메뉴 건너뛰기




Volumn 69, Issue 2, 2010, Pages 211-220

Symposium 1: Overnutrition: Consequences and solutions Non-alcoholic fatty liver disease: The hepatic consequence of obesity and the metabolic syndrome

Author keywords

Metabolic syndrome; Non alcoholic fatty liver disease; Systems biology

Indexed keywords

CARDIOVASCULAR RISK; CONFERENCE PAPER; DISEASE COURSE; DYSLIPIDEMIA; FATTY LIVER; GENETIC POLYMORPHISM; HUMAN; INSULIN RESISTANCE; LIVER CIRRHOSIS; LIVER FIBROSIS; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; OBESITY; OVERNUTRITION; SYSTEMS BIOLOGY; TREATMENT RESPONSE; REVIEW;

EID: 77955507529     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665110000030     Document Type: Conference Paper
Times cited : (189)

References (124)
  • 1
    • 0018686401 scopus 로고
    • Fatty liver hepatitis and cirrhosis in obese patients
    • DOI 10.1016/0002-9343(79)90740-X
    • Adler M & Schaffner F (1979) Fatty liver hepatitis and cirrhosis in obese patients. Am J Med 67, 811-816. (Pubitemid 10218835)
    • (1979) American Journal of Medicine , vol.67 , Issue.5 , pp. 811-816
    • Adler, M.1    Schaffner, F.2
  • 2
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis. Mayo Clinic experiences with a hitherto unnamed disease
    • Ludwig J, Viggiano TR, McGill DB et al. (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 55, 434-438. (Pubitemid 10057164)
    • (1980) Mayo Clinic Proceedings , vol.55 , Issue.7 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3    Ott, B.J.4
  • 3
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two 'hits'?
    • Day CP & James OF (1998) Steatohepatitis: a tale of two 'hits'? Gastroenterology 114, 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 4
    • 58949094415 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    • Vuppalanchi R & Chalasani N (2009) Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology 49, 306-317.
    • (2009) Hepatology , vol.49 , pp. 306-317
    • Vuppalanchi, R.1    Chalasani, N.2
  • 6
    • 68049120181 scopus 로고    scopus 로고
    • Noninvasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
    • Schwenzer NF, Springer F, Schraml C et al. (2009) Noninvasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J Hepatol 51, 433-445.
    • (2009) J. Hepatol. , vol.51 , pp. 433-445
    • Schwenzer, N.F.1    Springer, F.2    Schraml, C.3
  • 8
    • 41849148981 scopus 로고    scopus 로고
    • Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD)
    • Yoneda M, Yoneda M, Mawatari H et al. (2008) Noninvasive assessment of liver fibrosis by measurement of stiffness in patients with nonalcoholic fatty liver disease (NAFLD). Dig Liver Dis 40, 371-378.
    • (2008) Dig Liver Dis , vol.40 , pp. 371-378
    • Yoneda, M.1    Yoneda, M.2    Mawatari, H.3
  • 10
    • 33644521965 scopus 로고    scopus 로고
    • Prevalence and factors associated with failure of liver stiffness measurement using Fibro Scan in a prospective study of 2114 examinations
    • Foucher J, Castera L, Bernard PH et al. (2006) Prevalence and factors associated with failure of liver stiffness measurement using Fibro Scan in a prospective study of 2114 examinations. Eur J Gastroenterol Hepatol 18, 411-412.
    • (2006) Eur. J. Gastroenterol. Hepatol. , vol.18 , pp. 411-412
    • Foucher, J.1    Castera, L.2    Bernard, P.H.3
  • 11
    • 70350516182 scopus 로고    scopus 로고
    • Early detection of steatohepatitis in fatty rat liver by using MR elastography
    • Salameh N, Larrat B, Abarca-Quinones J et al. (2009) Early detection of steatohepatitis in fatty rat liver by using MR elastography. Radiology 253, 90-97.
    • (2009) Radiology , vol.253 , pp. 90-97
    • Salameh, N.1    Larrat, B.2    Abarca-Quinones, J.3
  • 15
    • 0033849619 scopus 로고    scopus 로고
    • Practices of liver biopsy in France: Results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF)
    • Cadranel JF, Rufat P & Degos F (2000) Practices of liver biopsy in France: results of a prospective nationwide survey. For the Group of Epidemiology of the French Association for the Study of the Liver (AFEF). Hepatology 32, 477-481.
