NhaA of Escherichia coli, as a model of a pH-regulated Na +/H+antiporter

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1658, Issue 1-2, 2004, Pages 2-13

  Padan, E ^a   Tzubery, T ^a   Herz, K ^a   Kozachkov, L ^a   Rimon, A ^a   Galili, L ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Active transport; EcNhaA or NhaA; Membrane protein; MIANS; Na+ H+ antiporter; NhaA; NhaA of Escherichia coli; NhaA of Vibrio cholerae; pH regulation; TMS; transmembrane segment; VcNhaA

Indexed keywords

ANTIPORTER; BACTERIAL PROTEIN; LIGAND; MEMBRANE PROTEIN; MUTANT PROTEIN; PROTEIN NHAA; PROTON; SODIUM ION; TRYPSIN; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; CONFORMATIONAL TRANSITION; ESCHERICHIA COLI; EUKARYOTIC CELL; HOMEOSTASIS; MUTATION; PH; PRIORITY JOURNAL; PROKARYOSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN STRUCTURE; REVIEW; SENSOR;

AMINO ACID SEQUENCE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; EUKARYOTIC CELLS; HOMEOSTASIS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUTATION; PROKARYOTIC CELLS; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER; VIBRIO CHOLERAE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; MAMMALIA; PROKARYOTA; VIBRIO; VIBRIO CHOLERAE;

EID: 3543038254     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2004.04.018     Document Type: Review

References (85)

