-
1
-
-
4344584507
-
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins
-
Kho Y, et al (2004) A tagging-via-substrate technology for detection and proteomics of farnesylated proteins. Proc Natl Acad Sci USA 101: 12479-12484
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12479-12484
-
-
Kho, Y.1
-
2
-
-
0037338365
-
Proteomic analysis of post-translational modifications
-
Mann M, Jensen ON (2003) Proteomic analysis of post-translational modifications. Nat Biotechnol 21: 255-261
-
(2003)
Nat Biotechnol
, vol.21
, pp. 255-261
-
-
Mann, M.1
Jensen, O.N.2
-
3
-
-
0020478687
-
Covalent affinity' purification of ubiquitin-activating enzyme
-
Ciechanover A, Elias S, Heller H, Hershko A (1982) 'Covalent affinity' purification of ubiquitin-activating enzyme. J Biol Chem 257: 2537-2542
-
(1982)
J Biol Chem
, vol.257
, pp. 2537-2542
-
-
Ciechanover, A.1
Elias, S.2
Heller, H.3
Hershko, A.4
-
4
-
-
0021099710
-
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown
-
Hershko A, Heller H, Elias S, Ciechanover A (1983) Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem 258: 8206-8214
-
(1983)
J Biol Chem
, vol.258
, pp. 8206-8214
-
-
Hershko, A.1
Heller, H.2
Elias, S.3
Ciechanover, A.4
-
5
-
-
33750219981
-
A ubiquitin ligase complex assembles linear polyubiquitin chains
-
Kirisako T, et al (2006) A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J 25: 4877-4887
-
(2006)
EMBO J
, vol.25
, pp. 4877-4887
-
-
Kirisako, T.1
-
6
-
-
70350461507
-
Building ubiquitin chains: E2 enzymes at work
-
Ye Y, Rape M (2009) Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol 10: 755-764
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 755-764
-
-
Ye, Y.1
Rape, M.2
-
7
-
-
79952290609
-
The mechanism of linkage-specific ubiquitin chain elongation by a singlesubunit e2
-
Wickliffe KE, Lorenz S, Wemmer DE, Kuriyan J, Rape M (2011) The mechanism of linkage-specific ubiquitin chain elongation by a singlesubunit E2. Cell 144: 769-781
-
(2011)
Cell
, vol.144
, pp. 769-781
-
-
Wickliffe, K.E.1
Lorenz, S.2
Wemmer, D.E.3
Kuriyan, J.4
Rape, M.5
-
8
-
-
67649227630
-
Polyubiquitination by hect e3s and the determinants of chain type specificity
-
Kim HC, Huibregtse JM (2009) Polyubiquitination by HECT E3s and the determinants of chain type specificity. Mol Cell Biol 29: 3307-3318
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3307-3318
-
-
Kim, H.C.1
Huibregtse, J.M.2
-
10
-
-
0032741446
-
Structure of an e6ap-ubch7 complex: Insights into ubiquitination by the e2-e3 enzyme cascade
-
Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP (1999) Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science 286: 1321-1326
-
(1999)
Science
, vol.286
, pp. 1321-1326
-
-
Huang, L.1
Kinnucan, E.2
Wang, G.3
Beaudenon, S.4
Howley, P.M.5
Huibregtse, J.M.6
Pavletich, N.P.7
-
11
-
-
84858135252
-
Following ariadne's thread: A new perspective on rbr ubiquitin ligases
-
Wenzel DM, Klevit RE (2012) Following Ariadne's thread: a new perspective on RBR ubiquitin ligases. BMC Biol 10: 24
-
(2012)
BMC Biol
, vol.10
, pp. 24
-
-
Wenzel, D.M.1
Klevit, R.E.2
-
12
-
-
67349132223
-
Physiological functions of the hect family of ubiquitin ligases
-
Rotin D, Kumar S (2009) Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 10: 398-409
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 398-409
-
-
Rotin, D.1
Kumar, S.2
-
13
-
-
79957949190
-
Ubch7 reactivity profile reveals parkin and hhari to be ring/hect hybrids
-
Wenzel DM, Lissounov A, Brzovic PS, Klevit RE (2011) UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature 474: 105-108
-
(2011)
Nature
, vol.474
, pp. 105-108
-
-
Wenzel, D.M.1
Lissounov, A.2
Brzovic, P.S.3
Klevit, R.E.4
-
14
-
-
84867096523
-
The e3 ligase hoip specifies linear ubiquitin chain assembly through its ring-ibr-ring domain and the unique ldd extension
-
Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK (2012) The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. EMBO J 31: 3833-3844
-
(2012)
EMBO J
, vol.31
, pp. 3833-3844
-
-
Smit, J.J.1
Monteferrario, D.2
Noordermeer, S.M.3
Van Dijk, W.J.4
Van Der Reijden, B.A.5
Sixma, T.K.6
-
15
-
-
84865709638
-
Lubac synthesizes linear ubiquitin chains via a thioester intermediate
-
Stieglitz B, Morris-Davies AC, Koliopoulos MG, Christodoulou E, Rittinger K (2012) LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Rep 13: 840-846
-
(2012)
EMBO Rep
, vol.13
, pp. 840-846
-
-
Stieglitz, B.1
Morris-Davies, A.C.2
Koliopoulos, M.G.3
Christodoulou, E.4
Rittinger, K.5
-
16
-
-
0024514688
-
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
-
Chau V, Tobias JW, Bachmair A, Marriott D, Ecker DJ, Gonda DK, Varshavsky A (1989) A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243: 1576-1583
-
(1989)
Science
, vol.243
, pp. 1576-1583
-
-
Chau, V.1
Tobias, J.W.2
Bachmair, A.3
Marriott, D.4
Ecker, D.J.5
Gonda, D.K.6
Varshavsky, A.7
-
17
-
-
59649086030
-
Nonproteolytic functions of ubiquitin in cell signaling
-
Chen ZJ, Sun LJ (2009) Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 33: 275-286
-
(2009)
Mol Cell
, vol.33
, pp. 275-286
-
-
Chen, Z.J.1
Sun, L.J.2
-
18
-
-
0042317328
-
The brca1/bard1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue k6 of ubiquitin
-
Wu-Baer F, Lagrazon K, Yuan W, Baer R (2003) The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin. J Biol Chem 278: 34743-34746
-
(2003)
J Biol Chem
, vol.278
, pp. 34743-34746
-
-
Wu-Baer, F.1
Lagrazon, K.2
Yuan, W.3
Baer, R.4
-
19
-
-
1042278177
-
Mass spectrometric and mutational analyses reveal lys-6-linked polyubiquitin chains catalyzed by brca1-bard1 ubiquitin ligase
-
Nishikawa H, Ooka S, Sato K, Arima K, Okamoto J, Klevit RE, Fukuda M, Ohta T (2004) Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase. J Biol Chem 279: 3916-3924
-
(2004)
J Biol Chem
, vol.279
, pp. 3916-3924
-
-
Nishikawa, H.1
Ooka, S.2
Sato, K.3
Arima, K.4
Okamoto, J.5
Klevit, R.E.6
Fukuda, M.7
Ohta, T.8
-
20
-
-
1942517849
-
Brca1: Bard1 induces the formation of conjugated ubiquitin structures, dependent on k6 of ubiquitin, in cells during dna replication and repair
-
Morris JR, Solomon E (2004) BRCA1: BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair. Hum Mol Genet 13: 807-817
-
(2004)
Hum Mol Genet
, vol.13
, pp. 807-817
-
-
Morris, J.R.1
Solomon, E.2
-
21
-
-
80755153309
-
K11-linked ubiquitin chains as novel regulators of cell division
-
Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M (2011) K11-linked ubiquitin chains as novel regulators of cell division. Trends Cell Biol 21: 656-663
-
(2011)
Trends Cell Biol
, vol.21
, pp. 656-663
-
-
Wickliffe, K.E.1
Williamson, A.2
Meyer, H.J.3
Kelly, A.4
Rape, M.5
-
22
-
-
73549090361
-
Efficient internalization of mhc i requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains
-
Boname JM, Thomas M, Stagg HR, Xu P, Peng J, Lehner PJ (2010) Efficient internalization of MHC I requires lysine-11 and lysine-63 mixed linkage polyubiquitin chains. Traffic 11: 210-220
-
(2010)
Traffic
, vol.11
, pp. 210-220
-
-
Boname, J.M.1
Thomas, M.2
Stagg, H.R.3
Xu, P.4
Peng, J.5
Lehner, P.J.6
-
23
-
-
78149276256
-
Contribution of lysine 11-linked ubiquitination to mir2-mediated major histocompatibility complex class i internalization
-
Goto E, et al (2010) Contribution of lysine 11-linked ubiquitination to MIR2-mediated major histocompatibility complex class I internalization. J Biol Chem 285: 35311-35319
-
(2010)
J Biol Chem
, vol.285
, pp. 35311-35319
-
-
Goto, E.1
-
24
-
-
78650300883
-
C-iap1 and ubch5 promote k11-linked polyubiquitination of rip1 in tnf signalling
-
Dynek JN, et al (2010) c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J 29: 4198-4209
-
(2010)
EMBO J
, vol.29
, pp. 4198-4209
-
-
Dynek, J.N.1
-
25
-
-
79953240109
-
Linear ubiquitination prevents inflammation and regulates immune signalling
-
Gerlach B, et al (2011) Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471: 591-596
-
(2011)
Nature
, vol.471
, pp. 591-596
-
-
Gerlach, B.1
-
26
-
-
79960493052
-
Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1
-
Glauser L, Sonnay S, Stafa K, Moore DJ (2011) Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1. J Neurochem 118: 636-645
-
(2011)
J Neurochem
, vol.118
, pp. 636-645
-
-
Glauser, L.1
Sonnay, S.2
Stafa, K.3
Moore, D.J.4
-
27
-
-
75949130828
-
Pink1/parkin-mediated mitophagy is dependent on vdac1 and p62/sqstm1
-
Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W (2010) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 12: 119-131