    • (2000) Hepatology , vol.32 , pp. 477-481
    • Cadranel, J.F.1    Rufat, P.2    Degos, F.3
  • 16
    • 0028913123 scopus 로고
    • Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: An audit by the British Society of Gastroenterology and the Royal College of Physicians of London
    • Gilmore IT, Burroughs A, Murray-Lyon IM et al. (1995) Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British Society of Gastroenterology and the Royal College of Physicians of London. Gut 36, 437-441.
    • (1995) Gut , vol.36 , pp. 437-441
    • Gilmore, I.T.1    Burroughs, A.2    Murray-Lyon, I.M.3
  • 18
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future
    • DOI 10.1002/hep.21768
    • Wieckowska A, McCullough AJ & Feldstein AE (2007) Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 46, 582-589. (Pubitemid 47344794)
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 20
    • 0025260531 scopus 로고
    • Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
    • Wanless IR & Lentz JS (1990) Fatty liver hepatitis (steatohepatitis) and obesity: an autopsy study with analysis of risk factors. Hepatology 12, 1106-1110.
    • (1990) Hepatology , vol.12 , pp. 1106-1110
    • Wanless, I.R.1    Lentz, J.S.2
  • 22
    • 68749106218 scopus 로고    scopus 로고
    • Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population
    • Dassanayake AS, Kasturiratne A, Rajindrajith S et al. (2009) Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population. J Gastroenterol Hepatol 24, 1284-1288.
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , pp. 1284-1288
    • Dassanayake, A.S.1    Kasturiratne, A.2    Rajindrajith, S.3
  • 23
    • 0033767987 scopus 로고    scopus 로고
    • Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity
    • Garcia-Monzon C, Martin-Perez E, Iacono OL et al. (2000) Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity. J Hepatol 33, 716-724.
    • (2000) J. Hepatol. , vol.33 , pp. 716-724
    • Garcia-Monzon, C.1    Martin-Perez, E.2    Iacono, O.L.3
  • 25
    • 0034950652 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese
    • Dixon JB, Bhathal PS & O'Brien PE (2001) Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 121, 91-100. (Pubitemid 32591518)
    • (2001) Gastroenterology , vol.121 , Issue.1 , pp. 91-100
    • Dixon, J.B.1    Bhathal, P.S.2    O'Brien, P.E.3
  • 29
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • DOI 10.2337/dc06-2247
    • Targher G, Bertolini L, Padovani R et al. (2007) Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients. Diabetes Care 30, 1212-1218. (Pubitemid 46684650)
    • (2007) Diabetes Care , vol.30 , Issue.5 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Tessari, R.5    Zenari, L.6    Day, C.7    Arcaro, G.8
  • 30
    • 57749183469 scopus 로고    scopus 로고
    • Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus
    • Leite NC, Salles GF, Araujo AL et al. (2009) Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus. Liver Int 29, 113-119.
    • (2009) Liver Int. , vol.29 , pp. 113-119
    • Leite, N.C.1    Salles, G.F.2    Araujo, A.L.3
  • 31
    • 12844280471 scopus 로고    scopus 로고
    • Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease
    • DOI 10.1002/hep.20554
    • Weston SR, Leyden W, Murphy R et al. (2005) Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. Hepatology 41, 372-379. (Pubitemid 40165382)
    • (2005) Hepatology , vol.41 , Issue.2 , pp. 372-379
    • Weston, S.R.1    Leyden, W.2    Murphy, R.3    Bass, N.M.4    Bell, B.P.5    Manos, M.M.6    Terrault, N.A.7
  • 36
    • 38049010038 scopus 로고    scopus 로고
    • Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents
    • Damaso AR, do Prado WL, de Piano A et al. (2008) Relationship between nonalcoholic fatty liver disease prevalence and visceral fat in obese adolescents. Dig Liver Dis 40, 132-139.
    • (2008) Dig Liver Dis , vol.40 , pp. 132-139
    • Damaso, A.R.1    Do Prado, W.L.2    De Piano, A.3
  • 37
    • 33847022752 scopus 로고    scopus 로고
    • Estimated burden of paediatric obesity and co-morbidities in Europe. Part 2. Numbers of children with indicators of obesity-related disease
    • Lobstein T & Jackson-Leach R (2006) Estimated burden of paediatric obesity and co-morbidities in Europe. Part 2. Numbers of children with indicators of obesity-related disease. Int J Pediatr Obes 1, 33-41.
