Acidosis-mediated regulation of the NHE1 isoform of the Na+/H+ exchanger in renal cells

American Journal of Physiology - Renal Physiology

Volumn 305, Issue 3, 2013, Pages

  Odunewu, Ayodeji ^a   Fliegel, Larry ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Acidosis; ERK; Phosphorylation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; AMINO ACID; COMPLEMENTARY DNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN INHIBITOR; SERINE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; THREONINE DEHYDRATASE;

ANIMAL CELL; ARTICLE; CELL TYPE; CYTOSOL; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY TUBULE ACIDOSIS; MDCK CELL; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WILD TYPE;

EID: 84880996014     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00598.2012     Document Type: Article

References (41)

1. Baum M, Biemesderfer D, Gentry D, Aronson PS. Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids. Am J Physiol Renal Fluid Electrolyte Physiol 268: F815-F820, 1995.
2. + exchanger in metastasis. Nat Rev 5: 786-795, 2005.
3. Carraro-Lacroix LR, Ramirez MA, Zorn TM, Reboucas NA, Malnic G. Increased NHE1 expression is associated with serum deprivation-induced differentiation in immortalized rat proximal tubule cells. Am J Physiol Renal Physiol 291: F129-F139, 2006.
4. 771. Am J Physiol Heart Circ Physiol 297: H846-H858, 2009.
5. Coccaro E, Mraiche F, Malo M, Vandertol-Vanier H, Bullis B, Robertson M, Fliegel L. Expression and characterization of the Na(+)/H (+) exchanger in the mammalian myocardium. Mol Cell Biochem 302: 145-155, 2007.
6. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 44: 1041-1045, 1993.
7. Ellis D. The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres. J Physiol 273: 211-240, 1977.
8. + exchanger isoform 1. Int J Biochem Cell Biol 37: 33-37, 2005.
9. + exchanger activity. Basic Res Cardiol 96: 301-305, 2001.
10. Gekle M, Freudinger R, Mildenberger S, Silbernagl S. Aldosterone interaction with epidermal growth factor receptor signaling in MDCK cells. Am J Physiol Renal Physiol 282: F669-F679, 2002.
11. Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 36: 59-74, 1977.
12. + exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway. J Biol Chem 278: 31676-31684, 2003.
13. Karki P, Coccaro E, Fliegel L. Sustained intracellular acidosis activates the myocardial Na(+)/H(+) exchanger independent of amino acid Ser(703) and p90(rsk). Biochim Biophys Acta 1798: 1565-1576, 2010.
14. + antiporter mRNA levels in response to respiratory and metabolic acidosis. J Clin Invest 87: 747-751, 1991.
15. Kuwahara M, Sasaki S, Uchida SC, Cragoe EJ Jr, Marumo F. Different development of apical and basolateral Na/H exchanger in LLC-PK1 renal epithelial cells: characterization by inhibitors and antisense oligonucleotides. Biochim Biophys Acta 1220: 132-138, 1994.
16. Lagana A, Vadnais J, Le PU, Nguyen TN, Laprade R, Nabi IR, Noel J. Regulation of the formation of tumor cell pseudopodia by the Na()/ H() exchanger NHE1. J Cell Sci 113: 3649-3662, 2000.
17. Liu H, Stupak J, Zheng J, Keller BO, Brix BJ, Fliegel L, Li L. Open tubular immobilized metal ion affinity chromatography combined with MALDI MS and MS/MS for identification of protein phosphorylation sites. Anal Chem 76: 4223-4232, 2004.
18. Maekawa N, Abe J, Shishido T, Itoh S, Ding B, Sharma VK, Sheu SS, Blaxall BC, Berk BC. Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation 113: 2516-2523, 2006.
19. 771. J Biol Chem 282: 6292-6299, 2007.
20. + exchange in M-1 cortical collecting duct cells via a PKC-MAPK pathway. Nephron Physiol 99: p1-9, 2005.
21. + Exchanger, edited by Fliegel L. Austin TX: R. G. Landes, 1996, p. 21-46.
22. Moe OW, Miller RT, Horie S, Cano A, Preisig PA, Alpern RJ. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. J Clin Invest 88: 1703-1708, 1991.
23. + exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium. J Biol Chem 27: 16113-16122, 2001.
24. + exchanger in the rat myocardium by MAP-kinase-dependent pathways. J Biol Chem 274: 22985-22992, 1999.
25. + exchanger. Eur J Biochem 268: 4674-4685, 2001.
26. + exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines. J Cell Sci 109: 929-939, 1996.
27. + exchanger subtypes in the renal tubule: function and regulation in physiology and disease. Exp Nephrol 5: 277-284, 1997.
28. + exchanger subtype 3 in various cell types. Pflügers Arch 436: 797-800, 1998.
29. Sharrocks AD, Yang SH, Galanis A. Docking domains and substrate-specificity determination for MAP kinases. Trends Biochem Sci 25: 448-453, 2000.
30. Shaw G, Morse S, Ararat M, Graham FL. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J 16: 869-871, 2002.
31. + exchanger isoform 1. Biochem J 379: 31-38, 2004.
32. + exchanger. J Biol Chem 280: 17863-17872, 2005.
33. Su HW, Wang SW, Ghishan FK, Kiela PR, Tang MJ. Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation. Am J Physiol Cell Physiol 296: C13-C24, 2009.
34. Su HW, Yeh HH, Wang SW, Shen MR, Chen TL, Kiela PR, Ghishan FK, Tang MJ. Cell confluence-induced activation of signal transducer and activator of transcription-3 (Stat3) triggers epithelial dome formation via augmentation of sodium hydrogen exchanger-3 (NHE3) expression. J Biol Chem 282: 9883-9894, 2007.
35. + exchanger isoforms in inner segment of inner medullary collecting duct. J Membr Biol 164: 293-300, 1998.
36. + exchanger isoform 1 (NHE1). J Biol Chem 269: 5583-5588, 1994.
37. Wallert MA, Fröhlich O. Na-H exchange in isolated myocytes from rat heart. Am J Physiol Cell Physiol 257: C207-C213, 1989.
38. + exchanger through mitogen-activated protein kinase. Biochemistry 36: 9151-9158, 1997.
39. + antiporter potentiates growth and retinoic-acid induced differentiation of P19 embryonal carcinoma cells. J Biol Chem 272: 26545-26549, 1997.
40. 2-regulated adenylyl cyclases from changes in intracellular pH. J Biol Chem 280: 30864-30872, 2005.
41. Wu ML, Vaughan-Jones RD. Interaction between Na and H ions on Na-H exchange in sheep cardiac Purkinje fibers. J Mol Cell Cardiol 29: 1131-1140, 1997.