardiovascular biology and disease
    • Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000, 86: 494-501.
    • (2000) Circ Res , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 78
    • 52049097072 scopus 로고    scopus 로고
    • Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes
    • Imanishi T, Tsujioka H, Ikejima H, et al. Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes. Hypertension 2008, 52: 563-72.
    • (2008) Hypertension , vol.52 , pp. 563-572
    • Imanishi, T.1    Tsujioka, H.2    Ikejima, H.3
  • 79
    • 42349086752 scopus 로고    scopus 로고
    • Renin inhibition by aliskiren prevents atherosclerosis progression: Comparison with irbesartan, atenolol, and amlodipine
    • Nussberger J, Aubert JF, Bouzourene K, Pellegrin M, Hayoz D, Mazzolai L. Renin inhibition by aliskiren prevents atherosclerosis progression: comparison with irbesartan, atenolol, and amlodipine. Hypertension 2008, 51: 1306-11.
    • (2008) Hypertension , vol.51 , pp. 1306-1311
    • Nussberger, J.1    Aubert, J.F.2    Bouzourene, K.3    Pellegrin, M.4    Hayoz, D.5    Mazzolai, L.6
  • 80
    • 0035852775 scopus 로고    scopus 로고
    • Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: Role of superoxide dismutase
    • Hornig B, Landmesser U, Kohler C, et al. Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase. Circulation 2001, 103: 799-805.
    • (2001) Circulation , vol.103 , pp. 799-805
    • Hornig, B.1    Landmesser, U.2    Kohler, C.3
  • 81
    • 0033586639 scopus 로고    scopus 로고
    • Increased NADHoxidase-mediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
    • Warnholtz A, Nickenig G, Schulz E, et al. Increased NADHoxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system. Circulation 1999, 99: 2027-33.
    • (1999) Circulation , vol.99 , pp. 2027-2033
    • Warnholtz, A.1    Nickenig, G.2    Schulz, E.3
  • 82
    • 33646390104 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker telmisartan suppresses superoxide production and reduces atherosclerotic lesion formation in apolipoprotein Edeficient mice
    • Takaya T, Kawashima S, Shinohara M, et al. Angiotensin II type 1 receptor blocker telmisartan suppresses superoxide production and reduces atherosclerotic lesion formation in apolipoprotein Edeficient mice. Atherosclerosis 2006, 186: 402-10.
    • (2006) Atherosclerosis , vol.186 , pp. 402-410
    • Takaya, T.1    Kawashima, S.2    Shinohara, M.3
  • 83
    • 56749182381 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy
    • Satoh M, Fujimoto S, Arakawa S, et al. Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy. Nephrol Dial Transplant 2008, 23: 3806-13.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3806-3813
    • Satoh, M.1    Fujimoto, S.2    Arakawa, S.3
  • 84
    • 33847073821 scopus 로고    scopus 로고
    • Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice
    • Oak JH, Cai H. Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice. Diabetes 2007, 56: 118-26.
    • (2007) Diabetes , vol.56 , pp. 118-126
    • Oak, J.H.1    Cai, H.2
  • 85
    • 80052968360 scopus 로고    scopus 로고
    • Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: Beneficial effects of therapy with the AT1 receptor blocker telmisartan
    • Knorr M, Hausding M, Kroller-Schuhmacher S, et al. Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan. Arterioscler Thromb Vasc Biol 2011, 31: 2223-31.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 2223-2231
    • Knorr, M.1    Hausding, M.2    Kroller-Schuhmacher, S.3
  • 86
    • 78650810596 scopus 로고    scopus 로고
    • S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
    • Chen CA, Wang TY, Varadharaj S, et al. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature 2010, 468: 1115-8.
    • (2010) Nature , vol.468 , pp. 1115-1118
    • Chen, C.A.1    Wang, T.Y.2    Varadharaj, S.3
  • 89
    • 84857694797 scopus 로고    scopus 로고
    • Statins as anti-inflammatory agents in atherogenesis: Molecular mechanisms and lessons from the recent clinical trials
    • Antonopoulos AS, Margaritis M, Lee R, Channon K, Antoniades C. Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials. Curr Pharm Des 2012, 18: 1519-30.
    • (2012) Curr Pharm Des , vol.18 , pp. 1519-1530
    • Antonopoulos, A.S.1    Margaritis, M.2    Lee, R.3    Channon, K.4    Antoniades, C.5
  • 90
    • 0345532411 scopus 로고    scopus 로고
    • HMGCoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells
    • Hattori Y, Nakanishi N, Akimoto K, Yoshida M, Kasai K. HMGCoA reductase inhibitor increases GTP cyclohydrolase I mRNA and tetrahydrobiopterin in vascular endothelial cells. Arterioscler Thromb Vasc Biol 2003, 23: 176-82.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 176-182
    • Hattori, Y.1    Nakanishi, N.2    Akimoto, K.3    Yoshida, M.4    Kasai, K.5
  • 91
    • 40949122403 scopus 로고    scopus 로고
    • Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
    • Wenzel P, Daiber A, Oelze M, et al. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis 2008, 198: 65-76.