    • (2006) Int J Pediatr Obes , vol.1 , pp. 33-41
    • Lobstein, T.1    Jackson-Leach, R.2
  • 38
    • 49149114288 scopus 로고    scopus 로고
    • Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease
    • Schwimmer JB, Pardee PE, Lavine JE et al. (2008) Cardiovascular risk factors and the metabolic syndrome in pediatric nonalcoholic fatty liver disease. Circulation 118, 277-283.
    • (2008) Circulation , vol.118 , pp. 277-283
    • Schwimmer, J.B.1    Pardee, P.E.2    Lavine, J.E.3
  • 40
    • 34250370233 scopus 로고    scopus 로고
    • Estimated burden of paediatric obesity and co-morbidities in Europe. Part 1. The increase in the prevalence of child obesity in Europe is itself increasing
    • Jackson-Leach R & Lobstein T (2006) Estimated burden of paediatric obesity and co-morbidities in Europe. Part 1. The increase in the prevalence of child obesity in Europe is itself increasing. Int J Pediatr Obes 1, 26-32.
    • (2006) Int J Pediatr Obes , vol.1 , pp. 26-32
    • Jackson-Leach, R.1    Lobstein, T.2
  • 41
    • 33846529926 scopus 로고    scopus 로고
    • Noninvasive indices of fibrosis in NAFLD: Starting to think about a three-hit (at least) phenomenon
    • DOI 10.1111/j.1572-0241.2006.01039.x
    • Charlton M (2007) Noninvasive indices of fibrosis in NAFLD: starting to think about a three-hit (at least) phenomenon. Am J Gastroenterol 102, 409-411. (Pubitemid 46160555)
    • (2007) American Journal of Gastroenterology , vol.102 , Issue.2 , pp. 409-411
    • Charlton, M.1
  • 42
    • 57649214103 scopus 로고    scopus 로고
    • Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)
    • Musso G, Gambino R & Cassader M (2009) Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res 48, 1-26.
    • (2009) Prog. Lipid Res. , vol.48 , pp. 1-26
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 43
    • 34247863931 scopus 로고    scopus 로고
    • Abnormal Lipid and Glucose Metabolism in Obesity: Implications for Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.03.055, PII S0016508507005811
    • Parekh S & Anania FA (2007) Abnormal lipid and glucose metabolism in obesity: implications for nonalcoholic fatty liver disease. Gastroenterology 132, 2191-2207. (Pubitemid 46693752)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2191-2207
    • Parekh, S.1    Anania, F.A.2
  • 44
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ et al. (2005) Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115, 1343-1351.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3
  • 45
    • 38649111018 scopus 로고    scopus 로고
    • Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease
    • DOI 10.1053/j.gastro.2007.11.038, PII S0016508507021154
    • Fabbrini E, Mohammed BS, Magkos F et al. (2008) Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology 134, 424-431. (Pubitemid 351173050)
    • (2008) Gastroenterology , vol.134 , Issue.2 , pp. 424-431
    • Fabbrini, E.1    Mohammed, B.S.2    Magkos, F.3    Korenblat, K.M.4    Patterson, B.W.5    Klein, S.6
  • 46
    • 63349086412 scopus 로고    scopus 로고
    • Ethnic differences in hepatic steatosis: An insulin resistance paradox?
    • Guerrero R, Vega GL, Grundy SM et al. (2009) Ethnic differences in hepatic steatosis: an insulin resistance paradox? Hepatology 49, 791-801.
    • (2009) Hepatology , vol.49 , pp. 791-801
    • Guerrero, R.1    Vega, G.L.2    Grundy, S.M.3
  • 47
    • 0028070562 scopus 로고
    • Nonalcoholic steatohepatitis: An expanded clinical entity
    • Bacon BR, Farahvash MJ, Janney CG et al. (1994) Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 107, 1103-1109.
    • (1994) Gastroenterology , vol.107 , pp. 1103-1109
    • Bacon, B.R.1    Farahvash, M.J.2    Janney, C.G.3
  • 48
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • DOI 10.1172/JCI200422422
    • Browning JD & Horton JD (2004) Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114, 147-152. (Pubitemid 39071617)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.2 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 49
    • 54049150442 scopus 로고    scopus 로고
    • Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis
    • Anderson N & Borlak J (2008) Molecular mechanisms and therapeutic targets in steatosis and steatohepatitis. Pharmacol Rev 60, 311-357.
