Structural dynamics and regulation of the mammalian SLC9A family of Na+/H+ exchangers

Current Topics in Membranes

Volumn 73, Issue , 2014, Pages 69-148

  Hendus Altenburger, Ruth ^a   Kragelund, Birthe B ^a   Pedersen, Stine Falsig ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Acid base transport, cellular pH regulation; Intrinsic disorder; NhaA; NHE1; Phosphorylation; Structure

Indexed keywords

SODIUM PROTON EXCHANGE PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE; CHEMISTRY; HUMAN; MAMMAL; METABOLISM; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; HUMANS; MAMMALS; MOLECULAR SEQUENCE DATA; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN TRANSPORT; SODIUM-HYDROGEN ANTIPORTER;

EID: 84898615008     PISSN: 10635823     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-800223-0.00002-5     Document Type: Chapter

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139. + exchanger. European Journal of Biochemistry 1998, 257:228-235.
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145. + exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. The Journal of Biological Chemistry 2007, 282:2741-2751.
146. + exchanger isoform I. Biochemistry 2005, 44:5842-5852.
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148. + exchanger isoform 1 overproduced in Saccharomyces cerevisiae. The Journal of Biological Chemistry 2008, 283:4145-4154.
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153. 2+-induced endocytosis by recruitment of AP2 and clathrin. The American Journal of Physiology 2007, 292:G1549-G1558.
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161. + exchanger isoform 6 are regulated by interaction with RACK1. Journal of Biological Chemistry 2008, 283:4417-4429.
162. + antiporter of Escherichia coli with functional implications. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:2629-2634.
163. Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., et al. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 2006, 127:635-648.
164. Onishi I., Lin P.J., Diering G.H., Williams W.P., Numata M. RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity. Cellular Signalling 2007, 19:194-203.
165. Orlowski J. Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger. Journal of Biological Chemistry 1993, 268:16369-16377.
166. Orlowski J., Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflügers Archiv 2004, 447:549-565.
167. Orlowski J., Grinstein S. Na+/H+exchangers. Comprehensive Physiology 2011, 1:2083-2100.
168. + exchanger that confer sensitivity to pharmacological antagonists. Journal of Biological Chemistry 1996, 271:19922-19927.
169. Orlowski J., Kandasamy R.A., Shull G.E. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. Journal of Biological Chemistry 1992, 267:9331-9339.
170. + exchanger in the pre-steady state. Implications for the exchange mechanism. Journal of Biological Chemistry 1993, 268:3184-3193.
171. + exchange. Proceedings of the National Academy of Sciences of the United States of America 1989, 86:4818-4822.
172. Padan E., Kozachkov L., Herz K., Rimon A. NhaA crystal structure: Functional-structural insights. The Journal of Experimental Biology 2009, 212:1593-1603.
173. + antiporter. Biochimica et Biophysica Acta 2004, 1658:2-13.
174. 2+ ions as important structural elements. Biochemistry 2004, 43:3628-3636.
175. + exchangers. Journal of Biological Chemistry 2001, 276:17367-17372.
176. + antiporter in quiescent fibroblasts by increasing its affinity for intracellular H+. Journal of Biological Chemistry 1984, 259:10989-10994.
177. 2+/CaM, and ERK. Biochimica et Biophysica Acta 2012, 1820:1618-1627.
178. Parker M.D., Boron W.F. The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiological Reviews 2013, 93:803-959.
179. Pedersen S.F. A novel NHE1 from red blood cells of the winter flounder: Regulation by multiple signaling pathways. Cell volume and signaling. Advances in experimental medicine and biology 2005, 89-99. Springer Science+Business Media, Inc., New York, NY. P.K. Lauf, N. Adragna (Eds.).
