-
1
-
-
43949105866
-
Regulatory T cells and immune tolerance
-
1:CAS:528:DC%2BD1cXntFaltrg%3D 18510923
-
Sakaguchi S, Yamaguchi T, Nomura T, Ono M (2008) Regulatory T cells and immune tolerance. Cell 133:775-787
-
(2008)
Cell
, vol.133
, pp. 775-787
-
-
Sakaguchi, S.1
Yamaguchi, T.2
Nomura, T.3
Ono, M.4
-
3
-
-
82155192945
-
Stability of regulatory T-cell lineage
-
22118405
-
Hori S (2011) Stability of regulatory T-cell lineage. Adv Immunol 112:1-24
-
(2011)
Adv Immunol
, vol.112
, pp. 1-24
-
-
Hori, S.1
-
4
-
-
66949171924
-
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
-
1:CAS:528:DC%2BD1MXpsFCnurk%3D 19464196
-
Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, Parizot C, Taflin C, Heike T, Valeyre D et al (2009) Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 30:899-911
-
(2009)
Immunity
, vol.30
, pp. 899-911
-
-
Miyara, M.1
Yoshioka, Y.2
Kitoh, A.3
Shima, T.4
Wing, K.5
Niwa, A.6
Parizot, C.7
Taflin, C.8
Heike, T.9
Valeyre, D.10
-
5
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
1:CAS:528:DC%2BD1MXltlSrsbY%3D 2712126 19412181
-
Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ (2009) The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 10:595-602
-
(2009)
Nat Immunol
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
Tucker-Heard, G.2
Perdue, N.R.3
Killebrew, J.R.4
Urdahl, K.B.5
Campbell, D.J.6
-
6
-
-
84866483591
-
The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology
-
3477519 22981537
-
Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS et al (2012) The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 37:511-523
-
(2012)
Immunity
, vol.37
, pp. 511-523
-
-
Hall, A.O.1
Beiting, D.P.2
Tato, C.3
John, B.4
Oldenhove, G.5
Lombana, C.G.6
Pritchard, G.H.7
Silver, J.S.8
Bouladoux, N.9
Stumhofer, J.S.10
-
7
-
-
84878169329
-
An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos
-
1:CAS:528:DC%2BC3sXnvVSit7w%3D 23684987
-
Sharma MD, Huang L, Choi JH, Lee EJ, Wilson JM, Lemos H, Pan F, Blazar BR, Pardoll DM, Mellor AL et al (2013) An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. Immunity 38:998-1012
-
(2013)
Immunity
, vol.38
, pp. 998-1012
-
-
Sharma, M.D.1
Huang, L.2
Choi, J.H.3
Lee, E.J.4
Wilson, J.M.5
Lemos, H.6
Pan, F.7
Blazar, B.R.8
Pardoll, D.M.9
Mellor, A.L.10
-
8
-
-
84862777225
-
Extrathymically generated regulatory T cells control mucosal TH2 inflammation
-
1:CAS:528:DC%2BC38XitVWnt7Y%3D 3485072 22318520
-
Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY (2012) Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 482:395-399
-
(2012)
Nature
, vol.482
, pp. 395-399
-
-
Josefowicz, S.Z.1
Niec, R.E.2
Kim, H.Y.3
Treuting, P.4
Chinen, T.5
Zheng, Y.6
Umetsu, D.T.7
Rudensky, A.Y.8
-
9
-
-
34247271308
-
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
-
1:CAS:528:DC%2BD2sXhslWmsrk%3D 17220892
-
Williams LM, Rudensky AY (2007) Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 8:277-284
-
(2007)
Nat Immunol
, vol.8
, pp. 277-284
-
-
Williams, L.M.1
Rudensky, A.Y.2
-
10
-
-
69549120242
-
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
-
1:CAS:528:DC%2BD1MXhtVersrzN 2859703 19696312
-
Pan F, Yu H, Dang EV, Barbi J, Pan X, Grosso JF, Jinasena D, Sharma SM, McCadden EM, Getnet D et al (2009) Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science 325:1142-1146
-
(2009)
Science
, vol.325
, pp. 1142-1146
-
-
Pan, F.1
Yu, H.2
Dang, E.V.3
Barbi, J.4
Pan, X.5
Grosso, J.F.6
Jinasena, D.7
Sharma, S.M.8
McCadden, E.M.9
Getnet, D.10
-
11
-
-
84866533054
-
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
-
1:CAS:528:DC%2BC38Xhtlajsb3L 3698954 22961053
-
Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S et al (2012) A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol 13:972-980
-
(2012)
Nat Immunol
, vol.13
, pp. 972-980
-
-
Fu, W.1
Ergun, A.2
Lu, T.3
Hill, J.A.4
Haxhinasto, S.5
Fassett, M.S.6
Gazit, R.7
Adoro, S.8
Glimcher, L.9
Chan, S.10
-
12
-
-
62649165369
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
-
1:CAS:528:DC%2BD1MXht1ehsLg%3D 2864791 19182775
-
Zheng Y, Chaudhry A, Kas A, deRoos P, Kim JM, Chu TT, Corcoran L, Treuting P, Klein U, Rudensky AY (2009) Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 458:351-356
-
(2009)
Nature
, vol.458
, pp. 351-356
-
-
Zheng, Y.1
Chaudhry, A.2
Kas, A.3
Deroos, P.4
Kim, J.M.5
Chu, T.T.6
Corcoran, L.7
Treuting, P.8
Klein, U.9
Rudensky, A.Y.10
-
13
-
-
84861424521
-
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes
-
1:CAS:528:DC%2BC38XmvFKksr0%3D 3386606 22579475
-
Darce J, Rudra D, Li L, Nishio J, Cipolletta D, Rudensky AY, Mathis D, Benoist C (2012) An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity 36:731-741
-
(2012)
Immunity
, vol.36
, pp. 731-741
-
-
Darce, J.1
Rudra, D.2
Li, L.3
Nishio, J.4
Cipolletta, D.5
Rudensky, A.Y.6
Mathis, D.7
Benoist, C.8
-
14
-
-
84861451140
-
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency
-
1:CAS:528:DC%2BC38XmvFKmu7k%3D 3361541 22579476
-
Bettini ML, Pan F, Bettini M, Finkelstein D, Rehg JE, Floess S, Bell BD, Ziegler SF, Huehn J, Pardoll DM et al (2012) Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity 36:717-730
-
(2012)
Immunity
, vol.36
, pp. 717-730
-
-
Bettini, M.L.1
Pan, F.2
Bettini, M.3
Finkelstein, D.4
Rehg, J.E.5
Floess, S.6
Bell, B.D.7
Ziegler, S.F.8
Huehn, J.9
Pardoll, D.M.10
-
15
-
-
33749346301
-
Modification of proteins by ubiquitin and ubiquitin-like proteins
-
1:CAS:528:DC%2BD28Xht1yjs7vI 16753028
-
Kerscher O, Felberbaum R, Hochstrasser M (2006) Modification of proteins by ubiquitin and ubiquitin-like proteins. Annu Rev Cell Dev Biol 22:159-180
-
(2006)
Annu Rev Cell Dev Biol
, vol.22
, pp. 159-180
-
-
Kerscher, O.1
Felberbaum, R.2
Hochstrasser, M.3
-
16
-
-
0031657807
-
The ubiquitin system
-
1:CAS:528:DyaK1cXlsFOmsLc%3D 9759494
-
Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425-479
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 425-479
-
-
Hershko, A.1
Ciechanover, A.2
-
17
-
-
0034308251
-
The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
-
1:CAS:528:DC%2BD3cXmsFyrsbw%3D 10998601
-
Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (2000) The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol 10:429-439
-
(2000)
Trends Cell Biol
, vol.10
, pp. 429-439
-
-
Jackson, P.K.1
Eldridge, A.G.2
Freed, E.3
Furstenthal, L.4
Hsu, J.Y.5
Kaiser, B.K.6
Reimann, J.D.7
-
18
-
-
24044547036
-
Regulating the regulators: Control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli
-
1:CAS:528:DC%2BD2MXhtVSkurrP 16137616
-
Gao M, Karin M (2005) Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Mol Cell 19:581-593
-
(2005)
Mol Cell
, vol.19
, pp. 581-593
-
-
Gao, M.1
Karin, M.2
-
20
-
-
68049084674
-
Breaking the chains: Structure and function of the deubiquitinases
-
1:CAS:528:DC%2BD1MXovFSru74%3D 19626045
-
Komander D, Clague MJ, Urbe S (2009) Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol 10:550-563
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 550-563
-
-
Komander, D.1
Clague, M.J.2
Urbe, S.3
-
21
-
-
67650620318
-
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes
-
1:CAS:528:DC%2BD1MXos1Ghtbc%3D 19489724
-
Reyes-Turcu FE, Ventii KH, Wilkinson KD (2009) Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem 78:363-397
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 363-397
-
-
Reyes-Turcu, F.E.1
Ventii, K.H.2
Wilkinson, K.D.3
-
22
-
-
84883754405
-
Generation and function of induced regulatory T cells
-
1:CAS:528:DC%2BC3sXht1ersL%2FM 3685796 23801990
-
Schmitt EG, Williams CB (2013) Generation and function of induced regulatory T cells. Front Immunol 4:152
-
(2013)
Front Immunol
, vol.4
, pp. 152
-
-
Schmitt, E.G.1
Williams, C.B.2
-
23
-
-
84880117751
-
T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells
