Tetrahydrobiopterin: Important endothelial mediator independent of endothelial nitric oxide synthase

Hypertension

Volumn 58, Issue 2, 2011, Pages 145-147

  Meininger, Cynthia J ^a   Wu, Guoyao ^a,b  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PYRUVOYLTETRAHYDROPTERIN SYNTHASE; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ANTIOXIDANT; ARGININE; AROMATIC AMINO ACID; ATORVASTATIN; BASIC FIBROBLAST GROWTH FACTOR; CYCLOSPORIN A; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR; ESTROGEN; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; INSULIN; INTERLEUKIN 1; NERVE GROWTH FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHENYLALANINE; PHOSPHATIDYLINOSITOL 3 KINASE; STATIN; TETRAHYDROBIOPTERIN; TUMOR NECROSIS FACTOR ALPHA;

BLOOD VESSEL INJURY; BONE MARROW; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL REGENERATION; CIRCULATION; DIABETES MELLITUS; DIET SUPPLEMENTATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERTENSION; NONHUMAN; OXIDATIVE STRESS; PHOSPHORYLATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVASCULARIZATION; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR;

ANIMALS; BIOPTERIN; ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE SYNTHASE TYPE III;

EID: 80051471390     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.174003     Document Type: Review

References (11)

1. Tanaka K, Kaufman S, Milstien S. Tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylases, is synthesized by and regulates proliferation of erythroid cells. Proc Natl Acad Sci USA. 1989;86: 5864-5867. (Pubitemid 19217549)
2. Marinos RS, Zhang W, Wu G, Kelly KA, Meininger CJ. Tetrahydrobiopterin levels regulate endothelial cell proliferation. Am J Physiol Heart Circ Physiol. 2001;281:H482-H489.
3. Anastasiadis PZ, Bezin L, Imerman BA, Kuhn DM, Louie MC, Levine RA. Tetrahydrobiopterin as a mediator of PC12 cell proliferation induced by EGF and NGF. Eur J Neurosci. 1997;9:1831-1837. (Pubitemid 27429901)
4. Wei CC, Crane BR, Steuhr DJ. Tetrahydrobiopterin radical enzymology. Chem Rev. 2003;103:2365-2383.
5. Shi W, Meininger CJ, Haynes TE, Hatakeyama K, Wu G. Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells. Cell Biochem Biophys. 2004;41:415-434.
6. He T, Smith LA, Lu T, Joyner MJ, Katusic ZS. Activation of peroxisome proliferator-activated receptor-enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin. Hypertension. 2011;58:287-294.
7. Wang S, Xu J, Song P, Viollet B, Zou M-H. In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I. Diabetes. 2009;58:1893-1901.
8. Xie HH, Zhou S, Chen DD, Channon KM, Su DF, Chen AF. GTP cyclohydrolase I/BH4 pathway protects EPCs via suppressing oxidative stress and thrombospondin-1 in salt-sensitive hypertension. Hypertension. 2010;56:1137-1144.
9. Wenzel P, Daiber A, Oelze M, Brandt M, Closs E, Xu J, Thum T, Bauersachs J, Ertl G, Zou M-H, Forstermann U, Munzel T. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis. 2008;198:65-76.
10. Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, Rutten H, Fichtischerer S, Martin H, Zeiher AM. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest. 2001;108:391-397. (Pubitemid 32730785)
11. Kohli R, Meininger CJ, Haynes TE, Yan W, Self JT, Wu G. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J Nutr. 2004;134: 600-608. (Pubitemid 38298503)