메뉴 건너뛰기




Volumn 5, Issue MAY, 2014, Pages

Mechanisms linking excess adiposity and carcinogenesis promotion

Author keywords

Adipokine; Adipose tissue; Carcinogenesis; Hypoxia; Inflammation; Insulin resistance; Obesity

Indexed keywords

ADIPOCYTOKINE RECEPTOR; ADIPONECTIN RECEPTOR; C REACTIVE PROTEIN; CHITINASE; INTERLEUKIN 6; LEPTIN RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; OSTEOPONTIN; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84905437572     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00065     Document Type: Review
Times cited : (119)

References (340)
  • 1
    • 84856487711 scopus 로고    scopus 로고
    • Prevalence of obesity and trends in the distribution of body mass index among US adults 1999-2010.
    • doi: 10.1001/jama.2012.39
    • Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA (2012) 307:491-7. doi: 10.1001/jama.2012.39
    • (2012) JAMA , vol.307 , pp. 491-497
    • Flegal, K.M.1    Carroll, M.D.2    Kit, B.K.3    Ogden, C.L.4
  • 2
    • 84857058884 scopus 로고    scopus 로고
    • Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity
    • doi:10.1038/ijo.2011.100
    • Gómez-Ambrosi J, Silva C, Galofré JC, Escalada J, Santos S, Millán D, et al. Body mass index classification misses subjects with increased cardiometabolic risk factors related to elevated adiposity. Int J Obes (2012) 36:286-94. doi:10.1038/ijo.2011.100
    • (2012) Int J Obes , vol.36 , pp. 286-294
    • Gómez-Ambrosi, J.1    Silva, C.2    Galofré, J.C.3    Escalada, J.4    Santos, S.5    Millán, D.6
  • 3
    • 84866624456 scopus 로고    scopus 로고
    • Obesity: screening for the evident in obesity
    • doi:10.1038/nrendo.2012.165
    • Frühbeck G. Obesity: screening for the evident in obesity. Nat Rev Endocrinol (2012) 8:570-2. doi:10.1038/nrendo.2012.165
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 570-572
    • Frühbeck, G.1
  • 4
    • 84875657566 scopus 로고    scopus 로고
    • Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe
    • doi:10.1159/000350627
    • Frühbeck G, Toplak H, Woodward E, Yumuk V, Maislos M, Oppert JM. Obesity: the gateway to ill health - an EASO position statement on a rising public health, clinical and scientific challenge in Europe. Obes Facts (2013) 6:117-20. doi:10.1159/000350627
    • (2013) Obes Facts , vol.6 , pp. 117-120
    • Frühbeck, G.1    Toplak, H.2    Woodward, E.3    Yumuk, V.4    Maislos, M.5    Oppert, J.M.6
  • 5
    • 84861908399 scopus 로고    scopus 로고
    • Severe obesity: the neglected epidemic
    • doi:10.1159/000338566
    • Kral JG, Kava RA, Catalano PM, Moore BJ. Severe obesity: the neglected epidemic. Obes Facts (2012) 5:254-69. doi:10.1159/000338566
    • (2012) Obes Facts , vol.5 , pp. 254-269
    • Kral, J.G.1    Kava, R.A.2    Catalano, P.M.3    Moore, B.J.4
  • 6
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors 2001
    • doi:10.1001/jama.289.1.76
    • Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA (2003) 289:76-9. doi:10.1001/jama.289.1.76
    • (2003) JAMA , vol.289 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3    Dietz, W.H.4    Vinicor, F.5    Bales, V.S.6
  • 7
    • 33646363759 scopus 로고    scopus 로고
    • NAFLD, obesity, and bariatric surgery
    • doi:10.1053/jgastro.2006.03.041
    • Angulo P. NAFLD, obesity, and bariatric surgery. Gastroenterology (2006) 130:1848-52. doi:10.1053/j.gastro.2006.03.041
    • (2006) Gastroenterology , vol.130 , pp. 1848-1852
    • Angulo, P.1
  • 8
    • 77955507529 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome
    • doi:10.1017/S0029665110000030
    • Moore JB. Non-alcoholic fatty liver disease: the hepatic consequence of obesity and the metabolic syndrome. Proc Nutr Soc (2010) 69:211-20. doi:10.1017/S0029665110000030
    • (2010) Proc Nutr Soc , vol.69 , pp. 211-220
    • Moore, J.B.1
  • 9
    • 77349119425 scopus 로고    scopus 로고
    • Hepatic complications of obesity
    • doi:10.1016/j.gtc.2009.12.001
    • Diehl AM. Hepatic complications of obesity. Gastroenterol Clin North Am (2010) 39:57-68. doi:10.1016/j.gtc.2009.12.001
    • (2010) Gastroenterol Clin North Am , vol.39 , pp. 57-68
    • Diehl, A.M.1
  • 10
    • 45249117481 scopus 로고    scopus 로고
    • Obesity and obstructive sleep apnea-hypopnea syndrome
    • doi:10.1111/j.1467-789X.2008.00478.x
    • de Sousa AG, Cercato C, Mancini MC, Halpern A. Obesity and obstructive sleep apnea-hypopnea syndrome. Obes Rev (2008) 9:340-54. doi:10.1111/j.1467-789X.2008.00478.x
    • (2008) Obes Rev , vol.9 , pp. 340-354
    • de Sousa, A.G.1    Cercato, C.2    Mancini, M.C.3    Halpern, A.4
  • 11
    • 34547557620 scopus 로고    scopus 로고
    • Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients
    • doi:10.1183/09031936.00115006
    • Campo A, Frühbeck G, Zulueta JJ, Iriarte J, Seijo LM, Alcaide AB, et al. Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. Eur Respir J (2007) 30:223-31. doi:10.1183/09031936.00115006
    • (2007) Eur Respir J , vol.30 , pp. 223-231
    • Campo, A.1    Frühbeck, G.2    Zulueta, J.J.3    Iriarte, J.4    Seijo, L.M.5    Alcaide, A.B.6
  • 12
    • 0035992631 scopus 로고    scopus 로고
    • Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors
    • doi:10.1016/S0009-9120(02)00320-X
    • Gómez-Ambrosi J, Salvador J, Paramo JA, Orbe J, de Irala J, Diez-Caballero A, et al. Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin Biochem (2002) 35:315-20. doi:10.1016/S0009-9120(02)00320-X
    • (2002) Clin Biochem , vol.35 , pp. 315-320
    • Gómez-Ambrosi, J.1    Salvador, J.2    Paramo, J.A.3    Orbe, J.4    de Irala, J.5    Diez-Caballero, A.6
  • 13
    • 84876252443 scopus 로고    scopus 로고
    • Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment - a position paper of the obesity society and the American society of hypertension
    • doi:10.1002/oby.20181
    • Landsberg L, Aronne LJ, Beilin LJ, Burke V, Igel LI, Lloyd-Jones D, et al. Obesity-related hypertension: pathogenesis, cardiovascular risk, and treatment - a position paper of the obesity society and the American society of hypertension. Obesity (2013) 21:8-24. doi:10.1002/oby.20181
    • (2013) Obesity , vol.21 , pp. 8-24
    • Landsberg, L.1    Aronne, L.J.2    Beilin, L.J.3    Burke, V.4    Igel, L.I.5    Lloyd-Jones, D.6
  • 14
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • doi:10.1038/nature05487
    • Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature (2006) 444:875-80. doi:10.1038/nature05487
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 15
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
    • doi:10.1038/nrc1408
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer (2004) 4:579-91. doi:10.1038/nrc1408
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 16
    • 84884221010 scopus 로고    scopus 로고
    • Obesity as a major risk factor for cancer
    • doi:10.1155/2013/291546
    • De Pergola G, Silvestris F. Obesity as a major risk factor for cancer. J Obes (2013) 2013:291546. doi:10.1155/2013/291546
    • (2013) J Obes , vol.2013 , pp. 291546
    • De Pergola, G.1    Silvestris, F.2
  • 17
    • 84870329450 scopus 로고    scopus 로고
    • Minireview: the year in obesity and cancer
    • doi:10.1210/me.2012-1283
    • Hursting SD. Minireview: the year in obesity and cancer. Mol Endocrinol (2012) 26:1961-6. doi:10.1210/me.2012-1283
    • (2012) Mol Endocrinol , vol.26 , pp. 1961-1966
    • Hursting, S.D.1
  • 18
    • 84885180277 scopus 로고    scopus 로고
    • Mechanisms linking obesity and cancer
    • doi:10.1016/j.bbalip.2013.02.008
    • Louie SM, Roberts LS, Nomura DK. Mechanisms linking obesity and cancer. Biochim Biophys Acta (2013) 1831:1499-508. doi:10.1016/j.bbalip.2013.02.008
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 1499-1508
    • Louie, S.M.1    Roberts, L.S.2    Nomura, D.K.3
  • 19
    • 84890316374 scopus 로고    scopus 로고
    • Obesity, metabolism and the microenvironment: links to cancer
    • doi:10.4103/1477-3163.119606
    • Sundaram S, Johnson AR, Makowski L. Obesity, metabolism and the microenvironment: links to cancer. J Carcinog (2013) 12:19. doi:10.4103/1477-3163.119606
    • (2013) J Carcinog , vol.12 , pp. 19
    • Sundaram, S.1    Johnson, A.R.2    Makowski, L.3
  • 21
    • 4444237280 scopus 로고    scopus 로고
    • Obesity cancer
    • doi:10.1038/sj.onc.1207751
    • Calle EE, Thun MJ. Obesity and cancer. Oncogene (2004) 23:6365-78. doi:10.1038/sj.onc.1207751
    • (2004) Oncogene , vol.23 , pp. 6365-6378
    • Calle, E.E.1    Thun, M.J.2
  • 22
    • 84890562275 scopus 로고    scopus 로고
    • Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team
    • doi:10.1016/j.jhep.2013.08.011
    • Dyson J, Jaques B, Chattopadyhay D, Lochan R, Graham J, Das D, et al. Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team. J Hepatol (2014) 60:110-7. doi:10.1016/j.jhep.2013.08.011
    • (2014) J Hepatol , vol.60 , pp. 110-117
    • Dyson, J.1    Jaques, B.2    Chattopadyhay, D.3    Lochan, R.4    Graham, J.5    Das, D.6
  • 23
    • 84883087610 scopus 로고    scopus 로고
    • Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial
    • doi:10.1200/JCO.2012.48.4691
    • Kitahara CM, Berndt SI, de Gonzalez AB, Coleman HG, Schoen RE, Hayes RB, et al. Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. J Clin Oncol (2013) 31:2450-9. doi:10.1200/JCO.2012.48.4691
    • (2013) J Clin Oncol , vol.31 , pp. 2450-2459
    • Kitahara, C.M.1    Berndt, S.I.2    de Gonzalez, A.B.3    Coleman, H.G.4    Schoen, R.E.5    Hayes, R.B.6
  • 25
    • 84872967522 scopus 로고    scopus 로고
    • Cancer statistics, 2013.
    • doi:10.3322/caac.21166
    • Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin (2013) 63:11-30. doi:10.3322/caac.21166
    • (2013) CA Cancer J Clin , vol.63 , pp. 11-30
    • Siegel, R.1    Naishadham, D.2    Jemal, A.3
  • 26
    • 84929844473 scopus 로고    scopus 로고
    • Recent trends in incidence of five common cancers in 26 European countries since 1988 analysis of the European cancer observatory
    • doi:10.1016/j.ejca.2013.09.002
    • Arnold M, Karim-Kos HE, Coebergh JW, Byrnes G, Antilla A, Ferlay J, et al. Recent trends in incidence of five common cancers in 26 European countries since 1988: analysis of the European cancer observatory. Eur J Cancer (2013). doi:10.1016/j.ejca.2013.09.002
    • (2013) Eur J Cancer
    • Arnold, M.1    Karim-Kos, H.E.2    Coebergh, J.W.3    Byrnes, G.4    Antilla, A.5    Ferlay, J.6
  • 27
    • 84875804295 scopus 로고    scopus 로고
    • Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012
    • doi:10.1016/j.ejca.2012.12.027
    • Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer (2013) 49:1374-403. doi:10.1016/j.ejca.2012.12.027
    • (2013) Eur J Cancer , vol.49 , pp. 1374-1403
    • Ferlay, J.1    Steliarova-Foucher, E.2    Lortet-Tieulent, J.3    Rosso, S.4    Coebergh, J.W.5    Comber, H.6
  • 28
    • 77956641580 scopus 로고    scopus 로고
    • Lifestyle changes and reduction of colon cancer incidence in Europe: a scenario study of physical activity promotion and weight reduction
    • doi:10.1016/j.ejca.2010.07.040
    • de Vries E, Soerjomataram I, Lemmens VE, Coebergh JW, Barendregt JJ, Oenema A, et al. Lifestyle changes and reduction of colon cancer incidence in Europe: a scenario study of physical activity promotion and weight reduction. Eur J Cancer (2010) 46:2605-16. doi:10.1016/j.ejca.2010.07.040
    • (2010) Eur J Cancer , vol.46 , pp. 2605-2616
    • de Vries, E.1    Soerjomataram, I.2    Lemmens, V.E.3    Coebergh, J.W.4    Barendregt, J.J.5    Oenema, A.6
  • 29
    • 84870804351 scopus 로고    scopus 로고
    • Colorectal cancer screening: practice guidelines
    • doi:10.1159/000341891
    • Lieberman D. Colorectal cancer screening: practice guidelines. Dig Dis (2012) 30(Suppl 2):34-8. doi:10.1159/000341891
    • (2012) Dig Dis , vol.30 , Issue.SUPPL. 2 , pp. 34-38
    • Lieberman, D.1
  • 30
    • 84871919116 scopus 로고    scopus 로고
    • Risk stratification in prostate cancer screening
    • doi:10.1038/nrurol.2013.84
    • Roobol MJ, Carlsson SV. Risk stratification in prostate cancer screening. Nat Rev Urol (2013) 10:38-48. doi:10.1038/nrurol.2013.84
    • (2013) Nat Rev Urol , vol.10 , pp. 38-48
    • Roobol, M.J.1    Carlsson, S.V.2
  • 31
    • 84874747481 scopus 로고    scopus 로고
    • Cancer screening in the United States 2013 a review of current American cancer society guidelines, current issues in cancer screening, and new guidance on cervical cancer screening and lung cancer screening
    • doi:10.3322/caac.21174
    • Smith RA, Brooks D, Cokkinides V, Saslow D, Brawley OW. Cancer screening in the United States, 2013: a review of current American cancer society guidelines, current issues in cancer screening, and new guidance on cervical cancer screening and lung cancer screening. CA Cancer J Clin (2013) 63:88-105. doi:10.3322/caac.21174
    • (2013) CA Cancer J Clin , vol.63 , pp. 88-105
    • Smith, R.A.1    Brooks, D.2    Cokkinides, V.3    Saslow, D.4    Brawley, O.W.5
  • 32
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U
    • doi:10.1056/NEJMoa021423
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 348:1625-38. doi:10.1056/NEJMoa021423
    • (2003) S. adults. N Engl J Med , vol.348 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 33
    • 84889061120 scopus 로고    scopus 로고
    • Obesity, mortality, and life years lost associated with breast cancer in nonsmoking US women, national health interview survey 1997-2000.
    • doi:10.5888/pcd10.130112
    • Chang SH, Pollack LM, Colditz GA. Obesity, mortality, and life years lost associated with breast cancer in nonsmoking US women, national health interview survey, 1997-2000. Prev Chronic Dis (2013) 10:E186. doi:10.5888/pcd10.130112
    • (2013) Prev Chronic Dis , vol.10
    • Chang, S.H.1    Pollack, L.M.2    Colditz, G.A.3
  • 34
    • 84893689729 scopus 로고    scopus 로고
    • The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis
    • doi:10.1016/j.diabres.2013.11.025
    • Ghaem Maralani H, Tai BC, Wong TY, Tai ES, Li J, Wang JJ, et al. The prognostic role of body mass index on mortality amongst the middle-aged and elderly: a competing risk analysis. Diabetes Res Clin Pract (2013) 103(1):42-50. doi:10.1016/j.diabres.2013.11.025
    • (2013) Diabetes Res Clin Pract , vol.103 , Issue.1 , pp. 42-50
    • Ghaem Maralani, H.1    Tai, B.C.2    Wong, T.Y.3    Tai, E.S.4    Li, J.5    Wang, J.J.6
  • 35
    • 84891823354 scopus 로고    scopus 로고
    • Obesity paradox does exist
    • doi:10.2337/dcS13-2023
    • Hainer V, Aldhoon-Hainerova I. Obesity paradox does exist. Diabetes Care (2013) 36(Suppl 2):S276-81. doi:10.2337/dcS13-2023
    • (2013) Diabetes Care , vol.36 , Issue.SUPPL. 2
    • Hainer, V.1    Aldhoon-Hainerova, I.2
  • 36
    • 0037138577 scopus 로고    scopus 로고
    • The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox?
    • doi:10.1016/S0735-1097(01)01802-2
    • Gruberg L, Weissman NJ, Waksman R, Fuchs S, Deible R, Pinnow EE, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol (2002) 39:578-84. doi:10.1016/S0735-1097(01)01802-2
    • (2002) J Am Coll Cardiol , vol.39 , pp. 578-584
    • Gruberg, L.1    Weissman, N.J.2    Waksman, R.3    Fuchs, S.4    Deible, R.5    Pinnow, E.E.6
  • 37
    • 84896712096 scopus 로고    scopus 로고
    • Body mass index and mortality in acutely decompensated heart failure across the world: a global obesity paradox
    • doi:10.1016/j.jacc.2013.09.072
    • Shah R, Gayat E, Januzzi JL Jr, Sato N, Cohen-Solal A, Disomma S, et al. Body mass index and mortality in acutely decompensated heart failure across the world: a global obesity paradox. J Am Coll Cardiol (2014) 63:778-85. doi:10.1016/j.jacc.2013.09.072
    • (2014) J Am Coll Cardiol , vol.63 , pp. 778-785
    • Shah, R.1    Gayat, E.2    Januzzi Jr., J.L.3    Sato, N.4    Cohen-Solal, A.5    Disomma, S.6
  • 38
    • 84871780946 scopus 로고    scopus 로고
    • Does body mass index adequately convey a patient's mortality risk?
