The deubiquitinase CYLD targets Smad7 protein to regulate transforming growth factor β (TGF-β) signaling and the development of regulatory T cells

Journal of Biological Chemistry

Volumn 286, Issue 47, 2011, Pages 40520-40530

  Zhao, Yongge ^a   Thornton, Angela M ^b   Kinney, Matthew C ^a   Ma, Chi A ^a   Spinner, Jacob J ^a   Fuss, Ivan J ^a   Shevach, Ethan M ^b   Jain, Ashish ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IN-VITRO; KNOCK OUTS; LYMPHOID ORGANS; SIGNALING FUNCTIONS; SITE-SPECIFIC; T CELLS; TRANSFORMING GROWTH FACTORS; UBIQUITINATION;

AMINO ACIDS; ENZYME ACTIVITY;

CELLS;

CYLINDROMATOSIS PROTEIN; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEINASE; SMAD7 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; THYMUS; UBIQUITINATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYSTEINE ENDOPEPTIDASES; FORKHEAD TRANSCRIPTION FACTORS; GENE KNOCKOUT TECHNIQUES; HELA CELLS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPH NODES; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; UBIQUITINATION;

MUS;

EID: 81755189052     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.292961     Document Type: Article

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