Gene transfer of human guanosine 5′-triphosphate cyclohydrolase I restores vascular tetrahydrobiopterin level and endothelial function in low renin hypertension

Circulation

Volumn 108, Issue 10, 2003, Pages 1238-1245

  Zheng, Jie Sheng ^a,b   Yang, Xiang Qun ^a   Lookingland, Keith J ^a   Fink, Gregory D ^a   Hesslinger, Christian ^c   Kapatos, Gregory ^d   Kovesdi, Imre ^e   Chen, Alex F ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b ZHEJIANG UNIVERSITY   (China)

^c ALTANA PHARMA AG   (Germany)

^d WAYNE STATE UNIVERSITY   (United States)

^e GENVEC INC   (United States)

Author keywords

Antioxidants; Endothelin; Free radicals; Gene therapy; Nitric oxide

Indexed keywords

APOCYNIN; ATRASENTAN; DEOXYCORTICOSTERONE ACETATE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RENIN; SUPEROXIDE; SUPEROXIDE DISMUTASE; TEMPOL; TETRAHYDROBIOPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM; ENDOTHELIUM LESION; ENZYME ACTIVITY; GENE TRANSFER; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETOPHENONES; ANIMALS; ANTIOXIDANTS; BIOPTERIN; CAROTID ARTERIES; CYCLIC N-OXIDES; DESOXYCORTICOSTERONE; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GTP CYCLOHYDROLASE; HUMANS; HYPERTENSION; MALE; NITRIC OXIDE; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN; SODIUM CHLORIDE; SPIN LABELS; SUPEROXIDES; VASODILATION;

EID: 0041915626     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000089082.40285.C3     Document Type: Article

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