Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure

Biochemical and Biophysical Research Communications

Volumn 338, Issue 4, 2005, Pages 1865-1874

  Daiber, Andreas ^a   Oelze, Matthias ^a   Coldewey, Meike ^a   Kaiser, K ^a   Huth, C ^a   Schildknecht, S ^b   Bachschmid, M ^b   Nazirisadeh, Y ^a   Ullrich, V ^b   Mulsch A ^a   Munzel T ^a   Tsilimingas, N ^c  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Hydralazine; Nitrate tolerance; NO signaling; Organic nitrates; Peroxynitrite; Radical scavenger; Superoxide

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; ANTIOXIDANT; CYCLIC GMP DEPENDENT PROTEIN KINASE; HYDRALAZINE; LUCIGENIN; NITRIC OXIDE; PEROXYNITRITE; PHENOL; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL FREE SYSTEM; CHEMOLUMINESCENCE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; FLUORESCENCE; MALE; MITOCHONDRION; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; RAT; SMOOTH MUSCLE;

ALDEHYDE DEHYDROGENASE; ANIMALS; ANTIOXIDANTS; CELL ADHESION MOLECULES; DRUG TOLERANCE; FREE RADICAL SCAVENGERS; HEART FAILURE, CONGESTIVE; HUMANS; HYDRALAZINE; MALE; MICROFILAMENT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NITROGLYCERIN; OXIDATIVE STRESS; PEROXYNITROUS ACID; PHOSPHOPROTEINS; PROGNOSIS; RATS; RATS, WISTAR; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES;

ANIMALIA;

EID: 27844580204     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.10.106     Document Type: Article

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