    • (2008) Pharmacol. Rev. , vol.60 , pp. 311-357
    • Anderson, N.1    Borlak, J.2
  • 50
    • 70449706044 scopus 로고    scopus 로고
    • Adipokines in nonalcoholic steatohepatitis: From pathogenesis to implications in diagnosis and therapy
    • Tsochatzis EA, Papatheodoridis GV & Archimandritis AJ (2009) Adipokines in nonalcoholic steatohepatitis: from pathogenesis to implications in diagnosis and therapy. Mediators Inflamm 2009, 831670.
    • (2009) Mediators Inflamm. , vol.2009 , pp. 831670
    • Tsochatzis, E.A.1    Papatheodoridis, G.V.2    Archimandritis, A.J.3
  • 53
    • 4644297019 scopus 로고    scopus 로고
    • Natural history of nonalcoholic steatohepatitis: A longitudinal study of repeat liver biopsies
    • DOI 10.1002/hep.20410
    • Fassio E, Alvarez E, Dominguez N et al. (2004) Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology 40, 820-826. (Pubitemid 39288114)
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 820-826
    • Fassio, E.1    Alvarez, E.2    Dominguez, N.3    Landeira, G.4    Longo, C.5
  • 56
    • 33645963121 scopus 로고    scopus 로고
    • Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C
    • Sanyal AJ, Banas C, Sargeant C et al. (2006) Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology 43, 682-689.
    • (2006) Hepatology , vol.43 , pp. 682-689
    • Sanyal, A.J.1    Banas, C.2    Sargeant, C.3
  • 57
    • 70350241227 scopus 로고    scopus 로고
    • The natural history of non-alcoholic fatty liver disease in children: A follow-up study for up to 20 years
    • Feldstein AE, Charatcharoenwitthaya P, Treeprasertsuk S et al. (2009) The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years. Gut 58, 1538-1544.
    • (2009) Gut , vol.58 , pp. 1538-1544
    • Feldstein, A.E.1    Charatcharoenwitthaya, P.2    Treeprasertsuk, S.3
  • 58
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P, Keach JC, Batts KP et al. (1999) Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 30, 1356-1362.
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3
  • 59
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
    • DOI 10.1016/j.jhep.2004.09.012, PII S0168827804004350
    • Adams LA, Sanderson S, Lindor KD et al. (2005) The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol 42, 132-138. (Pubitemid 40038911)
    • (2005) Journal of Hepatology , vol.42 , Issue.1 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3    Angulo, P.4
  • 60
    • 58849134985 scopus 로고    scopus 로고
    • Long-term follow-up of patients with nonalcoholic fatty liver
    • Rafiq N, Bai C, Fang Y et al. (2009) Long-term follow-up of patients with nonalcoholic fatty liver. Clin Gastroenterol Hepatol 7, 234-238.
    • (2009) Clin. Gastroenterol. Hepatol. , vol.7 , pp. 234-238
    • Rafiq, N.1    Bai, C.2    Fang, Y.3
  • 63
    • 67649306197 scopus 로고    scopus 로고
    • Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis
    • Argo CK, Northup PG, Al-Osaimi AM et al. (2009) Systematic review of risk factors for fibrosis progression in non-alcoholic steatohepatitis. J Hepatol 51, 371-379.
    • (2009) J. Hepatol. , vol.51 , pp. 371-379
    • Argo, C.K.1    Northup, P.G.2    Al-Osaimi, A.M.3
  • 66
    • 50549084740 scopus 로고    scopus 로고
    • Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease
    • Ong JP, Pitts A & Younossi ZM (2008) Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease. J Hepatol 49, 608-612.
    • (2008) J. Hepatol. , vol.49 , pp. 608-612
    • Ong, J.P.1    Pitts, A.2    Younossi, Z.M.3
  • 67
    • 50649094716 scopus 로고    scopus 로고
    • Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
    • Dunn W, Xu R, Wingard DL et al. (2008) Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study. Am J Gastroenterol 103, 2263-2271.
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 2263-2271
    • Dunn, W.1    Xu, R.2    Wingard, D.L.3
  • 68
    • 58649083017 scopus 로고    scopus 로고
    • Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population
    • e411
    • Ruhl CE & Everhart JE (2009) Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population. Gastroenterology 136, 477-485. e411.
    • (2009) Gastroenterology , vol.136 , pp. 477-485
    • Ruhl, C.E.1    Everhart, J.E.2
  • 69
    • 0343314903 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds
    • Struben VM, Hespenheide EE & Caldwell SH (2000) Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds. Am J Med 108, 9-13.
