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Volumn 272, Issue 5268, 1996, Pages 1621-1625

Sending and receiving the hedgehog signal: Control by the Drosophila gli protein Cubitus interruptus

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; ZINC FINGER PROTEIN;

EID: 0029896212     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5268.1621     Document Type: Article
Times cited : (276)

References (64)
  • 3
    • 0022803277 scopus 로고
    • T. Kornberg, I. Siden, P. O'Farrell, M. Simon, Cell 40, 45 (1985); D. L. Brower, EMBO J. 5, 2649 (1986).
    • (1986) EMBO J. , vol.5 , pp. 2649
    • Brower, D.L.1
  • 6
    • 0021993080 scopus 로고
    • A. Fjose, W. MacGinnis, W. Gehring, Nature 313, 284 (1985); S. J. Poole, L. Kauver, B. Drees, T. Kornberg, Cell 40, 31 (1985); C. Desplan, J. Theis, P. H. O'Farrell, Nature 318, 630 (1985).
    • (1985) Nature , vol.313 , pp. 284
    • Fjose, A.1    MacGinnis, W.2    Gehring, W.3
  • 7
    • 0021993080 scopus 로고
    • A. Fjose, W. MacGinnis, W. Gehring, Nature 313, 284 (1985); S. J. Poole, L. Kauver, B. Drees, T. Kornberg, Cell 40, 31 (1985); C. Desplan, J. Theis, P. H. O'Farrell, Nature 318, 630 (1985).
    • (1985) Cell , vol.40 , pp. 31
    • Poole, S.J.1    Kauver, L.2    Drees, B.3    Kornberg, T.4
  • 8
    • 0022347516 scopus 로고
    • A. Fjose, W. MacGinnis, W. Gehring, Nature 313, 284 (1985); S. J. Poole, L. Kauver, B. Drees, T. Kornberg, Cell 40, 31 (1985); C. Desplan, J. Theis, P. H. O'Farrell, Nature 318, 630 (1985).
    • (1985) Nature , vol.318 , pp. 630
    • Desplan, C.1    Theis, J.2    O'Farrell, P.H.3
  • 9
    • 0026783674 scopus 로고
    • J. J. Lee, D. P. von-Kessler, S. Parks, P. A. Beachy, Cell 71, 33 (1992); J. Mohler and K. Vani, Development 115, 957 (1992); T. Tabata, S. Eaton, T. B. Komberg, Genes Dev. 6, 2635 (1992).
    • (1992) Cell , vol.71 , pp. 33
    • Lee, J.J.1    Von-Kessler, D.P.2    Parks, S.3    Beachy, P.A.4
  • 10
    • 0026474841 scopus 로고
    • J. J. Lee, D. P. von-Kessler, S. Parks, P. A. Beachy, Cell 71, 33 (1992); J. Mohler and K. Vani, Development 115, 957 (1992); T. Tabata, S. Eaton, T. B. Komberg, Genes Dev. 6, 2635 (1992).
    • (1992) Development , vol.115 , pp. 957
    • Mohler, J.1    Vani, K.2
  • 11
    • 0027096741 scopus 로고
    • J. J. Lee, D. P. von-Kessler, S. Parks, P. A. Beachy, Cell 71, 33 (1992); J. Mohler and K. Vani, Development 115, 957 (1992); T. Tabata, S. Eaton, T. B. Komberg, Genes Dev. 6, 2635 (1992).
    • (1992) Genes Dev. , vol.6 , pp. 2635
    • Tabata, T.1    Eaton, S.2    Komberg, T.B.3
  • 12
    • 0028329349 scopus 로고
    • K. Basler and G. Struhl, Nature 368, 208 (1994); T. Tabata and T. B. Kornberg, Cell 76, 89 (1994).
    • (1994) Nature , vol.368 , pp. 208
    • Basler, K.1    Struhl, G.2
  • 13
    • 0028178786 scopus 로고
    • K. Basler and G. Struhl, Nature 368, 208 (1994); T. Tabata and T. B. Kornberg, Cell 76, 89 (1994).