1. + antiporters - molecular biology, biochemistry and physiology. Konings W.N., Kaback H.R., Lolkema J. The Handbook of Biological Physics. vol. II:1996;501-531 Elsevier, The Netherlands
2. Padan E., Krulwich T.A. Sodium stress. Storz G., Hengge-Aronis R. Bacterial Stress Responses. 2000;117-130 ASM Press, Washington, DC
3. + antiporters. Biochim. Biophys. Acta. 1505:2001;144-157
4. Orlowski J., Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch.-Eur. J. Physiol. 447:2003;549-565
5. + exchangers. Biochem. J. 357:2001;1-10
6. + exchangers. J. Biol. Chem. 275:2000;1-4
7. + antiporter system(s). J. Biol. Chem. 264:1989;20297-20302
8. + antiporter in Escherichia coli. J. Biol. Chem. 268:1993;1729-1734
9. + antiporter-deficient strains by the overexpressed gene. J. Biol. Chem. 268:1993;11296-11303
10. Rahav-Manor O., Carmel O., Karpel R., Taglicht D., Glaser G., Schuldiner S., Padan E. NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR), regulates nhaA, the sodium proton antiporter gene in Escherichia coli. J. Biol. Chem. 267:1992;10433-10438
11. + antiporter gene in Escherichia coli. EMBO J. 13:1994;1981-1989
12. + antiporter of Escherichia coli. EMBO J. 16:1997;5922-5929
13. Schell M. Molecular biology of the LysR family of transcriptional regulators. Annu. Rev. Microbiol. 47:1993;597-626
14. Storz G., Tartaglia L., Ames B. Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Science. 248:1990;189-194
15. + antiporter in Escherichia coli, is positively regulated by nhaR and affected by hns. J. Bacteriol. 178:1996;6508-6517
16. + antiporter activity in Escherichia coli. J. Biol. Chem. 263:1988;10408-10414
17. + and growth phase. J. Bacteriol. 183:2001;644-653
18. Hengge-Aronis R. Survival of hunger and stress: the role of rpoS in stationary phase gene regulation in Escherichia coli. Cell. 72:1993;165-168
19. Hengge-Aronis R. The general stress response in Escherichia coli. Storz G., Hengge-Aronis R. Bacterial Stress Responses. 2000;161-178 ASM Press, Washington, DC
20. Hengge-Aronis R. Recent insights into the general stress response regulatory network in Escherichia coli. J. Mol. Microbiol. Biotechnol. 4:2002;341-346
21. + antiporter involved in environmental survival of Vibrio cholerae. J. Bacteriol. 182:2000;2937-2944
22. + antiporters in the survival of Vibrio cholerae in saline environment. J. Bacteriol. 185:2002;1236-1244
23. + pump in the marine bacterium Vibrio alginolyticus. J. Biol. Chem. 257:1982;10007-10014
24. Hase C.C., Fedorova N.D., Galperin M.Y., Dibrov P.A. Sodium ion cycle in bacterial pathogens: evidence from cross-genome comparisons. Microbiol. Mol. Biol. Rev. 65:2001;353-370
25. Hase C.C., Barquera B. Role of sodium bioenergetics in Vibrio cholerae. Biochim. Biophys. Acta. 1505:2001;169-178
26. +and pH. Karmazyn M., Avkiran M., Fliegel L. The Sodium Hydrogen Exchanger, from Molecule to its Role in Disease. 2003;91-108 Kluwer Academic Publishers, The Netherlands
27. + antiporter coded by nhaA (ant) from Escherichia coli. J. Biol. Chem. 266:1991;11289-11294
28. Taglicht D., Padan E., Schuldiner S. Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli. J. Biol. Chem. 268:1993;5382-5387
29. + antiporter of Escherichia coli for 3D and 2D crystallization. Hunte C., Von Jagow G., Schagger H. A Practical Guide to Membrane Protein Purification. second ed.:2002;179-190 Academic Press, Amsterdam
30. + antiporter from Escherichia coli. J. Biol. Chem. 271:1996;32288-32292
31. + antiporter of Escherichia coli is exposed and faces the cell exterior. J. Biol. Chem. 272:1997;1761-1768
32. Williams K.A., Geldmacher-Kaufer U., Padan E., Schuldiner S., Kuhlbrandt W. Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 A resolution. EMBO J. 18:1999;3558-3563
33. + antiporter of Escherichia coli in the membrane and its functional and structural consequences. Biochemistry. 40:2001;3403-3412
34. Williams K.A. Three-dimensional structure of the ion-coupled transport protein NhaA. Nature. 403:2000;112-115
35. Kaback H.R., Sahin-Toth M., Weinglass A.B. The kamikaze approach to membrane transport. Nat. Rev., Mol. Cell. Biol. 2:2001;610-620
36. Yu H., Kono M., McKee T.D., Oprian D.D. A general method for mapping tertiary contacts between amino acid residues in membrane-embedded proteins. Biochemistry. 34:1995;14963-14969
37. Wu J., Kaback H.R. A general method for determining helix packing in membrane proteins in situ: helices I and II are close to helix VII in the lactose permease of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 93:1996;14498-14502
38. Kaback H.R., Voss J., Wu J. Helix packing in polytopic membrane proteins: the lactose permease of Escherichia coli. Curr. Opin. Struct. Biol. 7:1997;537-542
39. Careaga C.L., Falke J.J. Structure and dynamics of Escherichia coli chemosensory receptors, engineered sulfhydryl studies. Biophys. J. 62:1992;209-216
40. Green N.S., Reisler E., Houk K.N. Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers. Protein Sci. 10:2001;1293-1304
41. + antiporter of Escherichia coli as determined by site-directed thiol cross-linking. Biochemistry. 41:2002;14897-14905