    • doi:10.1001/jama.2012.185445
    • Heymsfield SB, Cefalu WT. Does body mass index adequately convey a patient's mortality risk? JAMA (2013) 309:87-8. doi:10.1001/jama.2012.185445
    • (2013) JAMA , vol.309 , pp. 87-88
    • Heymsfield, S.B.1    Cefalu, W.T.2
  • 39
    • 54549102428 scopus 로고    scopus 로고
    • Weight, height, body mass index and risk of breast cancer in postmenopausal women: a case-control study
    • doi:10.1186/1471-2407-8-278
    • Montazeri A, Sadighi J, Farzadi F, Maftoon F, Vahdaninia M, Ansari M, et al. Weight, height, body mass index and risk of breast cancer in postmenopausal women: a case-control study. BMC Cancer (2008) 8:278. doi:10.1186/1471-2407-8-278
    • (2008) BMC Cancer , vol.8 , pp. 278
    • Montazeri, A.1    Sadighi, J.2    Farzadi, F.3    Maftoon, F.4    Vahdaninia, M.5    Ansari, M.6
  • 40
    • 51649090407 scopus 로고    scopus 로고
    • Relationship between obesity and pathologic response to neoadjuvant chemotherapy among women with operable breast cancer
    • doi:10.1200/JCO.2007.14.4527
    • Litton JK, Gonzalez-Angulo AM, Warneke CL, Buzdar AU, Kau SW, Bondy M, et al. Relationship between obesity and pathologic response to neoadjuvant chemotherapy among women with operable breast cancer. J Clin Oncol (2008) 26:4072-7. doi:10.1200/JCO.2007.14.4527
    • (2008) J Clin Oncol , vol.26 , pp. 4072-4077
    • Litton, J.K.1    Gonzalez-Angulo, A.M.2    Warneke, C.L.3    Buzdar, A.U.4    Kau, S.W.5    Bondy, M.6
  • 41
    • 51649125007 scopus 로고    scopus 로고
    • Effect of obesity and other lifestyle factors on mortality in women with breast cancer
    • doi:10.1002/ijc.23747
    • Dal Maso L, Zucchetto A, Talamini R, Serraino D, Stocco CF, Vercelli M, et al. Effect of obesity and other lifestyle factors on mortality in women with breast cancer. Int J Cancer (2008) 123:2188-94. doi:10.1002/ijc.23747
    • (2008) Int J Cancer , vol.123 , pp. 2188-2194
    • Dal Maso, L.1    Zucchetto, A.2    Talamini, R.3    Serraino, D.4    Stocco, C.F.5    Vercelli, M.6
  • 42
    • 41549103014 scopus 로고    scopus 로고
    • Prognostic value of body mass index in locally advanced breast cancer
    • doi:10.1158/1078-0432.CCR-07-1479
    • Dawood S, Broglio K, Gonzalez-Angulo AM, Kau SW, Islam R, Hortobagyi GN, et al. Prognostic value of body mass index in locally advanced breast cancer. Clin Cancer Res (2008) 14:1718-25. doi:10.1158/1078-0432.CCR-07-1479
    • (2008) Clin Cancer Res , vol.14 , pp. 1718-1725
    • Dawood, S.1    Broglio, K.2    Gonzalez-Angulo, A.M.3    Kau, S.W.4    Islam, R.5    Hortobagyi, G.N.6
  • 45
    • 4043139452 scopus 로고    scopus 로고
    • Body size and breast cancer risk: findings from the European prospective investigation into cancer and nutrition (EPIC)
    • doi:10.1002/ijc.20315
    • Lahmann PH, Hoffmann K, Allen N, van Gils CH, Khaw KT, Tehard B, et al. Body size and breast cancer risk: findings from the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer (2004) 111:762-71. doi:10.1002/ijc.20315
    • (2004) Int J Cancer , vol.111 , pp. 762-771
    • Lahmann, P.H.1    Hoffmann, K.2    Allen, N.3    van Gils, C.H.4    Khaw, K.T.5    Tehard, B.6
  • 46
    • 33846846439 scopus 로고    scopus 로고
    • Body composition and breast cancer in postmenopausal women: a Danish prospective cohort study
    • doi:10.1038/oby.2006.214
    • Mellemkjaer L, Bigaard J, Tjonneland A, Christensen J, Thomsen B, Johansen C, et al. Body composition and breast cancer in postmenopausal women: a Danish prospective cohort study. Obesity (2006) 14:1854-62. doi:10.1038/oby.2006.214
    • (2006) Obesity , vol.14 , pp. 1854-1862
    • Mellemkjaer, L.1    Bigaard, J.2    Tjonneland, A.3    Christensen, J.4    Thomsen, B.5    Johansen, C.6
  • 48
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    • doi:10.1016/S0140-6736(08)60269-X
    • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet (2008) 371:569-78. doi:10.1016/S0140-6736(08)60269-X
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 49
    • 0142089885 scopus 로고    scopus 로고
    • Familial relative risk of colorectal cancer: a population-based study
    • doi:10.1016/S0959-8049(03)00420-9
    • Andrieu N, Launoy G, Guillois R, Ory-Paoletti C, Gignoux M. Familial relative risk of colorectal cancer: a population-based study. Eur J Cancer (2003) 39:1904-11. doi:10.1016/S0959-8049(03)00420-9
    • (2003) Eur J Cancer , vol.39 , pp. 1904-1911
    • Andrieu, N.1    Launoy, G.2    Guillois, R.3    Ory-Paoletti, C.4    Gignoux, M.5
  • 50
    • 77649088553 scopus 로고    scopus 로고
    • An association between colonic adenoma and abdominal obesity: a cross-sectional study
    • doi:10.1186/1471-230X-9-4
    • Kim Y, Lee S. An association between colonic adenoma and abdominal obesity: a cross-sectional study. BMC Gastroenterol (2009) 9:4. doi:10.1186/1471-230X-9-4
    • (2009) BMC Gastroenterol , vol.9 , pp. 4
    • Kim, Y.1    Lee, S.2
  • 51
    • 47249146075 scopus 로고    scopus 로고
    • Prospective weight change and colon cancer risk in male US health professionals
    • doi:10.1002/ijc.23612
    • Thygesen LC, Gronbaek M, Johansen C, Fuchs CS, Willett WC, Giovannucci E. Prospective weight change and colon cancer risk in male US health professionals. Int J Cancer (2008) 123:1160-5. doi:10.1002/ijc.23612
    • (2008) Int J Cancer , vol.123 , pp. 1160-1165
    • Thygesen, L.C.1    Gronbaek, M.2    Johansen, C.3    Fuchs, C.S.4    Willett, W.C.5    Giovannucci, E.6
  • 52
    • 84883300849 scopus 로고    scopus 로고
    • Linking obesity to colorectal cancer: recent insights into plausible biological mechanisms
    • doi:10.1097/MCO.0b013e328362d10b
    • Guffey CR, Fan D, Singh UP, Murphy EA. Linking obesity to colorectal cancer: recent insights into plausible biological mechanisms. Curr Opin Clin Nutr Metab Care (2013) 16:595-600. doi:10.1097/MCO.0b013e328362d10b
    • (2013) Curr Opin Clin Nutr Metab Care , vol.16 , pp. 595-600
    • Guffey, C.R.1    Fan, D.2    Singh, U.P.3    Murphy, E.A.4
  • 53
    • 84872508753 scopus 로고    scopus 로고
    • Obesity and risk of colorectal cancer: a systematic review of prospective studies
    • doi:10.1371/journal.pone.0053916
    • Ma Y, Yang Y, Wang F, Zhang P, Shi C, Zou Y, et al. Obesity and risk of colorectal cancer: a systematic review of prospective studies. PLoS One (2013) 8:e53916. doi:10.1371/journal.pone.0053916
    • (2013) PLoS One , vol.8
    • Ma, Y.1    Yang, Y.2    Wang, F.3    Zhang, P.4    Shi, C.5    Zou, Y.6
  • 54
    • 27744510730 scopus 로고    scopus 로고
    • High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish mammography cohort
    • Larsson SC, Bergkvist L, Wolk A. High-fat dairy food and conjugated linoleic acid intakes in relation to colorectal cancer incidence in the Swedish mammography cohort. Am J Clin Nutr (2005) 82:894-900.
    • (2005) Am J Clin Nutr , vol.82 , pp. 894-900
    • Larsson, S.C.1    Bergkvist, L.2    Wolk, A.3
  • 55
    • 84876911392 scopus 로고    scopus 로고
    • Obesity and colorectal cancer
    • doi:10.1136/gutjnl-2013-304701
    • Bardou M, Barkun AN, Martel M. Obesity and colorectal cancer. Gut (2013) 62:933-47. doi:10.1136/gutjnl-2013-304701
    • (2013) Gut , vol.62 , pp. 933-947
    • Bardou, M.1    Barkun, A.N.2    Martel, M.3
  • 56
    • 84867986644 scopus 로고    scopus 로고
    • Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer
    • doi:10.1007/s10552-012-0066-z
    • Chen J, Iverson D. Estrogen in obesity-associated colon cancer: friend or foe? Protecting postmenopausal women but promoting late-stage colon cancer. Cancer Causes Control (2012) 23:1767-73. doi:10.1007/s10552-012-0066-z
    • (2012) Cancer Causes Control , vol.23 , pp. 1767-1773
    • Chen, J.1    Iverson, D.2
  • 57
    • 84859412422 scopus 로고    scopus 로고
    • Body mass index increases risk for colorectal adenomas based on meta-analysis
    • doi:10.1053/j.gastro.2011.12.050
    • Ben Q, An W, Jiang Y, Zhan X, Du Y, Cai QC, et al. Body mass index increases risk for colorectal adenomas based on meta-analysis. Gastroenterology (2012) 142:762-72. doi:10.1053/j.gastro.2011.12.050
    • (2012) Gastroenterology , vol.142 , pp. 762-772
    • Ben, Q.1    An, W.2    Jiang, Y.3    Zhan, X.4    Du, Y.5    Cai, Q.C.6
  • 58
    • 4043156353 scopus 로고    scopus 로고
    • Body mass index and risk of colorectal cancer in women (United States)
    • doi:10.1023/B:CACO.0000036168.23351.f1
    • Lin J, Zhang SM, Cook NR, Rexrode KM, Lee IM, Buring JE. Body mass index and risk of colorectal cancer in women (United States). Cancer Causes Control (2004) 15:581-9. doi:10.1023/B:CACO.0000036168.23351.f1
    • (2004) Cancer Causes Control , vol.15 , pp. 581-589
    • Lin, J.1    Zhang, S.M.2    Cook, N.R.3    Rexrode, K.M.4    Lee, I.M.5    Buring, J.E.6
  • 59
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • doi:10.1038/nature12347
    • Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature (2013) 499:97-101. doi:10.1038/nature12347
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3    Kanda, H.4    Sato, S.5    Oyadomari, S.6
  • 60
    • 84860266865 scopus 로고    scopus 로고
    • International variation in prostate cancer incidence and mortality rates
    • doi:10.1016/j.eururo.2012.02.054
    • Center MM, Jemal A, Lortet-Tieulent J, Ward E, Ferlay J, Brawley O, et al. International variation in prostate cancer incidence and mortality rates. Eur Urol (2012) 61:1079-92. doi:10.1016/j.eururo.2012.02.054
    • (2012) Eur Urol , vol.61 , pp. 1079-1092
    • Center, M.M.1    Jemal, A.2    Lortet-Tieulent, J.3    Ward, E.4    Ferlay, J.5    Brawley, O.6
  • 61
    • 0035254979 scopus 로고    scopus 로고
    • Overweight as an avoidable cause of cancer in Europe
    • doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1053>3.0.CO;2-T
    • Bergström A, Pisani P, Tenet V, Wolk A, Adami HO. Overweight as an avoidable cause of cancer in Europe. Int J Cancer (2001) 91:421-30. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1053>3.0.CO;2-T
    • (2001) Int J Cancer , vol.91 , pp. 421-430
    • Bergström, A.1    Pisani, P.2    Tenet, V.3    Wolk, A.4    Adami, H.O.5
  • 62
    • 33747883049 scopus 로고    scopus 로고
    • Body size and composition and prostate cancer risk: systematic review and meta-regression analysis
    • doi:10.1007/s10552-006-0074-y
    • MacInnis RJ, English DR. Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control (2006) 17:989-1003. doi:10.1007/s10552-006-0074-y
    • (2006) Cancer Causes Control , vol.17 , pp. 989-1003
    • MacInnis, R.J.1    English, D.R.2
  • 63
    • 35148855370 scopus 로고    scopus 로고
    • Association of obesity with tumor characteristics and treatment failure of prostate cancer in African-American and European American men
    • doi:10.1016/j.juro.2007.07.021
    • Spangler E, Zeigler-Johnson CM, Coomes M, Malkowicz SB, Wein A, Rebbeck TR. Association of obesity with tumor characteristics and treatment failure of prostate cancer in African-American and European American men. J Urol (2007) 178:1939-44. doi:10.1016/j.juro.2007.07.021
    • (2007) J Urol , vol.178 , pp. 1939-1944
    • Spangler, E.1    Zeigler-Johnson, C.M.2    Coomes, M.3    Malkowicz, S.B.4    Wein, A.5    Rebbeck, T.R.6
  • 64
    • 0031052119 scopus 로고    scopus 로고
    • Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish construction workers
    • doi:10.1093/jnci/89.5.385
    • Andersson SO, Wolk A, Bergstrom R, Adami HO, Engholm G, Englund A, et al. Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish construction workers. J Natl Cancer Inst (1997) 89:385-9. doi:10.1093/jnci/89.5.385
    • (1997) J Natl Cancer Inst , vol.89 , pp. 385-389
    • Andersson, S.O.1    Wolk, A.2    Bergstrom, R.3    Adami, H.O.4    Engholm, G.5    Englund, A.6
  • 66
    • 0242298218 scopus 로고    scopus 로고
    • Height, body mass index, and prostate cancer: a follow-up of 950000 Norwegian men
    • doi:10.1038/sj.bjc.6601206
    • Engeland A, Tretli S, Bjorge T. Height, body mass index, and prostate cancer: a follow-up of 950000 Norwegian men. Br J Cancer (2003) 89:1237-42. doi:10.1038/sj.bjc.6601206
    • (2003) Br J Cancer , vol.89 , pp. 1237-1242
    • Engeland, A.1    Tretli, S.2    Bjorge, T.3
  • 67
    • 13544267779 scopus 로고    scopus 로고
    • Obesity and the risk of prostate cancer
    • doi:10.1002/pros.20121
    • Porter MP, Stanford JL. Obesity and the risk of prostate cancer. Prostate (2005) 62:316-21. doi:10.1002/pros.20121
    • (2005) Prostate , vol.62 , pp. 316-321
    • Porter, M.P.1    Stanford, J.L.2
  • 68
    • 33750530552 scopus 로고    scopus 로고
    • Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial
    • doi:10.1158/1055-9965.EPI-06-0477
    • Gong Z, Neuhouser ML, Goodman PJ, Albanes D, Chi C, Hsing AW, et al. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev (2006) 15:1977-83. doi:10.1158/1055-9965.EPI-06-0477
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1977-1983
    • Gong, Z.1    Neuhouser, M.L.2    Goodman, P.J.3    Albanes, D.4    Chi, C.5    Hsing, A.W.6
  • 69
    • 33846570585 scopus 로고    scopus 로고
    • Body mass index, weight change, and risk of prostate cancer in the cancer prevention study II nutrition cohort
    • doi:10.1158/1055-9965.EPI-06-0754
    • Rodriguez C, Freedland SJ, Deka A, Jacobs EJ, McCullough ML, Patel AV, et al. Body mass index, weight change, and risk of prostate cancer in the cancer prevention study II nutrition cohort. Cancer Epidemiol Biomarkers Prev (2007) 16:63-9. doi:10.1158/1055-9965.EPI-06-0754
    • (2007) Cancer Epidemiol Biomarkers Prev
    • Rodriguez, C.1    Freedland, S.J.2    Deka, A.3    Jacobs, E.J.4    McCullough, M.L.5    Patel, A.V.6
  • 70
    • 33846912761 scopus 로고    scopus 로고
    • Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality
    • doi:10.1002/cncr.22443
    • Wright ME, Chang SC, Schatzkin A, Albanes D, Kipnis V, Mouw T, et al. Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer (2007) 109:675-84. doi:10.1002/cncr.22443
    • (2007) Cancer , vol.16 , pp. 63-69
    • Wright, M.E.1    Chang, S.C.2    Schatzkin, A.3    Albanes, D.4    Kipnis, V.5    Mouw, T.6
  • 71
    • 84876059411 scopus 로고    scopus 로고
    • Obesity and prostate cancer: weighing the evidence
    • doi:10.1016/j.eururo.2012.11.013
    • Allott EH, Masko EM, Freedland SJ. Obesity and prostate cancer: weighing the evidence. Eur Urol (2013) 63:800-9. doi:10.1016/j.eururo.2012.11.013
    • (2013) Eur Urol , vol.63 , pp. 800-809
    • Allott, E.H.1    Masko, E.M.2    Freedland, S.J.3
  • 72
    • 84872842637 scopus 로고    scopus 로고
    • Obesity and incidence of lung cancer: a meta-analysis
    • doi:10.1002/ijc.27719
    • Yang Y, Dong J, Sun K, Zhao L, Zhao F, Wang L, et al. Obesity and incidence of lung cancer: a meta-analysis. Int J Cancer (2013) 132:1162-9. doi:10.1002/ijc.27719
    • (2013) Int J Cancer , vol.132 , pp. 1162-1169
    • Yang, Y.1    Dong, J.2    Sun, K.3    Zhao, L.4    Zhao, F.5    Wang, L.6
  • 73
    • 84873999011 scopus 로고    scopus 로고
    • Comments on a recent meta-analysis: obesity and lung cancer
    • doi:10.1002/ijc.27854
    • El-Zein M, Parent ME, Rousseau MC. Comments on a recent meta-analysis: obesity and lung cancer. Int J Cancer (2013) 132:1962-3. doi:10.1002/ijc.27854
    • (2013) Int J Cancer , vol.132 , pp. 1962-1963
    • El-Zein, M.1    Parent, M.E.2    Rousseau, M.C.3
  • 74
    • 0026696915 scopus 로고
    • Body mass index and lung cancer risk
    • Kabat GC, Wynder EL. Body mass index and lung cancer risk. Am J Epidemiol (1992) 135:769-74.
