Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin: Implications for metabolic regulation and bioactivity

Journal of Biological Chemistry

Volumn 278, Issue 11, 2003, Pages 9073-9085

  Pajvani, Utpal B ^a   Du, Xueliang ^a   Combs, Terry P ^a   Berg, Anders H ^a   Rajala, Michael W ^a   Schulthess, Therese ^b   Engel, Jürgen ^b   Brownlee, Michael ^a   Scherer, Philipp E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; METABOLISM; MOLECULAR WEIGHT; OLIGOMERS;

HEPATOCYTES;

BIOCHEMISTRY;

ADIPONECTIN; CYSTEINE; GLUCOSE; INSULIN; OLIGOMER; SECRETORY PROTEIN; DISULFIDE; DITHIOTHREITOL; LIGAND; OXIDOREDUCTASE; PROTEIN; RECOMBINANT PROTEIN; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; ENZYME ACTIVITY; FEMALE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEX DIFFERENCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; ADIPOCYTE; AMINO ACID SEQUENCE; ANIMAL; BLOOD; C57BL MOUSE; CELL LINE; CHEMISTRY; DIMERIZATION; ELECTRON MICROSCOPY; GEL CHROMATOGRAPHY; GENETIC TRANSFECTION; IMMUNOBLOTTING; METABOLISM; MOLECULAR GENETICS; MUTATION; PH; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; TEMPERATURE; TIME;

ANIMALIA;

ADIPOCYTES; ADIPONECTIN; AMINO ACID SEQUENCE; ANIMALS; BLOOD GLUCOSE; CELL LINE; CHROMATOGRAPHY, GEL; CYSTEINE; DIMERIZATION; DISULFIDES; DITHIOTHREITOL; FEMALE; GLUCOSE; HEPATOCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOBLOTTING; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDOREDUCTASES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RATS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SEX FACTORS; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE; TIME FACTORS; TRANSFECTION;

EID: 0037984387     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207198200     Document Type: Article

References (36)