    • (2008) Atherosclerosis , vol.198 , pp. 65-76
    • Wenzel, P.1    Daiber, A.2    Oelze, M.3
  • 92
    • 79961031512 scopus 로고    scopus 로고
    • Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterinmediated endothelial nitric oxide synthase coupling
    • Antoniades C, Bakogiannis C, Leeson P, et al. Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterinmediated endothelial nitric oxide synthase coupling. Circulation 2011, 124: 335-45.
    • (2011) Circulation , vol.124 , pp. 335-345
    • Antoniades, C.1    Bakogiannis, C.2    Leeson, P.3
  • 93
    • 0343048978 scopus 로고    scopus 로고
    • Improvement of nitric oxide-dependent vasodilatation by HMGCoA reductase inhibitors through attenuation of endothelial superoxide anion formation
    • Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMGCoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 2000, 20: 61-9.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 61-69
    • Wagner, A.H.1    Kohler, T.2    Ruckschloss, U.3    Just, I.4    Hecker, M.5
  • 94
    • 33745066138 scopus 로고    scopus 로고
    • Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway
    • Otto A, Fontaine J, Tschirhart E, Fontaine D, Berkenboom G. Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway. Br J Pharmacol 2006, 148: 544-52.
    • (2006) Br J Pharmacol , vol.148 , pp. 544-552
    • Otto, A.1    Fontaine, J.2    Tschirhart, E.3    Fontaine, D.4    Berkenboom, G.5
  • 95
    • 0035834028 scopus 로고    scopus 로고
    • Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: Antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy
    • Rueckschloss U, Galle J, Holtz J, Zerkowski HR, Morawietz H. Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy. Circulation 2001, 104: 1767-72.
    • (2001) Circulation , vol.104 , pp. 1767-1772
    • Rueckschloss, U.1    Galle, J.2    Holtz, J.3    Zerkowski, H.R.4    Morawietz, H.5
  • 96
    • 77957221105 scopus 로고    scopus 로고
    • Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity
    • Antoniades C, Bakogiannis C, Tousoulis D, et al. Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation 2010, 122: S66-73.
    • (2010) Circulation , vol.122
    • Antoniades, C.1    Bakogiannis, C.2    Tousoulis, D.3
  • 97
    • 0036492011 scopus 로고    scopus 로고
    • Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect
    • Carneado J, Alvarez de Sotomayor M, Perez-Guerrero C, et al. Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect. J Hypertens 2002, 20: 429-37.
    • (2002) J Hypertens , vol.20 , pp. 429-437
    • Carneado, J.1    De Alvarez Sotomayor, M.2    Perez-Guerrero, C.3
  • 98
    • 79960220800 scopus 로고    scopus 로고
    • Effect of n-3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and normocholesterolemic women
    • Carrepeiro MM, Rogero MM, Bertolami MC, Botelho PB, Castro N, Castro IA. Effect of n-3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and normocholesterolemic women. Atherosclerosis 2011, 217: 171-8.
    • (2011) Atherosclerosis , vol.217 , pp. 171-178
    • Carrepeiro, M.M.1    Rogero, M.M.2    Bertolami, M.C.3    Botelho, P.B.4    Castro, N.5    Castro, I.A.6
  • 99
    • 20844463066 scopus 로고    scopus 로고
    • Simvastatin versus ezetimibe: Pleiotropic and lipid-lowering effects on endothelial function in humans
    • Landmesser U, Bahlmann F, Mueller M, et al. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 2005, 111: 2356-63.
    • (2005) Circulation , vol.111 , pp. 2356-2363
    • Landmesser, U.1    Bahlmann, F.2    Mueller, M.3
  • 100
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998, 273: 24266-71.
    • (1998) J Biol Chem , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 101
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998, 97: 1129-35.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, V.2    Plutzky, J.3    Liao, J.K.4
  • 102
    • 0346736491 scopus 로고    scopus 로고
    • Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells
    • Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, et al. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 1998, 101: 2711-9.
    • (1998) J Clin Invest , vol.101 , pp. 2711-2719
    • Hernandez-Perera, O.1    Perez-Sala, D.2    Navarro-Antolin, J.3
  • 104
    • 23244457776 scopus 로고    scopus 로고
    • Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells
    • Sen-Banerjee S, Mir S, Lin Z, et al. Kruppel-like factor 2 as a novel mediator of statin effects in endothelial cells. Circulation 2005, 112: 720-6.
    • (2005) Circulation , vol.112 , pp. 720-726
    • Sen-Banerjee, S.1    Mir, S.2    Lin, Z.3
  • 105
    • 0035830412 scopus 로고    scopus 로고
    • Hydroxymethylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance
    • Feron O, Dessy C, Desager JP, Balligand JL. Hydroxymethylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 2001, 103: 113-8.
    • (2001) Circulation , vol.103 , pp. 113-118
    • Feron, O.1    Dessy, C.2    Desager, J.P.3    Balligand, J.L.4
  • 106
    • 0035834823 scopus 로고    scopus 로고
    • Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins
    • Brouet A, Sonveaux P, Dessy C, Moniotte S, Balligand JL, Feron O. Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ Res 2001, 89: 866-73.
