The Na+/H+ exchanger gene family

Journal of Nephrology

Volumn 15, Issue SUPPL. 5, 2002, Pages

  Burckhardt, Gerhard ^a   Di Sole, Francesca ^a   Helmle Kolb, Corinna ^a  

^a Abteilung Vegetative Physiologie und Pathophysiologie   (Germany)

Author keywords

Bicarbonate absorption; Disease; Kidney; NHE 1; NHE 3; Regulation

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 5 (N ETHYL N ISOPROPYL)AMILORIDE; AMILORIDE; AMINO ACID; BICARBONATE; CHELERYTHRINE; CYTOCHALASIN D; DEXAMETHASONE; DOPAMINE; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOXORUBICIN; ENDOTHELIN; GLUCOCORTICOID; ISOTHIOCYANIC ACID DERIVATIVE; OKADAIC ACID; PARATHYROID HORMONE; PHORBOL ESTER; PROTEIN KINASE; SODIUM CHLORIDE; SODIUM ION; SODIUM PROTON ECHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM PROTON EXCHANGE PROTEIN 4; SODIUM PROTON EXCHANGE PROTEIN 5; SODIUM PROTON EXCHANGE PROTEIN 6; STILBENE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WORTMANNIN;

ACIDOSIS; AMINO TERMINAL SEQUENCE; APICAL MEMBRANE; BINDING AFFINITY; BLOOD PRESSURE; CARBOXY TERMINAL SEQUENCE; CATION EXCHANGE; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; CLONE; CYTOSKELETON; DIURESIS; DOWN REGULATION; DRUG ACTIVITY; DRUG SCREENING; HUMAN; IC 50; ION EXCHANGE; KIDNEY; KIDNEY MEDULLA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE BASEMENT MEMBRANE; KIDNEY TUBULE CELL; KNOCKOUT GENE; MOLECULAR DYNAMICS; MULTIGENE FAMILY; MUSCLE HYPOTONIA; NEPHRON; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; RENOVASCULAR HYPERTENSION; REVIEW; SALURESIS; SODIUM ABSORPTION; SODIUM RESTRICTION; SURVIVAL; TISSUE DISTRIBUTION; WATER RETENTION; ABSORPTION; ANIMAL; GENETICS; METABOLISM; PHYSIOLOGY;

ABSORPTION; ANIMAL; BICARBONATES; HUMAN; KIDNEY; MULTIGENE FAMILY; SODIUM-HYDROGEN ANTIPORTER; TISSUE DISTRIBUTION; ANIMALS; HUMANS;

EID: 0036262995     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (183)