1. Mohamed-Ali, V., Pinkney, J. H., and Coppack, S. W. (1998) Int. J. Obes. Relat. Metab. Disord. 22, 1145-1158
2. Berg, A. H., Combs, T., Du, X., Brownlee, M., and Scherer, P. E. (2001) Nat. Med. 7, 947-953
3. Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y., Gavrilova, O., Vinson, C., Reitman, M. L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P., and Kadowaki, T. (2001) Nat. Med. 7, 941-946
4. Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., and Lazar, M. A. (2001) Nature 409, 307-312
5. Havel, P. J. (2002) Curr. Opin. Lipidol. 13, 51-59
6. Spiegelman, B. M., and Hotamisligil, G. S. (1993) Cell 73, 625-627
7. Hotamisligil, G. S. (1999) J. Intern. Med. 245, 621-625
8. Cook, K. S., Min, H. Y., Johnson, D., Chaplinsky, R. J., Flier, J. S., Hunt, C. R., and Spiegelman, B. M. (1987) Science 237, 402-405
9. Cianflone, K., Roneari, D. A., Maslowska, M., Baldo, A., Forden, J., and Sniderman, A. D. (1994) Biochemistry 33, 9489-9495
10. Shuldiner, A. R., Yang, R., and Gong, D. W. (2001) N. Engl. J. Med. 345, 1345-1346
11. Scherer, P. E., Williams, S., Fogliano, M., Baldini, G., and Lodish, H. F. (1995) J. Biol. Chem. 270, 26746-26749
12. Hu, E., Liang, P., and Spiegelman, B. M. (1996) J. Biol. Chem. 271, 10697-10703
13. Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., and Matsubara, K. (1996) Biochem. Biophys. Res. Commun. 221, 286-289
14. Nakano, Y., Tobe, T., Choi-Miura, N. H., Mazda, T., and Tomita, M. (1996) J. Biochem. (Tokyo) 120, 803-812
15. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., Kuriyama, H., Nishida, M., Yamashita, S., Okubo, K., Matsubara, K., Muraguchi, M., Ohmoto, Y., Funahashi, T., and Matsuzawa, Y. (1999) Biochem. Biophys. Res. Commun. 257, 79-83
16. Hotta, K., Funahashi, T., Bodkin, N. L., Ortmeyer, H. K., Arita, Y., Hansen, B. C., and Matsuzawa, Y. (2001) Diabetes 50, 1126-1133
17. Comuzzie, A. G., Funahashi, T., Sonnenberg, G., Martin, L. J., Jacob, H. J., Black, A. E., Maas, D., Takahashi, M., Kihara, S., Tanaka, S., Matsuzawa, Y., Blangero, J., Cohen, D., and Kissebah, A. (2001) J. Clin. Endocrinol. Metab. 86, 4321-4325
18. Fruebis, J., Tsao, T. S., Javorschi, S., Ebbets-Reed, D., Erickson, M. R., Yen, F. T., Bihain, B. E., and Lodish, H. F. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2005-2010
19. Combs, T. P., Wagner, J. A., Berger, J., Doebber, T., Wang, W. J., Zhang, B. B., Tanen, M., Berg, A. H., O'Rahilly, S., Savage, D. B, Chatterjee, K., Weiss, S., Larson, P. J., Gottesdiener, K. M., Gertz, B. J., Charron, M. J., Scherer, P. E., and Moller, D. E. (2002) Endocrinology 143, 998-1007
20. Hansen, S., and Holmskov, U. (1998) Irnmunobiology 199, 165-189
21. Brown-Augsburger, P., Chang, D., Rust, K., and Crouch, E. C. (1996) J. Biol. Chem. 271, 18912-18919
22. Zhang, L., Ikegami, M., Crouch, E. C., Korfhagen, T. R., and Whitsett, J. A. (2001) J. Biol. Chem. 276, 19214-19219
23. Brown-Augsburger, P., Hartshorn, K., Chang, D., Rust, K., Fliszar, C., Welgus, H. G., and Crouch, E. C. (1996) J. Biol. Chem. 271, 13724-13730
24. Scherer, P. E., Lisanti, M. P., Baldini, G., Sargiacomo, M., Corley-Mastick, C., and Lodish, H. F. (1994) J. Cell Biol. 127, 1233-1243
25. Engel, J. (1994) Methods Enzymol. 245, 469-488
26. Clayton, P. E., Gill, M. S., Hall, C. M., Tillmann, V., Whatmore, A. J., and Price, D. A. (1997) Clin. Endocrinol. (Oxford) 46, 727-733
27. Yang, W. S., Lee, W. J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C. L., Chen, C. L., Tai, T. Y., and Chuang, L. M. (2001) J. Clin. Endocrinol. Metab. 86, 3815-3819
28. Wang, Y., Xu, A., Knight, C., Xu, L. Y., and Cooper, G. J. (2002) J. Biol. Chem. 277, 19521-19529
29. Combs, T. P., Berg, A. H., Obici, S., Scherer, P. E., and Rossetti, L. (2002) J. Clin. Inv. 108, 1875-1881
30. Hevener, A., Reichart, D., Janez, A., and Olefsky, J. (2002) Diabetes 51, 1907-1912
31. Frias, J. P., Macaraeg, G. B., Ofrecio, J., Yu, J. G., Olefsky, J. M., and Kruszynska, Y. T. (2001) Diabetes 50, 1344-1350
32. Sato, C., Yasukawa, Z., Honda, N., Matsuda, T., and Kitajima, K. (2001) J. Biol. Chem. 276, 28849-28856
33. Tsao, T. S., Murrey, H. E., Hug, C., Lee, D. H., and Lodish, H. F. (2002) J. Biol. Chem. 277, 29359-29362
34. Lay, A. J., Jiang, X. M., Daly, E., Sun, L., and Hogg, P. J. (2002) J. Biol. Chem. 277, 9062-9068
35. Hotta, K., Funahashi, T., Arita, Y., Takahashi, M., Matsuda, M., Okamoto, Y., Iwahashi, H., Kuriyama, H., Ouchi, N., Maeda, K., Nishida, M., Kihara, S., Sakai, N., Nakajima, T., Hasegawa, K., Muraguchi, M., Ohmoto, Y., Nakamura, T., Yamashita, S., Hanafusa, T., and Matsuzawa, Y. (2000) Arterioscler. Thromb. Vasc. Biol. 20, 1595-1599
36. Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., and Tataranni, P. A. (2001) J. Clin. Endocrinol. Metab. 86, 1930-1935