    • (2001) Circ Res , vol.89 , pp. 866-873
    • Brouet, A.1    Sonveaux, P.2    Dessy, C.3    Moniotte, S.4    Balligand, J.L.5    Feron, O.6
  • 107
    • 0037023634 scopus 로고    scopus 로고
    • Double-edged role of statins in angiogenesis signaling
    • Urbich C, Dernbach E, Zeiher AM, Dimmeler S. Double-edged role of statins in angiogenesis signaling. Circ Res 2002, 90: 737-44.
    • (2002) Circ Res , vol.90 , pp. 737-744
    • Urbich, C.1    Dernbach, E.2    Zeiher, A.M.3    Dimmeler, S.4
  • 108
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000, 6: 1004-10.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3
  • 109
    • 33846604213 scopus 로고    scopus 로고
    • Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus
    • Tousoulis D, Antoniades C, Vasiliadou C, et al. Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus. Heart 2007, 93: 244-6.
    • (2007) Heart , vol.93 , pp. 244-246
    • Tousoulis, D.1    Antoniades, C.2    Vasiliadou, C.3
  • 110
    • 3142606890 scopus 로고    scopus 로고
    • Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia
    • Lu TM, Ding YA, Leu HB, Yin WH, Sheu WH, Chu KM. Effect of rosuvastatin on plasma levels of asymmetric dimethylarginine in patients with hypercholesterolemia. Am J Cardiol 2004, 94: 157-61.
    • (2004) Am J Cardiol , vol.94 , pp. 157-161
    • Lu, T.M.1    Ding, Y.A.2    Leu, H.B.3    Yin, W.H.4    Sheu, W.H.5    Chu, K.M.6
  • 111
    • 79952395245 scopus 로고    scopus 로고
    • Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients
    • Nishiyama Y, Ueda M, Otsuka T, et al. Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients. J Atheroscler Thromb 2011, 18: 131-7.
    • (2011) J Atheroscler Thromb , vol.18 , pp. 131-137
    • Nishiyama, Y.1    Ueda, M.2    Otsuka, T.3
  • 112
    • 70350445237 scopus 로고    scopus 로고
    • Nebivolol: The somewhat-different betaadrenergic receptor blocker
    • Munzel T, Gori T. Nebivolol: the somewhat-different betaadrenergic receptor blocker. J Am Coll Cardiol 2009, 54: 1491-9.
    • (2009) J am Coll Cardiol , vol.54 , pp. 1491-1499
    • Munzel, T.1    Gori, T.2
  • 113
    • 0037390324 scopus 로고    scopus 로고
    • Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells
    • Mollnau H, Schulz E, Daiber A, et al. Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells. Arterioscler Thromb Vasc Biol 2003, 23: 615-21.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 615-621
    • Mollnau, H.1    Schulz, E.2    Daiber, A.3
  • 114
    • 33750600184 scopus 로고    scopus 로고
    • Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats
    • Oelze M, Daiber A, Brandes RP, et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 2006, 48: 677-84.
    • (2006) Hypertension , vol.48 , pp. 677-684
    • Oelze, M.1    Daiber, A.2    Brandes, R.P.3
  • 115
    • 33644875667 scopus 로고    scopus 로고
    • Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans
    • Mason RP, Kalinowski L, Jacob RF, Jacoby AM, Malinski T. Nebivolol reduces nitroxidative stress and restores nitric oxide bioavailability in endothelium of black Americans. Circulation 2005, 112: 3795-801.
    • (2005) Circulation , vol.112 , pp. 3795-3801
    • Mason, R.P.1    Kalinowski, L.2    Jacob, R.F.3    Jacoby, A.M.4    Malinski, T.5
  • 116
    • 33747809601 scopus 로고    scopus 로고
    • Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: Role of antioxidant activity
    • Mason RP, Kubant R, Jacob RF, Walter MF, Boychuk B, Malinski T. Effect of nebivolol on endothelial nitric oxide and peroxynitrite release in hypertensive animals: Role of antioxidant activity. J Cardiovasc Pharmacol 2006, 48: 862-9.
    • (2006) J Cardiovasc Pharmacol , vol.48 , pp. 862-869
    • Mason, R.P.1    Kubant, R.2    Jacob, R.F.3    Walter, M.F.4    Boychuk, B.5    Malinski, T.6
  • 117
    • 70350566223 scopus 로고    scopus 로고
    • Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: Effect of beta-blockers
    • Mason RP, Kubant R, Jacob RF, et al. Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of beta-blockers. Am J Hypertens 2009, 22: 1160-6.
    • (2009) Am J Hypertens , vol.22 , pp. 1160-1166
    • Mason, R.P.1    Kubant, R.2    Jacob, R.F.3
  • 118
    • 44349127305 scopus 로고    scopus 로고
    • Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice
    • Baumhakel M, Schlimmer N, Buyukafsar K, Arikan O, Bohm M. Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice. J Pharmacol Exp Ther 2008, 325: 818-23.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 818-823
    • Baumhakel, M.1    Schlimmer, N.2    Buyukafsar, K.3    Arikan, O.4    Bohm, M.5
  • 119
    • 77950466818 scopus 로고    scopus 로고
    • Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat
    • Zhou X, Ma L, Habibi J, et al. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the Zucker obese rat. Hypertension 2010, 55: 880-8.