    • (2000) Am. J. Med. , vol.108 , pp. 9-13
    • Struben, V.M.1    Hespenheide, E.E.2    Caldwell, S.H.3
  • 70
    • 0034799113 scopus 로고    scopus 로고
    • Ninety patients with nonalcoholic steatohepatitis: Insulin resistance, familial tendency, and severity of disease
    • DOI 10.1016/S0002-9270(01)03229-4, PII S0002927001032294
    • Willner IR, Waters B, Patil SR et al. (2001) Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. Am J Gastroenterol 96, 2957-2961. (Pubitemid 32959539)
    • (2001) American Journal of Gastroenterology , vol.96 , Issue.10 , pp. 2957-2961
    • Willner, I.R.1    Waters, B.2    Patil, S.R.3    Reuben, A.4    Morelli, J.5    Riely, C.A.6
  • 71
    • 42249084876 scopus 로고    scopus 로고
    • Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH
    • DOI 10.1002/hep.22142
    • Musso G, Gambino R, De Michieli F et al. (2008) Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH. Hepatology 47, 1167-1177. (Pubitemid 351547903)
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1167-1177
    • Musso, G.1    Gambino, R.2    De Michieli, F.3    Durazzo, M.4    Pagano, G.5    Cassader, M.6
  • 72
    • 70349652353 scopus 로고    scopus 로고
    • Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease
    • Tokushige K, Hashimoto E, Noto H et al. (2009) Influence of adiponectin gene polymorphisms in Japanese patients with non-alcoholic fatty liver disease. J Gastroenterol 44, 976-982.
    • (2009) J. Gastroenterol. , vol.44 , pp. 976-982
    • Tokushige, K.1    Hashimoto, E.2    Noto, H.3
  • 73
    • 70349898246 scopus 로고    scopus 로고
    • Genetic polymorphisms in non-alcoholic fatty liver disease: Interleukin-6-174G/C polymorphism is associated with nonalcoholic steatohepatitis
    • Carulli L, Canedi I, Rondinella S et al. (2009) Genetic polymorphisms in non-alcoholic fatty liver disease: interleukin-6-174G/C polymorphism is associated with nonalcoholic steatohepatitis. Dig Liver Dis 41, 823-828.
    • (2009) Dig Liver Dis , vol.41 , pp. 823-828
    • Carulli, L.1    Canedi, I.2    Rondinella, S.3
  • 75
    • 42949143772 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms in patients with nonalcoholic steatohepatitis (NASH)
    • DOI 10.1002/cbf.1424
    • Sazci A, Akpinar G, Aygun C et al. (2008) Association of apolipoprotein e polymorphisms in patients with nonalcoholic steatohepatitis. Dig Dis Sci 53, 3218-3224. (Pubitemid 351613167)
    • (2008) Cell Biochemistry and Function , vol.26 , Issue.3 , pp. 291-296
    • Sazci, A.1    Ergul, E.2    Aygun, C.3    Akpinar, G.4    Senturk, O.5    Hulagu, S.6
  • 76
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C et al. (2008) Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 40, 1461-1465.
    • (2008) Nat. Genet. , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 77
    • 53049090077 scopus 로고    scopus 로고
    • Populationbased genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
    • Yuan X, Waterworth D, Perry JR et al. (2008) Populationbased genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet 83, 520-528.
    • (2008) Am. J. Hum. Genet. , vol.83 , pp. 520-528
    • Yuan, X.1    Waterworth, D.2    Perry, J.R.3
  • 80
    • 34848830434 scopus 로고    scopus 로고
    • Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): A population based study
    • DOI 10.1016/j.jhep.2007.06.020, PII S0168827807004278
    • Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R et al. (2007) Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD) : a population based study. J Hepatol 47, 711-717. (Pubitemid 47503432)
    • (2007) Journal of Hepatology , vol.47 , Issue.5 , pp. 711-717
    • Zelber-Sagi, S.1    Nitzan-Kaluski, D.2    Goldsmith, R.3    Webb, M.4    Blendis, L.5    Halpern, Z.6    Oren, R.7
  • 81
    • 77949265573 scopus 로고    scopus 로고
    • Nutritional assessments of patients with non-alcoholic fatty liver disease
    • Kim CH, Kallman JB, Bai C et al. (2010) Nutritional assessments of patients with non-alcoholic fatty liver disease. Obes Surg 20, 154-160.
