The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation

Immunity

Volumn 32, Issue 5, 2010, Pages 670-680

  Nurieva, Roza I ^a   Zheng, Shuling ^a   Jin, Wei ^a   Chung, Yeonseok ^a   Zhang, Yongliang ^a   Martinez, Gustavo J ^a   Reynolds, Joseph M ^a   Wang, Sung Ling ^a,b   Lin, Xin ^a   Sun, Shao Cong ^a   Lozano, Guillermina ^a   Dong, Chen ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Cellimmuno; Molimmuno

Indexed keywords

CD3 ANTIGEN; GENE RELATED TO ANERGY IN LYMPHOCYTE PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENETIC SUSCEPTIBILITY; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH17 CELL; WILD TYPE;

ANIMALS; ANTIGENS, CD3; GENE EXPRESSION REGULATION; IMMUNE TOLERANCE; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; UBIQUITIN-PROTEIN LIGASES;

EID: 77953289183     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2010.05.002     Document Type: Article

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