Role of macrophages in tumour progression

Immunology Letters

Volumn 123, Issue 2, 2009, Pages 97-102

  Siveen, K S ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Hypoxia; Invasion; Matrix; Metalloproteinase; Metastasis; Prognosis; Therapeutic intervention; Tumour associated macrophage

Indexed keywords

ABRUS PRECATORIUS EXTRACT; AMENTOFLAVONE; CELECOXIB; CHEMOKINE; CHEMOKINE RECEPTOR ANTAGONIST; CLODRONIC ACID; CYTOKINE; DEXAMETHASONE; GROWTH FACTOR; PACLITAXEL; PENTOXIFYLLINE; PROTEINASE; PYRROLIDINE DITHIOCARBAMATE; ROQUINIMEX; TINOSPORA CORDIFOLIA EXTRACT; TRABECTEDIN; ZOLEDRONIC ACID;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER CELL; CELL ACTIVATION; CELL FUNCTION; CELL INFILTRATION; CELL INTERACTION; CELL INVASION; CELL MIGRATION; CELL POPULATION; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CIRCULATION; DRUG EFFECT; DRUG MECHANISM; HOST PATHOGEN INTERACTION; HUMAN; HYPOXIA; INFLAMMATION; MACROPHAGE; METASTASIS; MICROENVIRONMENT; MONONUCLEAR CELL; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RHABDOMYOSARCOMA; SOLID TUMOR; TERATOCARCINOMA; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL; TUMOR GROWTH;

ANIMALS; ANOXIA; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; LYMPHOCYTES, TUMOR-INFILTRATING; MACROPHAGES; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 67349168435     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2009.02.011     Document Type: Review

References (93)

