GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype

Journal of Biological Chemistry

Volumn 282, Issue 13, 2007, Pages 9696-9702

  MacKenzie, Debra A ^a   Schartner, Jill ^a   Lin, Jack ^b   Timmel, Amanda ^a   Jennens Clough, Martha ^a   Fathman, C Garrison ^b   Seroogy, Christine M ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRAIL (GENE RELATED TO ANERGY IN LYMPHOCYTES); RETROVIRAL TRANSDUCTION; T CELLS;

ANIMALS; ANTIGENS; CELLS; DATA ACQUISITION; ENZYMES; RNA;

GENES;

GENE RELATED TO ANERGY IN LYMPHOCYTE PROTEIN; MESSENGER RNA; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR FOXP3; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; UBIQUITIN PROTEIN LIGASE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CLONAL ANERGY; CONTROLLED STUDY; GENETIC TRANSDUCTION; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; THYMUS; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

MURINAE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CLONAL ANERGY; IMMUNOPHENOTYPING; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; RNA, MESSENGER; T-LYMPHOCYTES, REGULATORY; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 34248151591     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604192200     Document Type: Article

References (29)

1. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., and Toda, M. (1995) J. Immunol. 155, 1151-1164
2. Chatila, T. A., Blaeser, F., Ho, N., Lederman, H. M., Voulgaropoulos, C., Helms, C., and Bowcock, A. M. (2000) J. Clin. Investig. 106, R75-81
3. Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B., Clark, L. B., Yasayko, S. A., Wilkinson, J. E., Galas, D., Ziegler, S. F., and Ramsdell, F. (2001) Nat. Genet. 27, 68-73
4. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., and Ochs, H. D. (2001) Nat. Genet. 27, 20-21
5. Gavin, M. A., Torgerson, T. R., Houston, E., Deroos, P., Ho, W. Y., Stray-Pedersen, A., Ocheltree, E. L., Greenberg, P. D., Ochs, H. D., and Rudensky, A. Y. (2006) Proc. Natl. Acad. Sci. U. S. A.
6. Thorstenson, K. M., and Khoruts, A. (2001) J. Immunol. 167, 188-195
7. Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C., and von Boehmer, H. (2005) Nat. Immunol. 6, 1219-1227
8. Apostolou, I., and Von Boehmer, H. (2004) J. Exp. Med. 199, 1401-1408
9. Schwartz, R. H., Mueller, D. L., Jenkins, M. K., and Quill, H. (1989) Cold Spring Harbor Symp. Quant. Biol. 54, 605-610
10. Anandasabapathy, N., Ford, G., Bloom, D., Holness, C., Seroogy, C., Skrenta, H., Hollenhurst, M., Fathman, C. G., and Soares, L. (2003) Immunity 18, 1-20
11. Dresser, D. W. (1961) Nature 191, 1169-1171
12. Seroogy, C. M., Soares, L., Ranheim, E. A., Su, L., Holness, C., Bloom, D., and Fathman, C. G. (2004) J. Immunol. 173, 79-85
13. Heissmeyer, V., Macian, F., Im, S. H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y. C., Dustin, M. L., and Rao, A. (2004) Nat. Immunol. 5, 255-265
14. Murphy, K. M., Heimberger, A. B., and Loh, D. Y. (1990) Science 250, 1720-1723
15. Costa, G. L., Benson, J. M., Seroogy, C. M., Achacoso, P., Fathman, C. G., and Nolan, G. P. (2000) J. Immunol. 164, 3581-3590
16. Oh, J. W., Seroogy, C. M., Meyer, E. H., Akbari, O., Berry, G., Fathman, C. G., Dekruyff, R. H., and Umetsu, D. T. (2002) J. Allergy Clin. Immunol. 110, 460-468
17. Ermann, J., Szanya, V., Ford, G. S., Paragas, V., Fathman, C. G., and Lejon, K. (2001) J. Immunol. 167, 4271-4275
18. Soares, L., Seroogy, C., Skrenta, H., Anandasabapathy, N., Lovelace, P., Chung, C. D., Engleman, E., and Fathman, C. G. (2004) Nat. Immunol 5, 45-54
19. Khattri, R., Cox, T., Yasayko, S. A., and Ramsdell, F. (2003) Nat. Immunol. 4, 337-342
20. Fontenot, J. D., Gavin, M. A., and Rudensky, A. Y. (2003) Nat. Immunol. 4, 330-336
21. Takahashi, T., Tagami, T., Yamazaki, S., Uede, T., Shimizu, J., Sakaguchi, N., Mak, T. W., and Sakaguchi, S. (2000) J. Exp. Med. 192, 303-310
22. Nakamura, K., Kitani, A., Fuss, I., Pedersen, A., Harada, N., Nawata, H., and Strober, W. (2004) J. Immunol. 172, 834-842
23. Stock, P., Akbari, O., Berry, G., Freeman, G. J., Dekruyff, R. H., and Umetsu, D. T. (2004) Nat. Immunol. 5, 1149-1156
24. Tanchot, C., Barber, D. L., Chiodetti, L., and Schwartz, R. H. (2001) J. Immunol. 167, 2030-2039
25. Pape, K. A., Merica, R., Mondino, A., Khoruts, A., and Jenkins, M. K. (1998) J. Immunol. 160, 4719-4729
26. Khattri, R., Kasprowicz, D., Cox, T., Mortrud, M., Appleby, M. W., Brunkow, M. E., Ziegler, S. F., and Ramsdell, F. (2001) J. Immunol. 167, 6312-6320
27. Tang, Q., Boden, E. K., Henriksen, K. J., Bour-Jordan, H., Bi, M., and Bluestone, J. A. (2004) Eur. J. Immunol. 34, 2996-3005
28. Piccirillo, C. A., Letterio, J. J., Thornton, A. M., McHugh, R. S., Mamura, M., Mizuhara, H., and Shevach, E. M. (2002) J. Exp. Med. 196, 237-246
29. Marie, J. C., Letterio, J. J., Gavin, M., and Rudensky, A. Y. (2005) J. Exp. Med. 201, 1061-1067