Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic mice

Oncogene

Volumn 24, Issue 1, 2005, Pages 39-46

  Alli, Patricia M ^a   Finn, Michael L ^a   Jaffee, Elizabeth M ^a   McFadden, Jill M ^b   Kuhajda, Francis P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FASgen Inc   (United States)

Author keywords

Fatty acid synthase; HER2; neu; Transgenic

Indexed keywords

FATTY ACID SYNTHASE INHIBITOR; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER RISK; CONTROLLED STUDY; DRUG TARGETING; EPITHELIUM CELL; GENE OVEREXPRESSION; GENETIC SUSCEPTIBILITY; MOUSE; NONHUMAN; ONCOGENE NEU; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR XENOGRAFT;

4-BUTYROLACTONE; ANIMALS; ANTIGENS, CD95; FATTY ACID SYNTHETASE COMPLEX; FEMALE; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 12444252156     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208174     Document Type: Article

References (42)

1. Alo PL, Visca P, Botti C, Galati GM, Sebastiani V, Andreano T, Di Tondo U and Pizer ES. (2001). Am. J. Clin. Pathol., 116, 129-134.
2. Boggio K, Di Carlo E, Rovero S, Cavallo F, Quaglino E, Lollini PL, Nanni P, Nicoletti G, Wolf S, Musiani P and Forni G. (2000). Cancer Res., 60, 359-364.
3. Boizard M, Le Liepvre X, Lemarchand P, Foufelle F, Ferre P and Dugail I. (1998). J. Biol. Chem., 273, 29164-29171.
4. Bull JH, Ellison G, Patel A, Muir G, Walker M, Underwood M, Khan F and Paskins L. (2001). Br. J. Cancer, 84, 1512-1519.
5. Epstein JI, Carmichael M and Partin AW. (1995). Urology, 45, 81-86.
6. Fabian CJ. (2001). Breast Cancer Res., 3, 99-103.
7. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L and Wolmark N. (1998). J. Natl. Cancer Inst., 90, 1371-1388.
8. Guy CT, Webster MA, Schaller M, Parsons TJ, Cardiff RD and Muller WJ. (1992). Proc. Natl. Acad. Sci. USA, 89, 10578-10582.
9. Jordan VC. (2000). J. Steroid Biochem. Mol. Biol., 74, 269-277.
10. Kim JB, Sarraf P, Wright M, Yao KM, Mueller E, Solanes G, Lowell BB and Spiegelman BM. (1998). J. Clin. Invest., 101, 1-9.
11. Krontiras H, Roye GD, Beenken SE, Myers RB, Mayo MS, Peters GE and Grizzle WE. (1999). Head Neck, 21, 325-329.
12. Kuhajda FP. (2000). Nutrition, 16, 202-208.
13. Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL and Townsend CA. (2000). Proc. Natl. Acad. Sci. USA, 97, 3450-3454.
14. Kumar-Sinha C, Ignatoski KW, Lippman ME, Ethier SP and Chinnaiyan AM. (2003). Cancer Res., 63, 132-139.
15. Kusakabe T, Nashimoto A, Honma K and Suzuki T. (2002). Histopathology, 40, 71-79.
16. Lofts FJ and Gullick WJ. (1992). Cancer Treat. Res., 61, 161-179.
17. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD and Kuhajda FP. (2000). Science, 288, 2379-2381.
18. McFadden JM, Frehywot GL and Townsend CA. (2002). Org. Lett., 4, 3859-3862.
19. McFadden JM, Medghalchi SM, Thupari JN, Finn ML, Vadlamudi A, Miller KI, Kuhajda FP and Townsend CA. (2004). J. Med. Chem. (in review).
20. Menendez JA, Vellon L, Mehmi I, Oza BP, Ropero S, Colomer R and Lupu R. (2004). Proc. Natl. Acad. Sci. USA, 101, 10715-10720.
21. Milgraum LZ, Witters LA, Pasternack GR and Kuhajda FP. (1997). Clin. Cancer Res., 3, 2115-2120.
22. Mueller SO, Clark JA, Myers PH and Korach KS. (2002). Endocrinology, 143, 2357-2365.
23. Nemoto T, Terashima S, Kogure M, Hoshino Y, Kusakabe T, Suzuki T and Gotoh M. (2001). Pathobiology, 69, 297-303.
24. Pflug BR, Pecher SM, Brink AW, Nelson JB and Foster BA. (2003). Prostate, 57, 245-254.
25. Pizer ES, Pflug BR, Bova GS, Han WF, Udan MS and Nelson JB. (2001). Prostate, 47, 102-110.
26. Pizer ES, Thupari J, Han WF, Finn ML, Chrest FJ, Frehywot GL, Townsend CA and Kuhajda FP. (2000). Cancer Res., 60, 213-218.
27. Pizer ES, Wood FD, Heine HS, Romantsev FE, Pasternack GR and Kuhajda FP. (1996). Cancer Res., 56, 1189-1193.
28. Rashid A, Pizer ES, Moga M, Milgraum LZ, Zahurak M, Pasternack GR, Kuhajda FP and Hamilton SR. (1997). Am. J. Pathol., 150, 201-208.
29. Reilly RT, Emens LA and Jaffee EM. (2001a). Curr. Opin. Investig. Drugs, 2, 133-135.
30. Reilly RT, Gottlieb MB, Ercolini AM, Machiels JP, Kane CE, Okoye FI, Muller WJ, Dixon KH and Jaffee EM. (2000). Cancer Res., 60, 3569-3576.
31. Reilly RT, Machiels JP, Emens LA, Ercolini AM, Okoye FI, Lei RY, Weintraub D and Jaffee EM. (2001b). Cancer Res., 61, 880-883.
32. Reilly RT, Machiels JP, Emens LA and Jaffee EM. (2002). Methods Mol. Med., 69, 233-257.
33. Thupari JN, Kim EK, Moran TH, Ronnett GV and Kuhajda FP. (2004). Am. J. Physiol. Endocrinol. Metab., 287, E97-E104.
34. Thupari JN, Landree LE, Ronnett GV and Kuhajda FP. (2002). Proc. Natl. Acad. Sci. USA, 99, 9498-9502.
35. Visca P, Alo PL, Del Nonno F, Bottie C, Trombetta G, Marandino F, Filippi S, Di Tondo U and Donnorso RP. (1999). Clin. Cancer Res., 5, 4111-4118.
36. Wakil SJ. (1989). Biochemistry, 28, 4523-4530.
37. Wang HQ, Altomare DA and Testa JR. (2003). Proc. Am. Assoc. Cancer Res., 44, 1100.
38. Weinstein IB. (2002). Science, 297, 63-64.
39. Xu R, Perle MA, Inghirami G, Chan W, Delgado Y and Feiner H. (2002). Mod. Pathol., 15, 116-124.
40. Yang YA, Han WF, Morin PJ, Chrest FJ and Pizer ES. (2002). Exp. Cell Res., 279, 80-90.
41. Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY and Hung MC. (2000). J. Biol. Chem., 275, 8027-8031.
42. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Finn ML, Ronnett GV and Kuhajda FP. (2003). Cancer Res., 63, 7330-7337.