1. Brigati C., Noonan D.M., Albini, Libby A., and Benelli R. Tumors and inflammatory infiltrates: friends or foes?. Clin Exp Metastasis 19 (2002) 247-258
2. Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
3. deVisser K.E., Eichten A., and Coussens L.M. Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6 (2006) 24-37
4. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
5. Kerbel R., and Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2 (2002) 727-739
6. Folkman J. Angiogenesis. Annu Rev Med 57 (2006) 1-18
7. Folkman J. Angiogenesis: an organizing principle for drug discovery?. Nat Rev Drug Discov 6 (2007) 273-286
8. Balkwill F., Charles K.A., and Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 7 (2005) 211-217
9. Balkwill F., and Mantovani A. Inflammation and cancer: back to Virchow?. Lancet 357 (2001) 539-545
10. Pollard J.W. Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4 (2004) 71-78
11. Orimo A., and Weinberg R.A. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5 (2006) 1597-1601
12. Adams D.O., and Hamilton T.A. The cell biology of macrophage activation. Annu Rev Immunol 2 (1984) 283-318
13. Nathan C.F., and Hibbs Jr. J.B. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 3 (1991) 65-75
14. Podolsky S., and Tauber A.I. Darwinism and antibody diversity: a historical perspective. Res Immunol 147 (1996) 199-202
15. Auger M.J., and Ross J.A. The biology of macrophage. In: Lewis C.E., and McGee J.O. (Eds). The macrophage (1992), Oxford University Press, Oxford 2-74
16. Mantovan A., Bottazzi B., Colotta F., Sozzani S., and Ruco L. The origin and function of tumor associated macrophages. Immunol Today 13 (1992) 265-270
17. Bingle L., Brown N.J., and Lewis C.E. The role of tumor-associated macrophages in tumor progression: implications for new anticancer therapies. J Pathol 196 (2002) 254-265
18. Mantovani A., Sozzani S., Locati M., Allavena P., and Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23 (2002) 549-555
19. Biswas S.K., Gangi L., Paul S., Schioppa T., Saccani A., Sironi M., et al. A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood 107 (2006) 2112-2122
20. Konur A., Kreutz M., Knuchel R., Krause S.W., and Andressen R. Three dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation. Int J Cancer 66 (1996) 645-652
21. Mantovani A. Tumour-associated macrophages in neoplastic progression: a paradigm for the in vivo function of chemokines. Lab Invest 71 (1994) 5-16
22. Graves D.T., Jiang Y.L., Williamson M.J., and Valente A.J. Identification of monocyte chemotactic activity produced by malignant cells. Science 245 (1989) 1490-1493
23. Leung S.Y., Wong M.P., Chung L.P., Chan A.S.Y., and Yuen S.T. Monocyte chemoattractant protein-1 expression and macrophage infiltration in gliomas. Acta Neuropathol 93 (1997) 518-527
24. Sato K., Kuratsu J., Takeshima H., Yoshimura T., and Ushio Y. Expression of monocyte chemoattractant protein-1 in meningioma. J Neurosurg 82 (1995) 874-878
25. Negus R.P., Stamp G.W., Relf M.G., Burke F., Malik S.T., Bernasconi S., et al. The detection and localisation of monocyte chemoattractant protein-1 in human ovarian cancer. J Clin Invest 95 (1995) 2391-2396
26. Riethdorf L., Riethdorf S., Gutzlaff K., Prall F., and Loning T. Differential expression of the monocyte chemoattractant protein-1 gene in human papillomavirus-16-infected squamous intraepithelial lesions and squamous cell carcinomas of the cervix uteri. Am J Pathol 149 (1996) 1469-1476
27. Murdock C., Giannoudis A., and Lewis C.E. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 104 (2004) 2224-2234
28. Lewis C.E., and Murdock C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 167 (2005) 627-635
29. Condeelis J., and Pollard J.W. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124 (2006) 263-266
30. Crowther M., Brown N.J., Bishop E.T., and Lewis C.E. Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J Leukoc Biol 70 (2001) 478-490
31. Folkman J. Tumor angiogenesis. Adv Cancer Res 43 (1985) 175-203
32. White E.S., Strom S.R.B., Wys N.L., and Arenberg D.A. Non-small cell lung cancer cells induce monocytes to increase expression of angiogenic activity. J Immunol 166 (2001) 7549-7555
33. Ueno T., Toi M., Saji H., Muta M., Bando H., Kuroi K., et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin Cancer Res 6 (2000) 3282-3289
34. Tanaka Y., Kobayashi H., Suzuki M., Kanayama N., Suzuki M., and Terao T. Thymidine phosphorylase expression in tumor-infiltrating macrophages may be correlated with poor prognosis in uterine endometrial cancer. Hum Pathol 33 (2002) 1105-1113
35. Thompson W.D., Smith E.B., Stirk C.M., Marshall F.I., Stou A.J., and Kocchar A. Angiogenic activity of fibrin degradation products is located in fibrin fragment. Eur J Pathol 168 (1992) 47-53
36. Pepper M.S. Role of the matrix metalloproteinase and plasminogen activator-plasmin systems in angiogenesis. Arterioscler Thromb Vasc Biol 21 (2001) 1104-1117