    • (1992) Am J Epidemiol , vol.135 , pp. 769-774
    • Kabat, G.C.1    Wynder, E.L.2
  • 75
    • 77952476547 scopus 로고    scopus 로고
    • Lifestyle as risk factor for cancer: evidence from human studies
    • doi:10.1016/j.canlet.2009.12.013
    • Khan N, Afaq F, Mukhtar H. Lifestyle as risk factor for cancer: evidence from human studies. Cancer Lett (2010) 293:133-43. doi:10.1016/j.canlet.2009.12.013
    • (2010) Cancer Lett , vol.293 , pp. 133-143
    • Khan, N.1    Afaq, F.2    Mukhtar, H.3
  • 76
    • 46749109232 scopus 로고    scopus 로고
    • Body mass index and waist circumference in relation to lung cancer risk in the women's health initiative
    • doi:10.1093/aje/kwn109
    • Kabat GC, Kim M, Hunt JR, Chlebowski RT, Rohan TE. Body mass index and waist circumference in relation to lung cancer risk in the women's health initiative. Am J Epidemiol (2008) 168:158-69. doi:10.1093/aje/kwn109
    • (2008) Am J Epidemiol , vol.168 , pp. 158-169
    • Kabat, G.C.1    Kim, M.2    Hunt, J.R.3    Chlebowski, R.T.4    Rohan, T.E.5
  • 77
    • 24944587110 scopus 로고    scopus 로고
    • Body mass index and lung cancer: a case-control study of subjects participating in a mass-screening program
    • doi:10.1378/chest.128.3.1490
    • Kanashiki M, Sairenchi T, Saito Y, Ishikawa H, Satoh H, Sekizawa K. Body mass index and lung cancer: a case-control study of subjects participating in a mass-screening program. Chest (2005) 128:1490-6. doi:10.1378/chest.128.3.1490
    • (2005) Chest , vol.128 , pp. 1490-1496
    • Kanashiki, M.1    Sairenchi, T.2    Saito, Y.3    Ishikawa, H.4    Satoh, H.5    Sekizawa, K.6
  • 78
    • 34547863833 scopus 로고    scopus 로고
    • Body mass index and lung cancer risk in women
    • doi:10.1097/EDE.0b013e31812713d1
    • Kabat GC, Miller AB, Rohan TE. Body mass index and lung cancer risk in women. Epidemiology (2007) 18:607-12. doi:10.1097/EDE.0b013e31812713d1
    • (2007) Epidemiology , vol.18 , pp. 607-612
    • Kabat, G.C.1    Miller, A.B.2    Rohan, T.E.3
  • 79
    • 84887109344 scopus 로고    scopus 로고
    • Hormones of adipose tissue and their biologic role in lung cancer
    • doi:10.1016/j.ctrv.2013.06.005
    • Ntikoudi E, Kiagia M, Boura P, Syrigos KN. Hormones of adipose tissue and their biologic role in lung cancer. Cancer Treat Rev (2014) 40:22-30. doi:10.1016/j.ctrv.2013.06.005
    • (2014) Cancer Treat Rev , vol.40 , pp. 22-30
    • Ntikoudi, E.1    Kiagia, M.2    Boura, P.3    Syrigos, K.N.4
  • 80
    • 84897836624 scopus 로고    scopus 로고
    • Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes? Health be damned! Pour on the sugar
    • doi:10.2337/dc13-2085
    • Bray GA, Popkin BM. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes? Health be damned! Pour on the sugar. Diabetes Care (2014) 37:950-6. doi:10.2337/dc13-2085
    • (2014) Diabetes Care , vol.37 , pp. 950-956
    • Bray, G.A.1    Popkin, B.M.2
  • 81
    • 0035901051 scopus 로고    scopus 로고
    • Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis
    • doi:10.1016/S0140-6736(00)04041-1
    • Ludwig DS, Peterson KE, Gortmaker SL. Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet (2001) 357:505-8. doi:10.1016/S0140-6736(00)04041-1
    • (2001) Lancet , vol.357 , pp. 505-508
    • Ludwig, D.S.1    Peterson, K.E.2    Gortmaker, S.L.3
  • 85
    • 34447560040 scopus 로고    scopus 로고
    • Visceral subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome?
    • doi:10.2174/138161207781039599
    • Rodríguez A, Catalán V, Gómez-Ambrosi J, Frühbeck G. Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome? Curr Pharm Des (2007) 13:2169-75. doi:10.2174/138161207781039599
    • (2007) Curr Pharm Des , vol.13 , pp. 2169-2175
    • Rodríguez, A.1    Catalán, V.2    Gómez-Ambrosi, J.3    Frühbeck, G.4
  • 86
    • 34347351228 scopus 로고    scopus 로고
    • Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study
    • doi:10.1161/CIRCULATIONAHA.106.675355
    • Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation (2007) 116:39-48. doi:10.1161/CIRCULATIONAHA.106.675355
    • (2007) Circulation , vol.116 , pp. 39-48
    • Fox, C.S.1    Massaro, J.M.2    Hoffmann, U.3    Pou, K.M.4    Maurovich-Horvat, P.5    Liu, C.Y.6
  • 87
    • 78649955475 scopus 로고    scopus 로고
    • Body fat distribution and inflammation among obese older adults with and without metabolic syndrome
    • doi:10.1038/oby.2010.86
    • Koster A, Stenholm S, Alley DE, Kim LJ, Simonsick EM, Kanaya AM, et al. Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (2010) 18:2354-61. doi:10.1038/oby.2010.86
    • (2010) Obesity , vol.18 , pp. 2354-2361
    • Koster, A.1    Stenholm, S.2    Alley, D.E.3    Kim, L.J.4    Simonsick, E.M.5    Kanaya, A.M.6
  • 88
    • 0023718023 scopus 로고
    • The associations between obesity, adipose tissue distribution and disease
    • Bjorntorp P. The associations between obesity, adipose tissue distribution and disease. Acta Med Scand Suppl (1988) 723:121-34.
    • (1988) Acta Med Scand Suppl , vol.723 , pp. 121-134
    • Bjorntorp, P.1
  • 89
    • 35348874911 scopus 로고    scopus 로고
    • Developmental origin of fat: tracking obesity to its source
    • doi:10.1016/j.cell.2007.10.004
    • Gesta S, Tseng YH, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell (2007) 131:242-56. doi:10.1016/j.cell.2007.10.004
    • (2007) Cell , vol.131 , pp. 242-256
    • Gesta, S.1    Tseng, Y.H.2    Kahn, C.R.3
  • 90
    • 63449111349 scopus 로고    scopus 로고
    • PRDM16: the interconvertible adipo-myocyte switch
    • doi:10.1016/j.tcb.2009.01.007
    • Frühbeck G, Sesma P, Burrell MA. PRDM16: the interconvertible adipo-myocyte switch. Trends Cell Biol (2009) 19:141-6. doi:10.1016/j.tcb.2009.01.007
    • (2009) Trends Cell Biol , vol.19 , pp. 141-146
    • Frühbeck, G.1    Sesma, P.2    Burrell, M.A.3
  • 92
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • doi:10.1056/NEJMoa0810780
    • Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med (2009) 360:1509-17. doi:10.1056/NEJMoa0810780
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3    Tal, I.4    Rodman, D.5    Goldfine, A.B.6
  • 93
    • 84875653241 scopus 로고    scopus 로고
    • Human adipose dynamics and metabolic health
    • doi:10.1111/nyas.12009
    • Feng B, Zhang T, Xu H. Human adipose dynamics and metabolic health. Ann N Y Acad Sci (2013) 1281:160-77. doi:10.1111/nyas.12009
    • (2013) Ann N Y Acad Sci , vol.1281 , pp. 160-177
    • Feng, B.1    Zhang, T.2    Xu, H.3
  • 94
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: function and physiological significance
    • doi:10.1152/physrev.00015.2003
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev (2004) 84:277-359. doi:10.1152/physrev.00015.2003
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 95
    • 0030688961 scopus 로고    scopus 로고
    • ABC of palliative care Anorexia, cachexia, and nutrition
    • doi:10.1136/bmj.315.7117.1219
    • Bruera E. ABC of palliative care. Anorexia, cachexia, and nutrition. BMJ (1997) 315:1219-22. doi:10.1136/bmj.315.7117.1219
    • (1997) BMJ , vol.315 , pp. 1219-1222
    • Bruera, E.1
  • 96
    • 84865798012 scopus 로고    scopus 로고
    • Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice
    • doi:10.1158/0008-5472.CAN-11-3536
    • Tsoli M, Moore M, Burg D, Painter A, Taylor R, Lockie SH, et al. Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice. Cancer Res (2012) 72:4372-82. doi:10.1158/0008-5472.CAN-11-3536
    • (2012) Cancer Res , vol.72 , pp. 4372-4382
    • Tsoli, M.1    Moore, M.2    Burg, D.3    Painter, A.4    Taylor, R.5    Lockie, S.H.6
  • 97
    • 84873518501 scopus 로고    scopus 로고
    • Adaptive thermogenesis in adipocytes: is beige the new brown?
    • doi:10.1101/gad.211649.112
    • Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 27:234-50. doi:10.1101/gad.211649.112
    • (2013) Genes Dev , vol.27 , pp. 234-250
    • Wu, J.1    Cohen, P.2    Spiegelman, B.M.3
  • 98
    • 76049099665 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome - an allostatic perspective
    • doi:10.1016/j.bbalip.2009.12.006
    • Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome - an allostatic perspective. Biochim Biophys Acta (2010) 1801:338-49. doi:10.1016/j.bbalip.2009.12.006
    • (2010) Biochim Biophys Acta , vol.1801 , pp. 338-349
    • Virtue, S.1    Vidal-Puig, A.2
  • 100
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • doi:10.2337/diabetes.44.9.1038
    • Rebrin K, Steil GM, Getty L, Bergman RN. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes (1995) 44:1038-45. doi:10.2337/diabetes.44.9.1038
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 101
    • 0025204639 scopus 로고
    • Receptor and postreceptor effects of free fatty acids (FFA) on hepatocyte insulin dynamics
    • Hennes MM, Shrago E, Kissebah AH. Receptor and postreceptor effects of free fatty acids (FFA) on hepatocyte insulin dynamics. Int J Obes (1990) 14:831-41.
    • (1990) Int J Obes , vol.14 , pp. 831-841
    • Hennes, M.M.1    Shrago, E.2    Kissebah, A.H.3
  • 102
    • 33847674065 scopus 로고    scopus 로고
    • MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines
    • Hunt DA, Lane HM, Zygmont ME, Dervan PA, Hennigar RA. MRNA stability and overexpression of fatty acid synthase in human breast cancer cell lines. Anticancer Res (2007) 27:27-34.
    • (2007) Anticancer Res , vol.27 , pp. 27-34
    • Hunt, D.A.1    Lane, H.M.2    Zygmont, M.E.3    Dervan, P.A.4    Hennigar, R.A.5
  • 103
    • 0031007392 scopus 로고    scopus 로고
    • Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival
    • doi:10.1016/S0046-8177(97)90177-5
    • Gansler TS, Hardman W III, Hunt DA, Schaffel S, Hennigar RA. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum Pathol (1997) 28:686-92. doi:10.1016/S0046-8177(97)90177-5
    • (1997) Hum Pathol , vol.28 , pp. 686-692
    • Gansler, T.S.1    Hardman III, W.2    Hunt, D.A.3    Schaffel, S.4    Hennigar, R.A.5
  • 104
    • 12444252156 scopus 로고    scopus 로고
    • Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice
    • doi:10.1038/sj.onc.1208174
    • Alli PM, Pinn ML, Jaffee EM, McFadden JM, Kuhajda FP. Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice. Oncogene (2005) 24:39-46. doi:10.1038/sj.onc.1208174
    • (2005) Oncogene , vol.24 , pp. 39-46
    • Alli, P.M.1    Pinn, M.L.2    Jaffee, E.M.3    McFadden, J.M.4    Kuhajda, F.P.5
  • 105
    • 77957568227 scopus 로고    scopus 로고
    • Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival
    • doi:10.1200/JCO.2009.27.0793
    • Nguyen PL, Ma J, Chavarro JE, Freedman ML, Lis R, Fedele G, et al. Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival. J Clin Oncol (2010) 28:3958-64. doi:10.1200/JCO.2009.27.0793
    • (2010) J Clin Oncol , vol.28 , pp. 3958-3964
    • Nguyen, P.L.1    Ma, J.2    Chavarro, J.E.3    Freedman, M.L.4    Lis, R.5    Fedele, G.6
  • 107
    • 73149109062 scopus 로고    scopus 로고
    • Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
    • doi:10.1016/j.cell.2009.11.027
    • Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell (2010) 140:49-61. doi:10.1016/j.cell.2009.11.027
    • (2010) Cell , vol.140 , pp. 49-61
    • Nomura, D.K.1    Long, J.Z.2    Niessen, S.3    Hoover, H.S.4    Ng, S.W.5    Cravatt, B.F.6
  • 108
    • 81255157465 scopus 로고    scopus 로고
    • Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    • doi:10.1038/nm.2492
    • Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 17:1498-503. doi:10.1038/nm.2492
    • (2011) Nat Med , vol.17 , pp. 1498-1503
    • Nieman, K.M.1    Kenny, H.A.2    Penicka, C.V.3    Ladanyi, A.4    Buell-Gutbrod, R.5    Zillhardt, M.R.6
  • 109
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • doi:10.1172/JCI200320514
    • Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest (2003) 112:1785-8. doi:10.1172/JCI200320514
    • (2003) J Clin Invest , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 110
    • 84871053603 scopus 로고    scopus 로고
    • Role of extracellular matrix remodelling in adipose tissue pathophysiology: relevance in the development of obesity
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Frühbeck G. Role of extracellular matrix remodelling in adipose tissue pathophysiology: relevance in the development of obesity. Histol Histopathol (2012) 27:1515-28.
    • (2012) Histol Histopathol , vol.27 , pp. 1515-1528
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Frühbeck, G.4
  • 111
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • doi:10.1038/nature07201
    • Medzhitov R. Origin and physiological roles of inflammation. Nature (2008) 454:428-35. doi:10.1038/nature07201
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1
  • 112
    • 30044449982 scopus 로고    scopus 로고
    • Resolution of inflammation: the beginning programs the end
    • doi:10.1038/ni1276
    • Serhan CN, Savill J. Resolution of inflammation: the beginning programs the end. Nat Immunol (2005) 6:1191-7. doi:10.1038/ni1276
    • (2005) Nat Immunol , vol.6 , pp. 1191-1197
    • Serhan, C.N.1    Savill, J.2
  • 113
    • 78049295202 scopus 로고    scopus 로고
    • Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss
    • doi:10.2337/db10-0585
    • Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, et al. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes (2010) 59:2817-25. doi:10.2337/db10-0585
    • (2010) Diabetes , vol.59 , pp. 2817-2825
    • Divoux, A.1    Tordjman, J.2    Lacasa, D.3    Veyrie, N.4    Hugol, D.5    Aissat, A.6
  • 114
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • doi:10.1038/nature05485
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature (2006) 444:860-7. doi:10.1038/nature05485
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 115
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • doi:10.1038/nm.1964
    • Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 15:914-20. doi:10.1038/nm.1964
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 116
    • 34249719581 scopus 로고    scopus 로고
    • Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels
    • doi:10.2337/db06-1749
    • Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, Fujita H, et al. Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes (2007) 56:1517-26. doi:10.2337/db06-1749
    • (2007) Diabetes , vol.56 , pp. 1517-1526
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Hosoya, Y.4    Yamashita, H.5    Fujita, H.6
  • 117
    • 77954672503 scopus 로고    scopus 로고
    • Adipose tissue macrophages: their role in adipose tissue remodeling
    • doi:10.1189/jlb.0210072
    • Suganami T, Ogawa Y. Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol (2010) 88:33-9. doi:10.1189/jlb.0210072
    • (2010) J Leukoc Biol , vol.88 , pp. 33-39
    • Suganami, T.1    Ogawa, Y.2
  • 118
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • doi:10.1016/S0140-6736(00)04046-0
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet (2001) 357:539-45. doi:10.1016/S0140-6736(00)04046-0
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 119
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation cancer
    • doi:10.1038/nature01322
    • Coussens LM, Werb Z. Inflammation and cancer. Nature (2002) 420:860-7. doi:10.1038/nature01322
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 120
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • doi:10.1016/j.ccr.2005.02.013
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell (2005) 7:211-7. doi:10.1016/j.ccr.2005.02.013
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 121
    • 13444256288 scopus 로고    scopus 로고
    • Inflammation and cancer: the long reach of Ras
    • doi:10.1038/nm0105-20
    • Karin M. Inflammation and cancer: the long reach of Ras. Nat Med (2005) 11:20-1. doi:10.1038/nm0105-20
    • (2005) Nat Med , vol.11 , pp. 20-21
    • Karin, M.1
  • 122
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-κB in cancer development and progression
    • doi:10.1038/nature04870
    • Karin M. Nuclear factor-κB in cancer development and progression. Nature (2006) 441:431-6. doi:10.1038/nature04870
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 123
    • 79960820132 scopus 로고    scopus 로고
    • The growing challenge of obesity and cancer: an inflammatory issue
    • doi:10.1111/j.1749-6632.2011.06096.x
    • Harvey AE, Lashinger LM, Hursting SD. The growing challenge of obesity and cancer: an inflammatory issue. Ann N Y Acad Sci (2011) 1229:45-52. doi:10.1111/j.1749-6632.2011.06096.x
    • (2011) Ann N Y Acad Sci , vol.1229 , pp. 45-52
    • Harvey, A.E.1    Lashinger, L.M.2    Hursting, S.D.3
  • 124
    • 0034141680 scopus 로고    scopus 로고
    • Prognostic value of intratumoral natural killer cells in gastric carcinoma
    • doi:10.1002/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.0.CO;2-V
    • Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Che X, Iwashige H, et al. Prognostic value of intratumoral natural killer cells in gastric carcinoma. Cancer (2000) 88:577-83. doi:10.1002/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.0.CO;2-V
    • (2000) Cancer , vol.88 , pp. 577-583
    • Ishigami, S.1    Natsugoe, S.2    Tokuda, K.3    Nakajo, A.4    Che, X.5    Iwashige, H.6
  • 125
    • 0037569416 scopus 로고    scopus 로고
    • Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma
    • doi:10.1046/j.1365-2362.2003.01152.x
    • Ribatti D, Ennas MG, Vacca A, Ferreli F, Nico B, Orru S, et al. Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur J Clin Invest (2003) 33:420-5. doi:10.1046/j.1365-2362.2003.01152.x