-
(2010)
Nat Cell Biol
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmstrom, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfuss, O.C.5
Kahle, P.J.6
Springer, W.7
-
28
-
-
79956194738
-
Noncanonical k27-linked polyubiquitination of tieg1 regulates foxp3 expression and tumor growth
-
Peng DJ, Zeng M, Muromoto R, Matsuda T, Shimoda K, Subramaniam M, Spelsberg TC, Wei WZ, Venuprasad K (2011) Noncanonical K27-linked polyubiquitination of TIEG1 regulates Foxp3 expression and tumor growth. J Immunol 186: 5638-5647
-
(2011)
J Immunol
, vol.186
, pp. 5638-5647
-
-
Peng, D.J.1
Zeng, M.2
Muromoto, R.3
Matsuda, T.4
Shimoda, K.5
Subramaniam, M.6
Spelsberg, T.C.7
Wei, W.Z.8
Venuprasad, K.9
-
29
-
-
42449090346
-
Control of ampk-related kinases by usp9x and atypical lys(29)/lys(33)-linked polyubiquitin chains
-
Al-Hakim AK, Zagorska A, Chapman L, Deak M, Peggie M, Alessi DR (2008) Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. Biochem J 411: 249-260
-
(2008)
Biochem J
, vol.411
, pp. 249-260
-
-
Al-Hakim, A.K.1
Zagorska, A.2
Chapman, L.3
Deak, M.4
Peggie, M.5
Alessi, D.R.6
-
30
-
-
77954953473
-
K33-linked polyubiquitination of t cell receptor-zeta regulates proteolysis-independent t cell signaling
-
Huang H, Jeon MS, Liao L, Yang C, Elly C, Yates JR 3rd, Liu YC (2010) K33-linked polyubiquitination of T cell receptor-zeta regulates proteolysis-independent T cell signaling. Immunity 33: 60-70
-
(2010)
Immunity
, vol.33
, pp. 60-70
-
-
Huang, H.1
Jeon, M.S.2
Liao, L.3
Yang, C.4
Elly, C.5
Yates, J.R.6
Liu, Y.C.7
-
31
-
-
71149105333
-
Recruitment of the linear ubiquitin chain assembly complex stabilizes the tnf-r1 signaling complex and is required for tnf-mediated gene induction
-
Haas TL, et al (2009) Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell 36: 831-844
-
(2009)
Mol Cell
, vol.36
, pp. 831-844
-
-
Haas, T.L.1
-
32
-
-
59649103156
-
Involvement of linear polyubiquitylation of nemo in nf-kappab activation
-
Tokunaga F, et al (2009) Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol 11: 123-132
-
(2009)
Nat Cell Biol
, vol.11
, pp. 123-132
-
-
Tokunaga, F.1
-
33
-
-
79953237668
-
Sharpin is a component of the nfkappab-activating linear ubiquitin chain assembly complex
-
Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K (2011) SHARPIN is a component of the NFkappaB-activating linear ubiquitin chain assembly complex. Nature 471: 633-636
-
(2011)
Nature
, vol.471
, pp. 633-636
-
-
Tokunaga, F.1
Nakagawa, T.2
Nakahara, M.3
Saeki, Y.4
Taniguchi, M.5
Sakata, S.6
Tanaka, K.7
Nakano, H.8
Iwai, K.9
-
34
-
-
79953239980
-
Sharpin forms a linear ubiquitin ligase complex regulating nf-kappab activity and apoptosis
-
Ikeda F, et al (2011) SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature 471: 637-641
-
(2011)
Nature
, vol.471
, pp. 637-641
-
-
Ikeda, F.1
-
35
-
-
84863000898
-
The ubiquitin ligase xiap recruits lubac for nod2 signaling in inflammation and innate immunity
-
Damgaard RB, et al (2012) The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol Cell 46: 746-758
-
(2012)
Mol Cell
, vol.46
, pp. 746-758
-
-
Damgaard, R.B.1
-
36
-
-
84880851215
-
Otulin restricts met1-linked ubiquitination to control innate immune signaling
-
Fiil BK, et al (2013) OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol Cell 50: 818-830
-
(2013)
Mol Cell
, vol.50
, pp. 818-830
-
-
Fiil, B.K.1
-
37
-
-
84884345970
-
Activation of the canonical ikk complex by k63/m1-linked hybrid ubiquitin chains
-
Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D, Cohen P (2013) Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci USA 110: 15247-15252
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 15247-15252
-
-
Emmerich, C.H.1
Ordureau, A.2
Strickson, S.3
Arthur, J.S.4
Pedrioli, P.G.5
Komander, D.6
Cohen, P.7
-
41
-
-
62549155321
-
Specific recognition of linear ubiquitin chains by nemo is important for nf-kappab activation
-
Rahighi S, et al (2009) Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 136: 1098-1109
-
(2009)
Cell
, vol.136
, pp. 1098-1109
-
-
Rahighi, S.1
-
42
-
-
4344712350
-
Tab 2 and tab 3 activate the nf-kappab pathway through binding to polyubiquitin chains
-
Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ (2004) TAB 2 and TAB 3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 15: 535-548
-
(2004)
Mol Cell
, vol.15
, pp. 535-548
-
-
Kanayama, A.1
Seth, R.B.2
Sun, L.3
Ea, C.K.4
Hong, M.5
Shaito, A.6
Chiu, Y.H.7
Deng, L.8
Chen, Z.J.9
-
43
-
-
67349231313
-
Molecular discrimination of structurally equivalent lys 63-linked and linear polyubiquitin chains
-
Komander D, Reyes-Turcu F, Licchesi JD, Odenwaelder P, Wilkinson KD, Barford D (2009) Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep 10: 466-473
-
(2009)
EMBO Rep
, vol.10
, pp. 466-473
-
-
Komander, D.1
Reyes-Turcu, F.2
Licchesi, J.D.3
Odenwaelder, P.4
Wilkinson, K.D.5
Barford, D.6
-
44
-
-
84886442156
-
Molecular control of the nemo family of ubiquitin-binding proteins
-
Clark K, Nanda S, Cohen P (2013) Molecular control of the NEMO family of ubiquitin-binding proteins. Nat Rev Mol Cell Biol 14: 673-685
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 673-685
-
-
Clark, K.1
Nanda, S.2
Cohen, P.3
-
45
-
-
68049084674
-
Breaking the chains: Structure and function of the deubiquitinases
-
Komander D, Clague MJ, Urbe S (2009) Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol 10: 550-563
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 550-563
-
-
Komander, D.1
Clague, M.J.2
Urbe, S.3
-
46
-
-
84864222562
-
Atypical ubiquitylation-The unexplored world of polyubiquitin beyond lys48 and lys63 linkages
-
Kulathu Y, Komander D (2012) Atypical ubiquitylation-The unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. Nat Rev Mol Cell Biol 13: 508-523
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 508-523
-
-
Kulathu, Y.1
Komander, D.2
-
47
-
-
77955417276
-
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase cezanne
-
Bremm A, Freund SM, Komander D (2010) Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol 17: 939-947
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 939-947
-
-
Bremm, A.1
Freund, S.M.2
Komander, D.3
-
48
-
-
84855465067
-
An ankyrin-repeat ubiquitin-binding domain determines trabid's specificity for atypical ubiquitin chains
-
Licchesi JD, et al (2012) An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains. Nat Struct Mol Biol 19: 62-71
-
(2012)
Nat Struct Mol Biol
, vol.19
, pp. 62-71
-
-
Licchesi, J.D.1
-
49
-
-
61449120240
-
Structural basis and specificity of human otubain 1-mediated deubiquitination
-
Edelmann MJ, Iphofer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM (2009) Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J 418: 379-390
-
(2009)
Biochem J
, vol.418
, pp. 379-390
-
-
Edelmann, M.J.1
Iphofer, A.2
Akutsu, M.3
Altun, M.4
Di Gleria, K.5
Kramer, H.B.6
Fiebiger, E.7
Dhe-Paganon, S.8
Kessler, B.M.9
-
50
-
-
0034730713
-
Failure to regulate tnf-induced nf-kappab and cell death responses in a20-deficient mice
-
Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A (2000) Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289: 2350-2354
-
(2000)
Science
, vol.289
, pp. 2350-2354
-
-
Lee, E.G.1
Boone, D.L.2
Chai, S.3
Libby, S.L.4
Chien, M.5
Lodolce, J.P.6
Ma, A.7
-
51
-
-
3943054838
-
De-ubiquitination and ubiquitin ligase domains of a20 downregulate nf-kappab signalling
-
Wertz IE, et al (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 430: 694-699
-
(2004)
Nature
, vol.430
, pp. 694-699
-
-
Wertz, I.E.1
-
52
-
-
38149051652
-
Structure of the a20 otu domain and mechanistic insights into deubiquitination
-
Komander D, Barford D (2008) Structure of the A20 OTU domain and mechanistic insights into deubiquitination. Biochem J 409: 77-85
-
(2008)
Biochem J
, vol.409
, pp. 77-85
-
-
Komander, D.1
Barford, D.2
-
53
-
-
84878187442
-
Dimerization and ubiquitin mediated recruitment of a20, a complex deubiquitinating enzyme
-
Lu TT, et al (2013) Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity 38: 896-905
-
(2013)
Immunity
, vol.38
, pp. 896-905
-
-
Lu, T.T.1
-
54
-
-
78649292467
-
Ubiquitin binding to a20 znf4 is required for modulation of nf-kappab signaling
-
Bosanac I, et al (2010) Ubiquitin binding to A20 ZnF4 is required for modulation of NF-kappaB signaling. Mol Cell 40: 548-557
-
(2010)
Mol Cell
, vol.40
, pp. 548-557
-
-
Bosanac, I.1
-
55
-
-