    • (1994) Cell , vol.76 , pp. 89
    • Tabata, T.1    Kornberg, T.B.2
  • 14
    • 0016742320 scopus 로고
    • G. Morata and P. A. Lawrence, Nature 255, 614 (1975); P. A. Lawrence and G. Morata, Dev. Biol. 50, 321 (1976); T. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 78, 1095 (1981); P. A. Lawrence and G. Struhl, EMBO J. 1, 827 (1982); D. L. Brower, Nature 319, 496 (1984); D. Gubb, Wilhelm Roux's Arch. Dev. Biol. 194, 236 (1985); I. Guillén et al., Development 121, 3447 (1995).
    • (1975) Nature , vol.255 , pp. 614
    • Morata, G.1    Lawrence, P.A.2
  • 15
    • 0017127630 scopus 로고
    • G. Morata and P. A. Lawrence, Nature 255, 614 (1975); P. A. Lawrence and G. Morata, Dev. Biol. 50, 321 (1976); T. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 78, 1095 (1981); P. A. Lawrence and G. Struhl, EMBO J. 1, 827 (1982); D. L. Brower, Nature 319, 496 (1984); D. Gubb, Wilhelm Roux's Arch. Dev. Biol. 194, 236 (1985); I. Guillén et al., Development 121, 3447 (1995).
    • (1976) Dev. Biol. , vol.50 , pp. 321
    • Lawrence, P.A.1    Morata, G.2
  • 16
    • 0011923794 scopus 로고
    • G. Morata and P. A. Lawrence, Nature 255, 614 (1975); P. A. Lawrence and G. Morata, Dev. Biol. 50, 321 (1976); T. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 78, 1095 (1981); P. A. Lawrence and G. Struhl, EMBO J. 1, 827 (1982); D. L. Brower, Nature 319, 496 (1984); D. Gubb, Wilhelm Roux's Arch. Dev. Biol. 194, 236 (1985); I. Guillén et al., Development 121, 3447 (1995).
    • (1981) Proc. Natl. Acad. Sci. U.S.A. , vol.78 , pp. 1095
    • Kornberg, T.1
  • 17
    • 0020216423 scopus 로고
    • G. Morata and P. A. Lawrence, Nature 255, 614 (1975); P. A. Lawrence and G. Morata, Dev. Biol. 50, 321 (1976); T. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 78, 1095 (1981); P. A. Lawrence and G. Struhl, EMBO J. 1, 827 (1982); D. L. Brower, Nature 319, 496 (1984); D. Gubb, Wilhelm Roux's Arch. Dev. Biol. 194, 236 (1985); I. Guillén et al., Development 121, 3447 (1995).
    • (1982) EMBO J. , vol.1 , pp. 827
    • Lawrence, P.A.1    Struhl, G.2
  • 18
    • 0021132769 scopus 로고
    • G. Morata and P. A. Lawrence, Nature 255, 614 (1975); P. A. Lawrence and G. Morata, Dev. Biol. 50, 321 (1976); T. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 78, 1095 (1981); P. A. Lawrence and G. Struhl, EMBO J. 1, 827 (1982); D. L. Brower, Nature 319, 496 (1984); D. Gubb, Wilhelm Roux's Arch. Dev. Biol. 194, 236 (1985); I. Guillén et al., Development 121, 3447 (1995).
    • (1984) Nature , vol.319 , pp. 496
    • Brower, D.L.1
  • 19
    • 0021991679 scopus 로고
    • G. Morata and P. A. Lawrence, Nature 255, 614 (1975); P. A. Lawrence and G. Morata, Dev. Biol. 50, 321 (1976); T. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 78, 1095 (1981); P. A. Lawrence and G. Struhl, EMBO J. 1, 827 (1982); D. L. Brower, Nature 319, 496 (1984); D. Gubb, Wilhelm Roux's Arch. Dev. Biol. 194, 236 (1985); I. Guillén et al., Development 121, 3447 (1995).
    • (1985) Wilhelm Roux's Arch. Dev. Biol. , vol.194 , pp. 236
    • Gubb, D.1
  • 20
    • 0028880509 scopus 로고
    • G. Morata and P. A. Lawrence, Nature 255, 614 (1975); P. A. Lawrence and G. Morata, Dev. Biol. 50, 321 (1976); T. Kornberg, Proc. Natl. Acad. Sci. U.S.A. 78, 1095 (1981); P. A. Lawrence and G. Struhl, EMBO J. 1, 827 (1982); D. L. Brower, Nature 319, 496 (1984); D. Gubb, Wilhelm Roux's Arch. Dev. Biol. 194, 236 (1985); I. Guillén et al., Development 121, 3447 (1995).