    • (2003) Eur J Clin Invest , vol.33 , pp. 420-425
    • Ribatti, D.1    Ennas, M.G.2    Vacca, A.3    Ferreli, F.4    Nico, B.5    Orru, S.6
  • 126
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • doi:10.1038/sj.bjc.6690158
    • Leek RD, Landers RJ, Harris AL, Lewis CE. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer (1999) 79:991-5. doi:10.1038/sj.bjc.6690158
    • (1999) Br J Cancer , vol.79 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 129
    • 84862688466 scopus 로고    scopus 로고
    • Human adipose tissue macrophages display activation of cancer-related pathways
    • doi:10.1074/jbc.M111.315200
    • Mayi TH, Daoudi M, Derudas B, Gross B, Bories G, Wouters K, et al. Human adipose tissue macrophages display activation of cancer-related pathways. J Biol Chem (2012) 287:21904-13. doi:10.1074/jbc.M111.315200
    • (2012) J Biol Chem , vol.287 , pp. 21904-21913
    • Mayi, T.H.1    Daoudi, M.2    Derudas, B.3    Gross, B.4    Bories, G.5    Wouters, K.6
  • 130
    • 84866532210 scopus 로고    scopus 로고
    • Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue
    • doi:10.1186/1741-7015-10-108
    • Ribeiro R, Monteiro C, Catalán V, Hu P, Cunha V, Rodríguez A, et al. Obesity and prostate cancer: gene expression signature of human periprostatic adipose tissue. BMC Med (2012) 10:108. doi:10.1186/1741-7015-10-108
    • (2012) BMC Med , vol.10 , pp. 108
    • Ribeiro, R.1    Monteiro, C.2    Catalán, V.3    Hu, P.4    Cunha, V.5    Rodríguez, A.6
  • 131
    • 78650918544 scopus 로고    scopus 로고
    • Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer
    • doi:10.1016/j.jnutbio.2010.04.015
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Silva C, Rotellar F, et al. Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. J Nutr Biochem (2011) 22:634-41. doi:10.1016/j.jnutbio.2010.04.015
    • (2011) J Nutr Biochem , vol.22 , pp. 634-641
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Silva, C.5    Rotellar, F.6
  • 132
    • 41149164902 scopus 로고    scopus 로고
    • The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    • doi:10.1111/j.1600-065X.2008.00607.x
    • Allavena P, Sica A, Garlanda C, Mantovani A. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol Rev (2008) 222:155-61. doi:10.1111/j.1600-065X.2008.00607.x
    • (2008) Immunol Rev , vol.222 , pp. 155-161
    • Allavena, P.1    Sica, A.2    Garlanda, C.3    Mantovani, A.4
  • 133
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • doi:10.1084/jem.20030896
    • Murphy CA, Langrish CL, Chen Y, Blumenschein W, McClanahan T, Kastelein RA, et al. Divergent pro- and anti-inflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med (2003) 198:1951-7. doi:10.1084/jem.20030896
    • (2003) J Exp Med , vol.198 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3    Blumenschein, W.4    McClanahan, T.5    Kastelein, R.A.6
  • 134
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    • doi:10.1084/jem.20091233
    • Smith AM, Rahman FZ, Hayee B, Graham SJ, Marks DJ, Sewell GW, et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med (2009) 206:1883-97. doi:10.1084/jem.20091233
    • (2009) J Exp Med , vol.206 , pp. 1883-1897
    • Smith, A.M.1    Rahman, F.Z.2    Hayee, B.3    Graham, S.J.4    Marks, D.J.5    Sewell, G.W.6
  • 135
    • 33750465224 scopus 로고    scopus 로고
    • Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    • doi:10.1038/nature05245
    • Kawane K, Ohtani M, Miwa K, Kizawa T, Kanbara Y, Yoshioka Y, et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature (2006) 443:998-1002. doi:10.1038/nature05245
    • (2006) Nature , vol.443 , pp. 998-1002
    • Kawane, K.1    Ohtani, M.2    Miwa, K.3    Kizawa, T.4    Kanbara, Y.5    Yoshioka, Y.6
  • 136
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • doi:10.1038/nri3073
    • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol (2011) 11:723-37. doi:10.1038/nri3073
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 137
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • doi:10.1146/annurev-physiol-021909-135846
    • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 72:219-46. doi:10.1146/annurev-physiol-021909-135846
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 138
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • doi:10.1038/nature07205
    • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature (2008) 454:436-44. doi:10.1038/nature07205
    • (2008) Nature , vol.454 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 139
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: from innocent bystander to major culprit
    • doi:10.1038/nrc780
    • Karin M, Cao Y, Greten FR, Li ZW. NF-κB in cancer: from innocent bystander to major culprit. Nat Rev Cancer (2002) 2:301-10. doi:10.1038/nrc780
    • (2002) Nat Rev Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 140
    • 80052014052 scopus 로고    scopus 로고
    • Inflammation meets cancer, with NF-κB as the matchmaker
    • doi:10.1038/ni.2060
    • Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol (2011) 12:715-23. doi:10.1038/ni.2060
    • (2011) Nat Immunol , vol.12 , pp. 715-723
    • Ben-Neriah, Y.1    Karin, M.2
  • 141
    • 33846682591 scopus 로고    scopus 로고
    • The inflammatory cytokine tumor necrosis factor-α generates an autocrine tumor-promoting network in epithelial ovarian cancer cells
    • doi:10.1158/0008-5472.CAN-06-2941
    • Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, et al. The inflammatory cytokine tumor necrosis factor-α generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res (2007) 67:585-92. doi:10.1158/0008-5472.CAN-06-2941
    • (2007) Cancer Res , vol.67 , pp. 585-592
    • Kulbe, H.1    Thompson, R.2    Wilson, J.L.3    Robinson, S.4    Hagemann, T.5    Fatah, R.6
  • 142
    • 34447327216 scopus 로고    scopus 로고
    • Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production
    • doi:10.1126/science.1140485
    • Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science (2007) 317:121-4. doi:10.1126/science.1140485
    • (2007) Science , vol.317 , pp. 121-124
    • Naugler, W.E.1    Sakurai, T.2    Kim, S.3    Maeda, S.4    Kim, K.5    Elsharkawy, A.M.6
  • 143
    • 47049116663 scopus 로고    scopus 로고
    • Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells
    • doi:10.1038/emboj.2008.105
    • Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, et al. Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells. EMBO J (2008) 27:1671-81. doi:10.1038/emboj.2008.105
    • (2008) EMBO J , vol.27 , pp. 1671-1681
    • Oguma, K.1    Oshima, H.2    Aoki, M.3    Uchio, R.4    Naka, K.5    Nakamura, S.6
  • 144
    • 84862128998 scopus 로고    scopus 로고
    • Differentiation and gene expression profile of tumor-associated macrophages
    • doi:10.1016/j.semcancer.2012.02.002
    • Schmieder A, Michel J, Schonhaar K, Goerdt S, Schledzewski K. Differentiation and gene expression profile of tumor-associated macrophages. Semin Cancer Biol (2012) 22:289-97. doi:10.1016/j.semcancer.2012.02.002
    • (2012) Semin Cancer Biol , vol.22 , pp. 289-297
    • Schmieder, A.1    Michel, J.2    Schonhaar, K.3    Goerdt, S.4    Schledzewski, K.5
  • 145
    • 39849107173 scopus 로고    scopus 로고
    • Interleukin-10 is a protective factor against diet-induced insulin resistance in liver
    • doi:10.1016/j.jhep.2007.12.017
    • Cintra DE, Pauli JR, Araujo EP, Moraes JC, de Souza CT, Milanski M, et al. Interleukin-10 is a protective factor against diet-induced insulin resistance in liver. J Hepatol (2008) 48:628-37. doi:10.1016/j.jhep.2007.12.017
    • (2008) J Hepatol , vol.48 , pp. 628-637
    • Cintra, D.E.1    Pauli, J.R.2    Araujo, E.P.3    Moraes, J.C.4    de Souza, C.T.5    Milanski, M.6
  • 146
    • 84884174190 scopus 로고    scopus 로고
    • Recent advances in obesity-induced inflammation and insulin resistance
    • doi:10.3389/fendo.2013.00093
    • Tateya S, Kim F, Tamori Y. Recent advances in obesity-induced inflammation and insulin resistance. Front Endocrinol (Lausanne) (2013) 4:93. doi:10.3389/fendo.2013.00093
    • (2013) Front Endocrinol (Lausanne) , vol.4 , pp. 93
    • Tateya, S.1    Kim, F.2    Tamori, Y.3
  • 147
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • doi:10.1172/JCI29881
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 117:175-84. doi:10.1172/JCI29881
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 148
    • 80052397157 scopus 로고    scopus 로고
    • COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps
    • doi:10.1093/carcin/bgr128
    • Nakanishi Y, Nakatsuji M, Seno H, Ishizu S, Akitake-Kawano R, Kanda K, et al. COX-2 inhibition alters the phenotype of tumor-associated macrophages from M2 to M1 in ApcMin/+ mouse polyps. Carcinogenesis (2011) 32:1333-9. doi:10.1093/carcin/bgr128
    • (2011) Carcinogenesis , vol.32 , pp. 1333-1339
    • Nakanishi, Y.1    Nakatsuji, M.2    Seno, H.3    Ishizu, S.4    Akitake-Kawano, R.5    Kanda, K.6
  • 150
    • 84888406185 scopus 로고    scopus 로고
    • Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways
    • doi:10.1016/j.cellsig.2013.11.004
    • Zhou D, Huang C, Lin Z, Zhan S, Kong L, Fang C, et al. Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal (2013) 26:192-7. doi:10.1016/j.cellsig.2013.11.004
    • (2013) Cell Signal , vol.26 , pp. 192-197
    • Zhou, D.1    Huang, C.2    Lin, Z.3    Zhan, S.4    Kong, L.5    Fang, C.6
  • 151
    • 33947416218 scopus 로고    scopus 로고
    • The Sir David Cuthbertson Medal Lecture Hunting for new pieces to the complex puzzle of obesity
    • doi:10.1079/PNS2006510
    • Frühbeck G. The Sir David Cuthbertson Medal Lecture. Hunting for new pieces to the complex puzzle of obesity. Proc Nutr Soc (2006) 65:329-47. doi:10.1079/PNS2006510
    • (2006) Proc Nutr Soc , vol.65 , pp. 329-347
    • Frühbeck, G.1
  • 152
    • 0034846529 scopus 로고    scopus 로고
    • Rationale for the existence of additional adipostatic hormones
    • doi:10.1096/fj.00-0829hyp
    • Frühbeck G, Gómez-Ambrosi J. Rationale for the existence of additional adipostatic hormones. FASEB J (2001) 15:1996-2006. doi:10.1096/fj.00-0829hyp
    • (2001) FASEB J , vol.15 , pp. 1996-2006
    • Frühbeck, G.1    Gómez-Ambrosi, J.2
  • 153
    • 0035128497 scopus 로고    scopus 로고
    • Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes
    • doi:10.1096/fj.00-0249com
    • Frühbeck G, Gómez-Ambrosi J, Salvador J. Leptin-induced lipolysis opposes the tonic inhibition of endogenous adenosine in white adipocytes. FASEB J (2001) 15:333-40. doi:10.1096/fj.00-0249com
    • (2001) FASEB J , vol.15 , pp. 333-340
    • Frühbeck, G.1    Gómez-Ambrosi, J.2    Salvador, J.3
  • 154
    • 82855168153 scopus 로고    scopus 로고
    • Increased levels of calprotectin in obesity are related to macrophage content: impact on inflammation and effect of weight loss
    • doi:10.2119/molmed.2011.00144
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valenti V, et al. Increased levels of calprotectin in obesity are related to macrophage content: impact on inflammation and effect of weight loss. Mol Med (2011) 17:1157-67. doi:10.2119/molmed.2011.00144
    • (2011) Mol Med , vol.17 , pp. 1157-1167
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valenti, V.6
  • 155
    • 78650917241 scopus 로고    scopus 로고
    • Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass
    • doi:10.1210/jc.2010-0994
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valenti V, et al. Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation: impact of conventional weight loss and gastric bypass. J Clin Endocrinol Metab (2011) 96:200-9. doi:10.1210/jc.2010-0994
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 200-209
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valenti, V.6
  • 156
    • 84867259104 scopus 로고    scopus 로고
    • Increased tenascin C and toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity
    • doi:10.1210/jc.2012-1670
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valentí V, et al. Increased tenascin C and toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity. J Clin Endocrinol Metab (2012) 97:E1880-9. doi:10.1210/jc.2012-1670
    • (2012) J Clin Endocrinol Metab , vol.97
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valentí, V.6
  • 157
    • 84875519919 scopus 로고    scopus 로고
    • Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients
    • doi:10.1016/j.soard.2011.11.001
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valentí V, et al. Increased levels of chemerin and its receptor, chemokine-like receptor-1, in obesity are related to inflammation: tumor necrosis factor-α stimulates mRNA levels of chemerin in visceral adipocytes from obese patients. Surg Obes Relat Dis (2013) 9:306-14. doi:10.1016/j.soard.2011.11.001
    • (2013) Surg Obes Relat Dis , vol.9 , pp. 306-314
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valentí, V.6
  • 158
    • 84891831269 scopus 로고    scopus 로고
    • Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity
    • doi:10.1007/s00394-012-0464-8
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Rotellar F, Valentí V, et al. Six-transmembrane epithelial antigen of prostate 4 and neutrophil gelatinase-associated lipocalin expression in visceral adipose tissue is related to iron status and inflammation in human obesity. Eur J Nutr (2013) 52:1587-95. doi:10.1007/s00394-012-0464-8
    • (2013) Eur J Nutr , vol.52 , pp. 1587-1595
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Rotellar, F.5    Valentí, V.6
  • 159
    • 28544441849 scopus 로고    scopus 로고
    • Obesity: aquaporin enters the picture
    • doi:10.1038/438436b
    • Frühbeck G. Obesity: aquaporin enters the picture. Nature (2005) 438:436-7. doi:10.1038/438436b
    • (2005) Nature , vol.438 , pp. 436-437
    • Frühbeck, G.1
  • 160
    • 34548759233 scopus 로고    scopus 로고
    • Plasma osteopontin levels and expression in adipose tissue are increased in obesity
    • doi:10.1210/jc.2007-0349
    • Gómez-Ambrosi J, Catalán V, Ramírez B, Rodríguez A, Colina I, Silva C, et al. Plasma osteopontin levels and expression in adipose tissue are increased in obesity. J Clin Endocrinol Metab (2007) 92:3719-27. doi:10.1210/jc.2007-0349
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3719-3727
    • Gómez-Ambrosi, J.1    Catalán, V.2    Ramírez, B.3    Rodríguez, A.4    Colina, I.5    Silva, C.6
  • 161
    • 0035928668 scopus 로고    scopus 로고
    • Do resistin and resistin-like molecules also link obesity to inflammatory diseases?
    • doi:10.7326/0003-4819-135-4-200108210-00030
    • Gómez-Ambrosi J, Frühbeck G. Do resistin and resistin-like molecules also link obesity to inflammatory diseases? Ann Intern Med (2001) 135:306-7. doi:10.7326/0003-4819-135-4-200108210-00030
    • (2001) Ann Intern Med , vol.135 , pp. 306-307
    • Gómez-Ambrosi, J.1    Frühbeck, G.2
  • 162
    • 84870435584 scopus 로고    scopus 로고
    • Peripheral signalling involved in energy homeostasis control
    • doi:10.1017/S0954422412000145
    • Lancha A, Frühbeck G, Gómez-Ambrosi J. Peripheral signalling involved in energy homeostasis control. Nutr Res Rev (2012) 25:223-48. doi:10.1017/S0954422412000145
    • (2012) Nutr Res Rev , vol.25 , pp. 223-248
    • Lancha, A.1    Frühbeck, G.2    Gómez-Ambrosi, J.3
  • 164
    • 0036035990 scopus 로고    scopus 로고
    • Immunocytochemical detection of leptin in non-mammalian vertebrate stomach
    • doi:10.1016/S0016-6480(02)00072-2
    • Muruzábal FJ, Frühbeck G, Gómez-Ambrosi J, Archanco M, Burrell MA. Immunocytochemical detection of leptin in non-mammalian vertebrate stomach. Gen Comp Endocrinol (2002) 128:149-52. doi:10.1016/S0016-6480(02)00072-2
    • (2002) Gen Comp Endocrinol , vol.128 , pp. 149-152
    • Muruzábal, F.J.1    Frühbeck, G.2    Gómez-Ambrosi, J.3    Archanco, M.4    Burrell, M.A.5
  • 165
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • doi:10.1074/jbc.270.45.26746
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem (1995) 270:26746-9. doi:10.1074/jbc.270.45.26746
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 166
    • 0141924849 scopus 로고    scopus 로고
    • Impaired multimerization of human adiponectin mutants associated with diabetesMolecular structure and multimer formation of adiponectin
    • doi:10.1074/jbc.M300365200
    • Waki H, Yamauchi T, Kamon J, Ito Y, Uchida S, Kita S, et al. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem (2003) 278:40352-63. doi:10.1074/jbc.M300365200
    • (2003) J Biol Chem , vol.278 , pp. 40352-40363
    • Waki, H.1    Yamauchi, T.2    Kamon, J.3    Ito, Y.4    Uchida, S.5    Kita, S.6
  • 167
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • doi:10.1210/er.2005-0005
    • Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev (2005) 26:439-51. doi:10.1210/er.2005-0005
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 168
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • doi:10.1172/JCI29126
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest (2006) 116:1784-92. doi:10.1172/JCI29126
    • (2006) J Clin Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 169
    • 0037984387 scopus 로고    scopus 로고
    • Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin Implications fpr metabolic regulation and bioactivity
    • doi:10.1074/jbc.M207198200
    • Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem (2003) 278:9073-85. doi:10.1074/jbc.M207198200
    • (2003) J Biol Chem , vol.278 , pp. 9073-9085