84878862687
-
Otulin antagonizes lubac signaling by specifically hydrolyzing met1-linked polyubiquitin
-
Keusekotten K, et al (2013) OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell 153: 1312-1326
-
(2013)
Cell
, vol.153
, pp. 1312-1326
-
-
Keusekotten, K.1
-
56
-
-
84879390723
-
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
-
Rivkin E, et al (2013) The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature 498: 318-324
-
(2013)
Nature
, vol.498
, pp. 318-324
-
-
Rivkin, E.1
-
57
-
-
35349016235
-
Recognition of microorganisms and activation of the immune response
-
Medzhitov R (2007) Recognition of microorganisms and activation of the immune response. Nature 449: 819-826
-
(2007)
Nature
, vol.449
, pp. 819-826
-
-
Medzhitov, R.1
-
58
-
-
0024955886
-
Approaching the asymptote? Evolution and revolution in immunology
-
Janeway CA Jr (1989) Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 54(Pt 1): 1-13
-
(1989)
Cold Spring Harb Symp Quant Biol
, vol.54
, Issue.PART 1
, pp. 1-13
-
-
Janeway Jr., C.A.1
-
60
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124: 783-801
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
61
-
-
22444433175
-
Nlrs join tlrs as innate sensors of pathogens
-
Martinon F, Tschopp J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol 26: 447-454
-
(2005)
Trends Immunol
, vol.26
, pp. 447-454
-
-
Martinon, F.1
Tschopp, J.2
-
62
-
-
0037066427
-
The danger model: A renewed sense of self
-
Matzinger P (2002) The danger model: a renewed sense of self. Science 296: 301-305
-
(2002)
Science
, vol.296
, pp. 301-305
-
-
Matzinger, P.1
-
64
-
-
8444245925
-
Toll-dependent control mechanisms of cd4 t cell activation
-
Pasare C, Medzhitov R (2004) Toll-dependent control mechanisms of CD4 T cell activation. Immunity 21: 733-741
-
(2004)
Immunity
, vol.21
, pp. 733-741
-
-
Pasare, C.1
Medzhitov, R.2
-
65
-
-
27844541797
-
Control of b-cell responses by toll-like receptors
-
Pasare C, Medzhitov R (2005) Control of B-cell responses by Toll-like receptors. Nature 438: 364-368
-
(2005)
Nature
, vol.438
, pp. 364-368
-
-
Pasare, C.1
Medzhitov, R.2
-
66
-
-
0032546352
-
Dendritic cells and the control of immunity
-
Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392: 245-252
-
(1998)
Nature
, vol.392
, pp. 245-252
-
-
Banchereau, J.1
Steinman, R.M.2
-
67
-
-
63649116570
-
Ubiquitylation in innate and adaptive immunity
-
Bhoj VG, Chen ZJ (2009) Ubiquitylation in innate and adaptive immunity. Nature 458: 430-437
-
(2009)
Nature
, vol.458
, pp. 430-437
-
-
Bhoj, V.G.1
Chen, Z.J.2
-
68
-
-
84869866718
-
Btb-zf factors recruit the e3 ligase cullin 3 to regulate lymphoid effector programs
-
Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A (2012) BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature 491: 618-621
-
(2012)
Nature
, vol.491
, pp. 618-621
-
-
Mathew, R.1
Seiler, M.P.2
Scanlon, S.T.3
Mao, A.P.4
Constantinides, M.G.5
Bertozzi-Villa, C.6
Singer, J.D.7
Bendelac, A.8
-
69
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140: 805-820
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
70
-
-
84860739314
-
Targeting pattern recognition receptors in cancer immunotherapy
-
Goutagny N, Estornes Y, Hasan U, Lebecque S, Caux C (2012) Targeting pattern recognition receptors in cancer immunotherapy. Target Oncol 7: 29-54
-
(2012)
Target Oncol
, vol.7
, pp. 29-54
-
-
Goutagny, N.1
Estornes, Y.2
Hasan, U.3
Lebecque, S.4
Caux, C.5
-
71
-
-
79960922705
-
Ciaps block ripoptosome formation, a rip1/caspase-8 containing intracellular cell death complex differentially regulated by cflip isoforms
-
Feoktistova M, et al (2011) cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell 43: 449-463
-
(2011)
Mol Cell
, vol.43
, pp. 449-463
-
-
Feoktistova, M.1
-
72
-
-
84865192787
-
Dsrna induces apoptosis through an atypical death complex associating tlr3 to caspase-8
-
Estornes Y, et al (2012) dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8. Cell Death Differ 19: 1482-1494
-
(2012)
Cell Death Differ
, vol.19
, pp. 1482-1494
-
-
Estornes, Y.1
-
73
-
-
84886656964
-
Toll-like receptor 3-mediated necrosis via trif, rip3 and mlkl
-
Kaiser WJ, et al (2013) Toll-like receptor 3-mediated necrosis via TRIF, RIP3 and MLKL. J Biol Chem 288: 31268-31279
-
(2013)
J Biol Chem
, vol.288
, pp. 31268-31279
-
-
Kaiser, W.J.1
-
74
-
-
74049136127
-
Different modes of ubiquitination of the adaptor traf3 selectively activate the expression of type i interferons and proinflammatory cytokines
-
Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M (2010) Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol 11: 70-75
-
(2010)
Nat Immunol
, vol.11
, pp. 70-75
-
-
Tseng, P.H.1
Matsuzawa, A.2
Zhang, W.3
Mino, T.4
Vignali, D.A.5
Karin, M.6
-
76
-
-
33645703930
-
Sensing of lys 63-linked polyubiquitination by nemo is a key event in nf-kappab activation [corrected]
-
Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD (2006) Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol 8: 398-406
-
(2006)
Nat Cell Biol
, vol.8
, pp. 398-406
-
-
Wu, C.J.1
Conze, D.B.2
Li, T.3
Srinivasula, S.M.4
Ashwell, J.D.5
-
77
-
-
48749090228
-
Essential cytoplasmic transloca-tion of a cytokine receptor-assembled signaling complex
-
Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M (2008) Essential cytoplasmic transloca-tion of a cytokine receptor-assembled signaling complex. Science 321: 663-668
-
(2008)
Science
, vol.321
, pp. 663-668
-
-
Matsuzawa, A.1
Tseng, P.H.2
Vallabhapurapu, S.3
Luo, J.L.4
Zhang, W.5
Wang, H.6
Vignali, D.A.7
Gallagher, E.8
Karin, M.9
-
78
-
-
70349472923
-
Peli1 facilitates trif-dependent toll-like receptor signaling and proinflammatory cytokine production
-
Chang M, Jin W, Sun SC (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol 10: 1089-1095
-
(2009)
Nat Immunol
, vol.10
, pp. 1089-1095
-
-
Chang, M.1
Jin, W.2
Sun, S.C.3
-
79
-
-
84655176306
-
The role of ubiquitylation in immune defence and pathogen evasion
-
Jiang X, Chen ZJ (2012) The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol 12: 35-48
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 35-48
-
-
Jiang, X.1
Chen, Z.J.2
-
80
-
-
30544451546
-
Specificity in toll-like receptor signalling through distinct effector functions of traf3 and traf6
-
Hacker H, et al (2006) Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439: 204-207
-
(2006)
Nature
, vol.439
, pp. 204-207
-
-
Hacker, H.1
-
81
-
-
84862549810
-
Toll-like receptor 3 agonist complexed with cationic liposome augments vaccine-elicited antitumor immunity by enhancing tlr3-irf3 signaling and type i interferons in dendritic cells
-
Wang C, Zhuang Y, Zhang Y, Luo Z, Gao N, Li P, Pan H, Cai L, Ma Y (2012) Toll-like receptor 3 agonist complexed with cationic liposome augments vaccine-elicited antitumor immunity by enhancing TLR3-IRF3 signaling and type I interferons in dendritic cells. Vaccine 30: 4790-4799
-
(2012)
Vaccine
, vol.30
, pp. 4790-4799
-
-
Wang, C.1
Zhuang, Y.2
Zhang, Y.3
Luo, Z.4
Gao, N.5
Li, P.6
Pan, H.7
Cai, L.8
Ma, Y.9
-
82
-
-
84884283799
-
Defective immune responses in mice lacking lubac-mediated linear ubiquitination in b cells
-
Sasaki Y, et al (2013) Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells. EMBO J 32: 2463-2476
-
(2013)
EMBO J
, vol.32
, pp. 2463-2476
-
-
Sasaki, Y.1
-
83
-
-
84877973388
-
Ubiquitin-specific protease 25 regulates tlr4-dependent innate immune responses through deubiquitination of the adaptor protein traf3
-
Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C (2013) Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci Signal 6: ra35
-
(2013)
Sci Signal
, vol.6
-
-
Zhong, B.1
Liu, X.2
Wang, X.3
Liu, X.4
Li, H.5
Darnay, B.G.6
Lin, X.7
Sun, S.C.8
Dong, C.9
-
84
-
-
84872202679
-
Deubiquitination of nf-kappab by ubiquitin-specific protease-7 promotes transcription
-
Colleran A, Collins PE, O'Carroll C, Ahmed A, Mao X, McManus B, Kiely PA, Burstein E, Carmody RJ (2013) Deubiquitination of NF-kappaB by Ubiquitin-Specific Protease-7 promotes transcription. Proc Natl Acad Sci USA 110: 618-623
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 618-623
-
-
Colleran, A.1
Collins, P.E.2
O'Carroll, C.3
Ahmed, A.4
Mao, X.5
McManus, B.6
Kiely, P.A.7
Burstein, E.8
Carmody, R.J.9
-
85
-
-
39549107115
-
Homeostatic myd88-dependent signals cause lethal inflammation in the absence of a20
-