42. + antiporter of Escherichia coli observed on site-directed chemical cross-linking. J. Biol. Chem. 275:2000;5270-5274
43. Sun J., Kaback H.R. Proximity of periplasmic loops in the lactose permease of Escherichia coli determined by site-directed cross-linking. Biochemistry. 36:1997;11959-11965
44. Ding P.Z., Wilson T.H. The proximity between helix I and helix XI in the melibiose carrier of Escherichia coli as determined by cross-linking. Biochim. Biophys. Acta. 1514:2001;230-238
45. + antiporter of Escherichia coli. Biochemistry. 41:2002;609-617
46. + antiporter (NhaA) from Escherichia coli. FEBS Lett. 363:1995;264-268
47. + antiporter (NhaA) from Escherichia coli by random mutagenesis. J. Biochem. (Tokyo). 121:1997;661-670
48. + in the c subunit of the ATP synthase from Propionigenium modestum. Biochemistry. 36:1997;9185-9194
49. + specificity as revealed by sequence comparison. FEBS Lett. 404:1997;269-271
50. + antiporter in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 90:1993;1212-1216
51. + antiporter of Escherichia coli, cysteine (H226C) or serine (H226S) retain both normal activity and pH sensitivity, aspartate (H226D) shifts the pH profile toward basic pH, and alanine (H226A) inactivates the carrier at all pH values. J. Biol. Chem. 270:1995;26813-26817
52. + antiporter as well as the growth phenotype of Escherichia coli. J. Biol. Chem. 273:1998;26470-26476
53. + antiporter of Escherichia coli. J. Biol. Chem. 279:2004;23104-23113
54. + antiporter of Escherichia coli. J. Biol. Chem. 275:2000;4734-4742
55. + antiporter of Escherichia coli involves loop VIII-IX, plays a role in the pH response of the protein, and is maintained by the pure protein in dodecyl maltoside. J. Biol. Chem. 274:1999;24617-24624
56. + antiporter of Escherichia coli. J. Biol. Chem. 279:2004;3265-3272
57. + antiporter of Escherichia coli. FEBS Lett. 441:1998;53-58
58. + antiporter NhaA from Escherichia coli. Biochem. Biophys. Acta. 1610:2003;46-50
59. + antiporter from Escherichia coli, with trypsin. Biochemistry. 36:1997;14572-14576
60. Gupte S.S., Lane L.K. Reaction of purified (Na,K)-ATPase with the fluorescent sulfhydryl probe 2-(4′-maleimidylanilino)naphthalene 6-sulfonic acid. Characterization and the effects of ligands. J. Biol. Chem. 254:1979;10362-10369
61. Wu J., Frillingos S., Voss J., Kaback H.R. Ligand-induced conformational changes in the lactose permease of Escherichia coli: evidence for two binding sites. Protein Sci. 3:1999;2294-2301
62. Gupte S.S., Lane L.K. Reaction of (Na,K)-ATPase with fluorescent maleimide derivatives. Probes for studying ATP site(s) function. J. Biol. Chem. 258:1983;5005-5012
63. Bigelow D.J., Inesi G. Frequency-domain fluorescence spectroscopy resolves the location of maleimide-directed spectroscopic probes within the tertiary structure of the Ca-ATPase of sarcoplasmic reticulum. Biochemistry. 30:1991;2113-2125
64. Phillips W.J., Cerione R.A. Labeling of the beta gamma subunit complex of transducin with an environmentally sensitive cysteine reagent. Use of fluorescence spectroscopy to monitor transducin subunit interactions. J. Biol. Chem. 266:1991;11017-11024
65. May J.M., Beechem J.M. Monitoring conformational change in the human erythrocyte glucose carrier: use of a fluorescent probe attached to an exofacial carrier sulfhydryl. Biochemistry. 32:1993;2907-2915
66. + antiporter in Escherichia coli. J. Exp. Biol. 196:1994;443-456
67. + antiporter of Vibrio parahaemolyticus. Biochem. Biophys. Res. Commun. 222:1996;774-779
68. Rosen B. Ion extrusion systems in Escherichia coli. Methods Enzymol. 125:1986;328-336
69. + antiporter gene of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 84:1987;2615-2619
70. + antiporter of Methanococcus jannaschii. FEBS Lett. 527:2002;245-249
71. + antiporters of Helicobacter pylori in antiporter-deficient Escherichia coli mutants. FEBS Lett. 443:1999;11-16
72. + antiporter of M. jannaschii. FEBS Lett. 542:2003;32-36
73. + antiporter, NhaD, of Vibrio cholerae. Mol. Cell. Biochem. 229:2002;119-124
74. + antiporters constructed from NhaA of Helicobacter pylori and Escherichia coli: implications for domains of NhaA for pH sensing. J. Biochem. (Tokyo). 129:2001;569-576
75. + antiporter (NhaA) protein from Helicobacter pylori required for ion transport and pH sensing. J. Biol. Chem. 278:2003;21467-21473
76. + exchanger in renal microvillus membrane vesicles. Nature. 299:1982;161-163
77. + exchanger. Annu. Rev. Physiol. 47:1985;545-560
78. + exchangers by measurement of reverse mode reaction. J. Biol. Chem. 278:2003;43580-43585
79. + exchangers. Physiol. Rev. 77:1997;51-74
80. + exchangers of mammalian cells. J. Biol. Chem. 272:1997;22373-22376
81. + exchanger 1. J. Biol. Chem. 278:2003;11828-11835
82. + exchanger isoform 3 (NHE3) determine the set point. J. Membr. Biol. 191:2003;49-58
83. + exchangers. Ann. N. Y. Acad. Sci. 976:2002;248-258
84. + exchanger-isoform. J. Biol. Chem. 277:2002;11090-11096
85. + exchanger of fission yeast. Biochemistry. 37:1998;8282-8288