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2. + antiporter in rat proximal tubule bicarbonate absorption
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4. +-ATPase in the medullary thick ascending limb of rat kidney
5. + exchange in rat medullary thick ascending limb
6. Sodium, bicarbonate, and chloride absorption by the proximal tubule
7. + exchanger isoforms
8. + exchanger gene family: Structure and function studies
9. + exchanger isoform NHE1: Role of phosphorylation
10. + exchanger subtypes in the renal tubule: Function and regulation in physiology and disease
11. + exchangers
12. + exchangers NHE2 and NHE3
13. Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: Role of phosphorylation, protein trafficking, and regulatory factors
14. + exchangers
15. Sodium chloride transport in the loop of Henle, distal convoluted tubule, and collecting duct
16. + exchanger isoform by the cytoskeleton
17. Sodium/proton antiport in brush border membrane vesicles isolated from rat small intestine and kidney
18. + exchanger
19. Properties and physiological roles of the plasma membrane sodium-hydrogen exchanger
20. + antiporter
21. + antiporter, a glycoprotein of 110 kDa
22. Molecular cloning of putative members of the Na/H exchanger gene family
23. + exchanger
24. + exchanger NHE-1
25. + antiporter: Localization to chromosome 1 by in situ hybridization
26. Na/H antiporter mRNA expression in single nephron segments of rat kidney cortex
27. Proton pathways in rat renal brush-border and basolateral membranes
28. + exchanger isoforms in inner segment of inner medullary collecting duct
29. Al-Adrenergic receptors activate. NHE1 and NHE3 through distinct signaling pathways in epithelial cells
30. + exchanger isoform NHE-1 in rabbit kidney
31. + exchanger in A6 cells
32. Different development of apical and basolateral Na-H exchangers in LLC-PK1 renal epithelial cells: Characterization by inhibitors and antisense oligonucleotide
33. + exchanger
34. + exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers
35. + exchanger: Identification of thiol-dependent transitions in apparent molecular size
36. + exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain
37. + exchanger in LLC-PK1 renal epithelial cells
38. + exchanger: Evidence that the cytoplasmic domain mediates hormonal regulation
39. + exchanger isoform 1
40. + exchanger NHE1 showing defective surface expression
41. +-sensing"
42. Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger
43. + exchanger-1
44. + exchanger reveal the participation of TM4 into a highly constrained sodium-binding-site
45. + exchanger
46. + exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis
47. + exchanger that confer sensitivity to pharmacological antagonists
48. + exchanger
49. 2+ responsiveness to the apical isoform NHE3
50. Ontogeny of basolateral membrane sodium-hydrogen exchange (NHE) activity and mRNA expression of NHE-1 and NHE-4 in rat kidney and jejunum
51. Effect of glucocorticoids on renal cortical NHE-3 and NHE-1 mRNA
52. Ontogeny of rabbit renal cortical NHE3 and NHE1: Effect of glucocorticoids
53. + exchanger isoforms NHE-2 and NHE-1 in inner medullary collecting duct cells. Expression, functional localization, and differential regulation
54. + antiporter
55. + exchanger: An update on structure, regulation and cardiac physiology
56. + exchanger, NHE-1, by phosphorylating a set of common sites
57. + exchanger isoform-1 kinase
58. + exchanger stably expressed in chinese hamster ovary cells
59. + exchangers stably expressed in a fibroblast cell line
60. -
61. + exchanger (NHE1): pH-maintenance, ATP-sensitive, and flexible loop domains
62. + exchange requires phosphatidylinositol 4,5-bisphosphate
63. + exchangers
64. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange
65. 2+-regulation-defective
66. + exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation
67. + exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins
68. + exchange
69. Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice
70. + exchanger null mutant mouse
71. Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension
72. Molecular mechanisms of sodium transport inhibition in proximal tubule during acute hypertension
73. Sodium proton exchanger (NHE) isoforms - Potential relevance to hypertension and its complications
74. + exchanger in the injured renal tissues of focal glomerulosclerosis in rats
75. +-proton exchanger
76. + exchange in glomerular mesangial cells
77. Why do we have to invoke genetic susceptibility for diabetic nephropathy?
78. + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
79. Regulation of the formation of tumor cell pseudopodia by Na/H exchanger NHE1
80. + exchanger by CD95 (Fas/Apo-1)-receptor stimulation
81. + exchanger (SLC9A2)
82. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger
83. + exchanger (NHE-2)
84. + exchanger isoform (NHE-2)
85. Molecular cloning and characterization of the rat NHE-2 gene promoter
86. Epidermal growth factor regulation of rat NHE2 gene expression
87. + exchanger-2 (NHE-2) gene
88. + exchanger isoforms NHE2 and NHE4 in rat intestine and kidney
89. + exchanger isoform 2 (NHE2) is expressed in the apical membrane of the medullary thick ascending limb
90. + exchanger mRNAs in rat medullary thick ascending limb
91. Increased NHE2 expression in rat intestinal epithelium during ontogeny is transcriptionally mediated
92. + exchanger isoform NHE2 in rat kidney
93. + exchanger-2 is an O-linked but not an N-linked sialoglycoprotein
94. Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells
95. + exchanger isoform (NHE-2)
96. + exchanger (NHE-2)
97. Expression of rat, renal NHE2 and NHE3 during postnatal development
98. + exchanger isoforms NHE2 and NHE3: An effect opposite to that on NHE1
99. + exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways
100. + exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion
101. + exchanger isoform, NHE3
102. + exchanger isoform (NHE-3)
103. + exchanger Nhe3 gene
104. Characterization of the rat NHE3 promoter
105. + exchanger (NHE3) isoform to chromosome 5p15.3
106. + exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA
107. + exchangers NHE2 and NHE3 alter net bicarbonate movement
108. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins
109. + exchanger isoform of renal brush border
110. Expression of NHE-3 in the apical membrane of rat renal proximal tubule and thick ascending limb
111. Monoclonal antibodies for high-resolution localization of NHE3 in adults and neonatal rat kidney
112. + exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines
113. + exchanger isoforms and their regulation by thyroid hormone
114. + exchanger isoform NHE-3 in rabbit and canine kidney
115. -) exit
116. Glucocorticoids regulate NHE-3 transcription in OKP cells
117. Chronic metabolic acidosis enhances NHE-3 protein abundance and transport activity in the rat thick ascending limb by increasing NHE-3 mRNA
118. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney
119. + exchangers: An epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic domain for regulation by protein kinases
120. + exchanger isoform 3 stably expressed in fibroblasts by fibroblasts growth factor and phorbol esters is not through changes in phosphorylation of the exchanger
121. + exchanger NHE3 isoform
122. + exchanger isoform NHE4 and localization in rat hippocampus
123. + exchanger in renal proximal tubule cells
124. Activation of protein kinase A acutely inhibits and phosphorylates Na/H exchanger NHE-3
125. Na/H exchange activities in NHE1-transfected OK-cells: Cell polarity and regulation
126. + exchange activity in LLC-PK1/PKW20 cells II. Hormonal regulation
127. + exchanger NHE3 isoform by binding to the PTH/PTHRP receptor type I and activating distinct signaling pathways
128. Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney
129. + exchange in opossum kidney cells by parathyroid hormone, cyclic AMP and phorbol esters
130. + exchanger NHE-3 isoform in renal cells (OK) via a dual signaling cascade involving protein kinase A and C
131. + exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors
132. + exchanger NHE3 and the cytoskeletal protein ezrin
133. + exchanger isoform NHE3 is regulated by the actin cytoskeleton
134. + exchanger NHE3 activity by cAMP-dependent protein kinases
135. Acute inhibition of Na/H exchanger NHE-3 by cAMP
136. + exchanger (NHE3) endocytosis via clathrin-coated vesicles
137. Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: Role of NHE3 phosphorylation
138. + exchanger by cAMP-dependent protein kinase
139. + exchanger
140. NHERF: Targeting and trafficking membrane proteins
141. Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins
142. Signal complex regulation of the renal transport proteins: NHERF and regulation of NHE3 by PKA
143. Differential renal distribution of NHERF isoforms and their localization with NHE3, ezrin, and ROMK
144. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3
145. + exchange in OK cells
146. + exchanger, NHE3, requires an associated regulatory protein
147. Parathyroid hormone-induced translocation of Na-H antiporters in rat proximal tubules
148. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition
149. + exchanger, NHE3, is internalized through a clathrin-mediated pathway
150. + exchanger NHE3 by parathyroid hormone via NHE3 phosphorylation and dynamin-dependent endocytosis
151. + exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway
152. + exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase
153. Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis
154. Reversible effects of acute hypertension on proximal tubule sodium transporters
155. + exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension
156. ETB receptor activation causes exocytotic insertion of NHE3 in OKP cells
157. Endothelin-1/endothelin-B receptor-mediated increase in NHE3 activity in chronic metabolic acidosis
158. Mechanism of proximal tubule bicarbonate absorption in NHE3 null mice
159. Micropuncture analysis of single-nephron function in NHE3-deficient mice
160. + exchange - Adaptation to metabolic acidosis
161. Acid incubation causes exocytic insertion of NHE3 in OKP cells
162. Adaptation of NHE-3 in the thick ascending limb: Effects of high sodium intake and metabolic alkalosis
163. Regulation of proximal tubule sodium/hydrogen antiporter with chronic volume contraction
164. + exchangers in health and disease processes
165. +-ATPase activities in spontaneously hypertensive rats
166. + exchanger isoforms 1 and 3 in kidney proximal tubules of hypertensive rats
167. + exchanger interactions in the kidney in hypertension
168. D1 dopamine receptor regulation of NHE3 during development in spontaneously hypertensive rats
169. Sodium-hydrogen exchange and glucose transport in renal microvillus vesicles from rats with diabetes mellitus
170. Chronic hyperosmolality increases NHE3 activity in OKP cells
171. Altered expression of Na transporters NHE-3, NaPi-II, Na-K-ATPase, BSC-1, and TSC in CRF rat kidneys
172. + transporters in kidneys of rats with ischemia-induced acute renal failure
173. A possible molecular basis of natriuresis during ischemic-reperfusion injury in the kidney
174. Distribution and regulation of renal ecto-5′-nucleotidase: Implications for physiological functions of adenosine
175. Adenosine activates aromatic L-amino acid decarboxylase activity in the kidney and increases dopamine
176. + exchanger in rat renal cortical tubules
177. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity
178. + exchanger isoform NHE4
179. + exchanger isoform
180. + exchanger isoforms in rabbit parietal and mucous cells
181. + exchanger (NHE5/SLC9A5) to chromosome 16q22.1
182. + exchanger isoform 5 (NHE5) from human brain
183. + exchanger