Turer EE, Tavares RM, Mortier E, Hitotsumatsu O, Advincula R, Lee B, Shifrin N, Malynn BA, Ma A (2008) Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med 205: 451-464
-
(2008)
J Exp Med
, vol.205
, pp. 451-464
-
-
Turer, E.E.1
Tavares, R.M.2
Mortier, E.3
Hitotsumatsu, O.4
Advincula, R.5
Lee, B.6
Shifrin, N.7
Malynn, B.A.8
Ma, A.9
-
86
-
-
5444223519
-
The ubiquitin-modifying enzyme a20 is required for termination of toll-like receptor responses
-
Boone DL, et al (2004) The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 5: 1052-1060
-
(2004)
Nat Immunol
, vol.5
, pp. 1052-1060
-
-
Boone, D.L.1
-
87
-
-
84858725584
-
Regulation of nf-kappab by deubiquitinases
-
Harhaj EW, Dixit VM (2012) Regulation of NF-kappaB by deubiquitinases. Immunol Rev 246: 107-124
-
(2012)
Immunol Rev
, vol.246
, pp. 107-124
-
-
Harhaj, E.W.1
Dixit, V.M.2
-
88
-
-
67649778720
-
A20: Central gatekeeper in inflammation and immunity
-
Coornaert B, Carpentier I, Beyaert R (2009) A20: central gatekeeper in inflammation and immunity. J Biol Chem 284: 8217-8221
-
(2009)
J Biol Chem
, vol.284
, pp. 8217-8221
-
-
Coornaert, B.1
Carpentier, I.2
Beyaert, R.3
-
89
-
-
39449129941
-
Inflammatory cardiac valvulitis in tax1bp1-deficient mice through selective nf-kappab activation
-
Iha H, et al (2008) Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J 27: 629-641
-
(2008)
EMBO J
, vol.27
, pp. 629-641
-
-
Iha, H.1
-
90
-
-
33750598021
-
Impaired regulation of nf-kappab and increased susceptibility to colitis-associated tumorigenesis in cyld-deficient mice
-
Zhang J, Stirling B, Temmerman ST, Ma CA, Fuss IJ, Derry JM, Jain A (2006) Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest 116: 3042-3049
-
(2006)
J Clin Invest
, vol.116
, pp. 3042-3049
-
-
Zhang, J.1
Stirling, B.2
Temmerman, S.T.3
Ma, C.A.4
Fuss, I.J.5
Derry, J.M.6
Jain, A.7
-
91
-
-
84862994793
-
Ubiquitin-induced oligomerization of the rna sensors rig-i and mda5 activates antiviral innate immune response
-
Jiang X, Kinch LN, Brautigam CA, Chen X, Du F, Grishin NV, Chen ZJ (2012) Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response. Immunity 36: 959-973
-
(2012)
Immunity
, vol.36
, pp. 959-973
-
-
Jiang, X.1
Kinch, L.N.2
Brautigam, C.A.3
Chen, X.4
Du, F.5
Grishin, N.V.6
Chen, Z.J.7
-
92
-
-
84882705934
-
Mavs recruits multiple ubiquitin e3 ligases to activate antiviral signaling cascades
-
Liu S, Chen J, Cai X, Wu J, Chen X, Wu YT, Sun L, Chen ZJ (2013) MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades. Elife 2: e00785
-
(2013)
Elife
, vol.2
-
-
Liu, S.1
Chen, J.2
Cai, X.3
Wu, J.4
Chen, X.5
Wu, Y.T.6
Sun, L.7
Chen, Z.J.8
-
93
-
-
43049174990
-
Tradd protein is an essential component of the rig-like helicase antiviral pathway
-
Michallet MC, et al (2008) TRADD protein is an essential component of the RIG-like helicase antiviral pathway. Immunity 28: 651-661
-
(2008)
Immunity
, vol.28
, pp. 651-661
-
-
Michallet, M.C.1
-
94
-
-
33645786318
-
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded rna
-
Takahashi K, Kawai T, Kumar H, Sato S, Yonehara S, Akira S (2006) Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA. J Immunol 176: 4520-4524
-
(2006)
J Immunol
, vol.176
, pp. 4520-4524
-
-
Takahashi, K.1
Kawai, T.2
Kumar, H.3
Sato, S.4
Yonehara, S.5
Akira, S.6
-
95
-
-
79952770123
-
Rig-i rna helicase activation of irf3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the rip1 protein
-
Rajput A, Kovalenko A, Bogdanov K, Yang SH, Kang TB, Kim JC, Du J, Wallach D (2011) RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 34: 340-351
-
(2011)
Immunity
, vol.34
, pp. 340-351
-
-
Rajput, A.1
Kovalenko, A.2
Bogdanov, K.3
Yang, S.H.4
Kang, T.B.5
Kim, J.C.6
Du, J.7
Wallach, D.8
-
96
-
-
84860499060
-
Emerging role of ubiquitination in antiviral rig-i signaling
-
Maelfait J, Beyaert R (2012) Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol Mol Biol Rev 76: 33-45
-
(2012)
Microbiol Mol Biol Rev
, vol.76
, pp. 33-45
-
-
Maelfait, J.1
Beyaert, R.2
-
97
-
-
77951247349
-
Virustriggered ubiquitination of traf3/6 by ciap1/2 is essential for induction of interferon-beta (ifn-beta) and cellular antiviral response
-
Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q, Teng C, Shu HB (2010) Virustriggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem 285: 9470-9476
-
(2010)
J Biol Chem
, vol.285
, pp. 9470-9476
-
-
Mao, A.P.1
Li, S.2
Zhong, B.3
Li, Y.4
Yan, J.5
Li, Q.6
Teng, C.7
Shu, H.B.8
-
98
-
-
34250632829
-
Negative regulation of the rig-i signaling by the ubiquitin ligase rnf125
-
Arimoto K, Takahashi H, Hishiki T, Konishi H, Fujita T, Shimotohno K (2007) Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125. Proc Natl Acad Sci USA 104: 7500-7505
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7500-7505
-
-
Arimoto, K.1
Takahashi, H.2
Hishiki, T.3
Konishi, H.4
Fujita, T.5
Shimotohno, K.6
-
99
-
-
79251550124
-
Linear ubiquitin assembly complex negatively regulates rig-i-and trim25-mediated type i interferon induction
-
Inn KS, Gack MU, Tokunaga F, Shi M, Wong LY, Iwai K, Jung JU (2011) Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type I interferon induction. Mol Cell 41: 354-365
-
(2011)
Mol Cell
, vol.41
, pp. 354-365
-
-
Inn, K.S.1
Gack, M.U.2
Tokunaga, F.3
Shi, M.4
Wong, L.Y.5
Iwai, K.6
Jung, J.U.7
-
100
-
-
84865119303
-
Linear ubiquitination of nemo negatively regulates the interferon antiviral response through disruption of the mavs-traf3 complex
-
Belgnaoui SM, et al (2012) Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex. Cell Host Microbe 12: 211-222
-
(2012)
Cell Host Microbe
, vol.12
, pp. 211-222
-
-
Belgnaoui, S.M.1
-
101
-
-
51049106824
-
The tumour suppressor cyld is a negative regulator of rig-i-mediated antiviral response
-
Friedman CS, et al (2008) The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep 9: 930-936
-
(2008)
EMBO Rep
, vol.9
, pp. 930-936
-
-
Friedman, C.S.1
-
102
-
-
49649123561
-
Regulation of ikappab kinase-related kinases and antiviral responses by tumor suppressor cyld
-
Zhang M, Wu X, Lee AJ, Jin W, Chang M, Wright A, Imaizumi T, Sun SC (2008) Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD. J Biol Chem 283: 18621-18626
-
(2008)
J Biol Chem
, vol.283
, pp. 18621-18626
-
-
Zhang, M.1
Wu, X.2
Lee, A.J.3
Jin, W.4
Chang, M.5
Wright, A.6
Imaizumi, T.7
Sun, S.C.8
-
103
-
-
36448943427
-
Duba: A deubiquitinase that regulates type i interferon production
-
Kayagaki N, et al (2007) DUBA: a deubiquitinase that regulates type I interferon production. Science 318: 1628-1632
-
(2007)
Science
, vol.318
, pp. 1628-1632
-
-
Kayagaki, N.1
-
104
-
-
33644850482
-
Negative regulation of the retinoic acid-inducible gene iinduced antiviral state by the ubiquitin-editing protein a20
-
Lin R, Yang L, Nakhaei P, Sun Q, Sharif-Askari E, Julkunen I, Hiscott J (2006) Negative regulation of the retinoic acid-inducible gene Iinduced antiviral state by the ubiquitin-editing protein A20. J Biol Chem 281: 2095-2103
-
(2006)
J Biol Chem
, vol.281
, pp. 2095-2103
-
-
Lin, R.1
Yang, L.2
Nakhaei, P.3
Sun, Q.4
Sharif-Askari, E.5
Julkunen, I.6
Hiscott, J.7
-
105
-
-
70449726455
-
Pcbp2 mediates degradation of the adaptor mavs via the hect ubiquitin ligase aip 4
-
You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z (2009) PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol 10: 1300-1308
-
(2009)
Nat Immunol
, vol.10
, pp. 1300-1308
-
-
You, F.1
Sun, H.2
Zhou, X.3
Sun, W.4
Liang, S.5
Zhai, Z.6
Jiang, Z.7
-
106
-
-
66949138341
-
Cellular inhibitors of apoptosis ciap1 and ciap2 are required for innate immunity signaling by the pattern recognition receptors nod1 and nod2
-
Bertrand MJ, Doiron K, Labbe K, Korneluk RG, Barker PA, Saleh M (2009) Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2. Immunity 30: 789-801
-
(2009)
Immunity
, vol.30
, pp. 789-801
-
-
Bertrand, M.J.1
Doiron, K.2
Labbe, K.3
Korneluk, R.G.4
Barker, P.A.5
Saleh, M.6
-
107
-
-
84878816379
-
Traf molecules in cell signaling and in human diseases
-
Xie P (2013) TRAF molecules in cell signaling and in human diseases. J Mol Signal 8: 7
-
(2013)
J Mol Signal
, vol.8
, pp. 7
-
-
Xie, P.1
-
108
-
-
70149099161
-
Xiap mediates nod signaling via interaction with rip2
-
Krieg A, Correa RG, Garrison JB, Le Negrate G, Welsh K, Huang Z, Knoefel WT, Reed JC (2009) XIAP mediates NOD signaling via interaction with RIP2. Proc Natl Acad Sci USA 106: 14524-14529
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14524-14529
-
-
Krieg, A.1
Correa, R.G.2
Garrison, J.B.3
Le Negrate, G.4
Welsh, K.5
