Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

Gut

Volumn 63, Issue 11, 2014, Pages 1760-1768

  Cockbain, Andrew J ^a   Volpato, Milene ^a   Race, Amanda D ^b   Munarini, Alessandra ^c   Fazio, Chiara ^c   Belluzzi, Andrea ^c   Loadman, Paul M ^b   Toogood, Giles J ^a   Hull, Mark A ^a  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CD31 ANTIGEN; ICOSAPENTAENOIC ACID;

ADULT; AGED; CLINICAL TRIAL; COLORECTAL NEOPLASMS; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; LIVER NEOPLASMS; MALE; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SECONDARY; TANDEM MASS SPECTROMETRY; VASCULARIZATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTICARCINOGENIC AGENTS; ANTIGENS, CD31; CHROMATOGRAPHY, LIQUID; COLORECTAL NEOPLASMS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; TANDEM MASS SPECTROMETRY;

EID: 84893021314     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2013-306445     Document Type: Article

References (31)

1. Tur JA, Bibiloni MM, Sureda A, et al. Dietary sources of omega-3 fatty acids: Public health risks and benefits. Br J Nutr 2012;107:S23-52.
2. Calder PC. Mechanisms of action of (n-3) fatty acids. J Nutr 2012;142:592S-9S.
3. Serra-Majem L, Nissensohn M, Overny NC, et al. Dietary methods and biomarkers of omega-3 fatty acids: A systematic review. Br J Nutr 2012;107:S64-76.
4. World Cancer Research Fund/American Institute for Cancer Research. Continuous update project interim report summary. Food, nutrition, physical activity, and the prevention of colorectal cancer, 2011.
5. Cockbain AJ, Toogood GJ, Hull MA. Omega-3 polyunsaturated fatty acids for the prevention and treatment of colorectal cancer. Gut 2012;61:135-49.
6. West NJ, Clark SK, Phillips RKS, et al. Eicosapentaenoic acid reduces rectal polyp number and size in familial adenomatous polyposis. Gut 2010;59:918-25.
7. Hawcroft G, Volpato M, Marston G, et al. The ω-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of prostaglandin E2-dependent cell motility. Br J Pharmacol 2012;166:1724-37.
8. Weber JC, Nakano H, Bachellier P, et al. Is a proliferation index of cancer cells a reliable prognostic factor after hepatectomy in patients with colorectal liver metastases? Am J Surg 2001;182:81-8.
9. Zhong YS, Lu SX, Xu JM. Tumor proliferation and apoptosis after preoperative hepatic and regional arterial infusion chemotherapy in prevention of liver metastasis after colorectal cancer surgery. Zhonghua Wai Ke Za Zhi 2008; 46:1229-33.
10. Fenwick SW, Toogood GJ, Lodge JPA, et al. The effect of the selective cyclooxygenase-2 inhibitor rofecoxib on human colorectal cancer liver metastases. Gastroenterology 2003;125:716-29.
11. Backus HHJ, Dukers DF, van Groeningen CJ, et al. 5-fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients. Ann Oncol 2001;12:209-16.
12. Hamady ZZR, Lodge JPA, Welsh FK, et al. One-millimeter cancer-free margin is curative for colorectal liver metastases. A propensity score case-match approach. Ann Surg Published Online First: 19 Jun 2013. doi:10.1097/SLA.0b013e3182902b6e
13. Farid SG, Aldouri A, Morris-Stiff G, et al. Correlation between postoperative infective complications and long-term outcomes after hepatic resection for colorectal liver metastasis. Ann Surg 2010;251:91-100.
14. Chen W, Tang T, Eastham-Anderson J, et al. Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells. Proc Natl Acad Sci USA 2011;108:9589-94.
15. Kant P, Perry SL, Dexter SP, et al. Mucosal biomarkers of colorectal cancer risk do not increase at 6 months following sleeve gastrectomy, unlike gastric bypass. Obesity Published Online First: 27 Apr 2013. doi:10.1002/oby.20493
16. Hawcroft G, Belluzzi A, Loadman PM, et al. The effect of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid on E-type prostaglandin synthesis and EP4 receptor signalling in human colorectal cancer cells. Neoplasia 2010;12:618-27.
17. Murphey LJ, Williams MK, Sanchez SC, et al. Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: Determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with lung cancer. Anal Biochem 2004;334:266-75.
18. Szymczak M, Murray M, Petrovic N. Modulation of angiogenesis by ω-3 polyunsaturated fatty acids is mediated by cyclooxygenases. Blood 2008;111:3514-21.
19. Sorensen LS, Thorlacius-Ussing O, Schmidt EB, et al. Randomized clinical trial of perioperative omega-3 fatty acid supplements in elective colorectal cancer surgery. Br J Surg 2014;101:33-44.
20. Hillier K, Jewell R, Dorrell L, et al. Incorporation of fatty acids from fish oil and olive oil into colonic mucosal lipids and effects upon eicosanoid synthesis in inflammatory bowel disease. Gut 1991;32:1151-5.
21. Gibney MJ, Hunter B. The effects of short-and long-term supplementation with fish oil on the incorporation of n-3 polyunsaturated fatty acids into cells of the immune system in healthy volunteers. Eur J Clin Nutr 1993;47:255-9.
22. Stephenson JA, Al-Taan O, Arshad A, et al. Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: Results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. Prostaglandins Leukot Essent Fatty Acids 2013; 88:405-10.
23. Schuchardt JP, Hahn A. Bioavailability of long-chain omega-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids 2013;89:1-8.
24. Rigas B, Goldman IS, Levine L. Altered eicosanoid levels in human colon cancer. J Lab Clin Med 1993;122:518-23.
25. Chan E, LaFleur B, Rothenberg ML, et al. Dual blockade of the EGFR and COX-2 pathways. A Phase II trial of cetuximab and celecoxib in patients with chemotherapy refractory metastatic colorectal cancer. Am J Clin Oncol 2011;34:581-6.
26. Spencer L, Mann C, Metcalfe M, et al. The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. Eur J Cancer 2009; 45:2077-86.
27. Spelt L, Andersson B, Nilsson J, et al. Prognostic models for outcome following liver resection for colorectal cancer metastases: A systematic review. Eur J Surg Oncol 2012;38:16-24.
28. Cao J, Schwichtenberg KA, Hanson NQ, et al. Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem 2006;52:2265-72.
29. Endres S, Ghorbani R, Kelley VE, et al. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989;320:265-71.
30. Ries A, Trottenberg P, Elsner F, et al. A systematic review on the role of fish oil for the treatment of cachexia in advanced cancer: An EPCRC cachexia guidelines project. Palliative Med 2012;26:294-304.
31. Bougnoux P, Hajjaji N, Ferrasson MN, et al. Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial. Br J Cancer 2009;101:1978-85.