Ci: A complex transducer of the Hedgehog signal

Trends in Genetics

Volumn 15, Issue 11, 1999, Pages 458-462

  Aza Blanc, Pedro ^a   Kornberg, Thomas B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHIMERIC PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; DNA BINDING PROTEIN; MORPHOGEN; PROTEIN SERINE THREONINE KINASE; TRANSCRIPTION FACTOR; TUBULIN;

CONCENTRATION (PARAMETERS); DNA TRANSCRIPTION; DROSOPHILA; GENE TARGETING; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; SIGNAL PROCESSING; SIGNAL TRANSDUCTION;

ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; INSECT PROTEINS; MEMBRANE PROTEINS; MORPHOGENESIS; PHENOTYPE; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WING;

CUBITUS; CUBITUS INTERRUPTUS; ERINACEIDAE;

EID: 0033230757     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(99)01869-7     Document Type: Review

References (58)

1. 1 Tabata, T. and Kornberg, T.B. (1994) Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs. Cell 76, 89-102
2. 2 Lee, J.J. et al. (1994) Autoproteolysis in hedgehog protein biogenesis. Science 266, 1528-1537
3. 3 Porter, J.A. et al. (1996) Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255-259
4. 4 Pepinsky, R.B. et al. (1998) Identification of a palmitic acid-modified form of human Sonic hedgehog. J. Biol. Chem. 273, 14037-14045
5. 5 Yang, Y. et al. (1997) Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404
6. 6 Strigini, M. and Cohen, S.M. (1997) A Hedgehog activity gradient contributes to AP axial patterning of the Drosophila wing. Development 124, 4697-4705
7. 7 Mullor, J.L. et al. (1997) Hedgehog activity, independent of decapentaplegic, participates in wing disc patterning. Development 124, 1227-1237
8. 8 Chen, Y. and Struhl, G. (1996) Dual roles for patched in sequestering and transducing Hedgehog. Cell 87, 553-563
9. 9 Bellaiche, Y. et al. (1998) Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature 394, 85-88
10. 10 Nakano, Y. et al. (1989) A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Nature 341, 508-513
11. 11 Hooper, J.E. and Scott, M.P. (1989) The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 59, 751-765
12. 12 Alcedo, J. et al. (1996) The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221-232
13. 13 van den Heuvel, M. and Ingham, P.W. (1996) smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature 382, 547-551
14. 14 Ingham, P.W. et al. (1991) Role of the Drosophila patched gene in positional signalling. Nature 353, 184-187
15. 15 Marigo, V. et al. (1996) Biochemical evidence that patched is the Hedgehog receptor. Nature 384, 176-179
16. 16 Stone, D.M. et al. (1996) The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature 384, 129-134
17. 17 Orenic, T. et al. (1987) Cell and cubitus interruptus Dominant: two segment polarity genes on the fourth chromosome in Drosophila. Dev. Biol. 124, 50-56
18. 18 Aza-Blanc, P. et al. (1997) Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89, 1043-1053
19. 19 Méthot, N. and Basler, K. (1999) Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96, 819-831
20. 20 Ohlmeyer, J.T. and Kalderon, D. (1998) Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 396, 749-753
21. 21 Alexandre, C. et al. (1996) Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10, 2003-2013
22. 22 Therond, P. et al. (1993) Molecular organisation and expression pattern of the segment polarity gene fused of Drosophila melanogaster. Mech. Dev. 44, 65-80
23. 23 Thérond, P.P. et al. (1996) Phosphorylation of the fused protein in response to signaling from hedgehog. Proc. Natl. Acad. Sci. U. S. A. 93, 4224-4228
24. 24 Préat, T. et al. (1993) Segmental polarity in Drosophila melanogaster. genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Genetics 135, 1047-1062
25. 25 Sisson, J.C. et al. (1997) Costal2, a novel kinesin-related protein in the Hedgehog/Patched signaling pathway. Cell 90, 235-245
26. 26 Robbins, D.J. et al. (1997) Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90, 225-234
27. 27 Lepage, T. et al. (1995) Signal transduction by cAMP-dependent protein kinase A in Drosophila limb patterning. Nature 373, 711-715
28. 28 Li, W. et al. (1995) Function of protein kinase A in hedgehog signal transduction and Drosophila imaginai disc development. Cell 80, 553-562