    • (2010) Obes. Surg. , vol.20 , pp. 154-160
    • Kim, C.H.1    Kallman, J.B.2    Bai, C.3
  • 83
    • 63449137594 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia
    • Zhu FS, Liu S, Chen XM et al. (2008) Effects of n-3 polyunsaturated fatty acids from seal oils on nonalcoholic fatty liver disease associated with hyperlipidemia. World J Gastroenterol 14, 6395-6400.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 6395-6400
    • Zhu, F.S.1    Liu, S.2    Chen, X.M.3
  • 86
    • 73149107279 scopus 로고    scopus 로고
    • Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    • Bruce KD, Cagampang FR, Argenton M et al. (2009) Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology 50, 1796-1808.
    • (2009) Hepatology , vol.50 , pp. 1796-1808
    • Bruce, K.D.1    Cagampang, F.R.2    Argenton, M.3
  • 87
    • 61749094289 scopus 로고    scopus 로고
    • Maternal high-fat diet triggers lipotoxicity in the Fetal livers of nonhuman primates
    • McCurdy CE, Bishop JM, Williams SM et al. (2009) Maternal high-fat diet triggers lipotoxicity in the Fetal livers of nonhuman primates. J Clin Invest 119, 323-335.
    • (2009) J. Clin. Invest. , vol.119 , pp. 323-335
    • McCurdy, C.E.1    Bishop, J.M.2    Williams, S.M.3
  • 88
    • 34249053143 scopus 로고    scopus 로고
    • Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis
    • DOI 10.1002/14651858.CD004996.pub3
    • Lirussi F, Azzalini L, Orando S et al. (2007) Antioxidant supplements for non-alcoholic fatty liver disease and/or steatohepatitis. Cochrane Database of Systematic Reviews 2007, issue 1, CD004996. Chichester, West Sussex: John Wiley and Sons, Ltd. (Pubitemid 351820394)
    • (2007) Cochrane Database of Systematic Reviews , Issue.1
    • Lirussi, F.1    Azzalini, L.2    Orando, S.3    Orlando, R.4    Angelico, F.5
  • 89
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study
    • Lavine JE (2000) Vitamin e treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr 136, 734-738. (Pubitemid 30415645)
    • (2000) Journal of Pediatrics , vol.136 , Issue.6 , pp. 734-738
    • Lavine, J.E.1
  • 90
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin E
    • DOI 10.1053/jhep.2003.50316
    • Kugelmas M, Hill DB, Vivian B et al. (2003) Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 38, 413-419. (Pubitemid 36919862)
    • (2003) Hepatology , vol.38 , Issue.2 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3    Marsano, L.4    McClain, C.J.5
  • 91
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin E and Vitamin C Treatment Improves Fibrosis in Patients with Nonalcoholic Steatohepatitis
    • DOI 10.1111/j.1572-0241.2003.08699.x
    • Harrison SA, Torgerson S, Hayashi P et al. (2003) Vitamin e and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 98, 2485-2490. (Pubitemid 37448761)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.11 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3    Ward, J.4    Schenker, S.5
  • 92
    • 57549107354 scopus 로고    scopus 로고
    • Pioglitazone versus vitamin e versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design
    • Chalasani NP, Sanyal AJ, Kowdley KV et al. (2009) Pioglitazone versus vitamin e versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design. Contemp Clin Trials 30, 88-96.
    • (2009) Contemp Clin. Trials , vol.30 , pp. 88-96
    • Chalasani, N.P.1    Sanyal, A.J.2    Kowdley, K.V.3
  • 93
    • 73049090978 scopus 로고    scopus 로고
    • Treatment of nonalcoholic fatty liver disease in children: TONIC trial design
    • Lavine JE, Schwimmer JB, Molleston JP et al. (2010) Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials 31, 62-70.
    • (2010) Contemp Clin. Trials , vol.31 , pp. 62-70
    • Lavine, J.E.1    Schwimmer, J.B.2    Molleston, J.P.3
  • 95
    • 0035125052 scopus 로고    scopus 로고
    • The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis
    • Wigg AJ, Roberts-Thomson IC, Dymock RB et al. (2001) The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis. Gut 48, 206-211.
    • (2001) Gut , vol.48 , pp. 206-211
    • Wigg, A.J.1    Roberts-Thomson, I.C.2    Dymock, R.B.3
  • 96
    • 43349107591 scopus 로고    scopus 로고
    • High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: A contributor to severe hepatic steatosis
    • Sabate JM, Jouet P, Harnois F et al. (2008) High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis. Obes Surg 18, 371-377.