    • (2010) Hypertension , vol.55 , pp. 880-888
    • Zhou, X.1    Ma, L.2    Habibi, J.3
  • 120
    • 84861762743 scopus 로고    scopus 로고
    • Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (MRen2) rat
    • Ma L, Gul R, Habibi J, et al. Nebivolol improves diastolic dysfunction and myocardial remodeling through reductions in oxidative stress in the transgenic (mRen2) rat. Am J Physiol Heart Circ Physiol 2012, 302: H2341-51.
    • (2012) Am J Physiol Heart Circ Physiol , vol.302
    • Ma, L.1    Gul, R.2    Habibi, J.3
  • 121
    • 0242552054 scopus 로고    scopus 로고
    • Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation
    • Cominacini L, Fratta Pasini A, Garbin U, et al. Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. J Am Coll Cardiol 2003, 42: 1838-44.
    • (2003) J am Coll Cardiol , vol.42 , pp. 1838-1844
    • Cominacini, L.1    Fratta Pasini, A.2    Garbin, U.3
  • 122
    • 26244465889 scopus 로고    scopus 로고
    • Explaining the phenomenon of nitrate tolerance
    • Munzel T, Daiber A, Mulsch A. Explaining the phenomenon of nitrate tolerance. Circ Res 2005, 97: 618-28.
    • (2005) Circ Res , vol.97 , pp. 618-628
    • Munzel, T.1    Daiber, A.2    Mulsch, A.3
  • 123
    • 59349090968 scopus 로고    scopus 로고
    • Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate
    • Gori T, Daiber A. Non-hemodynamic effects of organic nitrates and the distinctive characteristics of pentaerithrityl tetranitrate. Am J Cardiovasc Drugs 2009, 9: 7-15.
    • (2009) Am J Cardiovasc Drugs , vol.9 , pp. 7-15
    • Gori, T.1    Daiber, A.2
  • 124
    • 68149109919 scopus 로고    scopus 로고
    • Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo
    • Oppermann M, Balz V, Adams V, et al. Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo. J Cell Mol Med 2009, 13: 1271-8.
    • (2009) J Cell Mol Med , vol.13 , pp. 1271-1278
    • Oppermann, M.1    Balz, V.2    Adams, V.3
  • 125
    • 67650251652 scopus 로고    scopus 로고
    • Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: Evidence for cardiotoxic and cardioprotective effects
    • Pautz A, Rauschkolb P, Schmidt N, et al. Effects of nitroglycerin or pentaerithrityl tetranitrate treatment on the gene expression in rat hearts: evidence for cardiotoxic and cardioprotective effects. Physiol Genomics 2009, 38: 176-85.
    • (2009) Physiol Genomics , vol.38 , pp. 176-185
    • Pautz, A.1    Rauschkolb, P.2    Schmidt, N.3
  • 127
  • 128
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006, 5: 493-506.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 130
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 2011, 14: 612-22.
    • (2011) Cell Metab , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3
  • 131
    • 77950469163 scopus 로고    scopus 로고
    • Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4)
    • Spanier G, Xu H, Xia N, et al. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol 2009, 60 Suppl 4: 111-6.
    • (2009) J Physiol Pharmacol , vol.60 , pp. 111-116
    • Spanier, G.1    Xu, H.2    Xia, N.3
  • 132
    • 34147182364 scopus 로고    scopus 로고
    • Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages
    • Chow SE, Hshu YC, Wang JS, Chen JK. Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J Appl Physiol 2007, 102: 1520-7.
    • (2007) J Appl Physiol , vol.102 , pp. 1520-1527
    • Chow, S.E.1    Hshu, Y.C.2    Wang, J.S.3    Chen, J.K.4
  • 133
    • 84862215866 scopus 로고    scopus 로고
    • Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms
    • Tang Y, Xu J, Qu W, et al. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. J Nutr Biochem 2012, 23: 1410-6.
    • (2012) J Nutr Biochem , vol.23 , pp. 1410-1416
    • Tang, Y.1    Xu, J.2    Qu, W.3
  • 134
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price NL, Gomes AP, Ling AJ, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 2012, 15: 675-90.
    • (2012) Cell Metab , vol.15 , pp. 675-690
    • Price, N.L.1    Gomes, A.P.2    Ling, A.J.3
  • 136
    • 77950901103 scopus 로고    scopus 로고
    • Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
    • Tanno M, Kuno A, Yano T, et al. Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem 2010, 285: 8375-82.
    • (2010) J Biol Chem , vol.285 , pp. 8375-8382
    • Tanno, M.1    Kuno, A.2    Yano, T.3
  • 137
    • 34249669270 scopus 로고    scopus 로고
    • Sirt1 regulates aging and resistance to oxidative stress in the heart
    • Alcendor RR, Gao S, Zhai P, et al. Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res 2007, 100: 1512-21.
    • (2007) Circ Res , vol.100 , pp. 1512-1521
    • Alcendor, R.R.1    Gao, S.2    Zhai, P.3
  • 138
    • 26844449558 scopus 로고    scopus 로고
    • Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor
    • Kaga S, Zhan L, Matsumoto M, Maulik N. Resveratrol enhances neovascularization in the infarcted rat myocardium through the induction of thioredoxin-1, heme oxygenase-1 and vascular endothelial growth factor. J Mol Cell Cardiol 2005, 39: 813-22.
