Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels

Diabetes

Volumn 56, Issue 6, 2007, Pages 1517-1526

  Nishimura, Satoshi ^a   Manabe, Ichiro ^a,b,c   Nagasaki, Mika ^a   Hosoya, Yumiko ^a   Yamashita, Hiroshi ^a   Fujita, Hideo ^a   Ohsugi, Mitsuru ^d   Tobe, Kazuyuki ^d   Kadowaki, Takashi ^d   Nagai, Ryozo ^a   Sugiura, Seiryo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Nano Bioengineering Education Program   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CD68 ANTIGEN; VASCULOTROPIN ANTIBODY;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; CELL DIFFERENTIATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; LECTIN BINDING; MACROPHAGE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; STROMA CELL; THREE DIMENSIONAL IMAGING; VASCULARIZATION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BLOOD VESSELS; CELL DIFFERENTIATION; ENDOTHELIUM, VASCULAR; EPIDIDYMIS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, CONFOCAL; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; OBESITY; STROMAL CELLS;

EID: 34249719581     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1749     Document Type: Article

References (45)

1. Matsuzawa Y: Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 3:35-42, 2006
2. Koerner A, Kratzsch J, Kiess W: Adipocytokines: leptin-the classical, resistin-the controversical, adiponectin-the promising, and more to come. Best Pract Res Clin Endocrinol Metab 19:525-546, 2005
3. Rosen ED, Spiegelman BM: Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16:145-171, 2000
4. Morrison RF, Farmer SR: Hormonal signaling and transcriptional control of adipocyte differentiation. J Nutr 130:3116S-3121S, 2000
5. Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, Martin RJ: The biology of white adipocyte proliferation. Obes Rev 2:239-254, 2001
6. DiGirolamo M, Fine JB, Tagra K, Rossmanith R: Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rats fed ad libitum. Am J Physiol 274:R1460-1467, 1998
7. Tchoukalova YD, Sarr MG, Jensen MD: Measuring committed preadipocytes in human adipose tissue from severely obese patients by using adipocyte fatty acid binding protein. Am J Physiol Regul Integr Comp Physiol 287:R1132-1R140, 2004
8. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH: Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:4279-4295, 2002
9. Nakagami H, Morishita R, Maeda K, Kikuchi Y, Ogihara T, Kaneda Y: Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy. J Atheroscler Thromb 13:77-81, 2006
10. Dicker A, Le Blanc K, Astrom G, van Harmelen V, Gotherstrom C, Blomqvist L, Arner P, Ryden M: Functional studies of mesenchymal stem cells derived from adult human adipose tissue. Exp Cell Res 308:283-290, 2005
11. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW, Jr.: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796-1808, 2003
12. Wellen KE, Hotamisligil GS: Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112:1785-1788, 2003
13. Liu L, Meydani M: Angiogenesis inhibitors may regulate adiposity. Nutr Rev 61:384-387, 2003
14. Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W: Reversal of obesity by targeted ablation of adipose tissue. Nat Med 10:625-632, 2004
15. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ: Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A 99:10730-10735, 2002
16. Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK: Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res 93:e88-e97, 2003
17. McDonald DM, Choyke PL: Imaging of angiogenesis: from microscope to clinic. Nat Med 9:713-725, 2003
18. Rosen ED: The molecular control of adipogenesis, with special reference to lymphatic pathology. Ann N Y Acad Sci 979:143-158, 2002
19. Laitinen L: Griffonia simplicifolia lectins bind specifically to endothelial cells and some epithelial cells in mouse tissues. Histochem J 19:225-234, 1987
20. Hamid SA, Daly C, Campbell S: Visualization of live endothelial cells ex vivo and in vitro. Microvasc Res 66:159-163, 2003
21. Wang SM, Hwang RD, Greenberg AS, Yeo HL: Temporal and spatial assembly of lipid droplet-associated proteins in 3T3-L1 preadipocytes. Histochem Cell Biol 120:285-292, 2003
22. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46:2347-2355, 2005
23. Casey R, Rogers PA, Vollenhoven BJ: An immunohistochemical analysis of fibroid vasculature. Hum Reprod 15:1469-1475, 2000
24. Mattsson G, Carlsson PO, Olausson K, Jansson L: Histological markers for endothelial cells in endogenous and transplanted rodent pancreatic islets. Pancreatology 2:155-162, 2002
25. Hristov M, Weber C: Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance. J Cell Mol Med 8:498-508, 2004
26. Modarai B, Burnand KG, Sawyer B, Smith A: Endothelial progenitor cells are recruited into resolving venous thrombi. Circulation 111:2645-2653, 2005
27. Rumpold H, Wolf D, Koeck R, Gunsilius E: Endothelial progenitor cells: a source for therapeutic vasculogenesis? J Cell Mol Med 8:509-518, 2004
28. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821-1830, 2003
29. Rehman J, Li J, Orschell CM, March KL: Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 107:1164-1169, 2003
30. Fain JN: Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74:443-477, 2006
31. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, Pell CL, Johnstone BH, Considine RV, March KL: Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 109:1292-1298, 2004
32. Carmeliet P, Jain RK: Angiogenesis in cancer and other diseases. Nature 407:249-257, 2000
33. Kraemer FB, Shen WJ: Hormone-sensitive lipase knockouts. Nutr Metab (Lond) 3:12, 2006
34. Silha JV, Krsek M, Sucharda P, Murphy LJ: Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond) 29:1308-1314, 2005
35. Neels JG, Thinnes T, Loskutoff DJ: Angiogenesis in an in vivo model of adipose tissue development. Faseb J 18:983-985, 2004
36. Miyazawa-Hoshimoto S, Takahashi K, Bujo H, Hashimoto N, Yagui K, Saito Y: Roles of degree of fat deposition and its localization on VEGF expression in adipocytes. Am J Physiol Endocrinol Metab 288:E1128-E1136, 2005
37. Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med 9:669-676, 2003
38. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L: VEGF receptor signalling: in control of vascular function. Nat Rev Mol Cell Biol 7:359-371, 2006
39. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J: Vascular-specific growth factors and blood vessel formation. Nature 407:242-248, 2000
40. Zachary I, Mathur A, Yla-Herttuala S, Martin J: Vascular protection: a novel nonangiogenic cardiovascular role for vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 20:1512-1520, 2000
41. Liu Y, Yang H, Otaka K, Takatsuki H, Sakanishi A: Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate A on human monocytic THP-1 cell migration. Colloids Surf B Biointerfaces 43:216-220, 2005
42. Cummins EP, Taylor CT: Hypoxia-responsive transcription factors. Pflugers Arch 450:363-371, 2005
43. Asahara T, Takahashi T, Masuda H, Kalka C, Chen D, Iwaguro H, Inai Y, Silver M, Isner JM: VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. Embo J 18:3964-3972, 1999
44. Celletti FL, Waugh JM, Amabile PG, Brendolan A, Hilfiker PR, Dake MD: Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med 7:425-429, 2001
45. Haddad JJ, Harb HL: Cytokines and the regulation of hypoxia-inducible factor (HIF)-1alpha. Int Immunopharmacol 5:461-483, 2005 o:p