-
1:CAS:528:DC%2BC3sXhtVKgtLfK 23749633
-
Qiao G, Zhao Y, Li Z, Tang PQ, Langdon WY, Yang T, Zhang J (2013) T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells. J Immunol 191:632-639
-
(2013)
J Immunol
, vol.191
, pp. 632-639
-
-
Qiao, G.1
Zhao, Y.2
Li, Z.3
Tang, P.Q.4
Langdon, W.Y.5
Yang, T.6
Zhang, J.7
-
24
-
-
0034642499
-
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
-
1:CAS:528:DC%2BD3cXmslamsw%3D%3D 10646608
-
Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A et al (2000) Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403:211-216
-
(2000)
Nature
, vol.403
, pp. 211-216
-
-
Bachmaier, K.1
Krawczyk, C.2
Kozieradzki, I.3
Kong, Y.Y.4
Sasaki, T.5
Oliveira-Dos-Santos, A.6
Mariathasan, S.7
Bouchard, D.8
Wakeham, A.9
Itie, A.10
-
25
-
-
3142782879
-
Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice
-
1:CAS:528:DC%2BD2cXlsVGisrw%3D 15240694
-
Wohlfert EA, Callahan MK, Clark RB (2004) Resistance to CD4+CD25+ regulatory T cells and TGF-beta in Cbl-b-/- mice. J Immunol 173:1059-1065
-
(2004)
J Immunol
, vol.173
, pp. 1059-1065
-
-
Wohlfert, E.A.1
Callahan, M.K.2
Clark, R.B.3
-
26
-
-
77956942335
-
Cbl-b(-/-) T cells demonstrate in vivo resistance to regulatory T cells but a context-dependent resistance to TGF-beta
-
1:CAS:528:DC%2BC3cXpslWntbw%3D 20624942
-
Adams CO, Housley WJ, Bhowmick S, Cone RE, Rajan TV, Forouhar F, Clark RB (2010) Cbl-b(-/-) T cells demonstrate in vivo resistance to regulatory T cells but a context-dependent resistance to TGF-beta. J Immunol 185:2051-2058
-
(2010)
J Immunol
, vol.185
, pp. 2051-2058
-
-
Adams, C.O.1
Housley, W.J.2
Bhowmick, S.3
Cone, R.E.4
Rajan, T.V.5
Forouhar, F.6
Clark, R.B.7
-
27
-
-
41149113441
-
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
-
1:CAS:528:DC%2BD1cXjs1ahtbs%3D 2275380 18283119
-
Haxhinasto S, Mathis D, Benoist C (2008) The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med 205:565-574
-
(2008)
J Exp Med
, vol.205
, pp. 565-574
-
-
Haxhinasto, S.1
Mathis, D.2
Benoist, C.3
-
28
-
-
45549098562
-
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
-
1:CAS:528:DC%2BD1cXntF2rtbY%3D 2409380 18509048
-
Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E et al (2008) T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A 105:7797-7802
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 7797-7802
-
-
Sauer, S.1
Bruno, L.2
Hertweck, A.3
Finlay, D.4
Leleu, M.5
Spivakov, M.6
Knight, Z.A.7
Cobb, B.S.8
Cantrell, D.9
O'Connor, E.10
-
29
-
-
77953811224
-
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
-
1:CAS:528:DC%2BC3cXlvFOrsLs%3D 20467422
-
Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO (2010) Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol 11:618-627
-
(2010)
Nat Immunol
, vol.11
, pp. 618-627
-
-
Ouyang, W.1
Beckett, O.2
Ma, Q.3
Paik, J.H.4
Depinho, R.A.5
Li, M.O.6
-
30
-
-
77954395996
-
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
-
1:CAS:528:DC%2BC3cXovFaktL0%3D 2901074 20439537
-
Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC (2010) Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 207:1381-1391
-
(2010)
J Exp Med
, vol.207
, pp. 1381-1391
-
-
Harada, Y.1
Elly, C.2
Ying, G.3
Paik, J.H.4
Depinho, R.A.5
Liu, Y.C.6
-
31
-
-
0035895959
-
Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells
-
1:CAS:528:DC%2BD3MXhtlOqtLc%3D 11087752
-
Fang D, Wang HY, Fang N, Altman Y, Elly C, Liu YC (2001) Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells. J Biol Chem 276:4872-4878
-
(2001)
J Biol Chem
, vol.276
, pp. 4872-4878
-
-
Fang, D.1
Wang, H.Y.2
Fang, N.3
Altman, Y.4
Elly, C.5
Liu, Y.C.6
-
32
-
-
0035555195
-
Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells
-
1:CAS:528:DC%2BD3MXmsFehtb0%3D 11526404
-
Fang D, Liu YC (2001) Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol 2:870-875
-
(2001)
Nat Immunol
, vol.2
, pp. 870-875
-
-
Fang, D.1
Liu, Y.C.2
-
33
-
-
31144464767
-
Cutting edge: Deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo
-
1:CAS:528:DC%2BD28XlsFyisg%3D%3D 16424156
-
Wohlfert EA, Gorelik L, Mittler R, Flavell RA, Clark RB (2006) Cutting edge: deficiency in the E3 ubiquitin ligase Cbl-b results in a multifunctional defect in T cell TGF-beta sensitivity in vitro and in vivo. J Immunol 176:1316-1320
-
(2006)
J Immunol
, vol.176
, pp. 1316-1320
-
-
Wohlfert, E.A.1
Gorelik, L.2
Mittler, R.3
Flavell, R.A.4
Clark, R.B.5
-
34
-
-
84890413258
-
Cbl-b mediates TGFbeta sensitivity by downregulating inhibitory SMAD7 in primary T cells
-
1:CAS:528:DC%2BC3sXhvVOgt7fO 23709694
-
Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang CM, Viola A, Pfeifhofer-Obermair C, Baier G (2013) Cbl-b mediates TGFbeta sensitivity by downregulating inhibitory SMAD7 in primary T cells. J Mol Cell Biol 5:358-368
-
(2013)
J Mol Cell Biol
, vol.5
, pp. 358-368
-
-
Gruber, T.1
Hinterleitner, R.2
Hermann-Kleiter, N.3
Meisel, M.4
Kleiter, I.5
Wang, C.M.6
Viola, A.7
Pfeifhofer-Obermair, C.8
Baier, G.9
-
35
-
-
34848876937
-
Cutting edge: Trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
-
1:CAS:528:DC%2BD2sXosVyrtbY%3D 17675459
-
Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C (2007) Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol 179:2041-2045
-
(2007)
J Immunol
, vol.179
, pp. 2041-2045
-
-
Dominitzki, S.1
Fantini, M.C.2
Neufert, C.3
Nikolaev, A.4
Galle, P.R.5
Scheller, J.6
Monteleone, G.7
Rose-John, S.8
Neurath, M.F.9
Becker, C.10
-
36
-
-
33645531744
-
Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation
-
1:CAS:528:DC%2BD28XjsVWnurc%3D 1409741 16557301
-
Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M et al (2006) Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest 116:1117-1126
-
(2006)
J Clin Invest
, vol.116
, pp. 1117-1126
-
-
Venuprasad, K.1
Elly, C.2
Gao, M.3
Salek-Ardakani, S.4
Harada, Y.5
Luo, J.L.6
Yang, C.7
Croft, M.8
Inoue, K.9
Karin, M.10
-
37
-
-
4444223733
-
Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation
-
1:CAS:528:DC%2BD2cXnvFyhs7k%3D 15350225
-
Bai Y, Yang C, Hu K, Elly C, Liu YC (2004) Itch E3 ligase-mediated regulation of TGF-beta signaling by modulating smad2 phosphorylation. Mol Cell 15:825-831
-
(2004)
Mol Cell
, vol.15
, pp. 825-831
-
-
Bai, Y.1
Yang, C.2
Hu, K.3
Elly, C.4
Liu, Y.C.5
-
38
-
-
39449083806
-
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
-
1:CAS:528:DC%2BD1cXitVOjtrs%3D 2610020 18278048
-
Venuprasad K, Huang H, Harada Y, Elly C, Subramaniam M, Spelsberg T, Su J, Liu YC (2008) The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1. Nat Immunol 9:245-253
-
(2008)
Nat Immunol
, vol.9
, pp. 245-253
-
-
Venuprasad, K.1
Huang, H.2
Harada, Y.3
Elly, C.4
Subramaniam, M.5
Spelsberg, T.6
Su, J.7
Liu, Y.C.8
-
39
-
-
79956194738
-
Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth
-
1:CAS:528:DC%2BC3MXlsFGkurc%3D 3914214 21471442
-
Peng DJ, Zeng M, Muromoto R, Matsuda T, Shimoda K, Subramaniam M, Spelsberg TC, Wei WZ, Venuprasad K (2011) Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth. J Immunol 186:5638-5647
-
(2011)
J Immunol
, vol.186
, pp. 5638-5647
-
-
Peng, D.J.1
Zeng, M.2
Muromoto, R.3
Matsuda, T.4
Shimoda, K.5
Subramaniam, M.6
Spelsberg, T.C.7
Wei, W.Z.8
Venuprasad, K.9
-
40
-
-
84862170943
-
Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3+ regulatory T cells
-
1:CAS:528:DC%2BC38Xptlahsrc%3D 3386130 22645357
-
Wang D, Qin H, Du W, Shen YW, Lee WH, Riggs AD, Liu CP (2012) Inhibition of S-phase kinase-associated protein 2 (Skp2) reprograms and converts diabetogenic T cells to Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A 109:9493-9498
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 9493-9498
-
-
Wang, D.1
Qin, H.2
Du, W.3
Shen, Y.W.4
Lee, W.H.5
Riggs, A.D.6
Liu, C.P.7
-
41
-
-
67049097104
-