180. Pedersen S.F., Beisner K.H., Hougaard C., Willumsen B.M., Lambert I.H., Hoffmann E.K. Rho family GTP binding proteins are involved in the regulatory volume decrease process in NIH3T3 mouse fibroblasts. The Journal of Physiology 2002, 541:779-796.
181. + exchanger, NHE1. Archives of Biochemistry and Biophysics 2007, 462:195-201.
182. Pedersen S.F., King S.A., Nygaard E.B., Rigor R.R., Cala P.M. NHE1 inhibition by amiloride- and benzoylguanidine-type compounds. Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. The Journal of Biological Chemistry 2007, 282:19716-19727.
183. Pedersen S.F., Mills J.W., Hoffmann E.K. Role of the F-actin cytoskeleton in the RVD and RVI processes in Ehrlich ascites tumor cells. Experimental Cell Research 1999, 252:63-74.
184. Pedersen S.F., O'Donnell M.E., Anderson S.E., Cala P.M. Physiology and pathophysiology of Na+/H+exchange and Na+-K+-2Cl- cotransport in the heart, brain, and blood. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2006, 291:R1-R25.
185. Qadri Y.J., Song Y., Fuller C.M., Benos D.J. Amiloride docking to acid-sensing ion channel-1. The Journal of Biological Chemistry 2010, 285:9627-9635.
186. Rasmussen M., Alexander R.T., Darborg B.V., Mobjerg N., Hoffmann E.K., Kapus A., et al. Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: Activation mechanisms and physiological implications. AJP - Cell Physiology 2008, 294:C197-C212.
187. + exchanger. The Journal of Biological Chemistry 2008, 283:22018-22030.
188. + exchange in regulation of p38 mitogen-activated protein kinase activity and cell death after chemical anoxia in NIH3T3 fibroblasts. Pflügers Archiv 2007, 454:649-662.
189. + exchanger (NHE1) during osmotic cell shrinkage. PLoS One 2011, 6:e29210.
190. +. Journal of Biological Chemistry 2007, 282:26810-26821.
191. Rizoli S.B., Rotstein O.D., Parodo J., Phillips M.J., Kapus A. Hypertonic inhibition of exocytosis in neutrophils: Central role for osmotic actin skeleton remodeling. AJP - Cell Physiology 2000, 279:C619-C633.
192. Rosner H.I., Kragelund B.B. Structure and dynamic properties of membrane proteins using NMR. Comprehensive Physiology 2012, 2:1491-1539.
193. + antiporter from Escherichia coli, with trypsin. Biochemistry 1997, 36:14572-14576.
194. + antiporter from Escherichia coli. Journal of Biological Chemistry 1996, 271:32288-32292.
195. + antiporter. Cell 1989, 56:271-280.
196. Sarker R., Gronborg M., Cha B., Mohan S., Chen Y., Pandey A., et al. Casein kinase 2 binds to the C terminus of Na+/H+exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. Molecular Biology of the Cell 2008, 19:3859-3870.
197. Sato Y., Ariyoshi N., Mihara K., Sakaguchi M. Topogenesis of NHE1: Direct insertion of the membrane loop and sequestration of cryptic glycosylation and processing sites just after TM9. Biochemical and Biophysical Research Communications 2004, 324:281-287.
198. Schneider L., Stock C.M., Dieterich P., Jensen B.H., Pedersen L.B., Satir P., et al. The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium. The Journal of Cell Biology 2009, 185:163-176.
199. Schushan M., Rimon A., Haliloglu T., Forrest L.R., Padan E., Ben-Tal N. A model-structure of a periplasm-facing state of the NhaA antiporter suggests the molecular underpinnings of pH-induced conformational changes. Journal of Biological Chemistry 2012, 287:18249-18261.
200. + exchanger subtype 3 in various cell types. Pflügers Archiv 1998, 436:797-800.
201. Schweiger R., Linial M. Cooperativity within proximal phosphorylation sites is revealed from large-scale proteomics data. Biology Direct 2010, 5:6.
202. Screpanti E., Hunte C. Discontinuous membrane helices in transport proteins and their correlation with function. Journal of Structural Biology 2007, 159:261-267.
203. + exchanger 1 is an ATP-binding protein. The FEBS Journal 2013, 280:1430-1442.
204. + exchanger 1 is regulated via its lipid-interacting domain which functions as a molecular switch: A pharmacological approach using indolocarbazole compounds. Molecular Pharmacology 2014, 85:18-28.