37. Naylor M.S., Stamp G.W., Davies B.D., and Balkwill F.R. Expression and activity of MMPS and their regulators in ovarian cancer. Int J Cancer 58 (1994) 50-56
38. Wang F.Q., So J., Reierstad S., and Fishman D.A. Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase. Int J Cancer 114 (2005) 19-31
39. Hildenbrand R., Wolf G., Bohme B., Bleyl U., and Steinborn A. Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue. J Leukoc Biol 66 (1999) 40-49
40. Hu D.E., Hory Y., and Fan T.P. Interleukin-8 stimulates angiogenesis in rats. Inflammation 17 (1993) 135-143
41. Koch A.E., Polverini P.J., Kunkel S.L., Harlow L.A., DiPietro L.A., Elner V.M., et al. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 258 (1992) 1798-1801
42. Hildenbrand R., Dilger I., Horlin A., and Stutte H.J. Urokinase and macrophages in tumour angiogenesis. Br J Cancer 72 (1995) 818-823
43. Vaupel P., Kelleher D.K., and Hockel M. Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy. Semin Oncol 28 (2001) 29-35
44. Shannon A.M., Bouchier-Hayes D.J., Condron C.M., and Toomey D. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat Rev 29 (2003) 297-307
45. Leek R.D., Landers R.J., Harrism A.L., and Lewis C.E. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer 79 (1999) 991-995
46. Collingridge D.R., Hill S.A., and Chaplin D.J. Proportion of infiltrating IgG binding immune cells predict for tumor hypoxia. Br J Cancer 84 (2001) 626-630
47. Ohno S., Ohno Y., Suzuki N., Kamei T., Koike K., Inagawa H., et al. Correlation of histological localization of tumour associated macrophages with clinicopathological features in endometrial cancer. Anticancer Res 24 (2004) 3335-3342
48. Burton J.L., Wells J.M., Corke K.P., Maitland N., Hamdy F.C., and Lewis C.E. Macrophages accumulate in avascular, hypoxic areas of prostate tumors: implications for the targeted therapeutic gene delivery to such sites. J Pathol 192 (2000) 8A
49. Negus R.P., Stamp G.W., Hadley J., and Balkwill F.R. Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. Am J Pathol 150 (1997) 1723-1734
50. Grimshaw M.J., and Balkwill F.R. Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation-a potential mechanism. Eur J Immunol 31 (2001) 480-489
51. Ashida N., Arai H., Yamasaki M., and Kita T. Differential signaling for MCP-1-dependent integrin activation and chemotaxis. Ann N Y Acad Sci 947 (2001) 387-389
52. Wain J.H., Kirby J.A., and Ali S. Leucocyte chemotaxis: examination of mitogen-activated protein kinase and phosphoinositide 3-kinase activation by monocyte chemoattractant proteins-1, -2, -3 and -4. Clin Exp Immunol 127 (2002) 436-444
53. Sica A., Saccani A., Bottazzi B., Bernasconi S., Allavena P., Gaetano B., et al. Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma. J Immunol 164 (2000) 733-738
54. Bosco M.C., Reffo G., Puppo M., and Varesio L. Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages. Cell Immunol 228 (2004) 1-7
55. Burke B., Tang N., Corke K.P., Tazzyman D., Ameri K., Wells M., et al. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol 196 (2002) 204-212
56. Talks K.L., Turley H., Gatter K.C., Maxwell P.H., Pugh C.W., Ratcliffe P.J., et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157 (2000) 411-421
57. Sweet M.J., and Hume D.A. M-CSF as a regulator of macrophage activation and immune responses. Arch Immunol Ther Exp 51 (2003) 169-177
58. Scholl S.M., Pallud C., Beuvon F., Hacene K., Stanley E.R., Rohrschneider L., et al. Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J Natl Cancer Inst 86 (1994) 120-126
59. White J.R., Harris R.A., Lee S.R., Craigon M.H., Binley K., Price T., et al. Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics 83 (2004) 1-8
60. O'Sullivan C., Lewis C.E., Harris A.L., and McGee J.O. Secretion of epidermal growth factor by macrophages associated with breast carcinoma. Lancet 342 (1993) 148-149
61. Lewis J.S., Landers R.J., Underwood J.C., Harris A.L., and Lewis C.E. Expression of vascular endothelial growth factor by macrophages is upregulated in poorly vascularized areas of breast carcinomas. J Pathol 192 (2000) 150-158
62. Schmeisser A., Marquetant R., Illmer T., Graffy C., Garlichs C.D., Bockler D., et al. The expression of macrophage migration inhibitory factor 1alpha (MIF 1alpha) in human atherosclerotic plaques is induced by different proatherogenic stimuli and associated with plaque instability. Atherosclerosis 178 (2005) 83-94
63. Sun B., Nishihira J., Yoshiki T., Kondo M., Sato Y., Sasaki F., et al. Macrophage migration inhibitory factor promotes tumor invasion and metastasis via the Rho-dependent pathway. Clin Cancer Res 11 (2005) 1050-1058
64. Hagemann T., Robinson S.C., Schulz M., Trumper L., Balkwill F.R., and Binder C. Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis 25 (2004) 1543-1549
65. Grimshaw M.J., Wilson J.L., and Balkwill F.R. Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors. Eur J Immunol 32 (2002) 2393-2400
66. Sessa C., De Braud F., Perotti A., Bauer J., Curigliano G., Noberasco C., et al. Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails. J Clin Oncol 23 (2005) 1867-1874
