Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

Cell

Volumn 108, Issue 6, 2002, Pages 823-835

  Price, Mary Ann ^a   Kalderon, Daniel ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE I; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3; PHOSPHOSERINE; PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CI; UNCLASSIFIED DRUG;

ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DROSOPHILA; EMBRYO; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TARGET CELL; TRANSCRIPTION INITIATION;

CUBITUS INTERRUPTUS; DROSOPHILA; ERINACEIDAE; EUKARYOTA;

EID: 0037155737     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00664-5     Document Type: Article

References (54)

1. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
2. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
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9. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling
10. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis
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35. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
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