29. 29 Pan, D. and Rubin, G.M. (1995) Protein kinase and hedgehog act antagonistically in regulating decapentaplegic transcription in Drosophila imaginai discs. Cell 80, 543-552
30. 30 Jiang, J. and Struhl, G. (1995) Protein Kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563-572
31. 31 Akimaru, H. et al. (1997) Drosophila CBP is a co-activator of cubitus interruptus in Hedgehog signalling. Nature 386, 735-738
32. 32 Theodosiou, N.A. et al. (1998) slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. Development 125, 3411-3416
33. 33 Jiang, J. and Struhl, G. (1998) Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391, 493-496
34. 34 Tiniakov, G.G. and Terentieva, E.L. (1933) Cubitus interruptus, a new genovariation of the fourth chromosome of Drosophila melanogaster. Genetics 18, 117-120
35. 35 Eaton, S. and Kornberg. T.B. (1990) Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev. 4, 1068-1077
36. 36 Slusarski, D.C. et al. (1995) Mutations that alter the timing and pattern of cubitus interruptus gene expression in Drosophila melanogaster. Genetics 139, 229-240
37. 37 Schweizer, L. and Basler, K. (1998) Drosophila ciD encodes a hybrid Pangolin/Cubitus interruptus protein that diverts the Wingless into the Hedgehog signaling pathway. Mech. Dev. 78, 141-151
38. 38 Von Ohlen, T. and Hooper, J.E. (1999) The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling. Dev. Biol. 208, 147-156
39. 39 Schwartz, C. et al. (1995) Analysis of cubitus interruptus regulation in Drosophila embryos and imaginal disks. Development 121, 1625-1635
40. 40 Locke, J. and Tartof, K.D. (1994) Molecular analysis of cubitus interruptus (ci) mutations suggests an explanation for the unusual ci position effects. Mol. Gen. Genet. 243, 234-243
41. 41 Forbes, A.J. et al. (1993) Genetic analysis of hedgehog signaling in the Drosophila embryo. Development (Suppl.) 119, 115-124
42. 42 Domínguez, M. et al. (1996) Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-1625
43. 43 Hepker, J. et al. (1997) Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 124, 549-558
44. 44 Motzny, C.K. and Holmgren, R. (1995) The Drosophila Cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52, 137-150
45. 45 Orenic, T.V. et al. (1990) Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev. 4, 1053-1067
46. 46 Von Ohlen, T. et al. (1997) Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein. Proc. Natl. Acad. Sci. U. S. A. 94, 2404-2409
47. 47 Kissinger, C.R. et al. (1990) Structure of an engrailed homeodomain/DNA complex at 2.6 Å resolution: a framework for understanding homeodomain/DNA interactions. Cell 63, 579-590
48. 48 Vortkamp, A. et al. (1995) Identification of optimized target sequences for the GLI3 zinc finger protein. DNA Cell Biol. 14, 629-634
49. 49 Pavletich, N.P. and Pabo, C.O. (1993) Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers. Science 261, 1701-1707
50. 50 Lessing, D. and Nusse, R. (1998) Expression of wingless in the Drosophila embryo: a conserved cis-acting element lacking conserved Ci-binding sites is required for patched-mediated repression. Development 125, 1469-1476
51. 51 Chen, C-H. et al. (1999) Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98, 305-316
52. 52 Yoon, J.W. et al. (1998) GLI activates transcription through a herpes simplex viral protein 16-like activation domain. J. Biol. Chem. 273, 3496-3501
53. 53 Monnier, V. et al. (1998) Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway Curr. Biol. 8, 583-586
54. 54 Chen, Y. et al. (1998) Protein kinase A directly regulates the activity and proteolysis of cubitus interruptus. Proc. Natl. Acad. Sci. U. S. A. 95, 2349-2354
55. 55 Ohlmeyer, J.T. and Kalderon, D. (1997) Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos. Genes Dev. 11, 2250-2258
56. 56 Maschat, F. et al. (1998) engrailed and polyhomeotic interactions are required to maintain the A/P boundary of the Drosophila developing wing. Development 125, 2771-2780
57. 57 Liu, F. et al. (1998) Carboxy-terminally truncated Gli3 proteins associate with Smad. Nat. Genet. 20, 325-326
58. 58 Alves, G. et al. (1998) Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginai discs. Mech. Dev. 78, 17-31