Developmental plasticity of Th17 and Treg cells
-
1:CAS:528:DC%2BD1MXnsFOlsL0%3D 19524429
-
Lee YK, Mukasa R, Hatton RD, Weaver CT (2009) Developmental plasticity of Th17 and Treg cells. Curr Opin Immunol 21:274-280
-
(2009)
Curr Opin Immunol
, vol.21
, pp. 274-280
-
-
Lee, Y.K.1
Mukasa, R.2
Hatton, R.D.3
Weaver, C.T.4
-
42
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
1:CAS:528:DC%2BD28XksVGns7g%3D 16648838
-
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235-238
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.K.8
-
43
-
-
2942731503
-
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
-
1:CAS:528:DC%2BD2cXlsFWnu70%3D 15210114
-
Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB et al (2004) Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 117:941-952
-
(2004)
Cell
, vol.117
, pp. 941-952
-
-
Nakayama, K.1
Frew, I.J.2
Hagensen, M.3
Skals, M.4
Habelhah, H.5
Bhoumik, A.6
Kadoya, T.7
Erdjument-Bromage, H.8
Tempst, P.9
Frappell, P.B.10
-
44
-
-
35148828429
-
Hypoxia-inducible factor 1 (HIF-1) pathway
-
doi: 10.1126/stke.4072007cm8
-
Semenza GL (2007) Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007: cm8. doi: 10.1126/stke.4072007cm8
-
(2007)
Sci STKE 2007: Cm8
-
-
Semenza, G.L.1
-
45
-
-
33745816760
-
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states
-
1:CAS:528:DC%2BD28Xntlantbw%3D 16738015
-
Lecker SH, Goldberg AL, Mitch WE (2006) Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol 17:1807-1819
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1807-1819
-
-
Lecker, S.H.1
Goldberg, A.L.2
Mitch, W.E.3
-
46
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
1:CAS:528:DC%2BC3MXhtFakur3K 3387678 21871655
-
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR et al (2011) Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell 146:772-784
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
Bordman, Z.7
Fu, J.8
Kim, Y.9
Yen, H.R.10
-
47
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
1:CAS:528:DC%2BC3MXovVKhtLY%3D 3135370 21708926
-
Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H (2011) HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 208:1367-1376
-
(2011)
J Exp Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
Chi, H.7
-
48
-
-
84878238075
-
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways
-
1:CAS:528:DC%2BC3sXntVaqs7Y%3D 3711189 23644504
-
Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN et al (2013) Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nat Immunol 14:611-618
-
(2013)
Nat Immunol
, vol.14
, pp. 611-618
-
-
Kim, J.S.1
Sklarz, T.2
Banks, L.B.3
Gohil, M.4
Waickman, A.T.5
Skuli, N.6
Krock, B.L.7
Luo, C.T.8
Hu, W.9
Pollizzi, K.N.10
-
49
-
-
84867381718
-
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
-
1:CAS:528:DC%2BC38XhsFKntbjN 3478644 22988108
-
Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, de Zoeten EF, Cambier JC, Stenmark KR, Colgan SP et al (2012) Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A 109:E2784-E2793
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Clambey, E.T.1
McNamee, E.N.2
Westrich, J.A.3
Glover, L.E.4
Campbell, E.L.5
Jedlicka, P.6
De Zoeten, E.F.7
Cambier, J.C.8
Stenmark, K.R.9
Colgan, S.P.10
-
50
-
-
84883830476
-
Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer
-
1:CAS:528:DC%2BC3sXhsFOrsLfN 3753661 23986759
-
Burocchi A, Colombo MP, Piconese S (2013) Convergences and divergences of thymus- and peripherally derived regulatory T cells in cancer. Front Immunol 4:247
-
(2013)
Front Immunol
, vol.4
, pp. 247
-
-
Burocchi, A.1
Colombo, M.P.2
Piconese, S.3
-
51
-
-
84856101841
-
Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch
-
1:CAS:528:DC%2BC38XitFems78%3D 3264621 22292042
-
Wang C, Lee JH, Kim CH (2012) Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch. PLoS One 7:e30793
-
(2012)
PLoS One
, vol.7
, pp. 30793
-
-
Wang, C.1
Lee, J.H.2
Kim, C.H.3
-
52
-
-
79551521901
-
Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors
-
1:CAS:528:DC%2BC3MXhsVCisLY%3D 3128990 21156649
-
Hindley JP, Ferreira C, Jones E, Lauder SN, Ladell K, Wynn KK, Betts GJ, Singh Y, Price DA, Godkin AJ et al (2011) Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors. Cancer Res 71:736-746
-
(2011)
Cancer Res
, vol.71
, pp. 736-746
-
-
Hindley, J.P.1
Ferreira, C.2
Jones, E.3
Lauder, S.N.4
Ladell, K.5
Wynn, K.K.6
Betts, G.J.7
Singh, Y.8
Price, D.A.9
Godkin, A.J.10
-
53
-
-
77950473770
-
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha
-
1:CAS:528:DC%2BC3cXht1Wmtr0%3D 2823506 19940151
-
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL (2010) Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem 285:3651-3663
-
(2010)
J Biol Chem
, vol.285
, pp. 3651-3663
-
-
Luo, W.1
Zhong, J.2
Chang, R.3
Hu, H.4
Pandey, A.5
Semenza, G.L.6
-
54
-
-
84857542440
-
Dynamic regulation of Th17 differentiation by oxygen concentrations
-
1:CAS:528:DC%2BC38XivVeltr0%3D 22207131
-
Ikejiri A, Nagai S, Goda N, Kurebayashi Y, Osada-Oka M, Takubo K, Suda T, Koyasu S (2012) Dynamic regulation of Th17 differentiation by oxygen concentrations. Int Immunol 24:137-146
-
(2012)
Int Immunol
, vol.24
, pp. 137-146
-
-
Ikejiri, A.1
Nagai, S.2
Goda, N.3
Kurebayashi, Y.4
Osada-Oka, M.5
Takubo, K.6
Suda, T.7
Koyasu, S.8
-
55
-
-
39049164630
-
Pathophysiology of adult obstructive sleep apnea
-
2628457 18250206
-
Eckert DJ, Malhotra A (2008) Pathophysiology of adult obstructive sleep apnea. Proc Am Thorac Soc 5:144-153
-
(2008)
Proc Am Thorac Soc
, vol.5
, pp. 144-153
-
-
Eckert, D.J.1
Malhotra, A.2
-
56
-
-
84872777747
-
The treg/th17 imbalance in patients with obstructive sleep apnoea syndrome
-
Ye J, Liu H, Zhang G, Li P, Wang Z, Huang S, Yang Q, Li Y (2012) The treg/th17 imbalance in patients with obstructive sleep apnoea syndrome. Mediat Inflamm 2012:815308
-
(2012)
Mediat Inflamm
, vol.2012
, pp. 815308
-
-
Ye, J.1
Liu, H.2
Zhang, G.3
Li, P.4
Wang, Z.5
Huang, S.6
Yang, Q.7
Li, Y.8
-
57
-
-
65549145814
-
Control of regulatory T cell lineage commitment and maintenance
-
1:CAS:528:DC%2BD1MXosVCks7o%3D 19464984
-
Josefowicz SZ, Rudensky A (2009) Control of regulatory T cell lineage commitment and maintenance. Immunity 30:616-625
-
(2009)
Immunity
, vol.30
, pp. 616-625
-
-
Josefowicz, S.Z.1
Rudensky, A.2
-
58
-
-
54349086262
-
Differential requirement of PKC-theta in the development and function of natural regulatory T cells
-
1:CAS:528:DC%2BD1cXhtlWhtLvL 2700121 18842300
-
Gupta S, Manicassamy S, Vasu C, Kumar A, Shang W, Sun Z (2008) Differential requirement of PKC-theta in the development and function of natural regulatory T cells. Mol Immunol 46:213-224
-
(2008)
Mol Immunol
, vol.46
, pp. 213-224
-
-
Gupta, S.1
Manicassamy, S.2
Vasu, C.3
Kumar, A.4
Shang, W.5
Sun, Z.6
-
59
-
-
65549114796
-
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery
-
19260764
-
Barnes MJ, Krebs P, Harris N, Eidenschenk C, Gonzalez-Quintial R, Arnold CN, Crozat K, Sovath S, Moresco EM, Theofilopoulos AN et al (2009) Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biol 7:e51
-
(2009)
PLoS Biol
, vol.7
, pp. 51
-
-
Barnes, M.J.1
Krebs, P.2
Harris, N.3
Eidenschenk, C.4
Gonzalez-Quintial, R.5
Arnold, C.N.6
Crozat, K.7
Sovath, S.8
Moresco, E.M.9
Theofilopoulos, A.N.10
-
60
-
-
1842480966
-
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation
-
1:CAS:528:DC%2BD2cXjtFKis7o%3D 384787 15070758
-
Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K (2004) Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A 101:4566-4571
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 4566-4571
-
-
Schmidt-Supprian, M.1
Tian, J.2
Grant, E.P.3
Pasparakis, M.4
Maehr, R.5
Ovaa, H.6
Ploegh, H.L.7
Coyle, A.J.8
Rajewsky, K.9
-
61
-
-
60549113390
-
Differential requirement for CARMA1 in agonist-selected T-cell development
