Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure

Basic Research in Cardiology

Volumn 104, Issue 5, 2009, Pages 499-509

  Westermann, Dirk ^a   Riad, Alexander ^a   Richter, Utz ^a   Jäger, Sebastian ^a   Savvatis, Konstantinos ^a   Schuchardt, Mirjam ^a   Bergmann, Nora ^b   Tölle, Markus ^a   Nagorsen, Dirk ^a   Gotthardt, Michael ^b   Schultheiss, Heinz Peter ^a   Tschöpe, Carsten ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Diastolic dysfunction; Heart failure; Nitric oxide; Pressure volume loops

Indexed keywords

AVE 3085; CALCINEURIN; CARDIOVASCULAR AGENT; COLLAGEN; CONNECTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PLACEBO; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE SUBUNIT P22PHOX; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CONTROLLED STUDY; DAHL SALT SENSITIVE RAT; DIASTOLIC DYSFUNCTION; DIASTOLIC HEART FAILURE; DRUG MECHANISM; ECHOCARDIOGRAPHY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPERIMENTAL STUDY; GENE EXPRESSION REGULATION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; IMMUNOHISTOCHEMISTRY; MALE; MORTALITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRESSURE MEASUREMENT; PRESSURE VOLUME CURVE; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; SALT INTAKE; TRANSCRIPTION REGULATION;

ANIMALS; BENZODIOXOLES; BLOOD PRESSURE; CALCINEURIN; CARDIOMEGALY; CARDIOTONIC AGENTS; COLLAGEN; DISEASE MODELS, ANIMAL; FIBROSIS; HEART FAILURE, DIASTOLIC; HYPERTENSION; INDANS; MALE; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIUM; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, INBRED DAHL; RNA, MESSENGER; SIGNAL TRANSDUCTION; SODIUM CHLORIDE; TIME FACTORS; TRANSCRIPTION, GENETIC; UP-REGULATION; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 70349659801     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-009-0014-6     Document Type: Article

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