    • (2005) J Mol Cell Cardiol , vol.39 , pp. 813-822
    • Kaga, S.1    Zhan, L.2    Matsumoto, M.3    Maulik, N.4
  • 139
    • 9944248650 scopus 로고    scopus 로고
    • Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells
    • Juan SH, Cheng TH, Lin HC, Chu YL, Lee WS. Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells. Biochem Pharmacol 2005, 69: 41-8.
    • (2005) Biochem Pharmacol , vol.69 , pp. 41-48
    • Juan, S.H.1    Cheng, T.H.2    Lin, H.C.3    Chu, Y.L.4    Lee, W.S.5
  • 140
    • 77953741269 scopus 로고    scopus 로고
    • Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
    • Ungvari Z, Bagi Z, Feher A, et al. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol 2010, 299: H18-24.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Ungvari, Z.1    Bagi, Z.2    Feher, A.3
  • 141
    • 34547178903 scopus 로고    scopus 로고
    • Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries
    • Ungvari Z, Orosz Z, Labinskyy N, et al. Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries. Am J Physiol Heart Circ Physiol 2007, 293: H37-47.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Ungvari, Z.1    Orosz, Z.2    Labinskyy, N.3
  • 142
    • 33745000727 scopus 로고    scopus 로고
    • Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts
    • Wang Z, Chen Y, Labinskyy N, Hsieh TC, Ungvari Z, Wu JM. Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts. Biochem Biophys Res Commun 2006, 346: 367-76.
    • (2006) Biochem Biophys Res Commun , vol.346 , pp. 367-376
    • Wang, Z.1    Chen, Y.2    Labinskyy, N.3    Hsieh, T.C.4    Ungvari, Z.5    Wu, J.M.6
  • 143
    • 70350464512 scopus 로고    scopus 로고
    • Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    • Ungvari Z, Labinskyy N, Mukhopadhyay P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol 2009, 297: H1876-81.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Ungvari, Z.1    Labinskyy, N.2    Mukhopadhyay, P.3
  • 144
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006, 127: 1109-22.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 145
    • 78650172708 scopus 로고    scopus 로고
    • Silent information regulator 1 protects the heart from ischemia/reperfusion
    • Hsu CP, Zhai P, Yamamoto T, et al. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 2010, 122: 2170-82.
    • (2010) Circulation , vol.122 , pp. 2170-2182
    • Hsu, C.P.1    Zhai, P.2    Yamamoto, T.3
  • 146
    • 0037167677 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
    • Wallerath T, Deckert G, Ternes T, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002, 106: 1652-8.
    • (2002) Circulation , vol.106 , pp. 1652-1658
    • Wallerath, T.1    Deckert, G.2    Ternes, T.3
  • 147
    • 54149103338 scopus 로고    scopus 로고
    • Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
    • Zhang QJ, Wang Z, Chen HZ, et al. Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res 2008, 80: 191-9.
    • (2008) Cardiovasc Res , vol.80 , pp. 191-199
    • Zhang, Q.J.1    Wang, Z.2    Chen, H.Z.3
  • 149
    • 14844295766 scopus 로고    scopus 로고
    • Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells
    • Klinge CM, Blankenship KA, Risinger KE, et al. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J Biol Chem 2005, 280: 7460-8.
    • (2005) J Biol Chem , vol.280 , pp. 7460-7468
    • Klinge, C.M.1    Blankenship, K.A.2    Risinger, K.E.3
  • 150
    • 46749116365 scopus 로고    scopus 로고
    • Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells
    • Klinge CM, Wickramasinghe NS, Ivanova MM, Dougherty SM. Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. FASEB J 2008, 22: 2185-97.
    • (2008) FASEB J , vol.22 , pp. 2185-2197
    • Klinge, C.M.1    Wickramasinghe, N.S.2    Ivanova, M.M.3    Dougherty, S.M.4
  • 151
    • 78249238536 scopus 로고    scopus 로고
    • Essential role of ERalpha-dependent NO production in resveratrol-mediated inhibition of restenosis
    • Khandelwal AR, Hebert VY, Dugas TR. Essential role of ERalpha-dependent NO production in resveratrol-mediated inhibition of restenosis. Am J Physiol Heart Circ Physiol 2010, 299: H1451-8.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Khandelwal, A.R.1    Hebert, V.Y.2    Dugas, T.R.3
  • 152
    • 77955285843 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the activation of eNOS
    • Fleming I. Molecular mechanisms underlying the activation of eNOS. Pflugers Arch 2010, 459: 793-806.
    • (2010) Pflugers Arch , vol.459 , pp. 793-806
    • Fleming, I.1
  • 153
    • 69249216358 scopus 로고    scopus 로고
    • Resveratrol prevents hyperglycemiainduced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase
    • Xu Q, Hao X, Yang Q, Si L. Resveratrol prevents hyperglycemiainduced endothelial dysfunction via activation of adenosine monophosphate-activated protein kinase. Biochem Biophys Res Commun 2009, 388: 389-94.