    • Pajvani, U.B.1    Du, X.2    Combs, T.P.3    Berg, A.H.4    Rajala, M.W.5    Schulthess, T.6
  • 170
    • 0037677604 scopus 로고    scopus 로고
    • Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-α expression
    • doi:10.2337/diabetes.52.7.1779
    • Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G. Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-α expression. Diabetes (2003) 52:1779-85. doi:10.2337/diabetes.52.7.1779
    • (2003) Diabetes , vol.52 , pp. 1779-1785
    • Kern, P.A.1    Di Gregorio, G.B.2    Lu, T.3    Rassouli, N.4    Ranganathan, G.5
  • 171
    • 33646504461 scopus 로고    scopus 로고
    • Adiponectin cancer: a systematic review
    • doi:10.1038/sj.bjc.6603051
    • Kelesidis I, Kelesidis T, Mantzoros CS. Adiponectin and cancer: a systematic review. Br J Cancer (2006) 94:1221-5. doi:10.1038/sj.bjc.6603051
    • (2006) Br J Cancer , vol.94 , pp. 1221-1225
    • Kelesidis, I.1    Kelesidis, T.2    Mantzoros, C.S.3
  • 172
    • 84869864773 scopus 로고    scopus 로고
    • Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls
    • doi:10.1186/1471-2407-12-545
    • Hillenbrand A, Fassler J, Huber N, Xu P, Henne-Bruns D, Templin M, et al. Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls. BMC Cancer (2012) 12:545. doi:10.1186/1471-2407-12-545
    • (2012) BMC Cancer , vol.12 , pp. 545
    • Hillenbrand, A.1    Fassler, J.2    Huber, N.3    Xu, P.4    Henne-Bruns, D.5    Templin, M.6
  • 173
    • 27944506001 scopus 로고    scopus 로고
    • Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study
    • doi:10.1093/jnci/dji376
    • Wei EK, Giovannucci E, Fuchs CS, Willett WC, Mantzoros CS. Low plasma adiponectin levels and risk of colorectal cancer in men: a prospective study. J Natl Cancer Inst (2005) 97:1688-94. doi:10.1093/jnci/dji376
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1688-1694
    • Wei, E.K.1    Giovannucci, E.2    Fuchs, C.S.3    Willett, W.C.4    Mantzoros, C.S.5
  • 174
    • 83355163337 scopus 로고    scopus 로고
    • Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans
    • doi:10.1158/1535-7163.MCT-11-0545
    • Moon HS, Chamberland JP, Aronis K, Tseleni-Balafouta S, Mantzoros CS. Direct role of adiponectin and adiponectin receptors in endometrial cancer: in vitro and ex vivo studies in humans. Mol Cancer Ther (2011) 10:2234-43. doi:10.1158/1535-7163.MCT-11-0545
    • (2011) Mol Cancer Ther , vol.10 , pp. 2234-2243
    • Moon, H.S.1    Chamberland, J.P.2    Aronis, K.3    Tseleni-Balafouta, S.4    Mantzoros, C.S.5
  • 175
    • 84882776306 scopus 로고    scopus 로고
    • The role of adiponectin in breast cancer: a meta-analysis
    • doi:10.1371/journal.pone.0073183
    • Liu LY, Wang M, Ma ZB, Yu LX, Zhang Q, Gao DZ, et al. The role of adiponectin in breast cancer: a meta-analysis. PLoS One (2013) 8:e73183. doi:10.1371/journal.pone.0073183
    • (2013) PLoS One , vol.8
    • Liu, L.Y.1    Wang, M.2    Ma, Z.B.3    Yu, L.X.4    Zhang, Q.5    Gao, D.Z.6
  • 176
    • 84870437222 scopus 로고    scopus 로고
    • An anti-carcinogenic hormone? A systematic review on breast, colorectal, liver and prostate cancer
    • doi:10.2174/092986712803833137
    • Perrier S, Jarde T. Adiponectin, an anti-carcinogenic hormone? A systematic review on breast, colorectal, liver and prostate cancer. Curr Med Chem (2012) 19:5501-12. doi:10.2174/092986712803833137
    • (2012) Curr Med Chem , vol.19 , pp. 5501-5512
    • Perrier, S.1    Jarde, T.A.2
  • 177
    • 84872563233 scopus 로고    scopus 로고
    • Plasma adiponectin: a possible link between fat metabolism and pancreatic cancer risk
    • doi:10.1093/jnci/djs522
    • Zhang J, Hochwald SN. Plasma adiponectin: a possible link between fat metabolism and pancreatic cancer risk. J Natl Cancer Inst (2013) 105:79-80. doi:10.1093/jnci/djs522
    • (2013) J Natl Cancer Inst , vol.105 , pp. 79-80
    • Zhang, J.1    Hochwald, S.N.2
  • 178
    • 54349120590 scopus 로고    scopus 로고
    • Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition
    • doi:10.1136/gut.2008.159293
    • Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Takahashi H, Saito S, et al. Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut (2008) 57:1531-8. doi:10.1136/gut.2008.159293
    • (2008) Gut , vol.57 , pp. 1531-1538
    • Fujisawa, T.1    Endo, H.2    Tomimoto, A.3    Sugiyama, M.4    Takahashi, H.5    Saito, S.6
  • 179
    • 84866079242 scopus 로고    scopus 로고
    • The role of adiponectin in cancer: a review of current evidence
    • doi:10.1210/er.2011-1015
    • Dalamaga M, Diakopoulos KN, Mantzoros CS. The role of adiponectin in cancer: a review of current evidence. Endocr Rev (2012) 33:547-94. doi:10.1210/er.2011-1015
    • (2012) Endocr Rev , vol.33 , pp. 547-594
    • Dalamaga, M.1    Diakopoulos, K.N.2    Mantzoros, C.S.3
  • 180
    • 84883382309 scopus 로고    scopus 로고
    • Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastresophageal junction
    • doi:10.4161/cbt.25362
    • Clemons N, Phillips W, Lord RV. Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastresophageal junction. Cancer Biol Ther (2013) 14:782-95. doi:10.4161/cbt.25362
    • (2013) Cancer Biol Ther , vol.14 , pp. 782-795
    • Clemons, N.1    Phillips, W.2    Lord, R.V.3
  • 181
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • doi:10.1038/372425a0
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 372:425-32. doi:10.1038/372425a0
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 182
    • 30044434035 scopus 로고    scopus 로고
    • Intracellular signalling pathways activated by leptin
    • doi:10.1042/BJ20051578
    • Frühbeck G. Intracellular signalling pathways activated by leptin. Biochem J (2006) 393:7-20. doi:10.1042/BJ20051578
    • (2006) Biochem J , vol.393 , pp. 7-20
    • Frühbeck, G.1
  • 183
    • 0036790412 scopus 로고    scopus 로고
    • Peripheral actions of leptin and its involvement in disease
    • doi:10.1301/002966402320634931
    • Frühbeck G. Peripheral actions of leptin and its involvement in disease. Nutr Rev (2002) 60:S47-55. doi:10.1301/002966402320634931
    • (2002) Nutr Rev , vol.60
    • Frühbeck, G.1
  • 184
    • 0034880562 scopus 로고    scopus 로고
    • A heliocentric view of leptin
    • doi:10.1079/PNS200196
    • Frühbeck G. A heliocentric view of leptin. Proc Nutr Soc (2001) 60:301-18. doi:10.1079/PNS200196
    • (2001) Proc Nutr Soc , vol.60 , pp. 301-318
    • Frühbeck, G.1
  • 185
    • 0042023742 scopus 로고    scopus 로고
    • Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity
    • doi:10.2337/diacare.26.8.2383
    • Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, et al. Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care (2003) 26:2383-8. doi:10.2337/diacare.26.8.2383
    • (2003) Diabetes Care , vol.26 , pp. 2383-2388
    • Ryan, A.S.1    Berman, D.M.2    Nicklas, B.J.3    Sinha, M.4    Gingerich, R.L.5    Meneilly, G.S.6
  • 186
    • 77951699992 scopus 로고    scopus 로고
    • Differential roles of leptin in regulating cell migration in thyroid cancer cells
    • doi:10.3892/or_00000817
    • Cheng SP, Yin PH, Chang YC, Lee CH, Huang SY, Chi CW. Differential roles of leptin in regulating cell migration in thyroid cancer cells. Oncol Rep (2010) 23:1721-7. doi:10.3892/or_00000817
    • (2010) Oncol Rep , vol.23 , pp. 1721-1727
    • Cheng, S.P.1    Yin, P.H.2    Chang, Y.C.3    Lee, C.H.4    Huang, S.Y.5    Chi, C.W.6
  • 187
    • 84890115428 scopus 로고    scopus 로고
    • Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells
    • doi:10.1530/ERC-13-0329
    • Zheng Q, Banaszak L, Fracci S, Basali D, Dunlap SM, Hursting SD, et al. Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells. Endocr Relat Cancer (2013) 20:797-808. doi:10.1530/ERC-13-0329
    • (2013) Endocr Relat Cancer , vol.20 , pp. 797-808
    • Zheng, Q.1    Banaszak, L.2    Fracci, S.3    Basali, D.4    Dunlap, S.M.5    Hursting, S.D.6
  • 188
    • 78649484649 scopus 로고    scopus 로고
    • Leptin and gastro-intestinal malignancies
    • doi:10.1111/j.1467-789X.2010.00718.x
    • Howard JM, Pidgeon GP, Reynolds JV. Leptin and gastro-intestinal malignancies. Obes Rev (2010) 11:863-74. doi:10.1111/j.1467-789X.2010.00718.x
    • (2010) Obes Rev , vol.11 , pp. 863-874
    • Howard, J.M.1    Pidgeon, G.P.2    Reynolds, J.V.3
  • 189
    • 77954096916 scopus 로고    scopus 로고
    • Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma
    • doi:10.3109/10428191003802365
    • Uddin S, Bu R, Ahmed M, Hussain AR, Ajarim D, Al-Dayel F, et al. Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma. Leuk Lymphoma (2010) 51:1305-14. doi:10.3109/10428191003802365
    • (2010) Leuk Lymphoma , vol.51 , pp. 1305-1314
    • Uddin, S.1    Bu, R.2    Ahmed, M.3    Hussain, A.R.4    Ajarim, D.5    Al-Dayel, F.6
  • 190
    • 27644465299 scopus 로고    scopus 로고
    • Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-α- and interleukin-1β-treated human preadipocytes are potent leptin producers
    • doi:10.1016/j.cyto.2005.08.003
    • Simons PJ, van den Pangaart PS, van Roomen CP, Aerts JM, Boon L. Cytokine-mediated modulation of leptin and adiponectin secretion during in vitro adipogenesis: evidence that tumor necrosis factor-α- and interleukin-1β-treated human preadipocytes are potent leptin producers. Cytokine (2005) 32:94-103. doi:10.1016/j.cyto.2005.08.003
    • (2005) Cytokine , vol.32 , pp. 94-103
    • Simons, P.J.1    van den Pangaart, P.S.2    van Roomen, C.P.3    Aerts, J.M.4    Boon, L.5
  • 192
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance
    • doi:10.1126/science.7678183
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science (1993) 259:87-91. doi:10.1126/science.7678183
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 193
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: a double-edged sword
    • doi:10.1038/nri1184
    • Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol (2003) 3:745-56. doi:10.1038/nri1184
    • (2003) Nat Rev Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 194
    • 42649124339 scopus 로고    scopus 로고
    • TNF: a master switch for inflammation to cancer
    • doi:10.2741/3066
    • Sethi G, Sung B, Aggarwal BB. TNF: a master switch for inflammation to cancer. Front Biosci (2008) 13:5094-107. doi:10.2741/3066
    • (2008) Front Biosci , vol.13 , pp. 5094-5107
    • Sethi, G.1    Sung, B.2    Aggarwal, B.B.3
  • 195
    • 67349162130 scopus 로고    scopus 로고
    • Tumour necrosis factor and cancer
    • doi:10.1038/nrc2628
    • Balkwill F. Tumour necrosis factor and cancer. Nat Rev Cancer (2009) 9:361-71. doi:10.1038/nrc2628
    • (2009) Nat Rev Cancer , vol.9 , pp. 361-371
    • Balkwill, F.1
  • 196
    • 33845524008 scopus 로고    scopus 로고
    • TNF-α in promotion and progression of cancer
    • doi:10.1007/s10555-006-9005-3
    • Balkwill F. TNF-α in promotion and progression of cancer. Cancer Metastasis Rev (2006) 25:409-16. doi:10.1007/s10555-006-9005-3
    • (2006) Cancer Metastasis Rev , vol.25 , pp. 409-416
    • Balkwill, F.1
  • 197
    • 4644324186 scopus 로고    scopus 로고
    • NF-κB functions as a tumour promoter in inflammation-associated cancer
    • doi:10.1038/nature02924
    • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature (2004) 431:461-6. doi:10.1038/nature02924
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 198
    • 0027163955 scopus 로고
    • Tumor necrosis factor and its receptors in human ovarian cancer Potential role in disease progression
    • doi:10.1172/JCI116446
    • Naylor MS, Stamp GW, Foulkes WD, Eccles D, Balkwill FR. Tumor necrosis factor and its receptors in human ovarian cancer. Potential role in disease progression. J Clin Invest (1993) 91:2194-206. doi:10.1172/JCI116446
    • (1993) J Clin Invest , vol.91 , pp. 2194-2206
    • Naylor, M.S.1    Stamp, G.W.2    Foulkes, W.D.3    Eccles, D.4    Balkwill, F.R.5
  • 199
    • 0037103258 scopus 로고    scopus 로고
    • The clinical significance of tumor necrosis factor-α plasma level in patients having chronic lymphocytic leukemia
    • Ferrajoli A, Keating MJ, Manshouri T, Giles FJ, Dey A, Estrov Z, et al. The clinical significance of tumor necrosis factor-α plasma level in patients having chronic lymphocytic leukemia. Blood (2002) 100:1215-9.
    • (2002) Blood , vol.100 , pp. 1215-1219
    • Ferrajoli, A.1    Keating, M.J.2    Manshouri, T.3    Giles, F.J.4    Dey, A.5    Estrov, Z.6
  • 201
    • 35648995976 scopus 로고    scopus 로고
    • Interleukin-6 and its receptor in cancer: implications for translational therapeutics
    • doi:10.1002/cncr.22999
    • Hong DS, Angelo LS, Kurzrock R. Interleukin-6 and its receptor in cancer: implications for translational therapeutics. Cancer (2007) 110:1911-28. doi:10.1002/cncr.22999
    • (2007) Cancer , vol.110 , pp. 1911-1928
    • Hong, D.S.1    Angelo, L.S.2    Kurzrock, R.3
  • 202
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
    • doi:10.1016/j.molmed.2007.12.007
    • Naugler WE, Karin M. The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med (2008) 14:109-19. doi:10.1016/j.molmed.2007.12.007
    • (2008) Trends Mol Med , vol.14 , pp. 109-119
    • Naugler, W.E.1    Karin, M.2
  • 203
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • doi:10.1172/JCI31537
    • Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest (2007) 117:1175-83. doi:10.1172/JCI31537
    • (2007) J Clin Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 204
    • 0036469114 scopus 로고    scopus 로고
    • Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53
    • Angelo LS, Talpaz M, Kurzrock R. Autocrine interleukin-6 production in renal cell carcinoma: evidence for the involvement of p53. Cancer Res (2002) 62:932-40.
    • (2002) Cancer Res , vol.62 , pp. 932-940
    • Angelo, L.S.1    Talpaz, M.2    Kurzrock, R.3
  • 205
    • 17444419414 scopus 로고    scopus 로고
    • Involvement of proinflammatory cytokines IL-1β and IL-6 in progression of human gastric carcinoma
    • Kai H, Kitadai Y, Kodama M, Cho S, Kuroda T, Ito M, et al. Involvement of proinflammatory cytokines IL-1β and IL-6 in progression of human gastric carcinoma. Anticancer Res (2005) 25:709-13.
    • (2005) Anticancer Res , vol.25 , pp. 709-713
    • Kai, H.1    Kitadai, Y.2    Kodama, M.3    Cho, S.4    Kuroda, T.5    Ito, M.6
  • 206
    • 0042209597 scopus 로고    scopus 로고
    • Serum interleukin-6 levels reflect the disease status of colorectal cancer
    • doi:10.1002/jso.10269
    • Chung YC, Chang YF. Serum interleukin-6 levels reflect the disease status of colorectal cancer. J Surg Oncol (2003) 83:222-6. doi:10.1002/jso.10269
    • (2003) J Surg Oncol , vol.83 , pp. 222-226
    • Chung, Y.C.1    Chang, Y.F.2
  • 207
  • 208
    • 84878475744 scopus 로고    scopus 로고
    • An IL-6 link between obesity and cancer
    • doi:10.2741/E628
    • Ghosh S, Ashcraft K. An IL-6 link between obesity and cancer. Front Biosci (2013) 5:461-78. doi:10.2741/E628
    • (2013) Front Biosci , vol.5 , pp. 461-478
    • Ghosh, S.1    Ashcraft, K.2
  • 209
    • 84899124414 scopus 로고    scopus 로고
    • Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
    • doi:10.1038/ni.2865
    • Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, et al. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol (2014) 15:423-30. doi:10.1038/ni.2865
    • (2014) Nat Immunol , vol.15 , pp. 423-430
    • Mauer, J.1    Chaurasia, B.2    Goldau, J.3    Vogt, M.C.4    Ruud, J.5    Nguyen, K.D.6
  • 210
    • 79955650634 scopus 로고    scopus 로고
    • The pro- and anti-inflammatory properties of the cytokine interleukin-6
    • doi:10.1016/j.bbamcr.2011.01.034
    • Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta (2011) 1813:878-88. doi:10.1016/j.bbamcr.2011.01.034
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 878-888
    • Scheller, J.1    Chalaris, A.2    Schmidt-Arras, D.3    Rose-John, S.4
  • 211
    • 84874021754 scopus 로고    scopus 로고
    • Obesity and C-reactive protein in various populations: a systematic review and meta-analysis
    • doi:10.1111/obr.12003
    • Choi J, Joseph L, Pilote L. Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obes Rev (2013) 14:232-44. doi:10.1111/obr.12003
    • (2013) Obes Rev , vol.14 , pp. 232-244
    • Choi, J.1    Joseph, L.2    Pilote, L.3
  • 212
    • 34250873779 scopus 로고    scopus 로고
    • A systematic review of the association between circulating concentrations of C reactive protein and cancer
    • doi:10.1136/jech.2006.051292
    • Heikkila K, Ebrahim S, Lawlor DA. A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemiol Community Health (2007) 61:824-33. doi:10.1136/jech.2006.051292
    • (2007) J Epidemiol Community Health , vol.61
    • Heikkila, K.1    Ebrahim, S.2    Lawlor, D.A.3
  • 213
    • 33646013271 scopus 로고    scopus 로고
    • C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort study
    • doi:10.1016/j.ejca.2006.01.008
    • Helzlsouer KJ, Erlinger TP, Platz EA. C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort study. Eur J Cancer (2006) 42:704-7. doi:10.1016/j.ejca.2006.01.008
    • (2006) Eur J Cancer , vol.42 , pp. 704-707
    • Helzlsouer, K.J.1    Erlinger, T.P.2    Platz, E.A.3
  • 215
    • 84891458296 scopus 로고    scopus 로고
    • C-reactive protein as a significant prognostic factor for stage IV gastric cancer patients
    • Baba H, Kuwabara K, Ishiguro T, Hatano S, Matsuzawa T, Fukuchi M, et al. C-reactive protein as a significant prognostic factor for stage IV gastric cancer patients. Anticancer Res (2013) 33:5591-5.