205. Shimamura T., Weyand S., Beckstein O., Rutherford N.G., Hadden J.M., Sharples D., et al. Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter Mhp1. Science 2010, 328:470-473.
206. + exchanger interacts with mammalian heat shock protein. Biochemistry 1995, 34:10412-10420.
207. + exchanger using chymotryptic cleavage. The American Journal of Physiology 1998, 275:C431-C439.
208. Sigalov A.B., Uversky V.N. Differential occurrence of protein intrinsic disorder in the cytoplasmic signaling domains of cell receptors. Self Nonself 2011, 2:55-72.
209. + exchanger 1 ubiquitylation, endocytosis, and function. Journal of Biological Chemistry 2010, 285:38293-38303.
210. + exchanger. The Journal of Biological Chemistry 2005, 280:17863-17872.
211. + exchanger NHE1. Circulation Research 2008, 103:881-890.
212. Solcan N., Kwok J., Fowler P.W., Cameron A.D., Drew D., Iwata S., et al. Alternating access mechanism in the POT family of oligopeptide transporters. The EMBO Journal 2012, 31:3411-3421.
213. + exchange in renal proximal tubule cells. Journal of Biological Chemistry 1994, 269:15613-15618.
214. + exchangers NHE1 and NHE2. Biochemistry 2003, 42:1086-1094.
215. Szabo E.Z., Numata M., Lukashova V., Iannuzzi P., Orlowski J. beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+exchanger NHE5 isoform. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:2790-2795.
216. Takahashi E., Abe J., Gallis B., Aebersold R., Spring D.J., Krebs E.G., et al. p90(RSK) is a serum-stimulated Na+/H+exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+exchanger isoform-1. Journal of Biological Chemistry 1999, 274:20206-20214.
217. Tekpli X., Huc L., Lacroix J., Rissel M., Poet M., Noel J., et al. Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains. Journal of Cellular Physiology 2008, 216:207-220.
218. Tominaga T., Ishizaki T., Narumiya S., Barber D.L. p160ROCK mediates RhoA activation of Na-H exchange. The EMBO Journal 1998, 17:4712-4722.
219. Tompa P. Intrinsically unstructured proteins. Trends in Biochemical Sciences 2002, 27:527-533.
220. Tompa P., Fuxreiter M. Fuzzy complexes: Polymorphism and structural disorder in protein-protein interactions. Trends in Biochemical Sciences 2008, 33:2-8.
221. + exchanger reveal the participation of TM4 into a highly constrained sodium-binding site. Biochemistry 2001, 40:5095-5101.
222. Touret N., Tanneur V., Godart H., Seidler R., Taki N., Burger E., et al. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. European Journal of Pharmacology 2003, 459:151-158.
223. + exchanger-2 is an O-linked but not an N-linked sialoglycoprotein. Biochemistry 1994, 33:12954-12961.
224. Tsukita S., Yonemura S. Cortical actin organization: Lessons from ERM (ezrin/radixin/moesin) proteins. The Journal of Biological Chemistry 1999, 274:34507-34510.
225. + exchanger. Journal of Biological Chemistry 2010, 285:36656-36665.
226. + antiporter of Escherichia coli. Journal of Biological Chemistry 2004, 279:3265-3272.
227. + antiporter of Escherichia coli at physiological pH. Journal of Biological Chemistry 2008, 283:15975-15987.
228. Vacic V., Oldfield C.J., Mohan A., Radivojac P., Cortese M.S., Uversky V.N., et al. Characterization of molecular recognition features, MoRFs, and their binding partners. Journal of Proteome Research 2007, 6:2351-2366.
229. Vinothkumar K.R., Smits S.H., Kuhlbrandt W. pH-induced structural change in a sodium/proton antiporter from Methanococcus jannaschii. The EMBO Journal 2005, 24:2720-2729.
230. Waight A.B., Pedersen B.P., Schlessinger A., Bonomi M., Chau B.H., Roe-Zurz Z., et al. Structural basis for alternating access of a eukaryotic calcium/proton exchanger. Nature 2013, 499:107-110.
231. 2+ regulation-defective. Journal of Biological Chemistry 1994, 269:13710-13715.
232. + exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation. Journal of Biological Chemistry 1994, 269:5583-5588.