-
1:CAS:528:DC%2BD1MXhs1SitbY%3D 2747028 19130560
-
Medoff BD, Sandall BP, Landry A, Nagahama K, Mizoguchi A, Luster AD, Xavier RJ (2009) Differential requirement for CARMA1 in agonist-selected T-cell development. Eur J Immunol 39:78-84
-
(2009)
Eur J Immunol
, vol.39
, pp. 78-84
-
-
Medoff, B.D.1
Sandall, B.P.2
Landry, A.3
Nagahama, K.4
Mizoguchi, A.5
Luster, A.D.6
Xavier, R.J.7
-
62
-
-
84878592780
-
A new look at T cell receptor signaling to nuclear factor-kappaB
-
1:CAS:528:DC%2BC3sXktVOksbY%3D 23474202
-
Paul S, Schaefer BC (2013) A new look at T cell receptor signaling to nuclear factor-kappaB. Trends Immunol 34:269-281
-
(2013)
Trends Immunol
, vol.34
, pp. 269-281
-
-
Paul, S.1
Schaefer, B.C.2
-
63
-
-
73949090725
-
C-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
-
1:CAS:528:DC%2BD1MXhs1WlsbrO 2806473 19995950
-
Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L et al (2009) c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med 206:3001-3014
-
(2009)
J Exp Med
, vol.206
, pp. 3001-3014
-
-
Isomura, I.1
Palmer, S.2
Grumont, R.J.3
Bunting, K.4
Hoyne, G.5
Wilkinson, N.6
Banerjee, A.7
Proietto, A.8
Gugasyan, R.9
Wu, L.10
-
64
-
-
71749088574
-
Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
-
1:CAS:528:DC%2BC3cXht1Cjs7Y%3D 20064449
-
Long M, Park SG, Strickland I, Hayden MS, Ghosh S (2009) Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31:921-931
-
(2009)
Immunity
, vol.31
, pp. 921-931
-
-
Long, M.1
Park, S.G.2
Strickland, I.3
Hayden, M.S.4
Ghosh, S.5
-
65
-
-
71749094333
-
Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome
-
1:CAS:528:DC%2BC3cXht1Cjs7c%3D 2807990 20064450
-
Ruan Q, Kameswaran V, Tone Y, Li L, Liou HC, Greene MI, Tone M, Chen YH (2009) Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity 31:932-940
-
(2009)
Immunity
, vol.31
, pp. 932-940
-
-
Ruan, Q.1
Kameswaran, V.2
Tone, Y.3
Li, L.4
Liou, H.C.5
Greene, M.I.6
Tone, M.7
Chen, Y.H.8
-
66
-
-
77952767221
-
Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development
-
1:CAS:528:DC%2BC3cXkt1Wqsb8%3D 2851483 20228198
-
Vang KB, Yang J, Pagan AJ, Li LX, Wang J, Green JM, Beg AA, Farrar MA (2010) Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J Immunol 184:4074-4077
-
(2010)
J Immunol
, vol.184
, pp. 4074-4077
-
-
Vang, K.B.1
Yang, J.2
Pagan, A.J.3
Li, L.X.4
Wang, J.5
Green, J.M.6
Beg, A.A.7
Farrar, M.A.8
-
67
-
-
76749133610
-
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
-
1:CAS:528:DC%2BC3cXltlCguw%3D%3D 2884187 20072126
-
Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463:808-812
-
(2010)
Nature
, vol.463
, pp. 808-812
-
-
Zheng, Y.1
Josefowicz, S.2
Chaudhry, A.3
Peng, X.P.4
Forbush, K.5
Rudensky, A.Y.6
-
68
-
-
77749245821
-
C-Rel but not NF-kappaB1 is important for T regulatory cell development
-
1:CAS:528:DC%2BC3cXjtVWku7k%3D 20082358
-
Deenick EK, Elford AR, Pellegrini M, Hall H, Mak TW, Ohashi PS (2010) c-Rel but not NF-kappaB1 is important for T regulatory cell development. Eur J Immunol 40:677-681
-
(2010)
Eur J Immunol
, vol.40
, pp. 677-681
-
-
Deenick, E.K.1
Elford, A.R.2
Pellegrini, M.3
Hall, H.4
Mak, T.W.5
Ohashi, P.S.6
-
69
-
-
77749245828
-
C-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells
-
1:CAS:528:DC%2BC3cXjtVWrs74%3D 20049877
-
Visekruna A, Huber M, Hellhund A, Bothur E, Reinhard K, Bollig N, Schmidt N, Joeris T, Lohoff M, Steinhoff U (2010) c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells. Eur J Immunol 40:671-676
-
(2010)
Eur J Immunol
, vol.40
, pp. 671-676
-
-
Visekruna, A.1
Huber, M.2
Hellhund, A.3
Bothur, E.4
Reinhard, K.5
Bollig, N.6
Schmidt, N.7
Joeris, T.8
Lohoff, M.9
Steinhoff, U.10
-
70
-
-
80055107550
-
C-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells
-
1:CAS:528:DC%2BC3MXhsV2ltbnE 3204987 22066012
-
Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, Shannon F, Gerondakis S (2011) c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells. PLoS One 6:e26851
-
(2011)
PLoS One
, vol.6
, pp. 26851
-
-
Grigoriadis, G.1
Vasanthakumar, A.2
Banerjee, A.3
Grumont, R.4
Overall, S.5
Gleeson, P.6
Shannon, F.7
Gerondakis, S.8
-
71
-
-
79955021405
-
High TCR stimuli prevent induced regulatory T cell differentiation in a NF-kappaB-dependent manner
-
1:CAS:528:DC%2BC3MXkt1GqsLo%3D 3544303 21411734
-
Molinero LL, Miller ML, Evaristo C, Alegre ML (2011) High TCR stimuli prevent induced regulatory T cell differentiation in a NF-kappaB-dependent manner. J Immunol 186:4609-4617
-
(2011)
J Immunol
, vol.186
, pp. 4609-4617
-
-
Molinero, L.L.1
Miller, M.L.2
Evaristo, C.3
Alegre, M.L.4
-
72
-
-
77951158406
-
Protein kinase C-theta mediates negative feedback on regulatory T cell function
-
1:CAS:528:DC%2BC3cXks1Sgu7Y%3D 2905626 20339032
-
Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML (2010) Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science 328:372-376
-
(2010)
Science
, vol.328
, pp. 372-376
-
-
Zanin-Zhorov, A.1
Ding, Y.2
Kumari, S.3
Attur, M.4
Hippen, K.L.5
Brown, M.6
Blazar, B.R.7
Abramson, S.B.8
Lafaille, J.J.9
Dustin, M.L.10
-
73
-
-
0032567342
-
Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathway
-
1:CAS:528:DyaK1MXisFagsA%3D%3D 9857058
-
Chen E, Hrdlickova R, Nehyba J, Longo DL, Bose HR Jr, Li CC (1998) Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathway. J Biol Chem 273:35201-35207
-
(1998)
J Biol Chem
, vol.273
, pp. 35201-35207
-
-
Chen, E.1
Hrdlickova, R.2
Nehyba, J.3
Longo, D.L.4
Bose, Jr.H.R.5
Li, C.C.6
-
74
-
-
80052971340
-
The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity
-
1:CAS:528:DC%2BC3MXhtV2gtL%2FO 3178748 21874024
-
Chang M, Jin W, Chang JH, Xiao Y, Brittain GC, Yu J, Zhou X, Wang YH, Cheng X, Li P et al (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol 12:1002-1009
-
(2011)
Nat Immunol
, vol.12
, pp. 1002-1009
-
-
Chang, M.1
Jin, W.2
Chang, J.H.3
Xiao, Y.4
Brittain, G.C.5
Yu, J.6
Zhou, X.7
Wang, Y.H.8
Cheng, X.9
Li, P.10
-
75
-
-
78651482270
-
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation
-
1:CAS:528:DC%2BC3MXhtlCgtrk%3D 3023131 21220452
-
Tze LE, Horikawa K, Domaschenz H, Howard DR, Roots CM, Rigby RJ, Way DA, Ohmura-Hoshino M, Ishido S, Andoniou CE et al (2011) CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. J Exp Med 208:149-165
-
(2011)
J Exp Med
, vol.208
, pp. 149-165
-
-
Tze, L.E.1
Horikawa, K.2
Domaschenz, H.3
Howard, D.R.4
Roots, C.M.5
Rigby, R.J.6
Way, D.A.7
Ohmura-Hoshino, M.8
Ishido, S.9
Andoniou, C.E.10
-
76
-
-
84879688223
-
MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
-
1:CAS:528:DC%2BC3sXpt1Oruro%3D 3674695 23712430
-
Oh J, Wu N, Baravalle G, Cohn B, Ma J, Lo B, Mellman I, Ishido S, Anderson M, Shin JS (2013) MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med 210:1069-1077
-
(2013)
J Exp Med
, vol.210
, pp. 1069-1077
-
-
Oh, J.1
Wu, N.2
Baravalle, G.3
Cohn, B.4
Ma, J.5
Lo, B.6
Mellman, I.7
Ishido, S.8
Anderson, M.9
Shin, J.S.10
-
77
-
-
84934437953
-
Characteristics and biological functions of TRAF6
-
17633018
-
Inoue J, Gohda J, Akiyama T (2007) Characteristics and biological functions of TRAF6. Adv Exp Med Biol 597:72-79
-
(2007)
Adv Exp Med Biol
, vol.597
, pp. 72-79
-
-
Inoue, J.1
Gohda, J.2
Akiyama, T.3
-
78
-
-
16444377660
-
Dependence of self-tolerance on TRAF6-directed development of thymic stroma
-
1:CAS:528:DC%2BD2MXivFCgsLo%3D 15705807
-
Akiyama T, Maeda S, Yamane S, Ogino K, Kasai M, Kajiura F, Matsumoto M, Inoue J (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308:248-251
-
(2005)
Science
, vol.308
, pp. 248-251
-
-
Akiyama, T.1
Maeda, S.2
Yamane, S.3
Ogino, K.4
Kasai, M.5
Kajiura, F.6
Matsumoto, M.7
Inoue, J.8
-
79
-
-
0345016454
-
TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease
-
1:CAS:528:DC%2BD3sXptFOlu7g%3D 14634083