    • (2013) Anticancer Res , vol.33 , pp. 5591-5595
    • Baba, H.1    Kuwabara, K.2    Ishiguro, T.3    Hatano, S.4    Matsuzawa, T.5    Fukuchi, M.6
  • 217
    • 84873710333 scopus 로고    scopus 로고
    • Involvement of adipokines, AMPK PI3K and the PPAR signaling pathways in ovarian follicle development and cancer
    • doi:10.1387/ijdb.120134jd
    • Dupont J, Reverchon M, Cloix L, Froment P, Rame C. Involvement of adipokines, AMPK, PI3K and the PPAR signaling pathways in ovarian follicle development and cancer. Int J Dev Biol (2012) 56:959-67. doi:10.1387/ijdb.120134jd
    • (2012) Int J Dev Biol , vol.56 , pp. 959-967
    • Dupont, J.1    Reverchon, M.2    Cloix, L.3    Froment, P.4    Rame, C.5
  • 218
    • 70349972139 scopus 로고    scopus 로고
    • The role of resistin as a regulator of inflammation: implications for various human pathologies
    • doi:10.1016/j.clim.2009.07.013
    • Filkova M, Haluzik M, Gay S, Senolt L. The role of resistin as a regulator of inflammation: implications for various human pathologies. Clin Immunol (2009) 133:157-70. doi:10.1016/j.clim.2009.07.013
    • (2009) Clin Immunol , vol.133 , pp. 157-170
    • Filkova, M.1    Haluzik, M.2    Gay, S.3    Senolt, L.4
  • 219
    • 79955119237 scopus 로고    scopus 로고
    • Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway
    • doi:10.1002/jcp.22555
    • Hsu WY, Chao YW, Tsai YL, Lien CC, Chang CF, Deng MC, et al. Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway. J Cell Physiol (2011) 226:2181-8. doi:10.1002/jcp.22555
    • (2011) J Cell Physiol , vol.226 , pp. 2181-2188
    • Hsu, W.Y.1    Chao, Y.W.2    Tsai, Y.L.3    Lien, C.C.4    Chang, C.F.5    Deng, M.C.6
  • 220
    • 77953217397 scopus 로고    scopus 로고
    • Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer
    • doi:10.1111/j.1349-7006.2010.01518.x
    • Nakajima TE, Yamada Y, Hamano T, Furuta K, Matsuda T, Fujita S, et al. Adipocytokines as new promising markers of colorectal tumors: adiponectin for colorectal adenoma, and resistin and visfatin for colorectal cancer. Cancer Sci (2010) 101:1286-91. doi:10.1111/j.1349-7006.2010.01518.x
    • (2010) Cancer Sci , vol.101 , pp. 1286-1291
    • Nakajima, T.E.1    Yamada, Y.2    Hamano, T.3    Furuta, K.4    Matsuda, T.5    Fujita, S.6
  • 221
    • 84866095422 scopus 로고    scopus 로고
    • Expression of the adipocytokine resistin and its association with the clinicopathological features and prognosis of pancreatic ductal adenocarcinoma
    • doi:10.3892/ol.2012.865
    • Jiang CY, Wang W, Yin YL, Yuan ZR, Wang LB. Expression of the adipocytokine resistin and its association with the clinicopathological features and prognosis of pancreatic ductal adenocarcinoma. Oncol Lett (2012) 4:960-4. doi:10.3892/ol.2012.865
    • (2012) Oncol Lett , vol.4 , pp. 960-964
    • Jiang, C.Y.1    Wang, W.2    Yin, Y.L.3    Yuan, Z.R.4    Wang, L.B.5
  • 222
    • 84862551083 scopus 로고    scopus 로고
    • Adipokines linking obesity with colorectal cancer risk in postmenopausal women
    • doi:10.1158/0008-5472.CAN-11-2771
    • Ho GY, Wang T, Gunter MJ, Strickler HD, Cushman M, Kaplan RC, et al. Adipokines linking obesity with colorectal cancer risk in postmenopausal women. Cancer Res (2012) 72:3029-37. doi:10.1158/0008-5472.CAN-11-2771
    • (2012) Cancer Res , vol.72 , pp. 3029-3037
    • Ho, G.Y.1    Wang, T.2    Gunter, M.J.3    Strickler, H.D.4    Cushman, M.5    Kaplan, R.C.6
  • 223
    • 33745227263 scopus 로고    scopus 로고
    • Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes
    • doi:10.1677/joe.1.06610
    • Di Simone N, Di Nicuolo F, Sanguinetti M, Castellani R, D'Asta M, Caforio L, et al. Resistin regulates human choriocarcinoma cell invasive behaviour and endothelial cell angiogenic processes. J Endocrinol (2006) 189:691-9. doi:10.1677/joe.1.06610
    • (2006) J Endocrinol , vol.189 , pp. 691-699
    • Di Simone, N.1    Di Nicuolo, F.2    Sanguinetti, M.3    Castellani, R.4    D'Asta, M.5    Caforio, L.6
  • 224
    • 39749084162 scopus 로고    scopus 로고
    • Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass
    • doi:10.1007/s11695-008-9424-z
    • Catalán V, Gómez-Ambrosi J, Ramírez B, Rotellar F, Pastor C, Silva C, et al. Proinflammatory cytokines in obesity: impact of type 2 diabetes mellitus and gastric bypass. Obes Surg (2007) 17:1464-74. doi:10.1007/s11695-008-9424-z
    • (2007) Obes Surg , vol.17 , pp. 1464-1474
    • Catalán, V.1    Gómez-Ambrosi, J.2    Ramírez, B.3    Rotellar, F.4    Pastor, C.5    Silva, C.6
  • 225
    • 67349168435 scopus 로고    scopus 로고
    • Role of macrophages in tumour progression
    • doi:10.1016/j.imlet.2009.02.011
    • Siveen KS, Kuttan G. Role of macrophages in tumour progression. Immunol Lett (2009) 123:97-102. doi:10.1016/j.imlet.2009.02.011
    • (2009) Immunol Lett , vol.123 , pp. 97-102
    • Siveen, K.S.1    Kuttan, G.2
  • 226
    • 84866045373 scopus 로고    scopus 로고
    • Enforced effect of tk-MCP-1 fusion gene in ovarian cancer
    • doi:10.1186/1756-9966-31-74
    • Hong S, Zhang P, Zhang H, Jia L, Qu X, Yang Q, et al. Enforced effect of tk-MCP-1 fusion gene in ovarian cancer. J Exp Clin Cancer Res (2012) 31:74. doi:10.1186/1756-9966-31-74
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 74
    • Hong, S.1    Zhang, P.2    Zhang, H.3    Jia, L.4    Qu, X.5    Yang, Q.6
  • 227
    • 84870299455 scopus 로고    scopus 로고
    • Profiling of cytokines in human epithelial ovarian cancer ascites
    • Matte I, Lane D, Laplante C, Rancourt C, Piche A. Profiling of cytokines in human epithelial ovarian cancer ascites. Am J Cancer Res (2012) 2:566-80.
    • (2012) Am J Cancer Res , vol.2 , pp. 566-580
    • Matte, I.1    Lane, D.2    Laplante, C.3    Rancourt, C.4    Piche, A.5
  • 229
    • 19944433652 scopus 로고    scopus 로고
    • Visfatin: a protein secreted by visceral fat that mimics the effects of insulin
    • doi:10.1126/science.1097243
    • Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science (2005) 307:426-30. doi:10.1126/science.1097243
    • (2005) Science , vol.307 , pp. 426-430
    • Fukuhara, A.1    Matsuda, M.2    Nishizawa, M.3    Segawa, K.4    Tanaka, M.5    Kishimoto, K.6
  • 230
    • 79952702085 scopus 로고    scopus 로고
    • Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity
    • doi:10.1016/j.numecd.2009.09.008
    • Catalán V, Gómez-Ambrosi J, Rodríguez A, Ramírez B, Silva C, Rotellar F, et al. Association of increased visfatin/PBEF/NAMPT circulating concentrations and gene expression levels in peripheral blood cells with lipid metabolism and fatty liver in human morbid obesity. Nutr Metab Cardiovasc Dis (2011) 21:245-53. doi:10.1016/j.numecd.2009.09.008
    • (2011) Nutr Metab Cardiovasc Dis , vol.21 , pp. 245-253
    • Catalán, V.1    Gómez-Ambrosi, J.2    Rodríguez, A.3    Ramírez, B.4    Silva, C.5    Rotellar, F.6
  • 232
    • 35549002189 scopus 로고    scopus 로고
    • Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme
    • doi:10.1016/j.cmet.2007.09.003
    • Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, et al. Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme. Cell Metab (2007) 6:363-75. doi:10.1016/j.cmet.2007.09.003
    • (2007) Cell Metab , vol.6 , pp. 363-375
    • Revollo, J.R.1    Korner, A.2    Mills, K.F.3    Satoh, A.4    Wang, T.5    Garten, A.6
  • 233
    • 33846693322 scopus 로고    scopus 로고
    • The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals
    • doi:10.1097/MOG.0b013e32801b3c8f
    • Revollo JR, Grimm AA, Imai S. The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Curr Opin Gastroenterol (2007) 23:164-70. doi:10.1097/MOG.0b013e32801b3c8f
    • (2007) Curr Opin Gastroenterol , vol.23 , pp. 164-170
    • Revollo, J.R.1    Grimm, A.A.2    Imai, S.3
  • 234
    • 77955443309 scopus 로고    scopus 로고
    • Nampt/Pbef/visfatin and cancer
    • doi:10.4161/cbt.10.2.12581
    • Bi TQ, Che XM. Nampt/PBEF/visfatin and cancer. Cancer Biol Ther (2010) 10:119-25. doi:10.4161/cbt.10.2.12581
    • (2010) Cancer Biol Ther , vol.10 , pp. 119-125
    • Bi, T.Q.1    Che, X.M.2
  • 235
    • 0033461164 scopus 로고    scopus 로고
    • A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization
    • doi:10.1016/S0014-5793(99)01578-1
    • Hufton SE, Moerkerk PT, Brandwijk R, de Bruine AP, Arends JW, Hoogenboom HR. A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization. FEBS Lett (1999) 463:77-82. doi:10.1016/S0014-5793(99)01578-1
    • (1999) FEBS Lett , vol.463 , pp. 77-82
    • Hufton, S.E.1    Moerkerk, P.T.2    Brandwijk, R.3    de Bruine, A.P.4    Arends, J.W.5    Hoogenboom, H.R.6
  • 236
    • 0037056219 scopus 로고    scopus 로고
    • Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer
    • doi:10.1002/ijc.10584
    • Van Beijnum JR, Moerkerk PT, Gerbers AJ, De Bruine AP, Arends JW, Hoogenboom HR, et al. Target validation for genomics using peptide-specific phage antibodies: a study of five gene products overexpressed in colorectal cancer. Int J Cancer (2002) 101:118-27. doi:10.1002/ijc.10584
    • (2002) Int J Cancer , vol.101 , pp. 118-127
    • Van Beijnum, J.R.1    Moerkerk, P.T.2    Gerbers, A.J.3    De Bruine, A.P.4    Arends, J.W.5    Hoogenboom, H.R.6
  • 237
    • 27144459430 scopus 로고    scopus 로고
    • Gene expression profile associated with response to doxorubicin-based therapy in breast cancer
    • doi:10.1158/1078-0432.CCR-04-0548
    • Folgueira MA, Carraro DM, Brentani H, Patrao DF, Barbosa EM, Netto MM, et al. Gene expression profile associated with response to doxorubicin-based therapy in breast cancer. Clin Cancer Res (2005) 11:7434-43. doi:10.1158/1078-0432.CCR-04-0548
    • (2005) Clin Cancer Res , vol.11 , pp. 7434-7443
    • Folgueira, M.A.1    Carraro, D.M.2    Brentani, H.3    Patrao, D.F.4    Barbosa, E.M.5    Netto, M.M.6
  • 238
    • 49649118727 scopus 로고    scopus 로고
    • The bone-adipose axis in obesity and weight loss
    • doi:10.1007/s11695-008-9548-1
    • Gómez-Ambrosi J, Rodríguez A, Catalán V, Frühbeck G. The bone-adipose axis in obesity and weight loss. Obes Surg (2008) 18:1134-43. doi:10.1007/s11695-008-9548-1
    • (2008) Obes Surg , vol.18 , pp. 1134-1143
    • Gómez-Ambrosi, J.1    Rodríguez, A.2    Catalán, V.3    Frühbeck, G.4
  • 239
    • 34948813665 scopus 로고    scopus 로고
    • Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice
    • doi:10.1172/JCI31986
    • Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, et al. Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest (2007) 117:2877-88. doi:10.1172/JCI31986
    • (2007) J Clin Invest , vol.117 , pp. 2877-2888
    • Nomiyama, T.1    Perez-Tilve, D.2    Ogawa, D.3    Gizard, F.4    Zhao, Y.5    Heywood, E.B.6
  • 240
    • 32644467590 scopus 로고    scopus 로고
    • Osteopontin: role in cell signaling and cancer progression
    • doi:10.1016/j.tcb.2005.12.005
    • Rangaswami H, Bulbule A, Kundu GC. Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol (2006) 16:79-87. doi:10.1016/j.tcb.2005.12.005
    • (2006) Trends Cell Biol , vol.16 , pp. 79-87
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 241
    • 77957141336 scopus 로고    scopus 로고
    • Role of the metastasis-promoting protein osteopontin in the tumour microenvironment
    • doi:10.1111/j.1582-4934.2010.01115.x
    • Anborgh PH, Mutrie JC, Tuck AB, Chambers AF. Role of the metastasis-promoting protein osteopontin in the tumour microenvironment. J Cell Mol Med (2010) 14:2037-44. doi:10.1111/j.1582-4934.2010.01115.x
    • (2010) J Cell Mol Med , vol.14 , pp. 2037-2044
    • Anborgh, P.H.1    Mutrie, J.C.2    Tuck, A.B.3    Chambers, A.F.4
  • 242
    • 84871508773 scopus 로고    scopus 로고
    • Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers
    • doi:10.3748/wjg.v18.i30.3923
    • Cao DX, Li ZJ, Jiang XO, Lum YL, Khin E, Lee NP, et al. Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers. World J Gastroenterol (2012) 18:3923-30. doi:10.3748/wjg.v18.i30.3923
    • (2012) World J Gastroenterol , vol.18 , pp. 3923-3930
    • Cao, D.X.1    Li, Z.J.2    Jiang, X.O.3    Lum, Y.L.4    Khin, E.5    Lee, N.P.6
  • 243
    • 80052741548 scopus 로고    scopus 로고
    • The interplay of YKL-40 and leptin in type 2 diabetic obese patients
    • doi:10.1016/j.diabres.2011.05.040
    • El-Mesallamy HO, Mostafa AM, Amin AI, El Demerdash E. The interplay of YKL-40 and leptin in type 2 diabetic obese patients. Diabetes Res Clin Pract (2011) 93:e113-6. doi:10.1016/j.diabres.2011.05.040
    • (2011) Diabetes Res Clin Pract , vol.93
    • El-Mesallamy, H.O.1    Mostafa, A.M.2    Amin, A.I.3    El Demerdash, E.4
  • 244
    • 33748485114 scopus 로고    scopus 로고
    • YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis
    • doi:10.1007/s00011-006-0076-y
    • Rathcke CN, Vestergaard H. YKL-40, a new inflammatory marker with relation to insulin resistance and with a role in endothelial dysfunction and atherosclerosis. Inflamm Res (2006) 55:221-7. doi:10.1007/s00011-006-0076-y
    • (2006) Inflamm Res , vol.55 , pp. 221-227
    • Rathcke, C.N.1    Vestergaard, H.2
  • 245
    • 33646842919 scopus 로고    scopus 로고
    • Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer
    • Johansen JS. Studies on serum YKL-40 as a biomarker in diseases with inflammation, tissue remodelling, fibroses and cancer. Dan Med Bull (2006) 53:172-209.
    • (2006) Dan Med Bull , vol.53 , pp. 172-209
    • Johansen, J.S.1
  • 246
    • 20144389740 scopus 로고    scopus 로고
    • Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma
    • doi:10.1158/0008-5472.CAN-04-2921
    • Nigro JM, Misra A, Zhang L, Smirnov I, Colman H, Griffin C, et al. Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res (2005) 65:1678-86. doi:10.1158/0008-5472.CAN-04-2921
    • (2005) Cancer Res , vol.65 , pp. 1678-1686
    • Nigro, J.M.1    Misra, A.2    Zhang, L.3    Smirnov, I.4    Colman, H.5    Griffin, C.6
  • 247
    • 18244397978 scopus 로고    scopus 로고
    • Gene expression in papillary thyroid carcinoma reveals highly consistent profiles
    • doi:10.1073/pnas.251547398
    • Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, et al. Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proc Natl Acad Sci U S A (2001) 98:15044-9. doi:10.1073/pnas.251547398
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 15044-15049
    • Huang, Y.1    Prasad, M.2    Lemon, W.J.3    Hampel, H.4    Wright, F.A.5    Kornacker, K.6
  • 248
    • 0345074093 scopus 로고    scopus 로고
    • Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses
    • doi:10.1016/S0002-9440(10)63875-8
    • Sjogren H, Meis-Kindblom JM, Orndal C, Bergh P, Ptaszynski K, Aman P, et al. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma-cytogenetic, molecular genetic, and cDNA microarray analyses. Am J Pathol (2003) 162:781-92. doi:10.1016/S0002-9440(10)63875-8
    • (2003) Am J Pathol , vol.162 , pp. 781-792
    • Sjogren, H.1    Meis-Kindblom, J.M.2    Orndal, C.3    Bergh, P.4    Ptaszynski, K.5    Aman, P.6
  • 250
    • 79960286223 scopus 로고    scopus 로고
    • Signal transduction by reactive oxygen species
    • doi:10.1083/jcb.201102095
    • Finkel T. Signal transduction by reactive oxygen species. J Cell Biol (2011) 194:7-15. doi:10.1083/jcb.201102095
    • (2011) J Cell Biol , vol.194 , pp. 7-15
    • Finkel, T.1
  • 251
    • 0033188494 scopus 로고    scopus 로고
    • 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications
    • doi:10.1089/ars.1999.1.3-255
    • Parola M, Bellomo G, Robino G, Barrera G, Dianzani MU. 4-Hydroxynonenal as a biological signal: molecular basis and pathophysiological implications. Antioxid Redox Signal (1999) 1:255-84. doi:10.1089/ars.1999.1.3-255
    • (1999) Antioxid Redox Signal , vol.1 , pp. 255-284
    • Parola, M.1    Bellomo, G.2    Robino, G.3    Barrera, G.4    Dianzani, M.U.5
  • 252
    • 58149105356 scopus 로고    scopus 로고
    • Cancer cell killing via ROS: to increase or decrease, that is the question
    • doi:10.4161/cbt.7.12.7067
    • Wang J, Yi J. Cancer cell killing via ROS: to increase or decrease, that is the question. Cancer Biol Ther (2008) 7:1875-84. doi:10.4161/cbt.7.12.7067
    • (2008) Cancer Biol Ther , vol.7 , pp. 1875-1884
    • Wang, J.1    Yi, J.2
  • 253
    • 84880267827 scopus 로고    scopus 로고
    • Reactive oxygen species in the activation of MAP kinases
    • doi:10.1016/B978-0-12-405881-1.00002-1
    • Son Y, Kim S, Chung HT, Pae HO. Reactive oxygen species in the activation of MAP kinases. Methods Enzymol (2013) 528:27-48. doi:10.1016/B978-0-12-405881-1.00002-1
    • (2013) Methods Enzymol , vol.528 , pp. 27-48
    • Son, Y.1    Kim, S.2    Chung, H.T.3    Pae, H.O.4
  • 254
    • 85030434746 scopus 로고    scopus 로고
    • Increased oxidative stress in obesity and its impact on metabolic syndrome
    • doi:10.1172/JCI21625
    • Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest (2004) 114:1752-61. doi:10.1172/JCI21625
    • (2004) J Clin Invest , vol.114 , pp. 1752-1761
    • Furukawa, S.1    Fujita, T.2    Shimabukuro, M.3    Iwaki, M.4    Yamada, Y.5    Nakajima, Y.6
  • 255
    • 84884597384 scopus 로고    scopus 로고
    • Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer
    • doi:10.1016/j.orcp.2013.05.004
    • Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract (2013) 7:e330-41. doi:10.1016/j.orcp.2013.05.004
    • (2013) Obes Res Clin Pract , vol.7
    • Matsuda, M.1    Shimomura, I.2
  • 256
    • 0037342568 scopus 로고    scopus 로고
    • Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study
    • doi:10.1161/01.ATV.0000058402.34138.11
    • Keaney JF Jr, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, et al. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol (2003) 23:434-9. doi:10.1161/01.ATV.0000058402.34138.11
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 434-439
    • Keaney Jr., J.F.1    Larson, M.G.2    Vasan, R.S.3    Wilson, P.W.4    Lipinska, I.5    Corey, D.6
  • 257
    • 37549042853 scopus 로고    scopus 로고
    • Adipose expression of catalase is regulated via a novel remote PPARγ-responsive region
    • doi:10.1016/j.bbrc.2007.12.001
    • Okuno Y, Matsuda M, Kobayashi H, Morita K, Suzuki E, Fukuhara A, et al. Adipose expression of catalase is regulated via a novel remote PPARγ-responsive region. Biochem Biophys Res Commun (2008) 366:698-704. doi:10.1016/j.bbrc.2007.12.001
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 698-704
    • Okuno, Y.1    Matsuda, M.2    Kobayashi, H.3    Morita, K.4    Suzuki, E.5    Fukuhara, A.6
  • 258
    • 66849089586 scopus 로고    scopus 로고
    • Dysregulated glutathione metabolism links to impaired insulin action in adipocytes
    • doi:10.1152/ajpendo.90921.2008
    • Kobayashi H, Matsuda M, Fukuhara A, Komuro R, Shimomura I. Dysregulated glutathione metabolism links to impaired insulin action in adipocytes. Am J Physiol Endocrinol Metab (2009) 296:E1326-34. doi:10.1152/ajpendo.90921.2008
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Kobayashi, H.1    Matsuda, M.2    Fukuhara, A.3    Komuro, R.4    Shimomura, I.5
  • 259
    • 34748858784 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis: impact on cancer therapy
    • doi:10.1002/jps.20874
    • Ozben T. Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci (2007) 96:2181-96. doi:10.1002/jps.20874
    • (2007) J Pharm Sci , vol.96 , pp. 2181-2196
    • Ozben, T.1
  • 260
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • doi:10.1016/j.drup.2004.01.004
    • Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat (2004) 7:97-110. doi:10.1016/j.drup.2004.01.004
    • (2004) Drug Resist Updat , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 261
    • 0027300736 scopus 로고
    • Lipid peroxidation: its mechanism, measurement, and significance
    • Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr (1993) 57:715S-24S.