    • (1995) Development , vol.121 , pp. 3447
    • Guillén, I.1
  • 24
    • 0025283924 scopus 로고
    • S. Eaton and T. B. Kornberg, Genes Dev. 4, 1068 (1990); C. Schwartz, J. Locke, C. Nishida, T. B. Kornberg, Development 121, 1625 (1995).
    • (1990) Genes Dev. , vol.4 , pp. 1068
    • Eaton, S.1    Kornberg, T.B.2
  • 32
    • 0028354709 scopus 로고
    • + advantage in the clone (19). The frequency of the ci clones was very low, one wing clone for 50 to 100 larvae dissected.
    • (1994) Mol. Gen. Genet. , vol.243 , pp. 234
    • Locke, J.1    Tartof, K.D.2
  • 34
    • 0027741258 scopus 로고
    • + chromosome. The cells in these ci clones are haplo fourth. In Fig. 1G, we show an example of a true recombination event between the fourth chromosome arms. The irregular shape of the twin spot indicates that all aspects of ci clones can be attributed to the lack of ci activity.
    • (1993) Cell , vol.75 , pp. 927
    • Ma, C.1    Zhou, Y.2    Beachy, P.A.3    Moses, K.4
  • 35
    • 0027160708 scopus 로고
    • The full-length ci cDNA was inserted into the vector pUAST [A. H. Brand and N. Perrimon, Development 118, 401 (1993)]. Three independent UAS-Ci strains were analyzed.
    • (1993) Development , vol.118 , pp. 401
    • Brand, A.H.1    Perrimon, N.2
  • 36
    • 15844428579 scopus 로고    scopus 로고
    • M. Dominguez, M. Brunner, E. Hafen, K. Basler, not shown
    • M. Dominguez, M. Brunner, E. Hafen, K. Basler, not shown.
  • 37
    • 15844420322 scopus 로고    scopus 로고
    • note
    • The inability of ectopically expressed Ci to repress hh in en-expressing cells may be due to the existence of a Ci cofactor (X) that, like ci, is present only in A cells as a result of direct en repression. In P cells that lack en activity, both the expression of ci and that of the hypothetical factor X will be derepressed, resulting in hh repression.
  • 40
    • 0028897883 scopus 로고    scopus 로고
    • W. Li, J. T. Ohlmeyer, M. E. Lane, D. Kalderon, Cell 80, 553 (1995); J. Jiang and G. Struhl, ibid., p. 563; D. Pan and G. M. Rubin, ibid., p. 543.
    • (1995) Cell , vol.80 , pp. 553
    • Li, W.1    Ohlmeyer, J.T.2    Lane, M.E.3    Kalderon, D.4
  • 41
    • 0028897883 scopus 로고    scopus 로고
    • W. Li, J. T. Ohlmeyer, M. E. Lane, D. Kalderon, Cell 80, 553 (1995); J. Jiang and G. Struhl, ibid., p. 563; D. Pan and G. M. Rubin, ibid., p. 543.
    • Cell , pp. 563
    • Jiang, J.1    Struhl, G.2
  • 42
    • 0028897883 scopus 로고    scopus 로고
    • W. Li, J. T. Ohlmeyer, M. E. Lane, D. Kalderon, Cell 80, 553 (1995); J. Jiang and G. Struhl, ibid., p. 563; D. Pan and G. M. Rubin, ibid., p. 543.
    • Cell , pp. 543
    • Pan, D.1    Rubin, G.M.2
  • 43
    • 0025907542 scopus 로고
    • S2. ptc mutant clones were detected by two methods: (i) by the loss of the CD2 marker within the ptc mutant tissue and (ii) by the ectopic expression of dpp-lacZ (11, 23-25). Transcription of ci was monitored by means of an enhancer trap line in the ci locus.
