AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats

British Journal of Pharmacology

Volumn 163, Issue 5, 2011, Pages 1078-1085

  Yang, Qin ^a,f   Xue, Hong Mei ^a,f   Wong, Wing Tak ^b   Tian, Xiao Yu ^b   Huang, Yu ^b   Tsui, Stephen Kw ^b   Ng, Patrick Ks ^b   Wohlfart, Paulus ^c   Li, Huige ^d   Xia, Ning ^d   Tobias, Silke ^d   Underwood, Malcolm John ^a,f   He, Guo Wei ^a,e,f  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c Therapeutic Domain Cardiovascular   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f NANKAI UNIVERSITY   (China)

Author keywords

cardiovascular diseases; endothelium; nitric oxide; nitric oxide synthase; SHR

Indexed keywords

3 NITROTYROSINE; ANTIHYPERTENSIVE AGENT; AVE 3085; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AORTA; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HYPERTENSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; UPREGULATION; VASODILATATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIHYPERTENSIVE AGENTS; AORTA, THORACIC; BENZODIOXOLES; BLOOD PRESSURE; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HYPERTENSION; INDANS; MALE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79958789023     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01308.x     Document Type: Article

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