    • (2008) Obes. Surg. , vol.18 , pp. 371-377
    • Sabate, J.M.1    Jouet, P.2    Harnois, F.3
  • 97
    • 23944514253 scopus 로고    scopus 로고
    • Ciprofloxacin suppresses bacterial overgrowth, increases fasting insulin but does not correct low acylated ghrelin concentration in non-alcoholic steatohepatitis
    • DOI 10.1111/j.1365-2036.2005.02562.x
    • Sajjad A, Mottershead M, Syn WK et al. (2005) Ciprofloxacin suppresses bacterial overgrowth, increases fasting insulin but does not correct low acylated ghrelin concentration in non-alcoholic steatohepatitis. Aliment Pharmacol Ther 22, 291-299. (Pubitemid 41207458)
    • (2005) Alimentary Pharmacology and Therapeutics , vol.22 , Issue.4 , pp. 291-299
    • Sajjad, A.1    Mottershead, M.2    Syn, W.K.3    Jones, R.4    Smith, S.5    Nwokolo, C.U.6
  • 100
    • 63349101854 scopus 로고    scopus 로고
    • VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice
    • Velayudham A, Dolganiuc A, Ellis M et al. (2009) VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology 49, 989-997.
    • (2009) Hepatology , vol.49 , pp. 989-997
    • Velayudham, A.1    Dolganiuc, A.2    Ellis, M.3
  • 101
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM (1988) Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 37, 1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 102
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 103
    • 0038805259 scopus 로고    scopus 로고
    • The prevalence and etiology of elevated aminotransferase levels in the United States
    • DOI 10.1111/j.1572-0241.2003.07486.x
    • Clark JM, Brancati FL & Diehl AM (2003) The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 98, 960-967. (Pubitemid 36733754)
    • (2003) American Journal of Gastroenterology , vol.98 , Issue.5 , pp. 960-967
    • Clark, J.M.1    Brancati, F.L.2    Diehl, A.M.3
  • 105
    • 26244454605 scopus 로고    scopus 로고
    • Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women
    • Kim HC, Choi SH, Shin HW et al. (2005) Severity of ultrasonographic liver steatosis and metabolic syndrome in Korean men and women. World J Gastroenterol 11, 5314-5321.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 5314-5321
    • Kim, H.C.1    Choi, S.H.2    Shin, H.W.3
  • 109
    • 41949124892 scopus 로고    scopus 로고
    • Evaluation of metabolic syndrome frequency and carotid artery intima-media thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease
    • DOI 10.1007/s10620-007-9998-7
    • Aygun C, Kocaman O, Sahin T et al. (2008) Evaluation of metabolic syndrome frequency and carotid artery intimamedia thickness as risk factors for atherosclerosis in patients with nonalcoholic fatty liver disease. Dig Dis Sci 53, 1352-1357. (Pubitemid 351514649)
    • (2008) Digestive Diseases and Sciences , vol.53 , Issue.5 , pp. 1352-1357
    • Aygun, C.1    Kocaman, O.2    Sahin, T.3    Uraz, S.4    Eminler, A.T.5    Celebi, A.6    Senturk, O.7    Hulagu, S.8
  • 110
    • 51349083814 scopus 로고    scopus 로고
    • Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes
    • Fracanzani AL, Valenti L, Bugianesi E et al. (2008) Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 48, 792-798.
    • (2008) Hepatology , vol.48 , pp. 792-798
    • Fracanzani, A.L.1    Valenti, L.2    Bugianesi, E.3
  • 111
    • 67349209088 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome
    • Kim HC, Kim DJ & Huh KB (2009) Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. Atherosclerosis 204, 521-525.
    • (2009) Atherosclerosis , vol.204 , pp. 521-525
    • Kim, H.C.1    Kim, D.J.2    Huh, K.B.3
  • 112
    • 58149378362 scopus 로고    scopus 로고
    • Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: The Diabetes Heart Study
    • McKimmie RL, Daniel KR, Carr JJ et al. (2008) Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study. Am J Gastroenterol 103, 3029-3035.
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 3029-3035
    • McKimmie, R.L.1    Daniel, K.R.2    Carr, J.J.3
  • 113
    • 50849096389 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review
    • Sookoian S & Pirola CJ (2008) Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: a systematic review. J Hepatol 49, 600-607.
