Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: Implication of the NAD(P)H oxidase pathway

British Journal of Pharmacology

Volumn 148, Issue 4, 2006, Pages 544-552

  Otto, Anne ^a   Fontaine, Jeanine ^a   Tschirhart, Eric ^b   Fontaine, David ^a   Berkenboom, Guy ^c  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^c ERASME HOSPITAL   (Belgium)

Author keywords

eNOS knockout mice; NAD(P)H oxidase; Nitrate tolerance; Oxidative stress; Rosuvastatin

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; APOCYNIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLYCERYL TRINITRATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LUCIGENIN; MEMBRANE ENZYME; MESSENGER RNA; MEVALONIC ACID; NITRATE; NITRIC OXIDE; OXIDOREDUCTASE INHIBITOR; OXYGEN; PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; ROSUVASTATIN; SUPEROXIDE; THROMBOXANE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; BLOOD VESSEL REACTIVITY; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS TOLERANCE; DRUG ANTAGONISM; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; ENZYME SUBUNIT; FEMALE; GENE CONTROL; GENE EXPRESSION REGULATION; IN VIVO STUDY; KNOCKOUT MOUSE; LONG TERM EXPOSURE; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTECTION; PROTEIN CONTENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; THORACIC AORTA; TISSUE HOMOGENATE; VASCULAR ENDOTHELIUM; VASCULAR RING; WILD TYPE;

ACETYLCHOLINE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; FLUOROBENZENES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MICE, KNOCKOUT; NADPH OXIDASE; NITRIC OXIDE SYNTHASE TYPE III; NITROGLYCERIN; OXIDATIVE STRESS; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SULFONAMIDES;

EID: 33745066138     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706738     Document Type: Article

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