PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways

Journal of Cell Science

Volumn 126, Issue 4, 2013, Pages 953-965

  Clement, Ditte L ^a   Mally, Sabine ^b   Stock, Christian ^b   Lethan, Mette ^c   Satir, Peter ^c   Schwab, Albrecht ^b   Pedersen, Stine F ^a   Christensen, Søren T ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

AKT; Cell migration; MEK1 2 Erk1 2 p90RSK; NHE1; PDGFR ; Primary cilia

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN KINASE B; PROTEIN P90; SODIUM PROTON EXCHANGE PROTEIN 1;

ARTICLE; CELL MEMBRANE; CELL MIGRATION; EUKARYOTIC FLAGELLUM; FIBROBLAST; IMMUNOFLUORESCENCE MICROSCOPY; LAMELLIPODIUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATION TRANSPORT PROTEINS; CELL MOVEMENT; CILIA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLASTS; MAP KINASE SIGNALING SYSTEM; MICE; MICROSCOPY, FLUORESCENCE; NIH 3T3 CELLS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SODIUM-HYDROGEN ANTIPORTER;

EID: 84876315016     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.116426     Document Type: Article

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