What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?

Current Opinion in Lipidology

Volumn 24, Issue 1, 2013, Pages 49-56

  Xu, X Julia ^a   Pories, Walter J ^b   Dohm, Lynis G ^b   Ruderman, Neil B ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

Author keywords

AMP activated protein kinase; inflammation; insulin resistance; oxidative stress; SIRT1

Indexed keywords

CYTOKINE; FAT DROPLET; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; SIRTUIN 1;

ADIPOSE TISSUE; BARIATRIC SURGERY; BIOGENESIS; DIABETES MELLITUS; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION; HUMAN; INFANCY; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; METABOLIC SYNDROME X; MITOCHONDRION; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SUBCUTANEOUS FAT;

ADIPOSE TISSUE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BARIATRIC SURGERY; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; ENZYME ACTIVATION; HUMANS; INFLAMMATION; INSULIN; INSULIN RESISTANCE; METABOLIC SYNDROME X; MITOCHONDRIA; OBESITY, MORBID; OXIDATIVE STRESS; SIRTUIN 1;

EID: 84872836906     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0b013e32835b465b     Document Type: Review

References (52)

1. Ruderman NB, Xu XJ, Nelson L, et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab 2010; 298:E751-E760.
2. Karelis AD. Metabolically healthy but obese individuals. Lancet 2008; 372:1281-1283.
3. Samocha-Bonet D, Chisholm DJ, Tonks K, et al. Insulin-sensitive obesity in humans a 'favorable fat' phenotype? Trends Endocrinol Metab 2012; 23:116-124.
4. Sims EA. Are there persons who are obese, but metabolically healthy? Metabolism 2001; 50:1499-1504.
5. Hu G, Tuomilehto J, Silventoinen K, et al. The effects of physical activity and body mass index on cardiovascular, cancer and all-cause mortality among 47 212 middle-aged Finnish men and women. Int J Obes (Lond) 2005; 29:894-902.
6. Bruun JM, Helge JW, Richelsen B, et al. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 2006; 290:E961-E967.
7. Sjöstrom L, Peltonen M, Jacobson P, et al. Bariatric surgery and long-term cardiovascular events. JAMA 2012; 307:56-65.
8. Klöting N, Fasshauer M, Dietrich A, et al. Insulin-sensitive obesity. Am J Physiol Endocrinol Metab 2010; 299:E506-E515.
9. Gauthier MS, O'Brien EL, Bigornia S, et al. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun 2011; 404:382-387.
10. Hardy OT, Perugini RA, Nicoloro SM, et al. Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis 2011; 7:60-67.
11. Puri V, Ranjit S, Konda S, et al. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci USA 2008; 105:7833-7838.
12. Xu XJ, Gauthier MS, Hess DT, et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res 2012; 53:792-801.
13. Goossens GH, Bizzarri A, Venteclef N, et al. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation 2011; 124:67-76.
14. Gillum MP, Kotas ME, Erion DM, et al. SirT1 regulates adipose tissue inflammation. Diabetes 2011; 60:3235-3245.
15. Gregor MF, Yang L, Fabbrini E, et al. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 2009; 58:639-700.
16. Anderson EK, Gutierrez DA, Hasty AH. Adipose tissue recruitment of leukocytes. Curr Opin Lipidol 2010; 21:172-177.
17. Pasarica M, Gowronska-Kozakm B, Burk D, et al. Adipose tissue collagen VI in obesity. J Clin Endocrinol Metab 2009; 94:5155-5162.
18. Saha AK, Aviluceaa PR, Yeb J-M, et al. Pioglitazone treatment activates AMPactivated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun 2004; 314:580-585.
19. Nawrocki AR, Rajala MW, Tomas E, et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem 2006; 281:2654-2660.
20. Frohnert BI, Sinaiko AR, Serrot FJ, et al. Adipocyte biology. Obesity 2011; 19:1735-1741.
21. Gletsu-Miller N, Hansen JM, Jones DP, et al. Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery. Obesity 2008; 17:439-446.
22. Murri M, García-Fuentes E, García-Almeida JM, et al. Changes in oxidative stress and insulin resistance in morbidly obese patients after bariatric surgery. Obes Surg 2010; 20:363-368.
23. Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a casual role in multiple forms of insulin resistance. Nature 2006; 440:944-948.