    • (2009) Biochem Biophys Res Commun , vol.388 , pp. 389-394
    • Xu, Q.1    Hao, X.2    Yang, Q.3    Si, L.4
  • 154
    • 35549008884 scopus 로고    scopus 로고
    • SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
    • Mattagajasingh I, Kim CS, Naqvi A, et al. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci USA 2007, 104: 14855-60.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14855-14860
    • Mattagajasingh, I.1    Kim, C.S.2    Naqvi, A.3
  • 155
    • 77249158771 scopus 로고    scopus 로고
    • SIRT1 regulates oxidant-and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol
    • Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I. SIRT1 regulates oxidant-and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun 2010, 393: 66-72.
    • (2010) Biochem Biophys Res Commun , vol.393 , pp. 66-72
    • Arunachalam, G.1    Yao, H.2    Sundar, I.K.3    Caito, S.4    Rahman, I.5
  • 156
    • 79551616346 scopus 로고    scopus 로고
    • Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress
    • Frombaum M, Therond P, Djelidi R, Beaudeux JL, Bonnefont-Rousselot D, Borderie D. Piceatannol is more effective than resveratrol in restoring endothelial cell dimethylarginine dimethylaminohydrolase expression and activity after high-glucose oxidative stress. Free Radic Res 2011, 45: 293-302.
    • (2011) Free Radic Res , vol.45 , pp. 293-302
    • Frombaum, M.1    Therond, P.2    Djelidi, R.3    Beaudeux, J.L.4    Bonnefont-Rousselot, D.5    Borderie, D.6
  • 157
    • 80053073644 scopus 로고    scopus 로고
    • Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: Role of SIRT1
    • Yuan Q, Chen L, Xiang DX, Li YJ, Hu CP. Effect of resveratrol derivative BTM-0512 on high glucose-induced dysfunction of endothelial cells: role of SIRT1. Can J Physiol Pharmacol 2011.
    • (2011) Can J Physiol Pharmacol
    • Yuan, Q.1    Chen, L.2    Xiang, D.X.3    Li, Y.J.4    Hu, C.P.5
  • 158
    • 77951127089 scopus 로고    scopus 로고
    • Inhibitory effect of resveratrol derivative BTM-0512 on high glucose-induced cell senescence involves dimethylaminohydrolase/asymmetric dimethylarginine pathway
    • Yuan Q, Peng J, Liu SY, et al. Inhibitory effect of resveratrol derivative BTM-0512 on high glucose-induced cell senescence involves dimethylaminohydrolase/asymmetric dimethylarginine pathway. Clin Exp Pharmacol Physiol 2010, 37: 630-5.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 630-635
    • Yuan, Q.1    Peng, J.2    Liu, S.Y.3
  • 159
    • 51549090151 scopus 로고    scopus 로고
    • Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: Role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor
    • Penumathsa SV, Koneru S, Samuel SM, et al. Strategic targets to induce neovascularization by resveratrol in hypercholesterolemic rat myocardium: role of caveolin-1, endothelial nitric oxide synthase, hemeoxygenase-1, and vascular endothelial growth factor. Free Radic Biol Med 2008, 45: 1027-34.
    • (2008) Free Radic Biol Med , vol.45 , pp. 1027-1034
    • Penumathsa, S.V.1    Koneru, S.2    Samuel, S.M.3
  • 160
    • 78851469101 scopus 로고    scopus 로고
    • Bioavailability of resveratrol
    • Walle T. Bioavailability of resveratrol. Ann N Y Acad Sci 2011, 1215: 9-15.
    • (2011) Ann N Y Acad Sci , vol.1215 , pp. 9-15
    • Walle, T.1
  • 161
    • 78851469497 scopus 로고    scopus 로고
    • Safety of resveratrol with examples for high purity, trans-resveratrol, resVida((R))
    • Edwards JA, Beck M, Riegger C, Bausch J. Safety of resveratrol with examples for high purity, trans-resveratrol, resVida((R)). Ann N Y Acad Sci 2011, 1215: 131-7.
    • (2011) Ann N Y Acad Sci , vol.1215 , pp. 131-137
    • Edwards, J.A.1    Beck, M.2    Riegger, C.3    Bausch, J.4
  • 163
    • 0034739459 scopus 로고    scopus 로고
    • Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis
    • Tiefenbacher CP, Bleeke T, Vahl C, Amann K, Vogt A, Kubler W. Endothelial dysfunction of coronary resistance arteries is improved by tetrahydrobiopterin in atherosclerosis. Circulation 2000, 102: 2172-9.
    • (2000) Circulation , vol.102 , pp. 2172-2179
    • Tiefenbacher, C.P.1    Bleeke, T.2    Vahl, C.3    Amann, K.4    Vogt, A.5    Kubler, W.6
  • 164
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • Heitzer T, Krohn K, Albers S, Meinertz T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 2000, 43: 1435-8.
    • (2000) Diabetologia , vol.43 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 165
    • 33646402907 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production
    • Higashi Y, Sasaki S, Nakagawa K, et al. Tetrahydrobiopterin improves aging-related impairment of endothelium-dependent vasodilation through increase in nitric oxide production. Atherosclerosis 2006, 186: 390-5.
