Functional role of polar amino acid residues in Na+/H+ exchangers

Biochemical Journal

Volumn 357, Issue 1, 2001, Pages 1-10

  Wiebe, C A ^a   DiBattista, E R ^a   Fliegel, L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Cation co ordination; Charge relay system; Membrane protein; pH regulation; Salt tolerance

Indexed keywords

AMINO ACIDS; BINDING ENERGY; ESCHERICHIA COLI; ION EXCHANGERS; PHYSIOLOGY; YEAST;

FUNCTIONAL ANALOGUES;

BIOCHEMISTRY;

AMINO ACID; ANTIPORTER; ASPARTIC ACID; GLUTAMIC ACID; HISTIDINE; MEMBRANE PROTEIN; PROTEIN NHAA; PROTEIN SOD2; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; CARBOXY TERMINAL SEQUENCE; CATION EXCHANGE; CELL PH; ESCHERICHIA COLI; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; REGULATORY MECHANISM; REVIEW; SODIUM TRANSPORT; YEAST;

AMINO ACID SEQUENCE; ANIMALS; BACTERIA; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HISTIDINE; HUMANS; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM-HYDROGEN ANTIPORTER; YEASTS;

EID: 0035396616     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3570001     Document Type: Review

References (86)

1. + exchanger: An overview
2. + exchangers
3. Sodium tolerance and export from yeast cells
4. + antiporter coded by NhaA (ant) from Escherichia coli
5. + antiporter from Escherichia coli
6. Common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells
7. + exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation
8. + antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH
9. + antiporter isoforms in cell volume regulation
10. + exchanger. Structure, regulation, and its role in heart disease
11. + antiport?
12. + antiporter of Escherichia coli is exposed and faces the cell exterior
13. + exchanger in renal microvillus membrane vesicles
14. + exchangers of mammalian cells
15. +-sensing'
16. + exchangers: Its known and putative members, and what can be learned by comparing them with each other
17. + antiporters
18. Bioenergetic coupling to protonmotive force: Should we be considering hydronium ion coordination and not group protonation?
19. In the uncoupling protein (UCP-1) His-214 is involved in the regulation of purine nucleoside triphosphate but not diphosphate binding
20. Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
21. Interaction between residues Glu269 (helix VIII) and His322 (helix X) of the lactose permease of Escherichia coli is essential for substrate binding
22. Involvement of histidine-21 in the pH-induced switch in porin channel size
23. + transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-1 and UCP-3
24. Characterization of site-directed mutants in the lac permease of Escherichia coli. 1. Replacement of histidine residues
25. + translocation
26. + antiporter
27. Histidine-419 plays a role in energy coupling in the vesicular monoamine transporter from rat
28. Identification of histidine residues in Wolinella succinogenes hydrogenase that are essential for menaquinone reduction by H2
29. + transfer reactions on the donor side of photosystem II
30. Conserved residues and motifs in the NixA protein of Helicobacter pylori are critical for the high affinity transport of nickel ions
31. Protonation of histidine-132 promotes oligomerization of the channel-forming toxin aerolysin
32. A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors
33. pH and calcium regulate the water permeability of aquaporin O
34. + uptake channels
35. + channels KST1 and KAT1
36. + sensing of ROMK1 channel
37. + channel family
38. + channel. An extracellular histidine as pH sensor
39. Differential sensitivity of voltage-gated potassium channels Kv1.5 and Kv1.2 to acidic pH and molecular identification of pH sensor
40. A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2
41. Role of histidine 95 on pH gating of the cardiac gap junction protein connexin 43
42. Three-dimensional structure of the ion-coupled transport protein NhaA
43. + antiport in Escherichia coli membrane vesicles
44. + antiporter in Escherichia coli
45. + antiporter of Escherichia coli. Cysteine (H226C) or serine (H226S) retain both normal activity and pH sensitivity, aspartate (H226D) shifts the pH profile toward basic pH, and alanine (H226A) inactivates the carrier at all pH values
46. + antiporter of Escherichia coli involves loop VIII-IX, plays a role in the pH response of the protein, and is maintained by the pure protein in dodecyl maltoside
47. + exchanger of fission yeast
48. + antiporter confers sodium and lithium tolerance in fission yeast
49. + antiporter (NhaA) from Escherichia coli
50. + exchanger by histidine-specific reagents
51. + exchanger of thymic lymphocytes. Inhibition by N-ethylmaleimide
52. + exchanger
53. + exchanger isoform 1
54. + exchanger
55. Cation and sugar selectivity determinants in a novel family of transport proteins
56. + translocation by bacteriorhodopsin
57. + donor in the reprotonation of the Schiff base of bacteriorhodopsin
58. 2+ exchanger
59. 2+-ATPase of sarcoplasmic reticulum
60. +-ATPase
61. +-ATPase
62. +-ATPase
63. Single-cell analysis of the intracellular pH and its regulation during the monocytic differentiation of U937 human leukemic cells
64. +-ATPases studied by site-directed mutagenesis
65. +-ATPase is a pivotal residue for cation-induced conformational changes
66. + antiporter from Vibrio alginolyticus play a role in the activity of the carrier
67. + antiporter (NhaA) from Escherichia coli by random mutagenesis
68. + antiporter from Vibrio parahaemolyticus
69. +-antiporter of the yeast Saccharomyces cerevisiae
70. +-antiporter gene closely related to the salt-tolerance of yeast Zygosaccharomyces rouxii
71. + exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis
72. + exchanger that confer sensitivity to pharmacological antagonists
73. + exchanger isoform (NHE-2)
74. + exchanger
75. + antiporter (NHE-1) in baculovirus-infected cells
76. + antiporter from Escherichia coli
77. Cloning, sequencing and expression of the nhaA and nhaR genes from Salmonella entiritidis
78. + antiporter gene from the marine bacterium Vibrio alginolyticus
79. +-antiporter gene closely related to the salt-tolerance of yeast Zygosacchromyces rouxii
80. +-antiporter of the yeast Saccharomyces cerevisiae
81. + antiporter
82. + exchanger NHE2
83. + exchanger isoform, NHE3
84. + exchanger gene family
85. + exchanger: Evidence that the cytoplasmic domain mediates hormonal regulation
86. TopPredll: An improved software for membrane protein structure predictions