Activation of peroxisome proliferator-activated receptor-δ enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin

Hypertension

Volumn 58, Issue 2, 2011, Pages 287-294

  He, Tongrong ^a   Smith, Leslie A ^a   Lu, Tong ^b   Joyner, Michael J ^a   Katusic, Zvonimir S ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b Mayo Clinic College of Medicine   (United States)

Author keywords

endothelial NO synthase; endothelial progenitor cells; GTP cyclohydrolase I; Peroxisome proliferator activated receptor ; tetrahydrobiopterin

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMALL INTERFERING RNA; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; CAROTID ARTERY INJURY; CELL MIGRATION; CELL PROLIFERATION; CELL REGENERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIAL PROGENITOR CELL; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BIOPTERIN; CELL PROLIFERATION; ENDOTHELIAL CELLS; GTP CYCLOHYDROLASE; HUMANS; MICE; NG-NITROARGININE METHYL ESTER; PPAR DELTA; PROTO-ONCOGENE PROTEINS C-AKT; REGENERATION; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 80051470205     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.172189     Document Type: Article

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