Huang, Z.6
Knoefel, W.T.7
Reed, J.C.8
-
109
-
-
78649635741
-
To fight or die-inhibitor of apoptosis proteins at the crossroad of innate immunity and death
-
Lopez J, Meier P (2010) To fight or die-inhibitor of apoptosis proteins at the crossroad of innate immunity and death. Curr Opin Cell Biol 22: 872-881
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 872-881
-
-
Lopez, J.1
Meier, P.2
-
110
-
-
77953746329
-
Deficiency of xiap leads to sensitization for chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice
-
Prakash H, Albrecht M, Becker D, Kuhlmann T, Rudel T (2010) Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice. J Biol Chem 285: 20291-20302
-
(2010)
J Biol Chem
, vol.285
, pp. 20291-20302
-
-
Prakash, H.1
Albrecht, M.2
Becker, D.3
Kuhlmann, T.4
Rudel, T.5
-
111
-
-
50849091946
-
Xiap regulates cytosol-specific innate immunity to listeria infection
-
Bauler LD, Duckett CS, O'Riordan MX (2008) XIAP regulates cytosol-specific innate immunity to Listeria infection. PLoS Pathog 4: e1000142
-
(2008)
PLoS Pathog
, vol.4
-
-
Bauler, L.D.1
Duckett, C.S.2
O'Riordan, M.X.3
-
112
-
-
13244292161
-
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
-
Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nunez G, Flavell RA (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307: 731-734
-
(2005)
Science
, vol.307
, pp. 731-734
-
-
Kobayashi, K.S.1
Chamaillard, M.2
Ogura, Y.3
Henegariu, O.4
Inohara, N.5
Nunez, G.6
Flavell, R.A.7
-
113
-
-
84880774323
-
Disease-causing mutations in the xiap bir2 domain impair nod2-dependent immune signalling
-
Damgaard RB, et al (2013) Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling. EMBO Mol Med 5: 1278-1295
-
(2013)
EMBO Mol Med
, vol.5
, pp. 1278-1295
-
-
Damgaard, R.B.1
-
114
-
-
84863995539
-
The inositol phosphatase ship-1 inhibits nod2-induced nf-kappab activation by disturbing the interaction of xiap with rip2
-
Conde C, Rambout X, Lebrun M, Lecat A, Di Valentin E, Dequiedt F, Piette J, Gloire G, Legrand S (2012) The inositol phosphatase SHIP-1 inhibits NOD2-induced NF-kappaB activation by disturbing the interaction of XIAP with RIP2. PLoS ONE 7: e41005
-
(2012)
PLoS ONE
, vol.7
-
-
Conde, C.1
Rambout, X.2
Lebrun, M.3
Lecat, A.4
Di Valentin, E.5
Dequiedt, F.6
Piette, J.7
Gloire, G.8
Legrand, S.9
-
115
-
-
40449136493
-
The ubiquitin-editing enzyme a20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals
-
Hitotsumatsu O, et al (2008) The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity 28: 381-390
-
(2008)
Immunity
, vol.28
, pp. 381-390
-
-
Hitotsumatsu, O.1
-
116
-
-
84878237993
-
Activation and regulation of the inflammasomes
-
Latz E, Xiao TS, Stutz A (2013) Activation and regulation of the inflammasomes. Nat Rev Immunol 13: 397-411
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 397-411
-
-
Latz, E.1
Xiao, T.S.2
Stutz, A.3
-
117
-
-
84255178199
-
Cellular inhibitors of apoptosis proteins ciap1 and ciap2 are required for efficient caspase-1 activation by the inflammasome
-
Labbe K, McIntire CR, Doiron K, Leblanc PM, Saleh M (2011) Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome. Immunity 35: 897-907
-
(2011)
Immunity
, vol.35
, pp. 897-907
-
-
Labbe, K.1
McIntire, C.R.2
Doiron, K.3
Leblanc, P.M.4
Saleh, M.5
-
118
-
-
84857404572
-
Inhibitor of apoptosis proteins limit rip3 kinasedependent interleukin-1 activation
-
Vince JE, et al (2012) Inhibitor of apoptosis proteins limit RIP3 kinasedependent interleukin-1 activation. Immunity 36: 215-227
-
(2012)
Immunity
, vol.36
, pp. 215-227
-
-
Vince, J.E.1
-
119
-
-
84872782298
-
Deubiquitination of nlrp3 by brcc3 critically regulates inflammasome activity
-
Py BF, Kim MS, Vakifahmetoglu-Norberg H, Yuan J (2013) Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol Cell 49: 331-338
-
(2013)
Mol Cell
, vol.49
, pp. 331-338
-
-
Py, B.F.1
Kim, M.S.2
Vakifahmetoglu-Norberg, H.3
Yuan, J.4
-
120
-
-
84862962823
-
Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey
-
Aggarwal BB, Gupta SC, Kim JH (2012) Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey. Blood 119: 651-665
-
(2012)
Blood
, vol.119
, pp. 651-665
-
-
Aggarwal, B.B.1
Gupta, S.C.2
Kim, J.H.3
-
121
-
-
77449147556
-
Regulation of tnfrsf and innate immune signalling complexes by trafs and ciaps
-
Silke J, Brink R (2009) Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs. Cell Death Differ 17: 35-45
-
(2009)
Cell Death Differ
, vol.17
, pp. 35-45
-
-
Silke, J.1
Brink, R.2
-
122
-
-
0041853690
-
Induction of tnf receptor i-mediated apoptosis via two sequential signaling complexes
-
Micheau O, Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114: 181-190
-
(2003)
Cell
, vol.114
, pp. 181-190
-
-
Micheau, O.1
Tschopp, J.2
-
123
-
-
0016723594
-
An endotoxin-induced serum factor that causes necrosis of tumors
-
Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B (1975) An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 72: 3666-3670
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, pp. 3666-3670
-
-
Carswell, E.A.1
Old, L.J.2
Kassel, R.L.3
Green, S.4
Fiore, N.5
Williamson, B.6
-
124
-
-
0000392840
-
The treatment of malignant tumors by bacterial toxins as developed by the late william b. Coley, m.d., reviewed in the light of modern research
-
Nauts HC, Swift WE, Coley BL (1946) The treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D., reviewed in the light of modern research. Cancer Res 6: 205-216
-
(1946)
Cancer Res
, vol.6
, pp. 205-216
-
-
Nauts, H.C.1
Swift, W.E.2
Coley, B.L.3
-
125
-
-
0022411888
-
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
-
Beutler B, Milsark IW, Cerami AC (1985) Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229: 869-871
-
(1985)
Science
, vol.229
, pp. 869-871
-
-
Beutler, B.1
Milsark, I.W.2
Cerami, A.C.3
-
126
-
-
0023028369
-
Shock and tissue injury induced by recombinant human cachectin
-
Tracey KJ, et al (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234: 470-474
-
(1986)
Science
, vol.234
, pp. 470-474
-
-
Tracey, K.J.1
-
127
-
-
0029949257
-
Tnf-dependent recruitment of the protein kinase rip to the tnf receptor-1 signaling complex
-
Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (1996) TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4: 387-396
-
(1996)
Immunity
, vol.4
, pp. 387-396
-
-
Hsu, H.1
Huang, J.2
Shu, H.B.3
Baichwal, V.4
Goeddel, D.V.5
-
128
-
-
0030032106
-
Tradd-traf2 and traddfadd interactions define two distinct tnf receptor 1 signal transduction pathways
-
Hsu H, Shu HB, Pan MG, Goeddel DV (1996) TRADD-TRAF2 and TRADDFADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84: 299-308
-
(1996)
Cell
, vol.84
, pp. 299-308
-
-
Hsu, H.1
Shu, H.B.2
Pan, M.G.3
Goeddel, D.V.4
-
129
-
-
0029007855
-
The tnf receptor 1-associated protein tradd signals cell death and nf-kappa b activation
-
Hsu H, Xiong J, Goeddel DV (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81: 495-504
-
(1995)
Cell
, vol.81
, pp. 495-504
-
-
Hsu, H.1
Xiong, J.2
Goeddel, D.V.3
-
130
-
-
0033636538
-
Solution structure of n-tradd and characterization of the interaction of n-tradd and c-traf2, a key step in the tnfr1 signaling pathway
-
Tsao DH, McDonagh T, Telliez JB, Hsu S, Malakian K, Xu GY, Lin LL (2000) Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. Mol Cell 5: 1051-1057
-
(2000)
Mol Cell
, vol.5
, pp. 1051-1057
-
-
Tsao, D.H.1
McDonagh, T.2
Telliez, J.B.3
Hsu, S.4
Malakian, K.5
Xu, G.Y.6
Lin, L.L.7
-
131
-
-
72149117664
-
Traf2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-kappa}b and to prevent tnf-induced apoptosis
-
Vince JE, et al (2009) TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-kappa}b and to prevent tnf-induced apoptosis. J Biol Chem 284: 35906-35915
-
(2009)
J Biol Chem
, vol.284
, pp. 35906-35915
-
-
Vince, J.E.1
-
132
-
-
0029595282
-
The tnfr2-traf signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
-
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (1995) The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83: 1243-1252
-
(1995)
Cell
, vol.83
, pp. 1243-1252
-
-
Rothe, M.1
Pan, M.G.2
Henzel, W.J.3
Ayres, T.M.4
Goeddel, D.V.5
-
133
-
-
0030447483
-
The tumor necrosis factor receptor 2 signal transducers traf2 and c-iap1 are components of the tumor necrosis factor receptor 1 signaling complex
-
Shu HB, Takeuchi M, Goeddel DV (1996) The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc Natl Acad Sci USA 93: 13973-13978