    • (2008) J. Hepatol. , vol.49 , pp. 600-607
    • Sookoian, S.1    Pirola, C.J.2
  • 114
    • 34547673500 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients
    • DOI 10.2337/dc07-0349
    • Targher G, Bertolini L, Rodella S et al. (2007) Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care 30, 2119-2121. (Pubitemid 47219432)
    • (2007) Diabetes Care , vol.30 , Issue.8 , pp. 2119-2121
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Tessari, R.4    Zenari, L.5    Lippi, G.6    Arcaro, G.7
  • 116
    • 68349155831 scopus 로고    scopus 로고
    • The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans
    • Choi SY, Kim D, Kim HJ et al. (2009) The relation between non-alcoholic fatty liver disease and the risk of coronary heart disease in Koreans. Am J Gastroenterol 104, 1953-1960.
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 1953-1960
    • Choi, S.Y.1    Kim, D.2    Kim, H.J.3
  • 117
    • 33947169979 scopus 로고    scopus 로고
    • Alanine aminotransferase predicts coronary heart disease events: A 10-year follow-up of the Hoorn Study
    • DOI 10.1016/j.atherosclerosis.2006.04.006, PII S0021915006001948
    • Schindhelm RK, Dekker JM, Nijpels G et al. (2007) Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study. Atherosclerosis 191, 391-396. (Pubitemid 46400701)
    • (2007) Atherosclerosis , vol.191 , Issue.2 , pp. 391-396
    • Schindhelm, R.K.1    Dekker, J.M.2    Nijpels, G.3    Bouter, L.M.4    Stehouwer, C.D.A.5    Heine, R.J.6    Diamant, M.7
  • 119
    • 7444253428 scopus 로고    scopus 로고
    • Systems biology and new technologies enable predictive and preventative medicine
    • DOI 10.1126/science.1104635
    • Hood L, Heath JR, Phelps ME et al. (2004) Systems biology and new technologies enable predictive and preventative medicine. Science 306, 640-643. (Pubitemid 39440903)
    • (2004) Science , vol.306 , Issue.5696 , pp. 640-643
    • Hood, L.1    Heath, J.R.2    Phelps, M.E.3    Lin, B.4
  • 120
    • 4644335402 scopus 로고    scopus 로고
    • Systems Biology, Proteomics, and the Future of Health Care: Toward Predictive, Preventative, and Personalized Medicine
    • DOI 10.1021/pr0499693
    • Weston AD & Hood L (2004) Systems biology, proteomics, and the future of health care: toward predictive, preventative, and personalized medicine. J Proteome Res 3, 179-196. (Pubitemid 38500984)
    • (2004) Journal of Proteome Research , vol.3 , Issue.2 , pp. 179-196
    • Westont, A.D.1    Hood, L.2
  • 121
    • 34547488563 scopus 로고    scopus 로고
    • A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis
    • DOI 10.1002/hep.21688
    • Calvert VS, Collantes R, Elariny H et al. (2007) A systems biology approach to the pathogenesis of obesity-related nonalcoholic fatty liver disease using reverse phase protein microarrays for multiplexed cell signaling analysis. Hepatology 46, 166-172. (Pubitemid 47171933)
    • (2007) Hepatology , vol.46 , Issue.1 , pp. 166-172
    • Calvert, V.S.1    Collantes, R.2    Elariny, H.3    Afendy, A.4    Baranova, A.5    Mendoza, M.6    Goodman, Z.7    Liotta, L.A.8    Petricoin, E.F.9    Younossi, Z.M.10
  • 122
    • 65449121797 scopus 로고    scopus 로고
    • Differential expression of lumican and fatty acid binding protein-1: New insights into the histologic spectrum of nonalcoholic fatty liver disease
    • Charlton M, Viker K, Krishnan A et al. (2009) Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease. Hepatology 49, 1375-1384.
    • (2009) Hepatology , vol.49 , pp. 1375-1384
    • Charlton, M.1    Viker, K.2    Krishnan, A.3
  • 123
    • 73449090429 scopus 로고    scopus 로고
    • Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease
    • Bell LN, Theodorakis JL, Vuppalanchi R et al. (2010) Serum proteomics and biomarker discovery across the spectrum of nonalcoholic fatty liver disease. Hepatology 51, 111-120.
    • (2010) Hepatology , vol.51 , pp. 111-120
    • Bell, L.N.1    Theodorakis, J.L.2    Vuppalanchi, R.3
  • 124
    • 77955959225 scopus 로고    scopus 로고
    • British Liver Trust, accessed June 2009
    • British Liver Trust (2009) Facts about liver disease. http://www.britishlivertrust.org.uk/home/media-centre/facts-aboutliver-disease. aspx (accessed June 2009).
    • (2009) Facts About Liver Disease


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.