Omega-3 fatty acids in cancer

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 16, Issue 2, 2013, Pages 156-161

  Laviano, Alessandro ^a   Rianda, Serena ^a   Molfino, Alessio ^a   Fanelli, Filippo Rossi ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

cachexia; DHA; EPA; response rate; toxicity

Indexed keywords

DOCOSAHEXAENOIC ACID; FLUOROURACIL; FOLINIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID;

ANTINEOPLASTIC ACTIVITY; BLOOD TOXICITY; CACHEXIA; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER PREVENTION; CANCER THERAPY; DIET SUPPLEMENTATION; DRUG EFFICACY; DRUG SAFETY; GASTROINTESTINAL TOXICITY; HUMAN; INFLAMMATION; LUNG CANCER; MUCOSA INFLAMMATION; REVIEW; SKIN TOXICITY; TREATMENT OUTCOME; TUMOR MICROENVIRONMENT;

ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CACHEXIA; CLINICAL TRIALS AS TOPIC; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; HUMANS; MUSCLE, SKELETAL; NEOPLASMS; QUALITY OF LIFE;

EID: 84873410448     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e32835d2d99     Document Type: Review

References (34)

1. Mariotto AB, Yabroff KR, Shao Y, et al. Projection of the costs of cancer care in the United States: 2010-2020. J Natl Cancer Inst 2011; 103:117-128.
2. Sullivan R, Peppercorn J, Sikora K, et al. Delivering affordable cancer care in high-income countries. Lancet Oncol 2011; 12:933-980.
3. Laviano A, Molfino A, Rossi Fanelli F. Cancer treatment toxicity: can nutrition help? Nat Rev Clin Oncol 2012; 9:605.
4. Muscaritoli M, Molfino A, Gioia G, et al. The 'parallel pathway': a novel nutritional and metabolic approach to cancer patients. Intern Emerg Med 2011; 6:105-112.
5. Temel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic nonsmall-cell lung cancer. N Engl J Med 2010; 363:733-742.
6. Calder PC. Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? Br J Clin Pharmacol 2012 [Epub ahead of print]. doi: 10.1111/j.1365-2125.2012.04374.x
7. Kang KS, Wang P, Yamabe N, et al. Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. PLoS One 2010; 5:e10296.
8. Sawada N, Inoue M, Iwasaki M, et al. Consumption of n-3 fatty acids and fish reduces risk of hepatocellular carcinoma. Gastroenterology 2012; 142: 1468-1475.
9. Gerber M. Omega-3 fatty acids and cancers: a systematic update review of epidemiological studies. Br J Nutr 2012; 107:S228-S239.
10. Huang HY, Caballero B, Chang S, et al. The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference. Ann Intern Med 2006; 145:372-385.
11. Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 2011; 12: 489-495.
12. Lieffers JR, Bathe OF, Fassbender K, et al. Sarcopenia is associated with postoperative infection and delayed recovery from colorectal cancer resection surgery. Br J Cancer 2012; 107:931-936.
13. Parsons HA, Baracos VE, Dhillon N, et al. Body composition, symptoms, and survival in advanced cancer patients referred to a phase I service. PLoS One 2012; 7:e29330.
14. Prado CM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol 2008; 9:629-635.
15. Seruga B, Zhang H, Bernstein LJ, Tannock IF. Cytokines and their relationship to the symptoms and outcome of cancer. Nat Rev Cancer 2008; 8:887-899.
16. Ries A, Trottenberg P, Elsner F, et al. A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: an EPCRC cachexia guidelines project. Palliat Med 2012; 26:294-304.
17. Vander Meij BS, van Bokhorst-de Vander Schueren MA, Langius JA, et al. n-3 PUFAs in cancer, surgery, and critical care: a systematic review on clinical effects, incorporation, and washout of oral or enteral compared with parenteral supplementation. Am J Clin Nutr 2011; 94:1248-1265.
18. Murphy RA, Yeung E, Mazurak VC, Mourtzakis M. Influence of eicosapentaenoic acid supplementation on lean body mass in cancer cachexia. Br J Cancer 2011; 105:1469-1473.
19. Vander Meij BS, Langius JA, Spreeuwenberg MD, et al. Oral nutritional supplements containing n-3 polyunsaturated fatty acids affect quality of life and functional status in lung cancer patients during multimodality treatment: an RCT. Eur J Clin Nutr 2012; 66:399-404.
20. Murphy RA, Mourtzakis M, Chu QS, et al. Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy. Cancer 2011; 117:1775-1782.
21. Weed HG, Ferguson ML, Gaff RL, et al. Lean body mass gain in patients with head and neck squamous cell cancer treated perioperatively with a proteinand energy-dense nutritional supplement containing eicosapentaenoic acid. Head Neck 2011; 33:1027-1033.
22. Cleeland CS, Allen JD, Roberts SA, et al. Reducing the toxicity of cancer therapy: recognizing needs, taking action. Nat Rev Clin Oncol 2012; 9:471-478.
23. Antoun S, Baracos VE, Birdsell L, et al. Low body mass index and sarcopenia associated with dose-limiting toxicity of sorafenib in patients with renal cell carcinoma. Ann Oncol 2010; 21:1594-1598.
24. Mir O, Coriat R, Blanchet B, et al. Sarcopenia predicts early dose-limiting toxicities and pharmacokinetics of sorafenib in patients with hepatocellular carcinoma. PLoS One 2012; 7:e37563.
25. Murphy RA, Mourtzakis M, Chu QS, et al. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer 2011; 117:3774-3780.
26. Machon C, Thezenas S, Dupuy AM, et al. Immunonutrition before and during radiochemotherapy: improvement of inflammatory parameters in head and neck cancer patients. Support Care Cancer 2012 [Epub ahead of print].
27. Bonatto SJ, Oliveira HH, Nunes EA, et al. Fish oil supplementation improves neutrophil function during cancer chemotherapy. Lipids 2012; 47:383-389.
28. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation and cancer. Cell 2010; 140:883-899.
29. Lee C, Raffaghello L, Brandhorst S, et al. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med 2012; 4:124ra27.
30. Laviano A, Rossi Fanelli F. Toxicity in chemotherapy: when less is more. N Engl J Med 2012; 366:2319-2320.
31. Zhu Z, Jiang W, McGinley JN, et al. Mammary gland density predicts the cancer inhibitory activity of the N-3 to N-6 ratio of dietary fat. Cancer Prev Res (Phila) 2011; 4:1675-1685.
32. Benais-Pont G, Dupertuis YM, Kossovsky MP, et al. Omega-3 polyunsaturated fatty acids and ionizing radiation: combined cytotoxicity on human colorectal adenocarcinoma cells. Nutrition 2006; 22:931-939.
33. Fukui M, Kang KS, Okada K, Zhu BT. EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. J Cell Biochem 2012. doi: 10.1002/jcb.24354 [Epub ahead of print].
34. Bougnoux P, Hajjaji N, Ferrasson MN, et al. Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial. Br J Cancer 2009; 101:1978-1985.