NHE1 inhibition by amiloride- and benzoylguanidine-type compounds: Inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity

Journal of Biological Chemistry

Volumn 282, Issue 27, 2007, Pages 19716-19727

  Pedersen, Stine F ^b   King, Scott A ^a   Nygaard, Eva B ^b   Rigor, Robert R ^a   Cala, Peter M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; AMPHIUMA TRIDACTYLUM (ATNHE1); BENZOYLGUANIDINE; INHIBITOR SENSITIVITY;

BIOCHEMISTRY; CELL MEMBRANES; ION EXCHANGE; SENSITIVITY ANALYSIS;

ENZYME INHIBITION;

AMILORIDE; BENZOYLGUANIDINE; GUANIDINE DERIVATIVE; SODIUM PROTON EXCHANGE PROTEIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CHO CELL; CONTROLLED STUDY; MOLECULAR CLONING; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTON SODIUM EXCHANGE; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR SENSITIVITY; SALAMANDER; STRUCTURAL HOMOLOGY;

AMILORIDE; ANIMALS; BINDING SITES; CATION TRANSPORT PROTEINS; CELL LINE; CRICETINAE; CRICETULUS; FLOUNDER; GUANIDINES; HUMANS; MUTATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SODIUM CHANNEL BLOCKERS; SODIUM-HYDROGEN ANTIPORTER; SPECIES SPECIFICITY; SULFONES; URODELA;

AMPHIUMA TRIDACTYLUM; PSEUDOPLEURONECTES AMERICANUS;

EID: 34547115979     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701637200     Document Type: Article

References (36)

1. Putney, L. K., Denker, S. P., and Barber, D. L. (2002) Annu. Rev. Pharmacol. Toxicol. 42, 527-552
2. Orlowski, J., and Grinstein, S. (2004) Pfluegers Arch. 447, 549-565
3. Pedersen, S. F., and Cala, P. M. (2004) J. Exp. Zool. Part A Comp Exp. Biol. 301, 569-578
4. Pedersen, S. F. (2006) Pfluegers Arch. 452, 249-259
5. McLean, L. A., Roscoe, J., Jorgensen, N. K., Gorin, F. A., and Cala, P. M. (2000) Am. J. Physiol. 278, C676-C688
6. Lagana, A., Vadnais, J., Le, P. U., Nguyen, T. N., Laprade, R., Nabi, I. R., and Noel, J. (2000) J. Cell Sci. 113, 3649-3662
7. Reshkin, S. J., Bellizzi, A., Caldeira, S., Albarani, V., Malanchi, I., Poignee, M., Alunni-Fabbroni, M., Casavola, V., and Tommasino, M. (2000) FASEB J. 14, 2185-2197
8. Cardone, R. A., Casavola, V., and Reshkin, S. J. (2005) Nat. Rev. Cancer 5, 786-795
9. Anderson, S. E., Murphy, E., Steenbergen, C., London, R. E., and Cala, P. M. (1990) Am. J. Physiol. 259, C940-C948
10. Murphy, E., Cross, H., and Steenbergen, C. (1999) Circ. Res. 84, 1469-1470
11. Pedersen, S. F., O'Donnell, M. E., Anderson, S. E., and Cala, P. M. (2006) Am. J. Physiol. 291, R1-R25
12. Masereel, B., Pochet, L., and Laeckmann, D. (2003) Eur. J. Med. Chem. 38, 547-554
13. Burckhardt, G., Di Sole, F., and Helmle-Kolb, C. (2002) J. Nephrol. 15, Suppl. 5, 3-21
14. Wakabayashi, S., Pang, T., Su, X., and Shigekawa, M. (2000) J. Biol. Chem. 275, 7942-7949
15. Counillon, L., Franchi, A., and Pouyssegur, J. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 4508-4512
16. Touret, N., Poujeol, P., and Counillon, L. (2001) Biochemistry 40, 5095-5101
17. Yun, C. H., Little, P. J., Nath, S. K., Levine, S. A., Pouyssegur, J., Tse, C. M., and Donowitz, M. (1993) Biochem. Biophys. Res. Commun. 193, 532-539
18. Wang, D., Balkovetz, D. F., and Warnock, D. G. (1995) Am. J. Physiol. 269, C392-C402
19. Murtazina, R., Booth, B. J., Bullis, B. L., Singh, D. N., and Fliegel, L. (2001) Eur. J. Biochem. 268, 4674-4685
20. Khadilkar, A., Iannuzzi, P., and Orlowski, J. (2001) J. Biol. Chem. 276, 43792-43800
21. Orlowski, J., and Kandasamy, R. A. (1996) J. Biol. Chem. 271, 19922-19927
22. Noel, J., Germain, D., and Vadnais, J. (2003) Biochemistry 42, 15361-15368
23. McLean, L. A., Zia, S., Gorin, F. A., and Cala, P. M. (1999) Am. J. Physiol. 276, C1025-C1037
24. Pedersen, S. F., King, S. A., Rigor, R. R., Zhuang, Z., Warren, J. M., and Cala, P. M. (2003) Am. J. Physiol. 284, C1561-C1576
25. King, S. A., Pedersen, S. F., and Cala, P. M. (2005) FASEB J. 19, A1585
26. Baumgarth, M., Beier, N., and Gericke, R. (1997) J. Med. Chem. 40, 2017-2034
27. Cala, P. M. (1980) J. Gen. Physiol. 76, 683-708
28. Cala, P. M., and Maldonado, H. M. (1994) J. Gen. Physiol. 103, 1035-1053
29. Cala, P. M. (1977) J. Gen. Physiol. 69, 537-552
30. Rotin, D., and Grinstein, S. (1989) Am. J. Physiol. 257, C1158-C1165
31. Holt, M. E., King, S. A., Cala, P. M., and Pedersen, S. F. (2006) Cell Biochem. Biophys. 45, 1-18
32. Boyarsky, G., Ganz, M. B., Sterzel, R. B., and Boron, W. F. (1988) Am. J. Physiol. 255, C844-C856
33. Counillon, L., Noel, J., Reithmeier, R. A., and Pouyssegur, J. (1997) Biochemistry 36, 2951-2959
34. Hunte, C., Screpanti, E., Venturi, M., Rimon, A., Padan, E., and Michel, H. (2005) Nature 435, 1197-1202
35. Kinsella, J. L., and Aronson, P. S. (1981) Am. J. Physiol. 241, F374-F379
36. Counillon, L., Scholz, W., Lang, H. J., and Pouyssegur, J. (1993) Mol. Pharmacol. 44, 1041-1045