Double-edged role of statins in angiogenesis signaling

Circulation Research

Volumn 90, Issue 6, 2002, Pages 737-744

  Urbich, Carmen ^a   Dernbach, Elisabeth ^a   Zeiher, Andreas M ^a   Dimmeler, Stefanie ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitors; Angiogenesis; Endothelium; Progenitor cells

Indexed keywords

ATORVASTATIN; COMPACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B;

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BACTERIAL PROTEINS; CELL MOVEMENT; CELLS, CULTURED; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENTEROTOXINS; FIBROBLASTS; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MONOCYTES; NEOVASCULARIZATION, PHYSIOLOGIC; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PYRROLES; SIGNAL TRANSDUCTION;

EID: 0037023634     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000014081.30867.F8     Document Type: Article

References (42)

1. Current perspectives on statins
2. HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis
3. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
4. Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS)
5. Hyperlipidemia and coronary disease: Correction of the increased thrombogenic potential with cholesterol reduction
6. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts
7. Improvement in coronary flow reserve determined by positron emission tomography after 6 months of cholesterol-lowering therapy in patients with early stages of coronary atherosclerosis
8. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
9. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
10. Simvastatin inhibits leukocyte-endothelial cell interactions and protects against inflammatory processes in normocholesterolemic rats
11. Activation of nitric oxide synthase in endothelial cells via Akt-dependent phosphorylation
12. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
13. Phosphorylation of the endothelial nitric oxide synthase at ser-1177 is required for VEGF-induced endothelial cell migration
14. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt
15. Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: Contribution to its antiangiogenic effect
16. Influence of gender on the pharmacokinetics, safety, and tolerability of cerivastatin in healthy adults
17. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
18. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization
19. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
20. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
21. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation
22. Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
23. Inhibition of cell migration, spreading and focal adhesions by tumor suppressor PTEN
24. Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway
25. Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease
26. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
27. The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap 1-dependent pathways
28. Endothelial exposure to hypoxia induces Egr-1 expression involving PKCα-mediated Ras/Raf-1/ERK1/2 pathway
29. Congestive heart failure induces endothelial cell apoptosis: Protective role of carvedilol
30. An in vitro model of angiogenesis: Basic features
31. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
32. The activation of phosphatidylinositol 3-kinase by Ras
33. Ras and Rho GTPases: A family reunion
34. HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells
35. Pharmacodynamics and pharmacokinetic-pharmacodynamic relationships of atorvastatin, an HMG-CoA reductase inhibitor
36. Targeting Rho in cardiovascular disease
37. Phosphorylation of cardiac protein kinase B (PKB) is regulated by fatty acids
38. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability
39. Akt is more than just a Bad kinase
40. Akt takes centre stage in angiogenesis signaling
41. Rho signals to cell growth and apoptosis
42. Cytoskeletal effects of rho-like small guanine nucleotide-binding proteins in the vascular system