-
Chiffoleau E, Kobayashi T, Walsh MC, King CG, Walsh PT, Hancock WW, Choi Y, Turka LA (2003) TNF receptor-associated factor 6 deficiency during hemopoiesis induces Th2-polarized inflammatory disease. J Immunol 171:5751-5759
-
(2003)
J Immunol
, vol.171
, pp. 5751-5759
-
-
Chiffoleau, E.1
Kobayashi, T.2
Walsh, M.C.3
King, C.G.4
Walsh, P.T.5
Hancock, W.W.6
Choi, Y.7
Turka, L.A.8
-
80
-
-
79953015502
-
TRAF6 directs commitment to regulatory T cells in thymocytes
-
1:CAS:528:DC%2BC3MXkvVOltro%3D 21401811
-
Shimo Y, Yanai H, Ohshima D, Qin J, Motegi H, Maruyama Y, Hori S, Inoue J, Akiyama T (2011) TRAF6 directs commitment to regulatory T cells in thymocytes. Genes Cells 16:437-447
-
(2011)
Genes Cells
, vol.16
, pp. 437-447
-
-
Shimo, Y.1
Yanai, H.2
Ohshima, D.3
Qin, J.4
Motegi, H.5
Maruyama, Y.6
Hori, S.7
Inoue, J.8
Akiyama, T.9
-
81
-
-
69049107358
-
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
-
1:CAS:528:DC%2BD1MXovFylt7g%3D 2729804 19633673
-
Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martinez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA (2009) Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 10:1000-1007
-
(2009)
Nat Immunol
, vol.10
, pp. 1000-1007
-
-
Zhou, X.1
Bailey-Bucktrout, S.L.2
Jeker, L.T.3
Penaranda, C.4
Martinez-Llordella, M.5
Ashby, M.6
Nakayama, M.7
Rosenthal, W.8
Bluestone, J.A.9
-
82
-
-
65449125930
-
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
-
1:CAS:528:DC%2BD1MXltlamurw%3D 19291701
-
Duarte JH, Zelenay S, Bergman ML, Martins AC, Demengeot J (2009) Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions. Eur J Immunol 39:948-955
-
(2009)
Eur J Immunol
, vol.39
, pp. 948-955
-
-
Duarte, J.H.1
Zelenay, S.2
Bergman, M.L.3
Martins, A.C.4
Demengeot, J.5
-
83
-
-
46749138596
-
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
-
1:CAS:528:DC%2BD1cXptF2mtLo%3D 2630532 18585065
-
Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS et al (2008) Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29:44-56
-
(2008)
Immunity
, vol.29
, pp. 44-56
-
-
Yang, X.O.1
Nurieva, R.2
Martinez, G.J.3
Kang, H.S.4
Chung, Y.5
Pappu, B.P.6
Shah, B.7
Chang, S.H.8
Schluns, K.S.9
Watowich, S.S.10
-
84
-
-
84857416489
-
Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
-
1:CAS:528:DC%2BC38XitFals7w%3D 22326580
-
Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S (2012) Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36:262-275
-
(2012)
Immunity
, vol.36
, pp. 262-275
-
-
Miyao, T.1
Floess, S.2
Setoguchi, R.3
Luche, H.4
Fehling, H.J.5
Waldmann, H.6
Huehn, J.7
Hori, S.8
-
85
-
-
77957371028
-
Stability of the regulatory T cell lineage in vivo
-
1:CAS:528:DC%2BC3cXhtFOqsrvO 20929851
-
Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, Benoist C, Rudensky AY (2010) Stability of the regulatory T cell lineage in vivo. Science 329:1667-1671
-
(2010)
Science
, vol.329
, pp. 1667-1671
-
-
Rubtsov, Y.P.1
Niec, R.E.2
Josefowicz, S.3
Li, L.4
Darce, J.5
Mathis, D.6
Benoist, C.7
Rudensky, A.Y.8
-
86
-
-
84887512828
-
Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response
-
1:CAS:528:DC%2BC3sXhsl2gsrjO 24238343
-
Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone JA (2013) Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity 39:949-962
-
(2013)
Immunity
, vol.39
, pp. 949-962
-
-
Bailey-Bucktrout, S.L.1
Martinez-Llordella, M.2
Zhou, X.3
Anthony, B.4
Rosenthal, W.5
Luche, H.6
Fehling, H.J.7
Bluestone, J.A.8
-
87
-
-
84891838421
-
Pathogenic conversion of Foxp3(+) T cells into TH17 cells in autoimmune arthritis
-
1:CAS:528:DC%2BC3sXhvFOlu7zO 24362934
-
Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-Hora M, Kodama T, Tanaka S, Bluestone JA, Takayanagi H (2014) Pathogenic conversion of Foxp3(+) T cells into TH17 cells in autoimmune arthritis. Nat Med 20:62-68
-
(2014)
Nat Med
, vol.20
, pp. 62-68
-
-
Komatsu, N.1
Okamoto, K.2
Sawa, S.3
Nakashima, T.4
Oh-Hora, M.5
Kodama, T.6
Tanaka, S.7
Bluestone, J.A.8
Takayanagi, H.9
-
88
-
-
84865367294
-
STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease
-
1:CAS:528:DC%2BC38Xht1Gks7bP 3441059 22921119
-
Laurence A, Amarnath S, Mariotti J, Kim YC, Foley J, Eckhaus M, O'Shea JJ, Fowler DH (2012) STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease. Immunity 37:209-222
-
(2012)
Immunity
, vol.37
, pp. 209-222
-
-
Laurence, A.1
Amarnath, S.2
Mariotti, J.3
Kim, Y.C.4
Foley, J.5
Eckhaus, M.6
O'Shea, J.J.7
Fowler, D.H.8
-
89
-
-
84861039642
-
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
-
1:CAS:528:DC%2BC38Xnt1Gktrc%3D 3362361 22438251
-
Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell DJ (2012) Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood 119:4430-4440
-
(2012)
Blood
, vol.119
, pp. 4430-4440
-
-
Duhen, T.1
Duhen, R.2
Lanzavecchia, A.3
Sallusto, F.4
Campbell, D.J.5
-
90
-
-
84887416283
-
Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo
-
1:CAS:528:DC%2BC3sXhslWlsL%2FN 24123683
-
Zhang P, Tey SK, Koyama M, Kuns RD, Olver SD, Lineburg KE, Lor M, Teal BE, Raffelt NC, Raju J et al (2013) Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo. J Immunol 191:5291-5303
-
(2013)
J Immunol
, vol.191
, pp. 5291-5303
-
-
Zhang, P.1
Tey, S.K.2
Koyama, M.3
Kuns, R.D.4
Olver, S.D.5
Lineburg, K.E.6
Lor, M.7
Teal, B.E.8
Raffelt, N.C.9
Raju, J.10
-
91
-
-
84884206864
-
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis
-
1:CAS:528:DC%2BC3sXht1Whs7rF 23913274
-
Delgoffe GM, Woo SR, Turnis ME, Gravano DM, Guy C, Overacre AE, Bettini ML, Vogel P, Finkelstein D, Bonnevier J et al (2013) Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature 501:252-256
-
(2013)
Nature
, vol.501
, pp. 252-256
-
-
Delgoffe, G.M.1
Woo, S.R.2
Turnis, M.E.3
Gravano, D.M.4
Guy, C.5
Overacre, A.E.6
Bettini, M.L.7
Vogel, P.8
Finkelstein, D.9
Bonnevier, J.10
-
92
-
-
79958021546
-
IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo
-
1:CAS:528:DC%2BC3MXmtlykt70%3D 3098943 21525380
-
Chen Q, Kim YC, Laurence A, Punkosdy GA, Shevach EM (2011) IL-2 controls the stability of Foxp3 expression in TGF-beta-induced Foxp3+ T cells in vivo. J Immunol 186:6329-6337
-
(2011)
J Immunol
, vol.186
, pp. 6329-6337
-
-
Chen, Q.1
Kim, Y.C.2
Laurence, A.3
Punkosdy, G.A.4
Shevach, E.M.5
-
93
-
-
84890550163
-
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
-
10.1038/nature12726 24226773
-
Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, Deroos P, Liu H, Cross JR, Pfeffer K, Coffer PJ et al (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. doi: 10.1038/nature12726
-
(2013)
Nature
-
-
Arpaia, N.1
Campbell, C.2
Fan, X.3
Dikiy, S.4
Van Der Veeken, J.5
Deroos, P.6
Liu, H.7
Cross, J.R.8
Pfeffer, K.9
Coffer, P.J.10
-
94
-
-
84873337168
-
An obligate cell-intrinsic function for CD28 in Tregs
-
1:CAS:528:DC%2BC3sXitl2hs70%3D 3561819 23281398
-
Zhang R, Huynh A, Whitcher G, Chang J, Maltzman JS, Turka LA (2013) An obligate cell-intrinsic function for CD28 in Tregs. J Clin Invest 123:580-593
-
(2013)
J Clin Invest
, vol.123
, pp. 580-593
-
-
Zhang, R.1
Huynh, A.2
Whitcher, G.3
Chang, J.4
Maltzman, J.S.5
Turka, L.A.6
-
95
-
-
84875153425
-
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis
-
1:CAS:528:DC%2BC3sXit1ahtb0%3D 23396208
-
Nie H, Zheng Y, Li R, Guo TB, He D, Fang L, Liu X, Xiao L, Chen X, Wan B et al (2013) Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. Nat Med 19:322-328
-
(2013)
Nat Med
, vol.19
, pp. 322-328
-
-
Nie, H.1
Zheng, Y.2
Li, R.3
Guo, T.B.4
He, D.5
Fang, L.6
Liu, X.7
Xiao, L.8
Chen, X.9
Wan, B.10
-
96
-
-
84882692382
-
Canonical Wnt signaling negatively modulates regulatory T cell function
-
23954131
-
van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM et al (2013) Canonical Wnt signaling negatively modulates regulatory T cell function. Immunity 39:298-310