    • (2006) Atherosclerosis , vol.186 , pp. 390-395
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3
  • 166
    • 34249282381 scopus 로고    scopus 로고
    • (6R)-5,6,7,8-tetrahydro-Lbiopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm
    • Mayahi L, Heales S, Owen D, et al. (6R)-5,6,7,8-tetrahydro-Lbiopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm. Arterioscler Thromb Vasc Biol 2007, 27: 1334-9.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 1334-1339
    • Mayahi, L.1    Heales, S.2    Owen, D.3
  • 167
    • 84862794123 scopus 로고    scopus 로고
    • Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease
    • Cunnington C, Van Assche T, Shirodaria C, et al. Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease. Circulation 2012, 125: 1356-66.
    • (2012) Circulation , vol.125 , pp. 1356-1366
    • Cunnington, C.1    Van Assche, T.2    Shirodaria, C.3
  • 168
    • 84865243945 scopus 로고    scopus 로고
    • Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation
    • Schmidt K, Neubauer A, Kolesnik B, et al. Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation. Mol Pharmacol 2012, 82: 420-7.
    • (2012) Mol Pharmacol , vol.82 , pp. 420-427
    • Schmidt, K.1    Neubauer, A.2    Kolesnik, B.3
  • 169
    • 80051471390 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: Important endothelial mediator independent of endothelial nitric oxide synthase
    • Meininger CJ, Wu G. Tetrahydrobiopterin: important endothelial mediator independent of endothelial nitric oxide synthase. Hypertension 2011, 58: 145-7.
    • (2011) Hypertension , vol.58 , pp. 145-147
    • Meininger, C.J.1    Wu, G.2
  • 170
    • 80051470205 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin
    • He T, Smith LA, Lu T, Joyner MJ, Katusic ZS. Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin. Hypertension 2011, 58: 287-94.
    • (2011) Hypertension , vol.58 , pp. 287-294
    • He, T.1    Smith, L.A.2    Lu, T.3    Joyner, M.J.4    Katusic, Z.S.5
  • 171
    • 41149105370 scopus 로고    scopus 로고
    • Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia
    • Cosentino F, Hurlimann D, Delli Gatti C, et al. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia. Heart 2008, 94: 487-92.
    • (2008) Heart , vol.94 , pp. 487-492
    • Cosentino, F.1    Hurlimann, D.2    Delli Gatti, C.3
  • 172
    • 84870029955 scopus 로고    scopus 로고
    • The role of tetrahydrobiopterin in inflammation and cardiovascular disease
    • McNeill E, Channon KM. The role of tetrahydrobiopterin in inflammation and cardiovascular disease. Thrombosis and haemostasis 2012, 108: 832-9.
    • (2012) Thrombosis and Haemostasis , vol.108 , pp. 832-839
    • McNeill, E.1    Channon, K.M.2
  • 173
    • 79959746256 scopus 로고    scopus 로고
    • Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow
    • Li L, Chen W, Rezvan A, Jo H, Harrison DG. Tetrahydrobiopterin deficiency and nitric oxide synthase uncoupling contribute to atherosclerosis induced by disturbed flow. Arterioscler Thromb Vasc Biol 2011, 31: 1547-54.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , pp. 1547-1554
    • Li, L.1    Chen, W.2    Rezvan, A.3    Jo, H.4    Harrison, D.G.5
  • 174
    • 44049104413 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: A novel antihypertensive therapy
    • Porkert M, Sher S, Reddy U, et al. Tetrahydrobiopterin: a novel antihypertensive therapy. J Hum Hypertens 2008, 22: 401-7.
    • (2008) J Hum Hypertens , vol.22 , pp. 401-407
    • Porkert, M.1    Sher, S.2    Reddy, U.3
  • 175
    • 83655167072 scopus 로고    scopus 로고
    • Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: Treatment with folic acid
    • Gao L, Siu KL, Chalupsky K, et al. Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation: treatment with folic acid. Hypertension 2012, 59: 158-66.
    • (2012) Hypertension , vol.59 , pp. 158-166
    • Gao, L.1    Siu, K.L.2    Chalupsky, K.3
  • 176
    • 34247578183 scopus 로고    scopus 로고
    • Global improvement of vascular function and redox state with low-dose folic acid: Implications for folate therapy in patients with coronary artery disease
    • Shirodaria C, Antoniades C, Lee J, et al. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation 2007, 115: 2262-70.
    • (2007) Circulation , vol.115 , pp. 2262-2270
    • Shirodaria, C.1    Antoniades, C.2    Lee, J.3
  • 177
    • 33845503323 scopus 로고    scopus 로고
    • Effect of folic acid supplementation on risk of cardiovascular diseases: A meta-analysis of randomized controlled trials
    • Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. Jama 2006, 296: 2720-6.
    • (2006) Jama , vol.296 , pp. 2720-2726
    • Bazzano, L.A.1    Reynolds, K.2    Holder, K.N.3    He, J.4
  • 178
    • 78649357316 scopus 로고    scopus 로고
    • Is oxidative stress a therapeutic target in cardiovascular disease?
    • Munzel T, Gori T, Bruno RM, Taddei S. Is oxidative stress a therapeutic target in cardiovascular disease? Eur Heart J 2010, 31: 2741-8.