    • (1991) Science , vol.252 , pp. 958
    • Golic, K.G.1
  • 45
    • 0028874275 scopus 로고
    • En expression is not reduced in P cells that ectopically express Ci (21). Therefore, high levels of Ci can override the partial repression of dpp expression by En [M. Sanicola, J. J. Sekelsky, S. Elson, W. M. Gelbart, Genetics 139, 745 (1995)].
    • (1995) Genetics , vol.139 , pp. 745
    • Sanicola, M.1    Sekelsky, J.J.2    Elson, S.3    Gelbart, W.M.4
  • 46
    • 15844377643 scopus 로고    scopus 로고
    • note
    • +/+ flies were found in the progeny.
  • 48
    • 15844418485 scopus 로고    scopus 로고
    • note
    • Ptc expression is readily induced in all P cells, even by relatively low ectopic Ci expression levels (40), suggesting that, unlike dpp (28), ptc is not negatively regulated by En. Therefore, ptc expression is normally restricted to A cells because ci is not expressed in P cells. We observe higher levels of ptc expression in P cells than in A cells presumably because Ptc protein in P cells is inactive in repressing ptc expression because P cells are continuously exposed to the Hedgehog signal.
  • 52
    • 0027234988 scopus 로고
    • _, ibid. 364, 454 (1993).
    • (1993) Nature , vol.364 , pp. 454
  • 53
    • 0029004774 scopus 로고
    • J. S. Lee et al., Genes Dev. 9, 1188 (1995).
    • (1995) Genes Dev. , vol.9 , pp. 1188
    • Lee, J.S.1
  • 55
    • 0029022770 scopus 로고
    • F. Petrij et al., ibid. 376, 348 (1995).
    • (1995) Nature , vol.376 , pp. 348
    • Petrij, F.1
  • 57
    • 15844394661 scopus 로고    scopus 로고
    • note
    • W discs show a low level of ci misexpressed in the P compartment. This results in the transcriptional activation of ptc in P cells, indicating that ci positively regulates ptc transcription and that restriction of ptc expression to A cells by en is mediated indirectly by preventing ci expression in P cells.
  • 58
    • 0028281306 scopus 로고
    • C. C. Hui et al., Dev. Biol. 162, 402 (1994); A. L. Joyner, Trends Genet. 12, 15 (1996).
    • (1994) Dev. Biol. , vol.162 , pp. 402
    • Hui, C.C.1
  • 59
    • 0030069671 scopus 로고    scopus 로고
    • C. C. Hui et al., Dev. Biol. 162, 402 (1994); A. L. Joyner, Trends Genet. 12, 15 (1996).
    • (1996) Trends Genet. , vol.12 , pp. 15
    • Joyner, A.L.1
  • 60
    • 0025812172 scopus 로고
    • A. Vortkamp, M. Gessler, K.-H. Grzeschik, Nature 352, 539 (1991); T. Schimmang, F. van der Hoeven, U. Rüther, Prog. Clin. Biol. Res. 383A, 153 (1993); C. C. Hui and A. L. Joyner, Nature Genet. 3, 241 (1993).
    • (1991) Nature , vol.352 , pp. 539
    • Vortkamp, A.1    Gessler, M.2    Grzeschik, K.-H.3
  • 62
    • 0027478216 scopus 로고
    • A. Vortkamp, M. Gessler, K.-H. Grzeschik, Nature 352, 539 (1991); T. Schimmang, F. van der Hoeven, U. Rüther, Prog. Clin. Biol. Res. 383A, 153 (1993); C. C. Hui and A. L. Joyner, Nature Genet. 3, 241 (1993).
    • (1993) Nature Genet. , vol.3 , pp. 241
    • Hui, C.C.1    Joyner, A.L.2
  • 63
    • 0024964973 scopus 로고
    • N. H. Patel et al., Cell 58, 955 (1989).
    • (1989) Cell , vol.58 , pp. 955
    • Patel, N.H.1
  • 64
    • 15844393697 scopus 로고    scopus 로고
    • note
    • We thank R. Holmgren and J. Locke for antibodies to Ci and ci alleles, J. Alcedo and M. Noll for the ci cDNA, and S. Leevers and G. Struhl for comments on the manuscript. M. D. is supported by a postdoctoral fellowship from Human Frontier Science Program. This work was supported by grants from the Swiss National Science Foundation.


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