A novel carbonic anhydrase II binding site regulates NHE1 activity

Biochemistry

Volumn 45, Issue 7, 2006, Pages 2414-2424

  Li, Xiuju ^a   Liu, Yongsheng ^a   Alvarez, Bernardo V ^a   Casey, Joseph R ^a   Fliegel, Larry ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBON; CYTOLOGY; ION EXCHANGE; MUTAGENESIS; SODIUM;

CAII BINDING; CARBONIC ANHYDRASE II (CAII); NA +/H+; PHOSPHORYLATION;

ENZYMES;

AMINO ACID; BICARBONATE; CARBONATE DEHYDRATASE II; CELL EXTRACT; HYBRID PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1;

ACIDITY; ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HEART MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; BICARBONATES; BINDING SITES; CARBONIC ANHYDRASE II; GLUTATHIONE TRANSFERASE; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; SODIUM-HYDROGEN ANTIPORTER;

ANIMALIA; MAMMALIA;

EID: 33144457846     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051132d     Document Type: Article

References (38)

1. Fliegel, L. (2005) The Na(+)/H(+) exchanger isoform 1, Int. J. Biochem. Cell Biol. 37, 33-37.
2. + antiporter, Cell 56, 271-280.
3. + Exchanger, From Molecular to Its Role in Disease (Karmazyn, M., Avkiran, M., and Fliegel, L., Eds.) pp 17-34, Kluwer Academic Publishers, Boston/Dordrecht/London, 318 p.
4. + exchanger: a potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure, Drugs 61, 375-389.
5. Karmazyn, M., Liu, Q., Gan, X. T., Brix, B. J., and Fliegel, L. (2003) Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes, Hypertension 42, 1171-1176.
6. Karmazyn, M. (2001) Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target, Basic Res. Cardiol. 96, 325-328.
7. + exchangers, J. Biol. Chem. 276, 17367-17372.
8. + exchanger NHE1 through sequence specific interaction, Biochemistry 36, 12854-12861.
9. + exchanger interacts with mammalian heat shock protein, Biochemistry 34, 10412-10420.
10. + exchanger isoform 1 (NHE1) in ischemic and ischemic-reperfused rat heart, J. Biol. Chem. 27, 16113-16122.
11. Sly, W. S., and Hu, P. Y. (1995) Human carbonic anhydrase and carbonic anhydrase deficiencys, Annu. Rev. Biochem. 64, 375-601.
12. Cousin, J. L., Motais, R., and Sola, F. (1975) J. Physiol. (London) 253, 385-399.
13. - exchanger, J. Biol. Chem. 273, 28430-28437.
14. McMurtrie, H. L., Cleary, H. J., Alvarez, B. V., Loiselle, F. B., Sterling, D., Morgan, P. E., Johnson, D. E., and Casey, J. R. (2004) The bicarbonate transport metabolon, J. Enzyme Inhib. Med. Chem. 19, 231-236.
15. - anion exchanger AE1, Biochemistry 39, 5527-5533.
16. + exchanger, J. Biol. Chem. 277, 36085-36091.
17. + exchanger, Biochemistry 43, 16477-16486.
18. + exchanger, FEBS Lett. 279, 25-29.
19. + exchanger in the rat myocardium by MAP-kinase-dependent pathways, J. Biol. Chem. 274, 22985-22992.
20. + exchanger isoform 1, Biochem. J. 379, 31-38.
21. + exchanger, J. Biol. Chem. 280, 17863-17872.
22. + exchanger, Eur. J. Biochem. 268, 1-13.
23. + exchangers, Biochem. J. 357, 1-10.
24. Ro, H. A., and Carson, J. H. (2004) pH microdomains in oligodendrocytes, J. Biol. Chem. 279, 37115-37123.
25. Sterling, D., Reithmeier, R. A. F., and Casey, I. R. (2001) A transport metabolon: Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers, J. Biol. Chem. 276, 47886-47894.
26. 2+/calmodulin-dependent protein kinase II, Biochem. J. 282, 139-145.
27. Sterling, D., Reithmeier, R. A., and Casey, J. R. (2001) Carbonic anhydrase: in the driver's seat for bicarbonate transport, Jop 2, 165-170.
28. Sterling, D., Alvarez, B. V., and Casey, J. R. (2002) The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV, J. Biol. Chem, 277, 25239-25246.
29. Alvarez, B. V., Loiselle, F. B., Supuran, C. T., Schwartz, G. J., and Casey, J. R. (2003) Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter, Biochemistry 42, 12321-12329.
30. + isoform 1 mutant mice, J. Clin. Invest. 104, 637-645.
31. + antiport in lymphocytes, Am. J. Physiol. 256, C428-433.
32. + exchanger transcript, Biochim, Biophys. Acta 1129, 105-108.
33. + exchanger NHE1, Biochim. Biophys. Acta 1172, 343-345.
34. + exchanger gene family, J. Biol. Chem. 267, 9331-9339.
35. + exchanger: evidence that the cytoplasmic domain mediates hormonal regulation, Proc. Natl. Acad. Sci. U.S.A. 89, 6765-6769.
36. + exchanger from Amphiuma RBCs: resemblance to mammalian NHE1, Am. J. Physiol. 276, C1025-1037.
37. + exchanger isoform (NHE-3), J. Biol. Chem. 267, 9340-9346.
38. + exchanger isoform 5 (NHE5) from human brain, J. Biol. Chem. 274, 4377-4382.