-
(2013)
Immunity
, vol.39
, pp. 298-310
-
-
Van Loosdregt, J.1
Fleskens, V.2
Tiemessen, M.M.3
Mokry, M.4
Van Boxtel, R.5
Meerding, J.6
Pals, C.E.7
Kurek, D.8
Baert, M.R.9
Delemarre, E.M.10
-
97
-
-
84879087114
-
Cutting edge: Receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells
-
23690475
-
van der Touw W, Cravedi P, Kwan WH, Paz-Artal E, Merad M, Heeger PS (2013) Cutting edge: receptors for C3a and C5a modulate stability of alloantigen-reactive induced regulatory T cells. J Immunol 190:5921-5925
-
(2013)
J Immunol
, vol.190
, pp. 5921-5925
-
-
Van Der Touw, W.1
Cravedi, P.2
Kwan, W.H.3
Paz-Artal, E.4
Merad, M.5
Heeger, P.S.6
-
98
-
-
33646370647
-
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells
-
1:CAS:528:DC%2BD28XmsVOmurk%3D 1895836 16537805
-
Valencia X, Stephens G, Goldbach-Mansky R, Wilson M, Shevach EM, Lipsky PE (2006) TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood 108:253-261
-
(2006)
Blood
, vol.108
, pp. 253-261
-
-
Valencia, X.1
Stephens, G.2
Goldbach-Mansky, R.3
Wilson, M.4
Shevach, E.M.5
Lipsky, P.E.6
-
99
-
-
84872681454
-
Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells
-
1:CAS:528:DC%2BC38XhvVOqsrvK 23263555
-
Strainic MG, Shevach EM, An F, Lin F, Medof ME (2013) Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells. Nat Immunol 14:162-171
-
(2013)
Nat Immunol
, vol.14
, pp. 162-171
-
-
Strainic, M.G.1
Shevach, E.M.2
An, F.3
Lin, F.4
Medof, M.E.5
-
100
-
-
84897933432
-
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T-cell lineage stability
-
1:CAS:528:DC%2BC2cXmtFSis74%3D
-
Schaer DA (2013) GITR pathway activation abrogates tumor immune suppression through loss of regulatory T-cell lineage stability. Cancer Immunol Res 1:320-331
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 320-331
-
-
Schaer, D.A.1
-
101
-
-
67649185215
-
The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR
-
1:CAS:528:DC%2BD1MXms1aksrs%3D 2732340 19483717
-
Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H (2009) The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol 10:769-777
-
(2009)
Nat Immunol
, vol.10
, pp. 769-777
-
-
Liu, G.1
Burns, S.2
Huang, G.3
Boyd, K.4
Proia, R.L.5
Flavell, R.A.6
Chi, H.7
-
102
-
-
84874562997
-
Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells
-
1:CAS:528:DC%2BC3sXisV2qtL4%3D 3570105 23382542
-
Kwan WH, van der Touw W, Paz-Artal E, Li MO, Heeger PS (2013) Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells. J Exp Med 210:257-268
-
(2013)
J Exp Med
, vol.210
, pp. 257-268
-
-
Kwan, W.H.1
Van Der Touw, W.2
Paz-Artal, E.3
Li, M.O.4
Heeger, P.S.5
-
103
-
-
77649225958
-
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
-
19996091
-
van Loosdregt J, Vercoulen Y, Guichelaar T, Gent YY, Beekman JM, van Beekum O, Brenkman AB, Hijnen DJ, Mutis T, Kalkhoven E et al (2010) Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood 115:965-974
-
(2010)
Blood
, vol.115
, pp. 965-974
-
-
Van Loosdregt, J.1
Vercoulen, Y.2
Guichelaar, T.3
Gent, Y.Y.4
Beekman, J.M.5
Van Beekum, O.6
Brenkman, A.B.7
Hijnen, D.J.8
Mutis, T.9
Kalkhoven, E.10
-
104
-
-
52949138267
-
TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3
-
1:CAS:528:DC%2BD1cXhtFKiu77O 2544572 18779564
-
Samanta A, Li B, Song X, Bembas K, Zhang G, Katsumata M, Saouaf SJ, Wang Q, Hancock WW, Shen Y et al (2008) TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A 105:14023-14027
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 14023-14027
-
-
Samanta, A.1
Li, B.2
Song, X.3
Bembas, K.4
Zhang, G.5
Katsumata, M.6
Saouaf, S.J.7
Wang, Q.8
Hancock, W.W.9
Shen, Y.10
-
105
-
-
84887460706
-
Itch expression by Treg cells controls Th2 inflammatory responses
-
1:CAS:528:DC%2BC3sXhslKksbrP 3809788 24135136
-
Jin HS, Park Y, Elly C, Liu YC (2013) Itch expression by Treg cells controls Th2 inflammatory responses. J Clin Invest 123:4923-4934
-
(2013)
J Clin Invest
, vol.123
, pp. 4923-4934
-
-
Jin, H.S.1
Park, Y.2
Elly, C.3
Liu, Y.C.4
-
106
-
-
34547551085
-
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses
-
1:CAS:528:DC%2BD2sXks1Shur0%3D 1851032 17404240
-
Fukushima T, Matsuzawa S, Kress CL, Bruey JM, Krajewska M, Lefebvre S, Zapata JM, Ronai Z, Reed JC (2007) Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Proc Natl Acad Sci U S A 104:6371-6376
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 6371-6376
-
-
Fukushima, T.1
Matsuzawa, S.2
Kress, C.L.3
Bruey, J.M.4
Krajewska, M.5
Lefebvre, S.6
Zapata, J.M.7
Ronai, Z.8
Reed, J.C.9
-
107
-
-
84859900589
-
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells
-
1:CAS:528:DC%2BC38XltFOgtb0%3D 3361639 22484734
-
Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M et al (2012) Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol 13:481-490
-
(2012)
Nat Immunol
, vol.13
, pp. 481-490
-
-
Chang, J.H.1
Xiao, Y.2
Hu, H.3
Jin, J.4
Yu, J.5
Zhou, X.6
Wu, X.7
Johnson, H.M.8
Akira, S.9
Pasparakis, M.10
-
108
-
-
80555154007
-
SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production
-
1:CAS:528:DC%2BC3MXht1KjsbbO 3182063 21893603
-
Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Asakawa M, Chinen T, Yoshimura A (2011) SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production. J Exp Med 208:2055-2067
-
(2011)
J Exp Med
, vol.208
, pp. 2055-2067
-
-
Takahashi, R.1
Nishimoto, S.2
Muto, G.3
Sekiya, T.4
Tamiya, T.5
Kimura, A.6
Morita, R.7
Asakawa, M.8
Chinen, T.9
Yoshimura, A.10
-
109
-
-
70349741085
-
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance
-
1:CAS:528:DC%2BD1MXht1Ogs7zF 2757842 19805371
-
Kriegel MA, Rathinam C, Flavell RA (2009) E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance. Proc Natl Acad Sci U S A 106:16770-16775
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16770-16775
-
-
Kriegel, M.A.1
Rathinam, C.2
Flavell, R.A.3
-
110
-
-
77953289183
-
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation
-
1:CAS:528:DC%2BC3cXnt1Kls7k%3D 2915546 20493730
-
Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC et al (2010) The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity 32:670-680
-
(2010)
Immunity
, vol.32
, pp. 670-680
-
-
Nurieva, R.I.1
Zheng, S.2
Jin, W.3
Chung, Y.4
Zhang, Y.5
Martinez, G.J.6
Reynolds, J.M.7
Wang, S.L.8
Lin, X.9
Sun, S.C.10
-
111
-
-
34248151591
-
GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype
-
1:CAS:528:DC%2BD2sXjtlCitbg%3D 17259178
-
MacKenzie DA, Schartner J, Lin J, Timmel A, Jennens-Clough M, Fathman CG, Seroogy CM (2007) GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. J Biol Chem 282:9696-9702
-
(2007)
J Biol Chem
, vol.282
, pp. 9696-9702
-
-
MacKenzie, D.A.1
Schartner, J.2
Lin, J.3
Timmel, A.4
Jennens-Clough, M.5
Fathman, C.G.6
Seroogy, C.M.7
-
112
-
-
84890383529
-
Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism
-
1:CAS:528:DC%2BC3sXhvV2lsb7O 24218453
-
Chattopadhyay G, Shevach EM (2013) Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism. J Immunol 191:5875-5884
-
(2013)
J Immunol
, vol.191
, pp. 5875-5884
-
-
Chattopadhyay, G.1
Shevach, E.M.2
-
113
-
-
84884161974
-
TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity
-
1:CAS:528:DC%2BC3sXhsFSqsL3J 3772853 24058613
-
Muto G, Kotani H, Kondo T, Morita R, Tsuruta S, Kobayashi T, Luche H, Fehling HJ, Walsh M, Choi Y et al (2013) TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity. PLoS One 8:e74639
-
(2013)
PLoS One
, vol.8
, pp. 74639
-
-
Muto, G.1
Kotani, H.2
Kondo, T.3
Morita, R.4
Tsuruta, S.5
Kobayashi, T.6
Luche, H.7
Fehling, H.J.8
Walsh, M.9
Choi, Y.10
-
114
-
-
77954696814
-
TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2
-
1:CAS:528:DC%2BC3cXotlahtLc%3D 2890173 20351308
-
Cejas PJ, Walsh MC, Pearce EL, Han D, Harms GM, Artis D, Turka LA, Choi Y (2010) TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2. Blood 115:4750-4757
