Mechanism of reversal of high glucose-induced endothelial nitric oxide synthase uncoupling by tanshinone IIA in human endothelial cell line EA.hy926

European Journal of Pharmacology

Volumn 697, Issue 1-3, 2012, Pages 97-105

  Zhou, Zhi Wei ^a   Xie, Xiao Liang ^b   Zhou, Shu Feng ^c   Li, Chun Guang ^a,d  

^a RMIT UNIVERSITY   (Australia)

^b INSTITUTE OF CEREAL AND OIL CROPS   (China)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

^d UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Endothelial dysfunction; Endothelial nitric oxide synthase uncoupling; NADPH oxidase; Tanshinone IIA; Tetrahydrobiopterin

Indexed keywords

DIHYDROBIOPTERIN; DIHYDROFOLATE REDUCTASE; DIMER; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; HEAT SHOCK PROTEIN 90; MONOMER; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; TANSHINONE IIA; TETRAHYDROBIOPTERIN; WORTMANNIN;

ARTICLE; CELL ADHESION; CELL STRESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIMERIZATION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME BINDING; ENZYME REGULATION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN EXPRESSION; PROTEIN TARGETING;

BIOPTERIN; CELL LINE; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENDOTHELIAL CELLS; GLUCOSE; GTP CYCLOHYDROLASE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; NADPH OXIDASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN KINASE INHIBITORS; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; SUPEROXIDES; TETRAHYDROFOLATE DEHYDROGENASE; UP-REGULATION;

EID: 84869504420     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.09.051     Document Type: Article

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