    • (1993) Am J Clin Nutr , vol.57
    • Halliwell, B.1    Chirico, S.2
  • 262
    • 12144287363 scopus 로고    scopus 로고
    • Body mass index, circulating levels of sex-steroid hormones IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women
    • doi:10.1530/eje.0.1500161
    • Lukanova A, Lundin E, Zeleniuch-Jacquotte A, Muti P, Mure A, Rinaldi S, et al. Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women. Eur J Endocrinol (2004) 150:161-71. doi:10.1530/eje.0.1500161
    • (2004) Eur J Endocrinol , vol.150 , pp. 161-171
    • Lukanova, A.1    Lundin, E.2    Zeleniuch-Jacquotte, A.3    Muti, P.4    Mure, A.5    Rinaldi, S.6
  • 263
    • 84893559745 scopus 로고    scopus 로고
    • On estrogen, cholesterol metabolism, and breast cancer
    • doi:10.1056/NEJMcibr1315176
    • Warner M, Gustafsson JA. On estrogen, cholesterol metabolism, and breast cancer. N Engl J Med (2014) 370:572-3. doi:10.1056/NEJMcibr1315176
    • (2014) N Engl J Med , vol.370 , pp. 572-573
    • Warner, M.1    Gustafsson, J.A.2
  • 264
    • 66649098171 scopus 로고    scopus 로고
    • Minireview: obesity and breast cancer: the estrogen connection
    • doi:10.1210/en.2009-0070
    • Cleary MP, Grossmann ME. Minireview: obesity and breast cancer: the estrogen connection. Endocrinology (2009) 150:2537-42. doi:10.1210/en.2009-0070
    • (2009) Endocrinology , vol.150 , pp. 2537-2542
    • Cleary, M.P.1    Grossmann, M.E.2
  • 265
    • 84905484717 scopus 로고    scopus 로고
    • The estrogen receptor joins other cancer biomarkers as a predictor of outcome
    • doi:10.1155/2013/479541
    • Leslie KK, Thiel KW, Reyes HD, Yang S, Zhang Y, Carlson MJ, et al. The estrogen receptor joins other cancer biomarkers as a predictor of outcome. Obstet Gynecol Int (2013) 2013:479541. doi:10.1155/2013/479541
    • (2013) Obstet Gynecol Int , vol.2013 , pp. 479541
    • Leslie, K.K.1    Thiel, K.W.2    Reyes, H.D.3    Yang, S.4    Zhang, Y.5    Carlson, M.J.6
  • 267
    • 0034326252 scopus 로고    scopus 로고
    • Effects of estrogen on global gene expression: identification of novel targets of estrogen action
    • Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, et al. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res (2000) 60:5977-83.
    • (2000) Cancer Res , vol.60 , pp. 5977-5983
    • Charpentier, A.H.1    Bednarek, A.K.2    Daniel, R.L.3    Hawkins, K.A.4    Laflin, K.J.5    Gaddis, S.6
  • 268
    • 0141785350 scopus 로고    scopus 로고
    • Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype
    • doi:10.1210/en.2003-0567
    • Frasor J, Danes JM, Komm B, Chang KC, Lyttle CR, Katzenellenbogen BS. Profiling of estrogen up- and down-regulated gene expression in human breast cancer cells: insights into gene networks and pathways underlying estrogenic control of proliferation and cell phenotype. Endocrinology (2003) 144:4562-74. doi:10.1210/en.2003-0567
    • (2003) Endocrinology , vol.144 , pp. 4562-4574
    • Frasor, J.1    Danes, J.M.2    Komm, B.3    Chang, K.C.4    Lyttle, C.R.5    Katzenellenbogen, B.S.6
  • 269
    • 83655202585 scopus 로고    scopus 로고
    • Tissue physiology and pathology of aromatase
    • doi:10.1016/j.steroids.2011.10.013
    • Stocco C. Tissue physiology and pathology of aromatase. Steroids (2012) 77:27-35. doi:10.1016/j.steroids.2011.10.013
    • (2012) Steroids , vol.77 , pp. 27-35
    • Stocco, C.1
  • 270
    • 0037123341 scopus 로고    scopus 로고
    • Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies
    • Key T, Appleby P, Barnes I, Reeves G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst (2002) 94:606-16.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 606-616
    • Key, T.1    Appleby, P.2    Barnes, I.3    Reeves, G.4
  • 271
    • 0030666150 scopus 로고    scopus 로고
    • Endogenous estrogen and postmenopausal breast cancer: a quantitative review
    • doi:10.1023/A:1018476631561
    • Thomas HV, Reeves GK, Key TJ. Endogenous estrogen and postmenopausal breast cancer: a quantitative review. Cancer Causes Control (1997) 8:922-8. doi:10.1023/A:1018476631561
    • (1997) Cancer Causes Control , vol.8 , pp. 922-928
    • Thomas, H.V.1    Reeves, G.K.2    Key, T.J.3
  • 272
    • 84874158714 scopus 로고    scopus 로고
    • Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer
    • Carlson MJ, Thiel KW, Yang S, Leslie KK. Catch it before it kills: progesterone, obesity, and the prevention of endometrial cancer. Discov Med (2012) 14:215-22.
    • (2012) Discov Med , vol.14 , pp. 215-222
    • Carlson, M.J.1    Thiel, K.W.2    Yang, S.3    Leslie, K.K.4
  • 273
    • 0023736417 scopus 로고
    • The insulin receptor and the molecular mechanism of insulin action
    • doi:10.1172/JCI113711
    • Kahn CR, White MF. The insulin receptor and the molecular mechanism of insulin action. J Clin Invest (1988) 82:1151-6. doi:10.1172/JCI113711
    • (1988) J Clin Invest , vol.82 , pp. 1151-1156
    • Kahn, C.R.1    White, M.F.2
  • 274
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • doi:10.1161/01.RES.0000256090.42690.05
    • Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res (2007) 100:328-41. doi:10.1161/01.RES.0000256090.42690.05
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 275
    • 84872836906 scopus 로고    scopus 로고
    • What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
    • doi:10.1097/MOL.0b013e32835b465b
    • Xu XJ, Pories WJ, Dohm LG, Ruderman NB. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant? Curr Opin Lipidol (2013) 24:49-56. doi:10.1097/MOL.0b013e32835b465b
    • (2013) Curr Opin Lipidol , vol.24 , pp. 49-56
    • Xu, X.J.1    Pories, W.J.2    Dohm, L.G.3    Ruderman, N.B.4
  • 276
    • 54349083481 scopus 로고    scopus 로고
    • Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    • doi:10.1016/S1470-2045(08)70235-3
    • Ma J, Li H, Giovannucci E, Mucci L, Qiu W, Nguyen PL, et al. Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol (2008) 9:1039-47. doi:10.1016/S1470-2045(08)70235-3
    • (2008) Lancet Oncol , vol.9 , pp. 1039-1047
    • Ma, J.1    Li, H.2    Giovannucci, E.3    Mucci, L.4    Qiu, W.5    Nguyen, P.L.6
  • 277
    • 84863136847 scopus 로고    scopus 로고
    • Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells
    • doi:10.1042/BJ20111322
    • Liu Z, Yan R, Al-Salman A, Shen Y, Bu Y, Ma J, et al. Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells. Biochem J (2012) 442:273-82. doi:10.1042/BJ20111322
    • (2012) Biochem J , vol.442 , pp. 273-282
    • Liu, Z.1    Yan, R.2    Al-Salman, A.3    Shen, Y.4    Bu, Y.5    Ma, J.6
  • 278
    • 84861202836 scopus 로고    scopus 로고
    • Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are phosphatidylinositol 3-kinase/Akt dependent
    • doi:10.1016/j.ygyno.2012.03.012
    • Wang Y, Hua S, Tian W, Zhang L, Zhao J, Zhang H, et al. Mitogenic and anti-apoptotic effects of insulin in endometrial cancer are phosphatidylinositol 3-kinase/Akt dependent. Gynecol Oncol (2012) 125:734-41. doi:10.1016/j.ygyno.2012.03.012
    • (2012) Gynecol Oncol , vol.125 , pp. 734-741
    • Wang, Y.1    Hua, S.2    Tian, W.3    Zhang, L.4    Zhao, J.5    Zhang, H.6
  • 280
    • 70350098099 scopus 로고    scopus 로고
    • Obesity and cancer: the role of dysfunctional adipose tissue
    • doi:10.1158/1055-9965.EPI-09-0372
    • van Kruijsdijk RC, van der Wall E, Visseren FL. Obesity and cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomarkers Prev (2009) 18:2569-78. doi:10.1158/1055-9965.EPI-09-0372
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 2569-2578
    • van Kruijsdijk, R.C.1    van der Wall, E.2    Visseren, F.L.3
  • 281
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: biological actions
    • doi:10.1210/edrv-16-1-3
    • Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev (1995) 16:3-34. doi:10.1210/edrv-16-1-3
    • (1995) Endocr Rev , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 282
    • 0032559272 scopus 로고    scopus 로고
    • Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study
    • doi:10.1126/science.279.5350.563
    • Chan JM, Stampfer MJ, Giovannucci E, Gann PH, Ma J, Wilkinson P, et al. Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science (1998) 279:563-6. doi:10.1126/science.279.5350.563
    • (1998) Science , vol.279 , pp. 563-566
    • Chan, J.M.1    Stampfer, M.J.2    Giovannucci, E.3    Gann, P.H.4    Ma, J.5    Wilkinson, P.6
  • 283
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
    • doi:10.1016/S0140-6736(97)10384-1
    • Hankinson SE, Willett WC, Colditz GA, Hunter DJ, Michaud DS, Deroo B, et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet (1998) 351:1393-6. doi:10.1016/S0140-6736(97)10384-1
    • (1998) Lancet , vol.351 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3    Hunter, D.J.4    Michaud, D.S.5    Deroo, B.6
  • 284
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    • doi:10.1093/jnci/91.23.2052
    • Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst (1999) 91:620-5. doi:10.1093/jnci/91.23.2052
    • (1999) J Natl Cancer Inst , vol.91 , pp. 620-625
    • Ma, J.1    Pollak, M.N.2    Giovannucci, E.3    Chan, J.M.4    Tao, Y.5    Hennekens, C.H.6
  • 285
    • 0033585421 scopus 로고    scopus 로고
    • Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis
    • doi:10.1093/jnci/91.2.151
    • Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X. Plasma levels of insulin-like growth factor-I and lung cancer risk: a case-control analysis. J Natl Cancer Inst (1999) 91:151-6. doi:10.1093/jnci/91.2.151
    • (1999) J Natl Cancer Inst , vol.91 , pp. 151-156
    • Yu, H.1    Spitz, M.R.2    Mistry, J.3    Gu, J.4    Hong, W.K.5    Wu, X.6
  • 286
    • 0034692430 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor family in cancer development and progression
    • doi:10.1093/jnci/92.18.1472
    • Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst (2000) 92:1472-89. doi:10.1093/jnci/92.18.1472
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1472-1489
    • Yu, H.1    Rohan, T.2
  • 287
    • 0035160628 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factors and colon cancer: a review of the evidence
    • Giovannucci E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr (2001) 131:3109S-20S.
    • (2001) J Nutr , vol.131
    • Giovannucci, E.1
  • 288
    • 1942436958 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis
    • doi:10.1016/S0140-6736(04)16044-3
    • Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet (2004) 363:1346-53. doi:10.1016/S0140-6736(04)16044-3
    • (2004) Lancet , vol.363 , pp. 1346-1353
    • Renehan, A.G.1    Zwahlen, M.2    Minder, C.3    O'Dwyer, S.T.4    Shalet, S.M.5    Egger, M.6
  • 289
    • 84872290190 scopus 로고    scopus 로고
    • Hypoxia and adipose tissue function and dysfunction in obesity
    • doi:10.1152/physrev.00017.2012
    • Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev (2013) 93:1-21. doi:10.1152/physrev.00017.2012
    • (2013) Physiol Rev , vol.93 , pp. 1-21
    • Trayhurn, P.1
  • 290
    • 84873030540 scopus 로고    scopus 로고
    • Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression
    • doi:10.1146/annurev-med-121211-091527
    • Gilbert CA, Slingerland JM. Cytokines, obesity, and cancer: new insights on mechanisms linking obesity to cancer risk and progression. Annu Rev Med (2013) 64:45-57. doi:10.1146/annurev-med-121211-091527
    • (2013) Annu Rev Med , vol.64 , pp. 45-57
    • Gilbert, C.A.1    Slingerland, J.M.2
  • 291
    • 84861536618 scopus 로고    scopus 로고
    • High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases
    • doi:10.1002/hep.25572
    • Yan W, Chang Y, Liang X, Cardinal JS, Huang H, Thorne SH, et al. High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases. Hepatology (2012) 55:1863-75. doi:10.1002/hep.25572
    • (2012) Hepatology , vol.55 , pp. 1863-1875
    • Yan, W.1    Chang, Y.2    Liang, X.3    Cardinal, J.S.4    Huang, H.5    Thorne, S.H.6
  • 292
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • doi:10.1038/nrc2444
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer (2008) 8:618-31. doi:10.1038/nrc2444
    • (2008) Nat Rev Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 293
    • 47049089532 scopus 로고    scopus 로고
    • Nitric oxide, apoptosis and macrophage polarization during tumor progression
    • doi:10.1016/j.niox.2008.04.021
    • Weigert A, Brune B. Nitric oxide, apoptosis and macrophage polarization during tumor progression. Nitric Oxide (2008) 19:95-102. doi:10.1016/j.niox.2008.04.021
    • (2008) Nitric Oxide , vol.19 , pp. 95-102
    • Weigert, A.1    Brune, B.2
  • 294
    • 44849100198 scopus 로고    scopus 로고
    • NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
    • doi:10.1038/nature06905
    • Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, et al. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature (2008) 453:807-11. doi:10.1038/nature06905
    • (2008) Nature , vol.453 , pp. 807-811
    • Rius, J.1    Guma, M.2    Schachtrup, C.3    Akassoglou, K.4    Zinkernagel, A.S.5    Nizet, V.6
  • 295
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • doi:10.1182/blood-2004-03-1109
    • Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood (2004) 104:2224-34. doi:10.1182/blood-2004-03-1109
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 296
    • 84903278004 scopus 로고    scopus 로고
    • Expressions of hypoxia-inducible factor-1 and epithelial cell adhesion molecule are linked with aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation therapy
    • doi:10.1245/s10434-014-3575-z
    • Yamada S, Utsunomiya T, Morine Y, Imura S, Ikemoto T, Arakawa Y, et al. Expressions of hypoxia-inducible factor-1 and epithelial cell adhesion molecule are linked with aggressive local recurrence of hepatocellular carcinoma after radiofrequency ablation therapy. Ann Surg Oncol (2014). doi:10.1245/s10434-014-3575-z
    • (2014) Ann Surg Oncol
    • Yamada, S.1    Utsunomiya, T.2    Morine, Y.3    Imura, S.4    Ikemoto, T.5    Arakawa, Y.6
  • 297
    • 84870941135 scopus 로고    scopus 로고
    • Hypoxia-regulated target genes implicated in tumor metastasis
    • doi:10.1186/1423-0127-19-102
    • Tsai YP, Wu KJ. Hypoxia-regulated target genes implicated in tumor metastasis. J Biomed Sci (2012) 19:102. doi:10.1186/1423-0127-19-102
    • (2012) J Biomed Sci , vol.19 , pp. 102
    • Tsai, Y.P.1    Wu, K.J.2
  • 298
    • 84865575592 scopus 로고    scopus 로고
    • Molecular mechanisms mediating metastasis of hypoxic breast cancer cells
    • doi:10.1016/j.molmed.2012.08.001
    • Semenza GL. Molecular mechanisms mediating metastasis of hypoxic breast cancer cells. Trends Mol Med (2012) 18:534-43. doi:10.1016/j.molmed.2012.08.001
    • (2012) Trends Mol Med , vol.18 , pp. 534-543
    • Semenza, G.L.1
  • 300
    • 79954995170 scopus 로고    scopus 로고
    • Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy
    • doi:10.1254/jphs.10R20FM
    • Kizaka-Kondoh S, Kuchimaru T, Kadonosono T. Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: hypoxia-inducible factor-1 (HIF-1)-active cells as a target for cancer therapy. J Pharmacol Sci (2011) 115:440-5. doi:10.1254/jphs.10R20FM
    • (2011) J Pharmacol Sci , vol.115 , pp. 440-445
    • Kizaka-Kondoh, S.1    Kuchimaru, T.2    Kadonosono, T.3
  • 301
    • 79954991372 scopus 로고    scopus 로고
    • Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: drug discovery for targeting the tumor microenvironment
    • doi:10.1254/jphs.10R25FM
    • Nagasawa H. Pathophysiological response to hypoxia - from the molecular mechanisms of malady to drug discovery: drug discovery for targeting the tumor microenvironment. J Pharmacol Sci (2011) 115:446-52. doi:10.1254/jphs.10R25FM
    • (2011) J Pharmacol Sci , vol.115 , pp. 446-452
    • Nagasawa, H.1
  • 302
    • 84892412107 scopus 로고    scopus 로고
    • Nutrition and physical activity cancer prevention guidelines, cancer risk, and mortality in the women's health initiative
    • doi:10.1158/1940-6207.CAPR-13-0258
    • Thomson CA, McCullough ML, Wertheim BC, Chlebowski RT, Martinez ME, Stefanick ML, et al. Nutrition and physical activity cancer prevention guidelines, cancer risk, and mortality in the women's health initiative. Cancer Prev Res (2014) 7:42-53. doi:10.1158/1940-6207.CAPR-13-0258
    • (2014) Cancer Prev Res , vol.7 , pp. 42-53
    • Thomson, C.A.1    McCullough, M.L.2    Wertheim, B.C.3    Chlebowski, R.T.4    Martinez, M.E.5    Stefanick, M.L.6
  • 303
    • 84881058916 scopus 로고    scopus 로고
    • Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes
    • doi:10.6061/clinics/2013(07)20
    • Caponi PW, Lehnen AM, Pinto GH, Borges J, Markoski M, Machado UF, et al. Aerobic exercise training induces metabolic benefits in rats with metabolic syndrome independent of dietary changes. Clinics (2013) 68:1010-7. doi:10.6061/clinics/2013(07)20
