Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression

Journal of Clinical Investigation

Volumn 112, Issue 5, 2003, Pages 725-735

  Alp, Nicholas J ^a   Mussa, Shafi ^a   Khoo, Jeffrey ^a   Cai, Shijie ^a   Guzik, Tomasz ^a   Jefferson, Andrew ^b   Goh, Nicky ^a   Rockett, Kirk A ^b   Channon, Keith M ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPTERIN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TETRAHYDROBIOPTERIN; 5,6,7,8-TETRAHYDROBIOPTERIN; DRUG DERIVATIVE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NOS3 PROTEIN, MOUSE; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE OVEREXPRESSION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; ANIMAL; C57BL MOUSE; CBA MOUSE; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; BIOPTERIN; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; GTP CYCLOHYDROLASE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; RNA, MESSENGER; STREPTOZOCIN; SUPEROXIDES;

EID: 85047690420     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI17786     Document Type: Article

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