67. Allavena P., Signorelli M., Chieppa M., Erba E., Bianchi G., Marchesi F., et al. Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production. Cancer Res 65 (2005) 2964-2971
68. Singh N., Singh S., and Shrivastava P. Effect of Tinospora cordifolia on the antitumor activity of tumor-associated macrophages-derived dendritic cells. Immunopharmacol Immunotoxicol 27 (2005) 1-14
69. Ghosh D., and Maiti T.K. Effects of native and heat-denatured Abrus agglutinin on tumor-associated macrophages in Dalton's lymphoma mice. Immunobiology 212 (2007) 667-673
70. Guruvayoorappan C., and Kuttan G. Apoptotic effect of Biophytum sensitivum on B16F-10 cells and its regulatory effects on nitric oxide and cytokine production on tumor-associated macrophages. Integr Cancer Ther 6 (2007) 373-380
71. Guruvayoorappan C., and Kuttan G. Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. J Exp Therapeut Oncol 7 (2008) 207-218
72. Guruvayoorappan C., and Kuttan G. Antiangiogenic effect of rutin and its regulatory effect on the production of VEGF, IL-1β and TNF-α in tumor associated macrophages. J Biol Sci 7 (2007) 1511-1519
73. Manthey C.L., Brandes M.E., Perera P.Y., and Vogel S.N. Taxol increases steady-state levels of lipopolysaccharide-inducible genes and protein-tyrosine phosphorylation in murine macrophages. J Immunol 149 (1992) 2459-2465
74. Manthey C.L., Perera P.Y., Salkowski C.A., and Vogel S.N. Taxol provides a second signal for murine macrophage tumoricidal activity. J Immunol 152 (1994) 825-831
75. Ding A.B., Porteu F., Sanchez E., and Nathan C.F. Shared actions of endotoxin and taxol on INF receptors and TNF release. Science 248 (1990) 370-372
76. Bogdan C., and Ding A.H. Taxol, a microtubule-stabilizing antineoplastic agent, induces expression of tumor necrosis factor alpha and interleukin-1 in macrophages. J Leukoc Biol 52 (1992) 119-121
77. Pae H.O., Jun C.D., Yoo J.C., Kwak H.J., Lee S.J., Kook Y.A., et al. Enhancing and priming of macrophages for superoxide anion production by taxol. Immunopharmacol Immunotoxicol 20 (1998) 27-37
78. Hwang S., and Ding A.H. Activation of NF-kappa B in murine macrophages by taxol. Cancer Biochem Biophys 14 (1995) 265-272
79. Mullins D.W., Burger C.J., and Elgert K.D. Paclitaxel enhances macrophage IL-12 production in tumor-bearing hosts through nitric oxide. J Immunol 162 (1999) 6811-6818
80. Giraudo E., Inoue M., and Hanahan D. An amino-bisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J Clin Invest 114 (2004) 623-633
81. Joseph I.B., and Isaacs J.T. Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents. J Natl Cancer Inst 90 (1998) 1648-1653
82. Chen J.J., Yao P.L., Yuan A., Hong T.M., Shun C.T., Kuo M.L., et al. Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res 9 (2003) 729-737
83. Hong TM, Teng LJ, Shun CT, Peng MC, Tsai JC. Induced interleukin-8 expression in gliomas by tumor-associated macrophages. J Neurooncol; in press. doi:10.1007/s11060-008-9786-z.
84. Zeisberger S.M., Odermatt B., Marty C., Zehnder-Fjällman A.H., Ballmer-Hofer K., and Schwendener R.A. Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach. Br J Cancer 95 (2006) 272-281
85. Robinson S.C., Scott K.A., Wilson J.L., Thompson R.G., Proudfoot A.E., and Balkwill F.R. A chemokine receptor antagonist inhibits experimental breast tumor growth. Cancer Res 63 (2003) 8360-8365
86. Lissbrant I.F., Stattin P., Wikstrom P., Damber J.E., Egevad L., and Bergh A. Tumour associated macrophages in human prostate cancer: relation to clinicopathological variables and survival. Int J Oncol 17 (2000) 445-451
87. Shimura S., Yang G., Ebara S., Wheeler T.M., Frolov A., and Thompson T.C. Reduced infiltration of tumour-associated macrophages in human prostate cancer: association with cancer progression. Cancer Res 60 (2000) 5857-5861
88. Kerr K.M., Johnson S.K., King G., Kennedy M.M., Weir J., and Jeffrey R. Regression in primary carcinoma of the lung: does it occur?. Histopathology 33 (1998) 55-63
89. Takanami I., Takeuchi K., and Kodaira S. Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: association with angiogenesis and poor prognosis. Oncology 57 (1999) 138-142
90. Bolat F., Kayaselcuk F., Nursal T.Z., Yagmurdur M.C., Bal N., and Demirhan B. Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters. J Exp Clin Cancer Res 25 (2006) 365-372
91. Shieh YS, Hung YJ, Hsieh CB, Chen JS, Chou KC, Liu SY. Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands. Ann Surg Oncol; in press. doi:10.1245/s10434-008-0259-6.
92. Ding T., Xu J., Wang F., Shi M., Zhang Y., Li S.P., and Zheng L. High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. Hum Pathol 40 (2008) 381-389
93. Hansen B.D., Schmidt H., von der Maase H., Sjoegren P., Agger R., and Hokland M. Tumour-associated macrophages are related to progression in patients with metastatic melanoma following interleukin-2 based immunotherapy. Acta Oncol 45 (2006) 400-405