Differential roles of leptin in regulating cell migration in thyroid cancer cells

Oncology Reports

Volumn 23, Issue 6, 2010, Pages 1721-1727

  Cheng, Shih Ping ^a,b   Yin, Pen Hui ^c   Chang, Yuan Ching ^b   Lee, Chen Hsen ^a,c   Huang, Shih Yuan ^b   Chi, Chin Wen ^a,c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Adipokines; Leptin; Leptin receptor; Migration; Thyroid cancer

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; SODIUM IODIDE SYMPORTER; MESSENGER RNA;

ANAPLASTIC CARCINOMA; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL CYCLE; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STIMULATION; THYROID CANCER; THYROID FOLLICLE CELL; THYROID FOLLICULAR CARCINOMA; ADENOCARCINOMA; APOPTOSIS; CARCINOMA; CELL MOTION; CELL PROLIFERATION; GENETICS; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYROID TUMOR; WESTERN BLOTTING;

ADENOCARCINOMA, FOLLICULAR; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA; CARCINOMA, PAPILLARY; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; LEPTIN; RECEPTORS, LEPTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROID NEOPLASMS;

EID: 77951699992     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000817     Document Type: Article

References (29)

1. Davies L and Welch HG: Increasing incidence of thyroid cancer in the United States, 1973-2002. JAMA 295: 2164-2167, 2006.
2. Calle EE and Thun MJ: Obesity and cancer. Oncogene 23: 6365-6378, 2004.
3. Dal Maso L, Bosetti C, La Vecchia C and Franceschi S: Risk factors for thyroid cancer: an epidemiological review focused on nutritional factors. Cancer Causes Control 20: 75-86, 2009.
4. Engeland A, Tretli S, Akslen LA and Bjorge T: Body size and thyroid cancer in two million Norwegian men and women. Br J Cancer 95: 366-370, 2006. (Pubitemid 44187599)
5. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L and Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.
6. Huang L and Li C: Leptin: a multifunctional hormone. Cell Res 10: 81-92, 2000.
7. Myers MG, Cowley MA and Munzberg H: Mechanisms of leptin action and leptin resistance. Annu Rev Physiol 70: 537-556, 2008.
8. Garofalo C and Surmacz E: Leptin and cancer. J Cell Physiol 207: 12-22, 2006.
9. Vona-Davis L and Rose DP: Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 14: 189-206, 2007.
10. Somasundar P, Yu AK, Vona-Davis L and McFadden DW: Differential effects of leptin on cancer in vitro. J Surg Res 113: 50-55, 2003.
11. Chen C, Chang YC, Liu CL, Chang KJ and Guo IC: Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and downregulation of tumor suppressor p53 and p21WAF1/CIP1. Breast Cancer Res Treat 98: 121-132, 2006.
12. Chen C, Chang YC, Liu CL, Liu TP, Chang KJ and Guo IC: Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and downregulating Bax via a Janus kinase 2-linked pathway. Endocr Relat Cancer 14: 513-529, 2007.
13. Liu CL, Chang YC, Cheng SP, Chern SR, Yang TL, Lee JJ, Guo IC and Chen CP: The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer. Oncology 72: 75-81, 2007.
14. Feldt-Rasmussen U: Thyroid and leptin. Thyroid 17: 413-419, 2007.
15. Isozaki O, Tsushima T, Nozoe Y, Miyakawa M and Takano K: Leptin regulation of the thyroids: negative regulation on thyroid hormone levels in euthyroid subjects and inhibitory effects on iodide uptake and Na+/I- symporter mRNA expression in rat FRTL-5 cells. Endocr J 51: 415-423, 2004.
16. Nowak KW, Kaczmarek P, Mackowiak P, Ziolkowska A, Albertin G, Ginda WJ, Trejter M, Nussdorfer GG and Malendowicz LK: Rat thyroid gland expresses the long form of leptin receptors, and leptin stimulates the function of the gland in euthyroid non-fasted animals. Int J Mol Med 9: 31-34, 2002.
17. Lin JD, Chao TC, Weng HF, Huang HS and Ho YS: Establishment of xenografts and cell lines from well-differentiated human thyroid carcinoma. J Surg Oncol 63: 112-118, 1996.
18. Frankenberry KA, Somasundar P, McFadden DW and Vona-Davis LC: Leptin induces cell migration and the expression of growth factors in human prostate cancer cells. Am J Surg 188: 560-565, 2004.
19. Saxena NK, Sharma D, Ding X, Lin S, Marra F, Merlin D and Anania FA: Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells. Cancer Res 67: 2497-2507, 2007.
20. Jaffe T and Schwartz B: Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer 123: 2543-2556, 2008.
21. Yang SN, Chen HT, Tsou HK, Huang CY, Yang WH, Su CM, Fong YC, Tseng WP and Tang CH: Leptin enhances cell migration in human chondrosarcoma cells through OBRl leptin receptor. Carcinogenesis 30: 566-574, 2009.
22. de Oliveira E, Teixeira Silva Fagundes A, Teixeira Bonomo I, Curty FH, Fonseca Passos MC, de Moura EG and Lisboa PC: Acute and chronic leptin effect upon in vivo and in vitro rat thyroid iodide uptake. Life Sci 81: 1241-1246, 2007.
23. Hursting SD, Nunez NP, Varticovski L and Vinson C: The obesity-cancer link: lessons learned from a fatless mouse. Cancer Res 67: 2391-2393, 2007.
24. Friedl P and Wolf K: Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 3: 362-374, 2003.
25. Etienne-Manneville S: Polarity proteins in migration and invasion. Oncogene 27: 6970-6980, 2008.
26. Miyoshi Y, Funahashi T, Tanaka S, Taguchi T, Tamaki Y, Shimomura I and Noguchi S: High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. Int J Cancer 118: 1414-1419, 2006.
27. Wang SN, Chuang SC, Yeh YT, Yang SF, Chai CY, Chen WT, Kuo KK, Chen JS and Lee KT: Potential prognostic value of leptin receptor in hepatocellular carcinoma. J Clin Pathol 59: 1267-1271, 2006.
28. Paik SS, Jang SM, Jang KS, Lee KH, Choi D and Jang SJ: Leptin expression correlates with favorable clinicopathologic phenotype and better prognosis in colorectal adenocarcinoma. Ann Surg Oncol 16: 297-303, 2009.
29. Cheng SP, Liu CL, Tzen CY, Yang TL, Jeng KS, Liu TP and Lee JJ: Characteristics of well-differentiated thyroid cancer associated with multinodular goiter. Langenbecks Arch Surg 393: 729-732, 2008.