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 13973-13978
-
-
Shu, H.B.1
Takeuchi, M.2
Goeddel, D.V.3
-
134
-
-
33646034316
-
Activation of ikk by tnfalpha requires site-specific ubiquitination of rip1 and polyubiquitin binding by nemo
-
Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22: 245-257
-
(2006)
Mol Cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
Deng, L.2
Xia, Z.P.3
Pineda, G.4
Chen, Z.J.5
-
135
-
-
70350015537
-
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of ikk activation by tnfalpha and il-1beta
-
Xu M, Skaug B, Zeng W, Chen ZJ (2009) A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell 36: 302-314
-
(2009)
Mol Cell
, vol.36
, pp. 302-314
-
-
Xu, M.1
Skaug, B.2
Zeng, W.3
Chen, Z.J.4
-
136
-
-
67650895663
-
Nemo oligomerization and its ubiquitin-binding properties
-
Ivins FJ, Montgomery MG, Smith SJ, Morris-Davies AC, Taylor IA, Rittinger K (2009) NEMO oligomerization and its ubiquitin-binding properties. Biochem J 421: 243-251
-
(2009)
Biochem J
, vol.421
, pp. 243-251
-
-
Ivins, F.J.1
Montgomery, M.G.2
Smith, S.J.3
Morris-Davies, A.C.4
Taylor, I.A.5
Rittinger, K.6
-
137
-
-
61649103747
-
Structural basis for recognition of diubiquitins by nemo
-
Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD, Eliezer D, Wu H (2009) Structural basis for recognition of diubiquitins by NEMO. Mol Cell 33: 602-615
-
(2009)
Mol Cell
, vol.33
, pp. 602-615
-
-
Lo, Y.C.1
Lin, S.C.2
Rospigliosi, C.C.3
Conze, D.B.4
Wu, C.J.5
Ashwell, J.D.6
Eliezer, D.7
Wu, H.8
-
138
-
-
4344561190
-
Nf-kappab is essential for induction of cyld, the negative regulator of nf-kappab: Evidence for a novel inducible autoregulatory feedback pathway
-
Jono H, Lim JH, Chen LF, Xu H, Trompouki E, Pan ZK, Mosialos G, Li JD (2004) NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway. J Biol Chem 279: 36171-36174
-
(2004)
J Biol Chem
, vol.279
, pp. 36171-36174
-
-
Jono, H.1
Lim, J.H.2
Chen, L.F.3
Xu, H.4
Trompouki, E.5
Pan, Z.K.6
Mosialos, G.7
Li, J.D.8
-
139
-
-
0041967054
-
The tumour suppressor cyld negatively regulates nfkappab signalling by deubiquitination
-
Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G (2003) The tumour suppressor CYLD negatively regulates NFkappaB signalling by deubiquitination. Nature 424: 801-805
-
(2003)
Nature
, vol.424
, pp. 801-805
-
-
Kovalenko, A.1
Chable-Bessia, C.2
Cantarella, G.3
Israel, A.4
Wallach, D.5
Courtois, G.6
-
140
-
-
0042467554
-
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating nf-kappab
-
Brummelkamp TR, Nijman SM, Dirac AM, Bernards R (2003) Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 424: 797-801
-
(2003)
Nature
, vol.424
, pp. 797-801
-
-
Brummelkamp, T.R.1
Nijman, S.M.2
Dirac, A.M.3
Bernards, R.4
-
141
-
-
0042467558
-
Cyld is a deubiquitinating enzyme that negatively regulates nf-kappab activation by tnfr family members
-
Trompouki E, Hatzivassiliou E, Tsichritzis T, Farmer H, Ashworth A, Mosialos G (2003) CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 424: 793-796
-
(2003)
Nature
, vol.424
, pp. 793-796
-
-
Trompouki, E.1
Hatzivassiliou, E.2
Tsichritzis, T.3
Farmer, H.4
Ashworth, A.5
Mosialos, G.6
-
142
-
-
35548974703
-
Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme cyld
-
Wright A, Reiley WW, Chang M, Jin W, Lee AJ, Zhang M, Sun SC (2007) Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell 13: 705-716
-
(2007)
Dev Cell
, vol.13
, pp. 705-716
-
-
Wright, A.1
Reiley, W.W.2
Chang, M.3
Jin, W.4
Lee, A.J.5
Zhang, M.6
Sun, S.C.7
-
143
-
-
84856160569
-
Caspase 8 inhibits programmed necrosis by processing cyld
-
O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT (2011) Caspase 8 inhibits programmed necrosis by processing CYLD. Nat Cell Biol 13: 1437-1442
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1437-1442
-
-
O'Donnell, M.A.1
Perez-Jimenez, E.2
Oberst, A.3
Ng, A.4
Massoumi, R.5
Xavier, R.6
Green, D.R.7
Ting, A.T.8
-
144
-
-
43049152912
-
Tnf-alpha induces two distinct caspase-8 activation pathways
-
Wang L, Du F, Wang X (2008) TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133: 693-703
-
(2008)
Cell
, vol.133
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
145
-
-
84886305117
-
Regulation of rip1 kinase signalling at the crossroads of inflammation and cell death
-
Ofengeim D, Yuan J (2013) Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol 14: 727-736
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 727-736
-
-
Ofengeim, D.1
Yuan, J.2
-
146
-
-
84861653411
-
The 'complexities' of life and death: Death receptor signalling platforms
-
Dickens LS, Powley IR, Hughes MA, MacFarlane M (2012) The 'complexities' of life and death: death receptor signalling platforms. Exp Cell Res 318: 1269-1277
-
(2012)
Exp Cell Res
, vol.318
, pp. 1269-1277
-
-
Dickens, L.S.1
Powley, I.R.2
Hughes, M.A.3
MacFarlane, M.4
-
147
-
-
0026321219
-
The 'burnet era' of immunology: Origins and influence
-
Mackay IR (1991) The 'Burnet era' of immunology: origins and influence. Immunol Cell Biol 69(Pt 5): 301-305
-
(1991)
Immunol Cell Biol
, vol.69
, Issue.PART 5
, pp. 301-305
-
-
Mackay, I.R.1
-
148
-
-
0033587771
-
Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: The igg scaffold is important for induction and maintenance of immune hyporesponsiveness
-
Kang Y, Melo M, Deng E, Tisch R, El-Amine M, Scott DW (1999) Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the IgG scaffold is important for induction and maintenance of immune hyporesponsiveness. Proc Natl Acad Sci USA 96: 8609-8614
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8609-8614
-
-
Kang, Y.1
Melo, M.2
Deng, E.3
Tisch, R.4
El-Amine, M.5
Scott, D.W.6
-
149
-
-
0031871632
-
The peripheral deletion of autoreactive cd8+ t cells induced by cross-presentation of self-antigens involves signaling through cd95 (fas, apo-1)
-
Kurts C, Heath WR, Kosaka H, Miller JF, Carbone FR (1998) The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J Exp Med 188: 415-420
-
(1998)
J Exp Med
, vol.188
, pp. 415-420
-
-
Kurts, C.1
Heath, W.R.2
Kosaka, H.3
Miller, J.F.4
Carbone, F.R.5
-
151
-
-
42349101305
-
Immunosuppression induced by immature dendritic cells is mediated by tgf-beta/il-10 double-positive cd4+ regulatory t cells
-
Cools N, Van Tendeloo VF, Smits EL, Lenjou M, Nijs G, Van Bockstaele DR, Berneman ZN, Ponsaerts P (2008) Immunosuppression induced by immature dendritic cells is mediated by TGF-beta/IL-10 double-positive CD4+ regulatory T cells. J Cell Mol Med 12: 690-700
-
(2008)
J Cell Mol Med
, vol.12
, pp. 690-700
-
-
Cools, N.1
Van Tendeloo, V.F.2
Smits, E.L.3
Lenjou, M.4
Nijs, G.5
Van Bockstaele, D.R.6
Berneman, Z.N.7
Ponsaerts, P.8
-
152
-
-
0036360019
-
The enemy within: Keeping self-reactive t cells at bay in the periphery
-
Walker LS, Abbas AK (2002) The enemy within: keeping self-reactive T cells at bay in the periphery. Nat Rev Immunol 2: 11-19
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 11-19
-
-
Walker, L.S.1
Abbas, A.K.2
-
153
-
-
0033515520
-
Germline mutations in the extracellular domains of the 55 kda tnf receptor, tnfr1, define a family of dominantly inherited autoinflammatory syndromes
-
McDermott MF, et al (1999) Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97: 133-144
-
(1999)
Cell
, vol.97
, pp. 133-144
-
-
McDermott, M.F.1
-
154
-
-
36849043810
-
The role of e3 ligases in autoimmunity and the regulation of autoreactive t cells
-
Lin AE, Mak TW (2007) The role of E3 ligases in autoimmunity and the regulation of autoreactive T cells. Curr Opin Immunol 19: 665-673
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 665-673
-
-
Lin, A.E.1
Mak, T.W.2
-
155
-
-
0346599403
-
An autoimmune disease, apeced, caused by mutations in a novel gene featuring two phd-type zinc-finger domains
-
Anon (1997) An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat Genet 17: 399-403
-
(1997)
Nat Genet
, vol.17
, pp. 399-403
-
-
Anon1
-
156
-
-
34249717868
-
Lessons on immune tolerance from the monogenic disease aps1
-
DeVoss JJ, Anderson MS (2007) Lessons on immune tolerance from the monogenic disease APS1. Curr Opin Genet Dev 17: 193-200
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 193-200
-
-
DeVoss, J.J.1
Anderson, M.S.2
-
157
-
-
0033590981
-
Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla
-
Heino M, et al (1999) Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem Biophys Res Commun 257: 821-825
-
(1999)
Biochem Biophys Res Commun
, vol.257
, pp. 821-825
-
-
Heino, M.1
-
158
-
-