233. + exchangers by measurement of reverse mode reaction. Journal of Biological Chemistry 2003, 278:43580-43585.
234. + exchanger 1. Journal of Biological Chemistry 2003, 278:11828-11835.
235. + exchanger NHE1 through sequence-specific interaction. Biochemistry 1997, 36:12854-12861.
236. + exchanger. The Journal of Biological Chemistry 2010, 285:26652-26661.
237. + exchanger isoform 1. Journal of Biological Chemistry 2000, 275:7942-7949.
238. + exchangers. Physiological Reviews 1997, 77:51-74.
239. + exchanger. The American Journal of Physiology 1995, 269:C392-C402.
240. + exchanger through mitogen-activated protein kinase. Biochemistry 1997, 36:9151-9158.
241. Wang D., Sun H., Lang F., Yun C.C. Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1. American Journal of Physiology. Cell Physiology 2005, 289:C802-C810.
242. Ward J.J., McGuffin L.J., Bryson K., Buxton B.F., Jones D.T. The DISOPRED server for the prediction of protein disorder. Bioinformatics 2004, 20:2138-2139.
243. - absorption in renal thick ascending limb. The Journal of Clinical Investigation 1999, 104:1593-1602.
244. Weinman E.J., Minkoff C., Shenolikar S. Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. American Journal of Physiology. Renal Physiology 2000, 279:F393-F399.
245. + exchangers. The Biochemical Journal 2001, 357:1-10.
246. Wiederkehr M.R., Zhao H., Moe O.W. Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: Role of NHE3 phosphorylation. The American Journal of Physiology 1999, 276:C1205-C1217.
247. Williams K.A. Three-dimensional structure of the ion-coupled transport protein NhaA. Nature 2000, 403:112-115.
248. Williams K.A., Geldmacher-Kaufer U., Padan E., Schuldiner S., Kuhlbrandt W. Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 A resolution. The EMBO Journal 1999, 18:3558-3563.
249. + exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. The Journal of Biological Chemistry 2004, 279:26280-26286.
250. Xue B., Dunbrack R.L., Williams R.W., Dunker A.K., Uversky V.N. PONDR-FIT: A meta-predictor of intrinsically disordered amino acids. Biochimica et Biophysica Acta 2010, 1804:996-1010.
251. Xue J., Zhou D., Yao H., Gavrialov O., McConnell M.J., Gelb B.D., et al. Novel functional interaction between Na+/H+exchanger 1 and tyrosine phosphatase SHP-2. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 2007, 292:R2406-R2416.
252. Yamamoto M., Chen M.Z., Wang Y.J., Sun H.Q., Wei Y., Martinez M., et al. Hypertonic stress increases PI(4,5)P2 levels by activating PIP5KIbeta. The Journal of Biological Chemistry 2006, 281:32630-32638.
253. + exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor. Journal of Biological Chemistry 2001, 276:31349-31356.
254. 2+ oscillations. The Journal of Biological Chemistry 2009, 284:3855-3864.
255. Yonemura S., Hirao M., Doi Y., Takahashi N., Kondo T., Tsukita S., et al. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. The Journal of Cell Biology 1998, 140:885-895.
256. Yu F.H., Shull G.E., Orlowski J. Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells. Journal of Biological Chemistry 1993, 268:25536-25541.
257. + exchanger NHE3 and the cytoskeletal protein ezrin. Journal of Biological Chemistry 1998, 273:25856-25863.
258. + exchanger isoform (NHE-2). Biochemical and Biophysical Research Communications 1993, 193:532-539.
259. + exchanger 3 and is required for calcium regulation of exchange activity. Journal of Biological Chemistry 2009, 284:19437-19444.
260. + exchanger NHE1 isoform. The Journal of Biological Chemistry 2008, 283:12456-12467.
261. + exchanger NHE1 half-life and activity at the plasma membrane. Journal of Biological Chemistry 2012, 287:36883-36895.
262. Zhao H., Wiederkehr M.R., Fan L., Collazo R.L., Crowder L.A., Moe O.W. Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase a and NHE-3 phosphoserines 552 and 605. Journal of Biological Chemistry 1999, 274:3978-3987.
263. + exchanger 3 (NHE3) by a NHERF2 protein-dependent process. Journal of Biological Chemistry 2012, 287:13442-13456.