-
(2010)
Blood
, vol.115
, pp. 4750-4757
-
-
Cejas, P.J.1
Walsh, M.C.2
Pearce, E.L.3
Han, D.4
Harms, G.M.5
Artis, D.6
Turka, L.A.7
Choi, Y.8
-
115
-
-
84882592280
-
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity
-
23973222
-
van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Grone A et al (2013) Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity 39:259-271
-
(2013)
Immunity
, vol.39
, pp. 259-271
-
-
Van Loosdregt, J.1
Fleskens, V.2
Fu, J.3
Brenkman, A.B.4
Bekker, C.P.5
Pals, C.E.6
Meerding, J.7
Berkers, C.R.8
Barbi, J.9
Grone, A.10
-
116
-
-
84882683958
-
The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
-
1:CAS:528:DC%2BC3sXhtlCnsrbE 23973223
-
Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C et al (2013) The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity 39:272-285
-
(2013)
Immunity
, vol.39
, pp. 272-285
-
-
Chen, Z.1
Barbi, J.2
Bu, S.3
Yang, H.Y.4
Li, Z.5
Gao, Y.6
Jinasena, D.7
Fu, J.8
Lin, F.9
Chen, C.10
-
117
-
-
0033013126
-
Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions
-
1:CAS:528:DyaK1MXjt1yisL8%3D 104411 10330192
-
Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (1999) Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol 19:4535-4545
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4535-4545
-
-
Ballinger, C.A.1
Connell, P.2
Wu, Y.3
Hu, Z.4
Thompson, L.J.5
Yin, L.Y.6
Patterson, C.7
-
118
-
-
45349097474
-
CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation
-
1:CAS:528:DC%2BD1cXns1ymsL0%3D 2426947 18541707
-
Li X, Huang M, Zheng H, Wang Y, Ren F, Shang Y, Zhai Y, Irwin DM, Shi Y, Chen D et al (2008) CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation. J Cell Biol 181:959-972
-
(2008)
J Cell Biol
, vol.181
, pp. 959-972
-
-
Li, X.1
Huang, M.2
Zheng, H.3
Wang, Y.4
Ren, F.5
Shang, Y.6
Zhai, Y.7
Irwin, D.M.8
Shi, Y.9
Chen, D.10
-
119
-
-
84876446487
-
STUB1 is essential for T-cell activation by ubiquitinating CARMA1
-
1:CAS:528:DC%2BC3sXis1ajt7s%3D 23322406
-
Wang S, Li Y, Hu YH, Song R, Gao Y, Liu HY, Shu HB, Liu Y (2013) STUB1 is essential for T-cell activation by ubiquitinating CARMA1. Eur J Immunol 43:1034-1041
-
(2013)
Eur J Immunol
, vol.43
, pp. 1034-1041
-
-
Wang, S.1
Li, Y.2
Hu, Y.H.3
Song, R.4
Gao, Y.5
Liu, H.Y.6
Shu, H.B.7
Liu, Y.8
-
120
-
-
80052677833
-
TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function
-
1:CAS:528:DC%2BC3MXhtVGmsLnF 21775683
-
Nyirenda MH, Sanvito L, Darlington PJ, O'Brien K, Zhang GX, Constantinescu CS, Bar-Or A, Gran B (2011) TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function. J Immunol 187:2278-2290
-
(2011)
J Immunol
, vol.187
, pp. 2278-2290
-
-
Nyirenda, M.H.1
Sanvito, L.2
Darlington, P.J.3
O'Brien, K.4
Zhang, G.X.5
Constantinescu, C.S.6
Bar-Or, A.7
Gran, B.8
-
121
-
-
32444432610
-
Toll-like receptor 2 controls expansion and function of regulatory T cells
-
1:CAS:528:DC%2BD28Xht1Sqs7k%3D 1332026 16424940
-
Sutmuller RP, den Brok MH, Kramer M, Bennink EJ, Toonen LW, Kullberg BJ, Joosten LA, Akira S, Netea MG, Adema GJ (2006) Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest 116:485-494
-
(2006)
J Clin Invest
, vol.116
, pp. 485-494
-
-
Sutmuller, R.P.1
Den Brok, M.H.2
Kramer, M.3
Bennink, E.J.4
Toonen, L.W.5
Kullberg, B.J.6
Joosten, L.A.7
Akira, S.8
Netea, M.G.9
Adema, G.J.10
-
122
-
-
33646487278
-
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells
-
1:CAS:528:DC%2BD28XkslCkt74%3D 1444884 16632602
-
Liu H, Komai-Koma M, Xu D, Liew FY (2006) Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A 103:7048-7053
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 7048-7053
-
-
Liu, H.1
Komai-Koma, M.2
Xu, D.3
Liew, F.Y.4
-
123
-
-
2442655250
-
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
-
1:CAS:528:DC%2BD2cXjsV2gur4%3D 15064759
-
Yang Y, Huang CT, Huang X, Pardoll DM (2004) Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat Immunol 5:508-515
-
(2004)
Nat Immunol
, vol.5
, pp. 508-515
-
-
Yang, Y.1
Huang, C.T.2
Huang, X.3
Pardoll, D.M.4
-
124
-
-
23944509107
-
Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
-
1:CAS:528:DC%2BD2MXovVOjtLs%3D 16123302
-
Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, Wang DY, Li Y, Wang HY, Wang RF (2005) Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309:1380-1384
-
(2005)
Science
, vol.309
, pp. 1380-1384
-
-
Peng, G.1
Guo, Z.2
Kiniwa, Y.3
Voo, K.S.4
Peng, W.5
Fu, T.6
Wang, D.Y.7
Li, Y.8
Wang, H.Y.9
Wang, R.F.10
-
125
-
-
0037436119
-
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
-
1:CAS:528:DC%2BD3sXhtFarsLo%3D 12532024
-
Pasare C, Medzhitov R (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033-1036
-
(2003)
Science
, vol.299
, pp. 1033-1036
-
-
Pasare, C.1
Medzhitov, R.2
-
126
-
-
33748490733
-
TLR engagement prevents transplantation tolerance
-
1:CAS:528:DC%2BD28XhtFGqsrnO 16970798
-
Chen L, Wang T, Zhou P, Ma L, Yin D, Shen J, Molinero L, Nozaki T, Phillips T, Uematsu S et al (2006) TLR engagement prevents transplantation tolerance. Am J Transplant 6:2282-2291
-
(2006)
Am J Transplant
, vol.6
, pp. 2282-2291
-
-
Chen, L.1
Wang, T.2
Zhou, P.3
Ma, L.4
Yin, D.5
Shen, J.6
Molinero, L.7
Nozaki, T.8
Phillips, T.9
Uematsu, S.10
-
127
-
-
33846703313
-
CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells
-
1:CAS:528:DC%2BD2sXhs1Cit78%3D 1862558 17270282
-
LaRosa DF, Gelman AE, Rahman AH, Zhang J, Turka LA, Walsh PT (2007) CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett 108:183-188
-
(2007)
Immunol Lett
, vol.108
, pp. 183-188
-
-
Larosa, D.F.1
Gelman, A.E.2
Rahman, A.H.3
Zhang, J.4
Turka, L.A.5
Walsh, P.T.6
-
128
-
-
71649094864
-
Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival
-
1:CAS:528:DC%2BD1MXhsFyitLnK 2808455 19879295
-
Zhang N, Kruger B, Lal G, Luan Y, Yadav A, Zang W, Grimm M, Waaga-Gasser AM, Murphy B, Bromberg JS et al (2010) Inhibition of TLR4 signaling prolongs Treg-dependent murine islet allograft survival. Immunol Lett 127:119-125
-
(2010)
Immunol Lett
, vol.127
, pp. 119-125
-
-
Zhang, N.1
Kruger, B.2
Lal, G.3
Luan, Y.4
Yadav, A.5
Zang, W.6
Grimm, M.7
Waaga-Gasser, A.M.8
Murphy, B.9
Bromberg, J.S.10
-
129
-
-
84867162434
-
Absence of MyD88 signaling induces donor-specific kidney allograft tolerance
-
1:CAS:528:DC%2BC38Xhs1SqtrfF 3458459 22878960
-
Wu H, Noordmans GA, O'Brien MR, Ma J, Zhao CY, Zhang GY, Kwan TK, Alexander SI, Chadban SJ (2012) Absence of MyD88 signaling induces donor-specific kidney allograft tolerance. J Am Soc Nephrol 23:1701-1716
-
(2012)
J Am Soc Nephrol
, vol.23
, pp. 1701-1716
-
-
Wu, H.1
Noordmans, G.A.2
O'Brien, M.R.3
Ma, J.4
Zhao, C.Y.5
Zhang, G.Y.6
Kwan, T.K.7
Alexander, S.I.8
Chadban, S.J.9
-
130
-
-
79956199473
-
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B
-
1:CAS:528:DC%2BC3MXlsFGrsr0%3D 21498664
-
Gaddis DE, Michalek SM, Katz J (2011) TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B. J Immunol 186:5772-5783
-
(2011)
J Immunol
, vol.186
, pp. 5772-5783
-
-
Gaddis, D.E.1
Michalek, S.M.2
Katz, J.3
-
131
-
-
77954503874
-
Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands
-
1:CAS:528:DC%2BC3cXltVGiu70%3D 20363971
-
Oberg HH, Ly TT, Ussat S, Meyer T, Kabelitz D, Wesch D (2010) Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands. J Immunol 184:4733-4740
-
(2010)
J Immunol
, vol.184
, pp. 4733-4740
-
-
Oberg, H.H.1
Ly, T.T.2
Ussat, S.3
Meyer, T.4
Kabelitz, D.5
Wesch, D.6
-
132
-
-
79955432183
-
TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo
-
1:CAS:528:DC%2BC3MXlt12htb0%3D 3080372 21533081
-
Yamazaki S, Okada K, Maruyama A, Matsumoto M, Yagita H, Seya T (2011) TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo. PLoS One 6:e18833
-
(2011)
PLoS One
, vol.6
