Hydroxy-methylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease caveolin abundance

Circulation

Volumn 103, Issue 1, 2001, Pages 113-118

  Feron, Olivier ^a   Dessy, Chantal ^a   Desager, Jean Pierre ^a   Balligand, J L ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Atorvastatin; Cholesterol; Endothelium; Nitric oxide

Indexed keywords

ATORVASTATIN; CAVEOLIN; HEAT SHOCK PROTEIN 90; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NITRIC OXIDE SYNTHASE; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ANIMAL CELL; AORTA; ARTICLE; CATTLE; CHOLESTEROL METABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; LIPOPROTEIN METABOLISM; NONHUMAN; PRIORITY JOURNAL;

EID: 0035830412     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.103.1.113     Document Type: Article

References (23)

1. Current perspectives on statins
2. Effect of simvastatin on coronary atheroma: The Multicentre Anti-Atheroma Study (MAAS)
3. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels
4. Reduction in cardiovascular events during pravastatin therapy: Pooled analysis of clinical events of the Pravastatin Atherosclerosis Intervention Program
5. Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month
6. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture
7. Inhibition of cultured vascular smooth muscle cell migration by simvastatin (MK-733)
8. Direct effects of statins on the vascular wall
9. Effects of fluvastatin on growth of porcine and human vascular smooth muscle cells in vitro
10. Mevalonate-dependent inhibition of tmnsendothelial migration and chemotaxis of human peripheral blood neutrophils by pravastatin
11. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors increase fibrinolytic activity in rat aortic endothelial cells: Role of geranylgeranylation and Rho proteins
12. Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys
13. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells
14. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
15. Pravastatin sodium activates endothelial nitric oxide synthase independent of its cholesterol-lowering actions
16. Intracellular cholesterol transport
17. Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
18. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase
19. The endothelial nitric-oxide synthase-caveolin regulatory cycle
20. Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo
21. Dynamic activation of endothelial nitric oxide synthase by Hsp90
22. Caveolins, liquid-ordered domains, and signal transduction
23. Atherosclerosis and the two faces of endothelial nitric oxide synthase