    • (2013) Clinics , vol.68 , pp. 1010-1017
    • Caponi, P.W.1    Lehnen, A.M.2    Pinto, G.H.3    Borges, J.4    Markoski, M.5    Machado, U.F.6
  • 304
    • 78650678086 scopus 로고    scopus 로고
    • The effect of physical activity on 18-month weight change in overweight adults
    • doi:10.1038/oby.2010.122
    • Jakicic JM, Otto AD, Lang W, Semler L, Winters C, Polzien K, et al. The effect of physical activity on 18-month weight change in overweight adults. Obesity (2011) 19:100-9. doi:10.1038/oby.2010.122
    • (2011) Obesity , vol.19 , pp. 100-109
    • Jakicic, J.M.1    Otto, A.D.2    Lang, W.3    Semler, L.4    Winters, C.5    Polzien, K.6
  • 306
    • 0031052114 scopus 로고    scopus 로고
    • Differences in the concentration and composition of low-density lipoprotein subfraction particles between sedentary and trained hypercholesterolemic men
    • doi:10.1016/S0026-0495(97)90300-0
    • Halle M, Berg A, Konig D, Keul J, Baumstark MW. Differences in the concentration and composition of low-density lipoprotein subfraction particles between sedentary and trained hypercholesterolemic men. Metabolism (1997) 46:186-91. doi:10.1016/S0026-0495(97)90300-0
    • (1997) Metabolism , vol.46 , pp. 186-191
    • Halle, M.1    Berg, A.2    Konig, D.3    Keul, J.4    Baumstark, M.W.5
  • 307
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • doi:10.1056/NEJMoa012512
    • Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med (2002) 346:393-403. doi:10.1056/NEJMoa012512
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3    Hamman, R.F.4    Lachin, J.M.5    Walker, E.A.6
  • 308
    • 35349004714 scopus 로고    scopus 로고
    • The growth hormone/insulin-like growth factor-I axis in exercise and sport
    • doi:10.1210/er.2006-0052
    • Gibney J, Healy ML, Sonksen PH. The growth hormone/insulin-like growth factor-I axis in exercise and sport. Endocr Rev (2007) 28:603-24. doi:10.1210/er.2006-0052
    • (2007) Endocr Rev , vol.28 , pp. 603-624
    • Gibney, J.1    Healy, M.L.2    Sonksen, P.H.3
  • 309
    • 0344394255 scopus 로고    scopus 로고
    • Physical inactivity, excess adiposity and premature mortality
    • doi:10.1046/j.1467-789X.2003.00120.x
    • Katzmarzyk PT, Janssen I, Ardern CI. Physical inactivity, excess adiposity and premature mortality. Obes Rev (2003) 4:257-90. doi:10.1046/j.1467-789X.2003.00120.x
    • (2003) Obes Rev , vol.4 , pp. 257-290
    • Katzmarzyk, P.T.1    Janssen, I.2    Ardern, C.I.3
  • 310
    • 10844262691 scopus 로고    scopus 로고
    • Adiposity as compared with physical activity in predicting mortality among women
    • doi:10.1056/NEJMoa042135
    • Hu FB, Willett WC, Li T, Stampfer MJ, Colditz GA, Manson JE. Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med (2004) 351:2694-703. doi:10.1056/NEJMoa042135
    • (2004) N Engl J Med , vol.351 , pp. 2694-2703
    • Hu, F.B.1    Willett, W.C.2    Li, T.3    Stampfer, M.J.4    Colditz, G.A.5    Manson, J.E.6
  • 312
    • 84884721686 scopus 로고    scopus 로고
    • Nutrition and physical activity influence on breast cancer incidence and outcome
    • doi:10.1016/j.breast.2013.07.006
    • Chlebowski RT. Nutrition and physical activity influence on breast cancer incidence and outcome. Breast (2013) 22(Suppl 2):S30-7. doi:10.1016/j.breast.2013.07.006
    • (2013) Breast , vol.22 , Issue.SUPPL. 2
    • Chlebowski, R.T.1
  • 313
    • 84883166701 scopus 로고    scopus 로고
    • Lifestyle factors associated with survival after colorectal cancer diagnosis
    • doi:10.1038/bjc.2013.310
    • Boyle T, Fritschi L, Platell C, Heyworth J. Lifestyle factors associated with survival after colorectal cancer diagnosis. Br J Cancer (2013) 109:814-22. doi:10.1038/bjc.2013.310
    • (2013) Br J Cancer , vol.109 , pp. 814-822
    • Boyle, T.1    Fritschi, L.2    Platell, C.3    Heyworth, J.4
  • 314
    • 84881555862 scopus 로고    scopus 로고
    • Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans
    • doi:10.1007/s10552-013-0247-4
    • Song JH, Kim YS, Yang SY, Chung SJ, Park MJ, Lim SH, et al. Physical activity and other lifestyle factors in relation to the prevalence of colorectal adenoma: a colonoscopy-based study in asymptomatic Koreans. Cancer Causes Control (2013) 24:1717-26. doi:10.1007/s10552-013-0247-4
    • (2013) Cancer Causes Control , vol.24 , pp. 1717-1726
    • Song, J.H.1    Kim, Y.S.2    Yang, S.Y.3    Chung, S.J.4    Park, M.J.5    Lim, S.H.6
  • 315
    • 84875031994 scopus 로고    scopus 로고
    • Prostate cancer and physical activity: adaptive response to oxidative stress
    • doi:10.1016/j.freeradbiomed.2013.02.009
    • Rebillard A, Lefeuvre-Orfila L, Gueritat J, Cillard J. Prostate cancer and physical activity: adaptive response to oxidative stress. Free Radic Biol Med (2013) 60:115-24. doi:10.1016/j.freeradbiomed.2013.02.009
    • (2013) Free Radic Biol Med , vol.60 , pp. 115-124
    • Rebillard, A.1    Lefeuvre-Orfila, L.2    Gueritat, J.3    Cillard, J.4
  • 316
    • 33845273560 scopus 로고    scopus 로고
    • ABC of obesity Obesity and cancer
    • doi:10.1136/bmj.39042.565035.BE1
    • McMillan DC, Sattar N, McArdle CS. ABC of obesity. Obesity and cancer. BMJ (2006) 333:1109-11. doi:10.1136/bmj.39042.565035.BE1
    • (2006) BMJ , vol.333 , pp. 1109-1111
    • McMillan, D.C.1    Sattar, N.2    McArdle, C.S.3
  • 317
    • 84888261305 scopus 로고    scopus 로고
    • ω-3 polyunsaturated fatty acids and cancer
    • doi:10.2174/18715206113139990319
    • Jing K, Wu T, Lim K. ω-3 polyunsaturated fatty acids and cancer. Anticancer Agents Med Chem (2013) 13:1162-77. doi:10.2174/18715206113139990319
    • (2013) Anticancer Agents Med Chem , vol.13 , pp. 1162-1177
    • Jing, K.1    Wu, T.2    Lim, K.3
  • 318
    • 84873410448 scopus 로고    scopus 로고
    • Rossi Fanelli F ω-3 fatty acids in cancer
    • doi:10.1097/MCO.0b013e32835d2d99
    • Laviano A, Rianda S, Molfino A, Rossi Fanelli F. ω-3 fatty acids in cancer. Curr Opin Clin Nutr Metab Care (2013) 16:156-61. doi:10.1097/MCO.0b013e32835d2d99
    • (2013) Curr Opin Clin Nutr Metab Care , vol.16 , pp. 156-161
    • Laviano, A.1    Rianda, S.2    Molfino, A.3
  • 319
    • 84893021314 scopus 로고    scopus 로고
    • Anticolorectal cancer activity of the ω-3 polyunsaturated fatty acid eicosapentaenoic acid
    • doi:10.1136/gutjnl-2013-306445
    • Cockbain AJ, Volpato M, Race AD, Munarini A, Fazio C, Belluzzi A, et al. Anticolorectal cancer activity of the ω-3 polyunsaturated fatty acid eicosapentaenoic acid. Gut (2014). doi:10.1136/gutjnl-2013-306445
    • (2014) Gut
    • Cockbain, A.J.1    Volpato, M.2    Race, A.D.3    Munarini, A.4    Fazio, C.5    Belluzzi, A.6
  • 320
    • 84878736557 scopus 로고    scopus 로고
    • Mechanisms of ω-3 polyunsaturated fatty acids in prostate cancer prevention
    • doi:10.1155/2013/824563
    • Gu Z, Suburu J, Chen H, Chen YQ. Mechanisms of ω-3 polyunsaturated fatty acids in prostate cancer prevention. Biomed Res Int (2013) 2013:824563. doi:10.1155/2013/824563
    • (2013) Biomed Res Int , vol.2013 , pp. 824563
    • Gu, Z.1    Suburu, J.2    Chen, H.3    Chen, Y.Q.4
  • 321
    • 34347387832 scopus 로고    scopus 로고
    • Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity
    • doi:10.1126/science.1140958
    • Chen Z, Odstrcil EA, Tu BP, McKnight SL. Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity. Science (2007) 316:1916-9. doi:10.1126/science.1140958
    • (2007) Science , vol.316 , pp. 1916-1919
    • Chen, Z.1    Odstrcil, E.A.2    Tu, B.P.3    McKnight, S.L.4
  • 322
    • 77951081705 scopus 로고    scopus 로고
    • Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate
    • doi:10.1073/pnas.1002422107
    • Silverman SJ, Petti AA, Slavov N, Parsons L, Briehof R, Thiberge SY, et al. Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate. Proc Natl Acad Sci U S A (2010) 107:6946-51. doi:10.1073/pnas.1002422107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 6946-6951
    • Silverman, S.J.1    Petti, A.A.2    Slavov, N.3    Parsons, L.4    Briehof, R.5    Thiberge, S.Y.6
  • 323
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • doi:10.1101/gad.189365.112
    • Dang CV. Links between metabolism and cancer. Genes Dev (2012) 26:877-90. doi:10.1101/gad.189365.112
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 324
    • 80052522837 scopus 로고    scopus 로고
    • Sucrose, high-sugar foods, and risk of endometrial cancer - a population-based cohort study
    • doi:10.1158/1055-9965.EPI-11-0402
    • Friberg E, Wallin A, Wolk A. Sucrose, high-sugar foods, and risk of endometrial cancer - a population-based cohort study. Cancer Epidemiol Biomarkers Prev (2011) 20:1831-7. doi:10.1158/1055-9965.EPI-11-0402
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , pp. 1831-1837
    • Friberg, E.1    Wallin, A.2    Wolk, A.3
  • 325
    • 34848886867 scopus 로고    scopus 로고
    • Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort
    • doi:10.1093/aje/kwm161
    • Cust AE, Slimani N, Kaaks R, van Bakel M, Biessy C, Ferrari P, et al. Dietary carbohydrates, glycemic index, glycemic load, and endometrial cancer risk within the European prospective investigation into cancer and nutrition cohort. Am J Epidemiol (2007) 166:912-23. doi:10.1093/aje/kwm161
    • (2007) Am J Epidemiol , vol.166 , pp. 912-923
    • Cust, A.E.1    Slimani, N.2    Kaaks, R.3    van Bakel, M.4    Biessy, C.5    Ferrari, P.6
  • 326
    • 80955177511 scopus 로고    scopus 로고
    • Sugars in diet and risk of cancer in the NIH-AARP diet and health study
    • doi:10.1002/ijc.25990
    • Tasevska N, Jiao L, Cross AJ, Kipnis V, Subar AF, Hollenbeck A, et al. Sugars in diet and risk of cancer in the NIH-AARP diet and health study. Int J Cancer (2012) 130:159-69. doi:10.1002/ijc.25990
    • (2012) Int J Cancer , vol.130 , pp. 159-169
    • Tasevska, N.1    Jiao, L.2    Cross, A.J.3    Kipnis, V.4    Subar, A.F.5    Hollenbeck, A.6
  • 327
    • 75249094454 scopus 로고    scopus 로고
    • Calorie restriction and cancer prevention: metabolic and molecular mechanisms
    • doi:10.1016/j.tips.2009.11.004
    • Longo VD, Fontana L. Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci (2010) 31:89-98. doi:10.1016/j.tips.2009.11.004
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 89-98
    • Longo, V.D.1    Fontana, L.2
  • 328
    • 84884496377 scopus 로고    scopus 로고
    • Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus
    • doi:10.1097/SLA.0b013e3182a5034b
    • Brethauer SA, Aminian A, Romero-Talamas H, Batayyah E, Mackey J, Kennedy L, et al. Can diabetes be surgically cured? Long-term metabolic effects of bariatric surgery in obese patients with type 2 diabetes mellitus. Ann Surg (2013) 258:628-37. doi:10.1097/SLA.0b013e3182a5034b
    • (2013) Ann Surg , vol.258 , pp. 628-637
    • Brethauer, S.A.1    Aminian, A.2    Romero-Talamas, H.3    Batayyah, E.4    Mackey, J.5    Kennedy, L.6
  • 329
    • 84881524012 scopus 로고    scopus 로고
    • The effects of bariatric procedures versus medical therapy for obese patients with type 2 diabetes: meta-analysis of randomized controlled trials
    • doi:10.1155/2013/410609
    • Guo X, Liu X, Wang M, Wei F, Zhang Y. The effects of bariatric procedures versus medical therapy for obese patients with type 2 diabetes: meta-analysis of randomized controlled trials. Biomed Res Int (2013) 2013:410609. doi:10.1155/2013/410609
    • (2013) Biomed Res Int , vol.2013 , pp. 410609
    • Guo, X.1    Liu, X.2    Wang, M.3    Wei, F.4    Zhang, Y.5
  • 330
    • 84888036496 scopus 로고    scopus 로고
    • Bariatric surgery reduces risk factors for development of type 2 diabetes mellitus in morbidly obese, nondiabetic patients
    • doi:10.1089/met.2013.0085
    • Nestvold TK, Nielsen EW, Lappegard KT. Bariatric surgery reduces risk factors for development of type 2 diabetes mellitus in morbidly obese, nondiabetic patients. Metab Syndr Relat Disord (2013) 11:441-6. doi:10.1089/met.2013.0085
    • (2013) Metab Syndr Relat Disord , vol.11 , pp. 441-446
    • Nestvold, T.K.1    Nielsen, E.W.2    Lappegard, K.T.3
  • 331
    • 66149125232 scopus 로고    scopus 로고
    • Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis
    • doi:10.1016/j.amjmed.2008.10.037
    • Greenburg DL, Lettieri CJ, Eliasson AH. Effects of surgical weight loss on measures of obstructive sleep apnea: a meta-analysis. Am J Med (2009) 122:535-42. doi:10.1016/j.amjmed.2008.10.037
    • (2009) Am J Med , vol.122 , pp. 535-542
    • Greenburg, D.L.1    Lettieri, C.J.2    Eliasson, A.H.3
  • 332
    • 71149110534 scopus 로고    scopus 로고
    • Effects of weight loss on lipid transfer proteins in morbidly obese women
    • doi:10.1007/s11745-009-3349-8
    • Laimer MW, Engl J, Tschoner A, Kaser S, Ritsch A, Tatarczyk T, et al. Effects of weight loss on lipid transfer proteins in morbidly obese women. Lipids (2009) 44:1125-30. doi:10.1007/s11745-009-3349-8
    • (2009) Lipids , vol.44 , pp. 1125-1130
    • Laimer, M.W.1    Engl, J.2    Tschoner, A.3    Kaser, S.4    Ritsch, A.5    Tatarczyk, T.6
  • 333
    • 84862631238 scopus 로고    scopus 로고
    • Effect of bariatric surgery on liver fibrosis
    • doi:10.1007/s11695-011-0559-y
    • Moretto M, Kupski C, da Silva VD, Padoin AV, Mottin CC. Effect of bariatric surgery on liver fibrosis. Obes Surg (2012) 22:1044-9. doi:10.1007/s11695-011-0559-y
    • (2012) Obes Surg , vol.22 , pp. 1044-1049
    • Moretto, M.1    Kupski, C.2    da Silva, V.D.3    Padoin, A.V.4    Mottin, C.C.5
  • 334
    • 79959239180 scopus 로고    scopus 로고
    • Cardiovascular benefits of bariatric surgery in morbidly obese patients
    • doi:10.1111/j.1467-789X.2010.00831.x
    • Athyros VG, Tziomalos K, Karagiannis A, Mikhailidis DP. Cardiovascular benefits of bariatric surgery in morbidly obese patients. Obes Rev (2011) 12:515-24. doi:10.1111/j.1467-789X.2010.00831.x
    • (2011) Obes Rev , vol.12 , pp. 515-524
    • Athyros, V.G.1    Tziomalos, K.2    Karagiannis, A.3    Mikhailidis, D.P.4
  • 335
    • 84889767375 scopus 로고    scopus 로고
    • New insights on bariatric surgery outcomes
    • doi:10.1001/jama.2013.280927
    • Ikramuddin S, Livingston EH. New insights on bariatric surgery outcomes. JAMA (2013) 310:2401-2. doi:10.1001/jama.2013.280927
    • (2013) JAMA , vol.310 , pp. 2401-2402
    • Ikramuddin, S.1    Livingston, E.H.2
  • 336
    • 56049102585 scopus 로고    scopus 로고
    • Bariatric surgery reduces cancer risk in morbidly obese patients
    • doi:10.1016/j.soard.2008.08.025
    • Christou NV, Lieberman M, Sampalis F, Sampalis JS. Bariatric surgery reduces cancer risk in morbidly obese patients. Surg Obes Relat Dis (2008) 4:691-5. doi:10.1016/j.soard.2008.08.025
    • (2008) Surg Obes Relat Dis , vol.4 , pp. 691-695
    • Christou, N.V.1    Lieberman, M.2    Sampalis, F.3    Sampalis, J.S.4
  • 337
    • 63049095081 scopus 로고    scopus 로고
    • Cancer incidence and mortality after gastric bypass surgery
    • doi:10.1038/oby.2008.610
    • Adams TD, Stroup AM, Gress RE, Adams KF, Calle EE, Smith SC, et al. Cancer incidence and mortality after gastric bypass surgery. Obesity (2009) 17:796-802. doi:10.1038/oby.2008.610
    • (2009) Obesity , vol.17 , pp. 796-802
    • Adams, T.D.1    Stroup, A.M.2    Gress, R.E.3    Adams, K.F.4    Calle, E.E.5    Smith, S.C.6
  • 338
    • 79955441997 scopus 로고    scopus 로고
    • Metabolic surgery and cancer: protective effects of bariatric procedures
    • doi:10.1002/cncr.25738
    • Ashrafian H, Ahmed K, Rowland SP, Patel VM, Gooderham NJ, Holmes E, et al. Metabolic surgery and cancer: protective effects of bariatric procedures. Cancer (2011) 117:1788-99. doi:10.1002/cncr.25738
    • (2011) Cancer , vol.117 , pp. 1788-1799
    • Ashrafian, H.1    Ahmed, K.2    Rowland, S.P.3    Patel, V.M.4    Gooderham, N.J.5    Holmes, E.6
  • 339
    • 67649344115 scopus 로고    scopus 로고
    • Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial
    • doi:10.1016/S1470-2045(09)70159-7
    • Sjöström L, Gummesson A, Sjöström CD, Narbro K, Peltonen M, Wedel H, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol (2009) 10:653-62. doi:10.1016/S1470-2045(09)70159-7
    • (2009) Lancet Oncol , vol.10 , pp. 653-662
    • Sjöström, L.1    Gummesson, A.2    Sjöström, C.D.3    Narbro, K.4    Peltonen, M.5    Wedel, H.6
  • 340
    • 67649354242 scopus 로고    scopus 로고
    • Bariatric surgery, weight reduction, and cancer prevention
    • doi:10.1016/S1470-2045(09)70170-6
    • Renehan AG. Bariatric surgery, weight reduction, and cancer prevention. Lancet Oncol (2009) 10:640-1. doi:10.1016/S1470-2045(09)70170-6
    • (2009) Lancet Oncol , vol.10 , pp. 640-641
    • Renehan, A.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.