Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Götschel, Frank ^a   Berg, Daniela ^a   Gruber, Wolfgang ^b   Bender, Christian ^a   Eberl, Markus ^b,d   Friedel, Myriam ^a   Sonntag, Johanna ^a   Rüngeler, Elena ^a   Hache, Hendrik ^c   Wierling, Christoph ^c   Nietfeld, Wilfried ^c   Lehrach, Hans ^c   Frischauf, Annemarie ^b   Schwartz Albiez, Reinhard ^a   Aberger, Fritz ^b   Korf, Ulrike ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF SALZBURG   (Austria)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^d Comprehensive Cancer Center ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; EPIDERMAL GROWTH FACTOR RECEPTOR; INTERLEUKIN 8; MATRILYSIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN PATCHED; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; VASCULOTROPIN A;

ARTICLE; CONTROLLED STUDY; DAOY CELL LINE; ENZYME ACTIVITY; ENZYME REGULATION; GENE SEQUENCE; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MEDULLOBLASTOMA; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; TUMOR CELL LINE;

BLOTTING, WESTERN; CARRIER PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; CEREBELLAR NEOPLASMS; CYCLOHEXYLAMINES; DERMIS; DRUG SYNERGISM; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENE EXPRESSION PROFILING; HEDGEHOG PROTEINS; HEK293 CELLS; HUMANS; INTERLEUKIN-8; MATRIX METALLOPROTEINASE 7; MEDULLOBLASTOMA; MEMBRANE GLYCOPROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHORYLATION; PROTEIN ARRAY ANALYSIS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THIOPHENES; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VERATRUM ALKALOIDS;

ERINACEIDAE;

EID: 84878884934     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065403     Document Type: Article

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