, pp. 18833
-
-
Yamazaki, S.1
Okada, K.2
Maruyama, A.3
Matsumoto, M.4
Yagita, H.5
Seya, T.6
-
133
-
-
70449721164
-
Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival
-
1:CAS:528:DC%2BD1MXhtFGjsL7O 2788511 19748987
-
Chen Q, Davidson TS, Huter EN, Shevach EM (2009) Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival. J Immunol 183:4458-4466
-
(2009)
J Immunol
, vol.183
, pp. 4458-4466
-
-
Chen, Q.1
Davidson, T.S.2
Huter, E.N.3
Shevach, E.M.4
-
134
-
-
79955157031
-
TLR2 signaling improves immunoregulation to prevent type 1 diabetes
-
1:CAS:528:DC%2BC3MXltFGrsrw%3D 3100206 21469083
-
Filippi CM, Ehrhardt K, Estes EA, Larsson P, Oldham JE, von Herrath MG (2011) TLR2 signaling improves immunoregulation to prevent type 1 diabetes. Eur J Immunol 41:1399-1409
-
(2011)
Eur J Immunol
, vol.41
, pp. 1399-1409
-
-
Filippi, C.M.1
Ehrhardt, K.2
Estes, E.A.3
Larsson, P.4
Oldham, J.E.5
Von Herrath, M.G.6
-
135
-
-
28344456279
-
A genomic and functional inventory of deubiquitinating enzymes
-
1:CAS:528:DC%2BD2MXhtlWntLjP 16325574
-
Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, Sixma TK, Bernards R (2005) A genomic and functional inventory of deubiquitinating enzymes. Cell 123:773-786
-
(2005)
Cell
, vol.123
, pp. 773-786
-
-
Nijman, S.M.1
Luna-Vargas, M.P.2
Velds, A.3
Brummelkamp, T.R.4
Dirac, A.M.5
Sixma, T.K.6
Bernards, R.7
-
136
-
-
84884234601
-
USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex
-
1:CAS:528:DC%2BC3sXht1SnurrF 3727316 23825189
-
Liu X, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X, Dong C (2013) USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med 210:1575-1590
-
(2013)
J Exp Med
, vol.210
, pp. 1575-1590
-
-
Liu, X.1
Li, H.2
Zhong, B.3
Blonska, M.4
Gorjestani, S.5
Yan, M.6
Tian, Q.7
Zhang, D.E.8
Lin, X.9
Dong, C.10
-
137
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
1:CAS:528:DyaK2MXntFWnurs%3D 7636184
-
Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M (1995) Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 155:1151-1164
-
(1995)
J Immunol
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
138
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
1:CAS:528:DC%2BD2sXjvVSnsL8%3D 17363300
-
Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L et al (2007) Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371-381
-
(2007)
Immunity
, vol.26
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
Yao, Z.6
Blank, R.B.7
Meylan, F.8
Siegel, R.9
Hennighausen, L.10
-
139
-
-
84864146433
-
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
-
1:CAS:528:DC%2BC38XpsVSqsrY%3D 3541018 22751139
-
Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J et al (2012) Aiolos promotes TH17 differentiation by directly silencing Il2 expression. Nat Immunol 13:770-777
-
(2012)
Nat Immunol
, vol.13
, pp. 770-777
-
-
Quintana, F.J.1
Jin, H.2
Burns, E.J.3
Nadeau, M.4
Yeste, A.5
Kumar, D.6
Rangachari, M.7
Zhu, C.8
Xiao, S.9
Seavitt, J.10
-
140
-
-
81755189052
-
The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor beta (TGF-beta) signaling and the development of regulatory T cells
-
1:CAS:528:DC%2BC3MXhsVOqu7rO 3220473 21931165
-
Zhao Y, Thornton AM, Kinney MC, Ma CA, Spinner JJ, Fuss IJ, Shevach EM, Jain A (2011) The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor beta (TGF-beta) signaling and the development of regulatory T cells. J Biol Chem 286:40520-40530
-
(2011)
J Biol Chem
, vol.286
, pp. 40520-40530
-
-
Zhao, Y.1
Thornton, A.M.2
Kinney, M.C.3
Ma, C.A.4
Spinner, J.J.5
Fuss, I.J.6
Shevach, E.M.7
Jain, A.8
-
141
-
-
84860284249
-
CYLD negatively regulates transforming growth factor-beta-signalling via deubiquitinating Akt
-
3337989 22491319
-
Lim JH, Jono H, Komatsu K, Woo CH, Lee J, Miyata M, Matsuno T, Xu X, Huang Y, Zhang W et al (2012) CYLD negatively regulates transforming growth factor-beta-signalling via deubiquitinating Akt. Nat Commun 3:771
-
(2012)
Nat Commun
, vol.3
, pp. 771
-
-
Lim, J.H.1
Jono, H.2
Komatsu, K.3
Woo, C.H.4
Lee, J.5
Miyata, M.6
Matsuno, T.7
Xu, X.8
Huang, Y.9
Zhang, W.10
-
142
-
-
84868513906
-
The tumor suppressor CYLD controls the function of murine regulatory T cells
-
1:CAS:528:DC%2BC38Xhs1WjtbvJ 23066153
-
Reissig S, Hovelmeyer N, Weigmann B, Nikolaev A, Kalt B, Wunderlich TF, Hahn M, Neurath MF, Waisman A (2012) The tumor suppressor CYLD controls the function of murine regulatory T cells. J Immunol 189:4770-4776
-
(2012)
J Immunol
, vol.189
, pp. 4770-4776
-
-
Reissig, S.1
Hovelmeyer, N.2
Weigmann, B.3
Nikolaev, A.4
Kalt, B.5
Wunderlich, T.F.6
Hahn, M.7
Neurath, M.F.8
Waisman, A.9
-
144
-
-
84872395016
-
PKCtheta/beta and CYLD are antagonistic partners in the NFkappaB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes
-
1:CAS:528:DC%2BC3sXhsFWqur4%3D 3546006 23335970
-
Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, Leitges M, Thome M, Massoumi R, Baier G (2013) PKCtheta/beta and CYLD are antagonistic partners in the NFkappaB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes. PLoS One 8:e53709
-
(2013)
PLoS One
, vol.8
, pp. 53709
-
-
Thuille, N.1
Wachowicz, K.2
Hermann-Kleiter, N.3
Kaminski, S.4
Fresser, F.5
Lutz-Nicoladoni, C.6
Leitges, M.7
Thome, M.8
Massoumi, R.9
Baier, G.10
-
145
-
-
80555136815
-
GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice
-
1:CAS:528:DC%2BC3MXhsVCksLrN 3204837 21965331
-
Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R et al (2011) GATA3 controls Foxp3(+) regulatory T cell fate during inflammation in mice. J Clin Invest 121:4503-4515
-
(2011)
J Clin Invest
, vol.121
, pp. 4503-4515
-
-
Wohlfert, E.A.1
Grainger, J.R.2
Bouladoux, N.3
Konkel, J.E.4
Oldenhove, G.5
Ribeiro, C.H.6
Hall, J.A.7
Yagi, R.8
Naik, S.9
Bhairavabhotla, R.10
-
146
-
-
80053130719
-
An essential role of the transcription factor GATA-3 for the function of regulatory T cells
-
1:CAS:528:DC%2BC3MXht1WmurrP 3182399 21924928
-
Wang Y, Su MA, Wan YY (2011) An essential role of the transcription factor GATA-3 for the function of regulatory T cells. Immunity 35:337-348
-
(2011)
Immunity
, vol.35
, pp. 337-348
-
-
Wang, Y.1
Su, M.A.2
Wan, Y.Y.3
-
147
-
-
84875979211
-
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3
-
1:CAS:528:DC%2BC3sXltVSjsrk%3D 3611007 23395819
-
Zhang J, Chen C, Hou X, Gao Y, Lin F, Yang J, Gao Z, Pan L, Tao L, Wen C et al (2013) Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3. J Biol Chem 288:9373-9382
-
(2013)
J Biol Chem
, vol.288
, pp. 9373-9382
-
-
Zhang, J.1
Chen, C.2
Hou, X.3
Gao, Y.4
Lin, F.5
Yang, J.6
Gao, Z.7
Pan, L.8
Tao, L.9
Wen, C.10
-
148
-
-
79955438868
-
Rapid temporal control of Foxp3 protein degradation by sirtuin-1
-
3080399 21533107
-
van Loosdregt J, Brunen D, Fleskens V, Pals CE, Lam EW, Coffer PJ (2011) Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One 6:e19047
-
(2011)
PLoS One
, vol.6
, pp. 19047
-
-
Van Loosdregt, J.1
Brunen, D.2
Fleskens, V.3
Pals, C.E.4
Lam, E.W.5
Coffer, P.J.6
-
149
-
-
84883164348
-
Foxp3 protein stability is regulated by cyclin-dependent kinase 2
-
1:CAS:528:DC%2BC3sXhtlarsr3O 23853094
-
Morawski PA, Mehra P, Chen C, Bhatti T, Wells AD (2013) Foxp3 protein stability is regulated by cyclin-dependent kinase 2. J Biol Chem 288:24494-24502
-
(2013)
J Biol Chem
, vol.288
, pp. 24494-24502
-
-
Morawski, P.A.1
Mehra, P.2
Chen, C.3
Bhatti, T.4
Wells, A.D.5
-
150
-
-
84863229506
-
Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells
-
1:CAS:528:DC%2BC38Xjt1Gnt7s%3D 3478122 22312127
-
Kwon HS, Lim HW, Wu J, Schnolzer M, Verdin E, Ott M (2012) Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol 188:2712-2721
-
(2012)
J Immunol
, vol.188
, pp. 2712-2721
-
-
Kwon, H.S.1
Lim, H.W.2
Wu, J.3
Schnolzer, M.4
Verdin, E.5
Ott, M.6
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