24. Kola B, Christ-Crain M, Lolli F, et al. Changes in adenosine 50-monophosphate- activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome. J Clin Endocrinol Metab 2008; 93:4969-4973.
25. Dolinsky VW, Chan AY, Robillard FI, et al. Resveratrol prevents the prohypertrophic effects of oxidative stress onLKB1. Circulation2009;119:1643- 1652.
26. Gauthier MS, Miyoshi H, Souza SC, et al. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte. J Biol Chem 2008; 283:16514-16524.
27. Kim J-E, Song SE, Kim Y-W, et al. Adiponectin inhibits palmitate-induced apoptosis through suppression of reactive oxygen species in endothelial cells: involvement of cAMP/protein kinase A and AMP-activated protein kinase. J Endocrinol 2010; 207:35-44.
28. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112:1821-1830.
29. Baker RG, Hayden MS, Ghosh S. NF-kB inflammation metabolic disease. Cell Metab 2011; 13:11-22.
30. Choi AMK, Nakahira K. Dampening insulin signaling by an NLRP3 'metaflammasome'. Nat Immunol 2011; 12:379-380.
31. Vandanmagsar B, Youm YH, Ravussin A, et al. The NALP3/NLRP3 inflammasome instigates obesity-induced autoinflammation and insulin resistance. Nat Med 2011; 17:179-188.
32. Wen H, Gris D, Lei Y, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 2011; 12:408-415.
33. Choo HJ, Kim JH, Kwon OB, et al. Mitochondria are impaired in the adipocytes of type 2 diabetic. Diabetologia 2006; 49:784-791.
34. Rong JX, Qiu Y, Hansen MK, et al. Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone. Diabetes 2007; 56:1751-1760.
35. Bogacka I, Xie H, Bray GA, et al. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 2005; 54:1392-1399.
36. Dahlman I, Forsgren M, Sjogren A, et al. Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha. Diabetes 2006; 55:1792-1799.
37. Cacicedo JM, Yagihashi N, Keaney JF, et al. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun 2004; 324:1204-1209.
38. Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan. J Mol Med 2011; 89:667-676.
39. Yu X, McCorkle S, Wang M, et al. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 2004; 47:2012-2021.
40. Sag D, Carling D, Stout RD, et al. AMP-activated protein kinase promotes macrophage polarization to anti-inflammatory functional phenotype. J Immunol 2008; 181:8633-8641.
41. Nogueiras R, Habegger KM, Chaudhary N, et al. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev 2012; 92:1479-1514.
42. Chalkiadaki A, Guarente L. High fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 2012; 16:180-188.
43. Yang Z, Kahn BB, Shi H, et al. Macrophage a1 AMP-activated protein kinase (a1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem 2010; 285:19051-19059.
44. Liang F, Kume S, Koya D. SIRT1 and insulin resistance. Nat Rev Endocrinol 2009; 5:367-373.
45. Peng Y, Rideout DA, Rakita SS, et al. Does LKB1 mediate activation of hepatic AMP-protein kinase (AMPK) and sirtuin1 (SIRT1) after Roux-en-Y gastric bypass on obese rats? J Gastrointest Surg 2009; 14:221-228.
46. Adams TD, Hunt SC. Cancer and obesity: effect of bariatric surgery. World J Surg 2009; 33:2028-2033.
47. Sjöstrom L, Narbro K, Sjöstrom CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 57:741-752.
48. Christou NV, Sampalis JS, Liberman M, et al. Surgery decreases long-term mortality, morbidity, and healthcare use in morbidly obese patients. Ann Surg 2004; 240:416-424.
49. Reed MA, Pories W, Chapman W. Insulin sensitivity and not insulin secretion is associated with resolution of type 2 diabetes following gastric bypass surgery. Diabetes 2010; 59:A479.
50. Reed MA, Pories WJ, Chapman W, et al. Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes. J Clin Endocrinol Metab 2011; 96:2525-2531.
51. Bikman BT, Zheng D, Pories WJ, et al. Mechanism for improved insulin sensitivity after gastric bypass surgery. J Clin Endocrinol Metab 2008; 93:4656-4663.
52. Illán-Gómez F, Gonzá lvez-Ortega M, Orea-Soler I, et al. Obesity and inflammation: change in adiponectin, c-reactive protein, tumour necrosis factoralpha and interleukin-6 after bariatric surgery. Obes Surg 2012; 22:950-955.