0038486459
-
Localization of the apeced protein in distinct nuclear structures
-
Bjorses P, Pelto-Huikko M, Kaukonen J, Aaltonen J, Peltonen L, Ulmanen I (1999) Localization of the APECED protein in distinct nuclear structures. Hum Mol Genet 8: 259-266
-
(1999)
Hum Mol Genet
, vol.8
, pp. 259-266
-
-
Bjorses, P.1
Pelto-Huikko, M.2
Kaukonen, J.3
Aaltonen, J.4
Peltonen, L.5
Ulmanen, I.6
-
159
-
-
22344449972
-
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
-
Derbinski J, Gabler J, Brors B, Tierling S, Jonnakuty S, Hergenhahn M, Peltonen L, Walter J, Kyewski B (2005) Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med 202: 33-45
-
(2005)
J Exp Med
, vol.202
, pp. 33-45
-
-
Derbinski, J.1
Gabler, J.2
Brors, B.3
Tierling, S.4
Jonnakuty, S.5
Hergenhahn, M.6
Peltonen, L.7
Walter, J.8
Kyewski, B.9
-
160
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the aire protein
-
Anderson MS, et al (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401
-
(2002)
Science
, vol.298
, pp. 1395-1401
-
-
Anderson, M.S.1
-
161
-
-
0037084784
-
Aire deficient mice develop multiple features of apeced phenotype and show altered immune response
-
Ramsey C, Winqvist O, Puhakka L, Halonen M, Moro A, Kampe O, Eskelin P, Pelto-Huikko M, Peltonen L (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11: 397-409
-
(2002)
Hum Mol Genet
, vol.11
, pp. 397-409
-
-
Ramsey, C.1
Winqvist, O.2
Puhakka, L.3
Halonen, M.4
Moro, A.5
Kampe, O.6
Eskelin, P.7
Pelto-Huikko, M.8
Peltonen, L.9
-
162
-
-
13544262691
-
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of aire-deficient mice
-
Kuroda N, et al (2005) Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice. J Immunol 174: 1862-1870
-
(2005)
J Immunol
, vol.174
, pp. 1862-1870
-
-
Kuroda, N.1
-
164
-
-
1642500086
-
Aire functions as an e3 ubiquitin ligase
-
Uchida D, et al (2004) AIRE functions as an E3 ubiquitin ligase. J Exp Med 199: 167-172
-
(2004)
J Exp Med
, vol.199
, pp. 167-172
-
-
Uchida, D.1
-
165
-
-
15744397285
-
Nmr structure of the first phd finger of autoimmune regulator protein (aire1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (apeced) disease
-
Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, Akhtar A, Sattler M, Musco G (2005) NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy- candidiasis-ectodermal dystrophy (APECED) disease. J Biol Chem 280: 11505-11512
-
(2005)
J Biol Chem
, vol.280
, pp. 11505-11512
-
-
Bottomley, M.J.1
Stier, G.2
Pennacchini, D.3
Legube, G.4
Simon, B.5
Akhtar, A.6
Sattler, M.7
Musco, G.8
-
166
-
-
16444377660
-
Dependence of self-tolerance on traf6-directed development of thymic stroma
-
Akiyama T, Maeda S, Yamane S, Ogino K, Kasai M, Kajiura F, Matsumoto M, Inoue J (2005) Dependence of self-tolerance on TRAF6-directed development of thymic stroma. Science 308: 248-251
-
(2005)
Science
, vol.308
, pp. 248-251
-
-
Akiyama, T.1
Maeda, S.2
Yamane, S.3
Ogino, K.4
Kasai, M.5
Kajiura, F.6
Matsumoto, M.7
Inoue, J.8
-
167
-
-
0032959111
-
Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice
-
Naquet P, Naspetti M, Boyd R (1999) Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice. Semin Immunol 11: 47-55
-
(1999)
Semin Immunol
, vol.11
, pp. 47-55
-
-
Naquet, P.1
Naspetti, M.2
Boyd, R.3
-
168
-
-
51349111243
-
The tumor necrosis factor family receptors rank and cd40 cooperatively establish the thymic medullary microenvironment and self-tolerance
-
Akiyama T, et al (2008) The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity 29: 423-437
-
(2008)
Immunity
, vol.29
, pp. 423-437
-
-
Akiyama, T.1
-
169
-
-
39549121805
-
Ubiquitination system and autoimmunity: The bridge towards the modulation of the immune response
-
Gomez-Martin D, Diaz-Zamudio M, Alcocer-Varela J (2008) Ubiquitination system and autoimmunity: the bridge towards the modulation of the immune response. Autoimmun Rev 7: 284-290
-
(2008)
Autoimmun Rev
, vol.7
, pp. 284-290
-
-
Gomez-Martin, D.1
Diaz-Zamudio, M.2
Alcocer-Varela, J.3
-
170
-
-
0035316576
-
Cbl: Many adaptations to regulate protein tyrosine kinases
-
Thien CB, Langdon WY (2001) Cbl: many adaptations to regulate protein tyrosine kinases. Nat Rev Mol Cell Biol 2: 294-307
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 294-307
-
-
Thien, C.B.1
Langdon, W.Y.2
-
171
-
-
0029006745
-
Cloning and characterization of cbl-b: A sh3 binding protein with homology to the c-cbl proto-oncogene
-
Keane MM, Rivero-Lezcano OM, Mitchell JA, Robbins KC, Lipkowitz S (1995) Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. Oncogene 10: 2367-2377
-
(1995)
Oncogene
, vol.10
, pp. 2367-2377
-
-
Keane, M.M.1
Rivero-Lezcano, O.M.2
Mitchell, J.A.3
Robbins, K.C.4
Lipkowitz, S.5
-
172
-
-
0034642534
-
Cbl-b regulates the cd28 dependence of t-cell activation
-
Chiang YJ, et al (2000) Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403: 216-220
-
(2000)
Nature
, vol.403
, pp. 216-220
-
-
Chiang, Y.J.1
-
173
-
-
0033680925
-
Cbl-b is a negative regulator of receptor clustering and raft aggregation in t cells
-
Krawczyk C, et al (2000) Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity 13: 463-473
-
(2000)
Immunity
, vol.13
, pp. 463-473
-
-
Krawczyk, C.1
-
174
-
-
0034642499
-
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor cbl-b
-
Bachmaier K, et al (2000) Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature 403: 211-216
-
(2000)
Nature
, vol.403
, pp. 211-216
-
-
Bachmaier, K.1
-
175
-
-
4143137360
-
Essential role of the e3 ubiquitin ligase cbl-b in t cell anergy induction
-
Jeon MS, et al (2004) Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21: 167-177
-
(2004)
Immunity
, vol.21
, pp. 167-177
-
-
Jeon, M.S.1
-
176
-
-
0035555195
-
Proteolysis-independent regulation of pi3k by cbl-b-mediated ubiquitination in t cells
-
Fang D, Liu YC (2001) Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat Immunol 2: 870-875
-
(2001)
Nat Immunol
, vol.2
, pp. 870-875
-
-
Fang, D.1
Liu, Y.C.2
-
177
-
-
77953289183
-
The e3 ubiquitin ligase grail regulates t cell tolerance and regulatory t cell function by mediating t cell receptor-cd3 degradation
-
Nurieva RI, et al (2010) The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity 32: 670-680
-
(2010)
Immunity
, vol.32
, pp. 670-680
-
-
Nurieva, R.I.1
-
178
-
-
0037396674
-
Grail: An e3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic cd4+ t cells
-
Anandasabapathy N, et al (2003) GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity 18: 535-547
-
(2003)
Immunity
, vol.18
, pp. 535-547
-
-
Anandasabapathy, N.1
-
179
-
-
34248151591
-
Grail is up-regulated in cd4+ cd25+ t regulatory cells and is sufficient for conversion of t cells to a regulatory phenotype
-
MacKenzie DA, Schartner J, Lin J, Timmel A, Jennens-Clough M, Fathman CG, Seroogy CM (2007) GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. J Biol Chem 282: 9696-9702
-
(2007)
J Biol Chem
, vol.282
, pp. 9696-9702
-
-
MacKenzie, D.A.1
Schartner, J.2
Lin, J.3
Timmel, A.4
Jennens-Clough, M.5
Fathman, C.G.6
Seroogy, C.M.7
-
180
-
-
2942707976
-
The gene related to anergy in lymphocytes, an e3 ubiquitin ligase, is necessary for anergy induction in cd4 t cells
-
Seroogy CM, Soares L, Ranheim EA, Su L, Holness C, Bloom D, Fathman CG (2004) The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. J Immunol 173: 79-85
-
(2004)
J Immunol
, vol.173
, pp. 79-85
-
-
Seroogy, C.M.1
Soares, L.2
Ranheim, E.A.3
Su, L.4
Holness, C.5
Bloom, D.6
Fathman, C.G.7
-
181
-
-
49649126399
-
Cutting edge: The transmembrane e3 ligase grail ubiquitinates the costimulatory molecule cd40 ligand during the induction of t cell anergy
-
Lineberry NB, Su LL, Lin JT, Coffey GP, Seroogy CM, Fathman CG (2008) Cutting edge: the transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. J Immunol 181: 1622-1626
-
(2008)
J Immunol
, vol.181
, pp. 1622-1626
-
-
Lineberry, N.B.1
Su, L.L.2
Lin, J.T.3
Coffey, G.P.4
Seroogy, C.M.5
Fathman, C.G.6
-
182
-
-
57649121585
-
The single subunit transmembrane e3 ligase gene related to anergy in lymphocytes (grail) captures and then ubiquitinates transmembrane proteins across the cell membrane
-
Lineberry N, Su L, Soares L, Fathman CG (2008) The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. J Biol Chem 283: 28497-28505
-
(2008)
J Biol Chem
, vol.283
, pp. 28497-28505
-
-
Lineberry, N.1
Su, L.2
Soares, L.3
Fathman, C.G.4
-
183
-
-
68949110141
-
The transmembrane e3 ligase grail ubiquitinates and degrades cd83 on cd4 t cells
-