    • (2010) Eur Heart J , vol.31 , pp. 2741-2748
    • Munzel, T.1    Gori, T.2    Bruno, R.M.3    Taddei, S.4
  • 179
    • 70349659801 scopus 로고    scopus 로고
    • Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure
    • Westermann D, Riad A, Richter U, et al. Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure. Basic Res Cardiol 2009, 104: 499-509.
    • (2009) Basic Res Cardiol , vol.104 , pp. 499-509
    • Westermann, D.1    Riad, A.2    Richter, U.3
  • 180
    • 33749239638 scopus 로고    scopus 로고
    • Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy
    • Sasaki K, Heeschen C, Aicher A, et al. Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy. Proc Natl Acad Sci USA 2006, 103: 14537-41.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14537-14541
    • Sasaki, K.1    Heeschen, C.2    Aicher, A.3
  • 181
    • 53749096012 scopus 로고    scopus 로고
    • Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction
    • Fraccarollo D, Widder JD, Galuppo P, et al. Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction. Circulation 2008, 118: 818-27.
    • (2008) Circulation , vol.118 , pp. 818-827
    • Fraccarollo, D.1    Widder, J.D.2    Galuppo, P.3
  • 182
    • 79958789023 scopus 로고    scopus 로고
    • AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats
    • Yang Q, Xue HM, Wong WT, et al. AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats. Br J Pharmacol 2011, 163: 1078-85.
    • (2011) Br J Pharmacol , vol.163 , pp. 1078-1085
    • Yang, Q.1    Xue, H.M.2    Wong, W.T.3
  • 183
    • 80054119745 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice
    • Cheang WS, Wong WT, Tian XY, et al. Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice. Cardiovasc Res 2011, 92: 267-75.
    • (2011) Cardiovasc Res , vol.92 , pp. 267-275
    • Cheang, W.S.1    Wong, W.T.2    Tian, X.Y.3
  • 184
    • 84865694338 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery
    • Xuan C, Chang FJ, Liu XC, et al. Endothelial nitric oxide synthase enhancer for protection of endothelial function from asymmetric dimethylarginine-induced injury in human internal thoracic artery. J Thorac Cardiovasc Surg 2012, 144: 697-703.
    • (2012) J Thorac Cardiovasc Surg , vol.144 , pp. 697-703
    • Xuan, C.1    Chang, F.J.2    Liu, X.C.3
  • 185
    • 84867990157 scopus 로고    scopus 로고
    • AVE3085 Protects Coronary Endothelium from the Impairment of Asymmetric Dimethylarginine by Activation and Recoupling of eNOS
    • Xue HM, Yu CM, Underwood MJ, Huang JH, Yang Q. AVE3085 Protects Coronary Endothelium from the Impairment of Asymmetric Dimethylarginine by Activation and Recoupling of eNOS. Cardiovasc Drugs Ther 2012, 26: 383-92.
    • (2012) Cardiovasc Drugs Ther , vol.26 , pp. 383-392
    • Xue, H.M.1    Yu, C.M.2    Underwood, M.J.3    Huang, J.H.4    Yang, Q.5
  • 186
    • 55649114859 scopus 로고    scopus 로고
    • Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes
    • Riad A, Westermann D, Van Linthout S, et al. Enhancement of endothelial nitric oxide synthase production reverses vascular dysfunction and inflammation in the hindlimbs of a rat model of diabetes. Diabetologia 2008, 51: 2325-32.
    • (2008) Diabetologia , vol.51 , pp. 2325-2332
    • Riad, A.1    Westermann, D.2    Van Linthout, S.3
  • 187
    • 19544384182 scopus 로고    scopus 로고
    • Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse
    • Li H, Hergert SM, Schafer SC, et al. Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse. Nitric Oxide 2005, 12: 231-6.
    • (2005) Nitric Oxide , vol.12 , pp. 231-236
    • Li, H.1    Hergert, S.M.2    Schafer, S.C.3
  • 188
    • 34547096987 scopus 로고    scopus 로고
    • Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells
    • Steinkamp-Fenske K, Bollinger L, Xu H, et al. Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells. J Pharmacol Exp Ther 2007, 322: 836-42.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 836-842
    • Steinkamp-Fenske, K.1    Bollinger, L.2    Xu, H.3
  • 189
    • 35248872474 scopus 로고    scopus 로고
    • Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells
    • Steinkamp-Fenske K, Bollinger L, Voller N, et al. Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells. Atherosclerosis 2007, 195: e104-11.
    • (2007) Atherosclerosis , vol.195
    • Steinkamp-Fenske, K.1    Bollinger, L.2    Voller, N.3
  • 190
    • 79954628009 scopus 로고    scopus 로고
    • Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress
    • Lu Q, Xia N, Xu H, et al. Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress. Nitric Oxide 2011, 24: 132-8.
    • (2011) Nitric Oxide , vol.24 , pp. 132-138
    • Lu, Q.1    Xia, N.2    Xu, H.3
  • 191
    • 84869504420 scopus 로고    scopus 로고
    • Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.Hy926
    • Zhou ZW, Xie XL, Zhou SF, Li CG. Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926. Eur J Pharm 2012, 697: 97-105.
    • (2012) Eur J Pharm , vol.697 , pp. 97-105
    • Zhou, Z.W.1    Xie, X.L.2    Zhou, S.F.3    Li, C.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.