Su LL, Iwai H, Lin JT, Fathman CG (2009) The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells. J Immunol 183: 438-444
-
(2009)
J Immunol
, vol.183
, pp. 438-444
-
-
Su, L.L.1
Iwai, H.2
Lin, J.T.3
Fathman, C.G.4
-
184
-
-
83355163383
-
Grail (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of arp2/3 subunit 5 and coronin 1a
-
Ichikawa D, Mizuno M, Yamamura T, Miyake S (2011) GRAIL (gene related to anergy in lymphocytes) regulates cytoskeletal reorganization through ubiquitination and degradation of Arp2/3 subunit 5 and coronin 1A. J Biol Chem 286: 43465-43474
-
(2011)
J Biol Chem
, vol.286
, pp. 43465-43474
-
-
Ichikawa, D.1
Mizuno, M.2
Yamamura, T.3
Miyake, S.4
-
185
-
-
12144290293
-
Calcineurin imposes t cell unresponsiveness through targeted proteolysis of signaling proteins
-
Heissmeyer V, et al (2004) Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 5: 255-265
-
(2004)
Nat Immunol
, vol.5
, pp. 255-265
-
-
Heissmeyer, V.1
-
186
-
-
77949264165
-
Human itch e3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease
-
Lohr NJ, et al (2010) Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. Am J Hum Genet 86: 447-453
-
(2010)
Am J Hum Genet
, vol.86
, pp. 447-453
-
-
Lohr, N.J.1
-
187
-
-
0031915677
-
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18h mice
-
Perry WL, Hustad CM, Swing DA, O'Sullivan TN, Jenkins NA, Copeland NG (1998) The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet 18: 143-146
-
(1998)
Nat Genet
, vol.18
, pp. 143-146
-
-
Perry, W.L.1
Hustad, C.M.2
Swing, D.A.3
O'Sullivan, T.N.4
Jenkins, N.A.5
Copeland, N.G.6
-
188
-
-
34249293370
-
The e3 ubiquitin ligase itch in t cell activation, differentiation, and tolerance
-
Liu YC (2007) The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance. Semin Immunol 19: 197-205
-
(2007)
Semin Immunol
, vol.19
, pp. 197-205
-
-
Liu, Y.C.1
-
189
-
-
0036197639
-
Dysregulation of t lymphocyte function in itchy mice: A role for itch in th2 differentiation
-
Fang D, et al (2002) Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. Nat Immunol 3: 281-287
-
(2002)
Nat Immunol
, vol.3
, pp. 281-287
-
-
Fang, D.1
-
190
-
-
1942453854
-
Degradation of bcl10 induced by t-cell activation negatively regulates nf-kappa b signaling
-
Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D (2004) Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol 24: 3860-3873
-
(2004)
Mol Cell Biol
, vol.24
, pp. 3860-3873
-
-
Scharschmidt, E.1
Wegener, E.2
Heissmeyer, V.3
Rao, A.4
Krappmann, D.5
-
191
-
-
84872820481
-
Linear ubiquitination: A newly discovered regulator of cell signalling
-
Rieser E, Cordier SM, Walczak H (2013) Linear ubiquitination: a newly discovered regulator of cell signalling. Trends Biochem Sci 38: 94-102
-
(2013)
Trends Biochem Sci
, vol.38
, pp. 94-102
-
-
Rieser, E.1
Cordier, S.M.2
Walczak, H.3
-
192
-
-
0027773019
-
A spontaneous mutation characterized by chronic proliferative dermatitis in c57bl mice
-
HogenEsch H, Gijbels MJ, Offerman E, van Hooft J, van Bekkum DW, Zurcher C (1993) A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am J Pathol 143: 972-982
-
(1993)
Am J Pathol
, vol.143
, pp. 972-982
-
-
HogenEsch, H.1
Gijbels, M.J.2
Offerman, E.3
Van Hooft, J.4
Van Bekkum, D.W.5
Zurcher, C.6
-
193
-
-
0035081842
-
Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with il-12
-
HogenEsch H, Torregrosa SE, Boggess D, Sundberg BA, Carroll J, Sundberg JP (2001) Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12. Eur J Immunol 31: 734-742
-
(2001)
Eur J Immunol
, vol.31
, pp. 734-742
-
-
HogenEsch, H.1
Torregrosa, S.E.2
Boggess, D.3
Sundberg, B.A.4
Carroll, J.5
Sundberg, J.P.6
-
194
-
-
0033120961
-
Absence of peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice
-
HogenEsch H, Janke S, Boggess D, Sundberg JP (1999) Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm/cpdm) mice. J Immunol 162: 3890-3896
-
(1999)
J Immunol
, vol.162
, pp. 3890-3896
-
-
HogenEsch, H.1
Janke, S.2
Boggess, D.3
Sundberg, J.P.4
-
195
-
-
34547422758
-
Spontaneous mutations in the mouse sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis
-
Seymour RE, Hasham MG, Cox GA, Shultz LD, Hogenesch H, Roopenian DC, Sundberg JP (2007) Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun 8: 416-421
-
(2007)
Genes Immun
, vol.8
, pp. 416-421
-
-
Seymour, R.E.1
Hasham, M.G.2
Cox, G.A.3
Shultz, L.D.4
Hogenesch, H.5
Roopenian, D.C.6
Sundberg, J.P.7
-
197
-
-
77953247287
-
Innovative uses of tumor necrosis factor alpha inhibitors
-
Mazza J, Rossi A, Weinberg JM (2010) Innovative uses of tumor necrosis factor alpha inhibitors. Dermatol Clin 28: 559-575
-
(2010)
Dermatol Clin
, vol.28
, pp. 559-575
-
-
Mazza, J.1
Rossi, A.2
Weinberg, J.M.3
-
198
-
-
70349967965
-
Anti-tnf biologic agents: Still the therapy of choice for rheumatoid arthritis
-
Taylor PC, Feldmann M (2009) Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol 5: 578-582
-
(2009)
Nat Rev Rheumatol
, vol.5
, pp. 578-582
-
-
Taylor, P.C.1
Feldmann, M.2
-
199
-
-
84869429707
-
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited hoil-1 and lubac deficiency
-
Boisson B, et al (2012) Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol 13: 1178-1186
-
(2012)
Nat Immunol
, vol.13
, pp. 1178-1186
-
-
Boisson, B.1
-
200
-
-
79960121968
-
Infectious diseases in patients with irak-4, myd88, nemo, or ikappabalpha deficiency
-
Picard C, Casanova JL, Puel A (2011) Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IkappaBalpha deficiency. Clin Microbiol Rev 24: 490-497
-
(2011)
Clin Microbiol Rev
, vol.24
, pp. 490-497
-
-
Picard, C.1
Casanova, J.L.2
Puel, A.3
-
201
-
-
68149139538
-
The ubiquitin-editing enzyme a20 (tnfaip3) is a central regulator of immunopathology
-
Vereecke L, Beyaert R, van Loo G (2009) The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology. Trends Immunol 30: 383-391
-
(2009)
Trends Immunol
, vol.30
, pp. 383-391
-
-
Vereecke, L.1
Beyaert, R.2
Van Loo, G.3
-
202
-
-
79960467121
-
The ubiquitin-editing protein a20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity
-
Kool M, et al (2011) The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity 35: 82-96
-
(2011)
Immunity
, vol.35
, pp. 82-96
-
-
Kool, M.1
-
203
-
-
50449103533
-
Multiple polymorphisms in the tnfaip3 region are independently associated with systemic lupus erythematosus
-
Musone SL, et al (2008) Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet 40: 1062-1064
-
(2008)
Nat Genet
, vol.40
, pp. 1062-1064
-
-
Musone, S.L.1
-
204
-
-
79951833148
-
B cells lacking the tumor suppressor tnfaip3/a20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
-
Chu Y, et al (2011) B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood 117: 2227-2236
-
(2011)
Blood
, vol.117
, pp. 2227-2236
-
-
Chu, Y.1
-
205
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Anon (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
Anon1
-
206
-
-
50149098200
-
Signature biomarkers in crohn's disease: Toward a molecular classification
-
Arsenescu R, Bruno ME, Rogier EW, Stefka AT, McMahan AE, Wright TB, Nasser MS, de Villiers WJ, Kaetzel CS (2008) Signature biomarkers in Crohn's disease: toward a molecular classification. Mucosal Immunol 1: 399-411
-
(2008)
Mucosal Immunol
, vol.1
, pp. 399-411
-
-
Arsenescu, R.1
Bruno, M.E.2
Rogier, E.W.3
Stefka, A.T.4
McMahan, A.E.5
Wright, T.B.6
Nasser, M.S.7
De Villiers, W.J.8
Kaetzel, C.S.9
-
207
-
-
66049120977
-
Coeliac disease-associated risk variants in tnfaip3 and rel implicate altered nf-kappab signalling
-
Trynka G, et al (2009) Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut 58: 1078-1083
-
(2009)
Gut
, vol.58
, pp. 1078-1083
-
-
Trynka, G.1
-
208
-
-
36549003138
-
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
-
Plenge RM, et al (2007) Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 39: 1477-1482
-
(2007)
Nat Genet
, vol.39
, pp. 1477-1482
-
-
Plenge, R.M.1
-
209
-
-
80052195163
-
A20 (tnfaip3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
-
Matmati M, et al (2011) A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 43: 908-912
-
(2011)
Nat Genet
, vol.43
, pp. 908-912
-
-
Matmati, M.1
-
210
-
-
34250368115
-
Deubiquitinating enzyme cyld negatively regulates the ubiquitin-dependent kinase tak1 and prevents abnormal t cell responses
-
Reiley WW, et al (2007) Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med 204: 1475-1485
-
(2007)
J Exp Med
, vol.204
, pp. 1475-1485
-
-
Reiley, W.W.1
|