Molecular physiology of vertebrate Na+/H+ exchangers

Physiological Reviews

Volumn 77, Issue 1, 1997, Pages 51-74

  Wakabayashi, Shigeo ^a   Shigekawa, Munekazu ^a   Pouyssegur, Jacques ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

PROTON PUMP;

ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSPORT KINETICS;

EID: 0031035914     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.1997.77.1.51     Document Type: Article

References (308)

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148. 13 regulate NHE-1 and intracellular
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165. + exchanger by phorbol esters and growth factors. J. Biol. Chem. 265: 7188-7194, 1990.
166. + antiport activity in rat alveolar epithelial cells. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L138-L147, 1994.
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186. MOE, O. W., R. T. MILLER, S. HORIE, A. CANO, P. A. PREISIG, AND R. J. ALPERN. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. J. Clin. Invest. 88: 1703-1708, 1991.
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189. + exchange and cytopasmic pH in the action of growth factors in human fibroblasts. Nature Lond. 304: 645-648, 1983.
190. + exchange activity. Proc. Natl. Acad. Sci. USA 91: 5898-5902, 1994.
191. + exchanger regulatory cofactor in rabbit renal BBM. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol. 28): F867-F871, 1990.
192. MÜRER, H., U. HOPFER, AND R. KINNE. Sodium/proton antiport in brush border-membrane vesicles isolated from rat small intestine and kidney. Biochem. J. 154: 597-604, 1976.
193. + antiporter from Vibrio alginolyticus play a role in the activity of the carrier. Biochim. Biophys. Acta 1230: 170-176, 1995.
194. + exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1. Am. J. Physiol. 270 (Gastrointest. Liver Physiol. 33): G431-G441, 1996.
195. + exchange assessed by quantification of extracellular acidification. J. Biol. Chem. 267: 25748-25753, 1992.
196. + antiport activity in human hypertension. J. Hypertens. 7: 471-475, 1989.
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198. + exchange in reconstituted liposomal systems. J. Biol. Chem. 257: 2350-2356, 1982.
199. + exchanger isoforms. Am. J. Physiol. 268 (Cell Physiol. 37): C283-C296, 1995.
200. +-antiporter and PKC. Biochim. Biophys. Acta 1178: 267-272, 1993.
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203. ORLOWSKI, J., R. A. KANDASAMY, AND G. E. SHULL. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. J. Biol. Chem. 267: 9331-9339, 1992.
204. + exchanger in the pre-steady state. Implications for the exchange mechanism. J. Biol. Chem. 268: 3184-3193, 1993.
205. OTSU, K., J. L. KINSELLA, E. KOH, AND J. P. FROEHLICH. Proton dependence of the partial reactions of the sodium-proton exchanger in renal brush border membranes. J. Biol. Chem. 267: 8089-8096, 1992.
206. + exchange. Proc. Natl. Acad. Sci. USA 86: 4818-4822, 1989.
207. + influx in human fibroplasts. Proc. Natl. Acad. Sci. USA 79: 3537-3541, 1982.
208. + in cells. Biochim. Biophys. Acta 1185: 129-151, 1994.
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210. +. J. Biol Chem. 259: 10989-10994, 1984.
211. PATHAK, B. G., G. E. SHULL, N. A. JENKINS, AND N. G. COPELAND. Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics 31: 261-263, 1996.
212. + exchanger in Ehrlich ascites tumor cells: mechanisms involved in the activation and a role for the exchanger in cell volume regulation. J. Membr. Biol. 149: 141-159, 1996.
213. +) antiporter. Arch. Biochem. Biophys. 313: 184-188, 1994.
214. + exchanger in platelets. Biochem. J. 290: 617-622, 1993.
215. + exchanger in essential hypertension. Kidney Int. 45: 1037-1043, 1994.
216. + exchange system: a genetic approach. Trends Biochem. Sci. 11: 453-455, 1985.
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218. + antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. Proc. Natl. Acad. Sci. USA 81: 4833-4837, 1984.
219. + exchanger activity and NHE-1 mRNA levels in human lymphocytes during metabolic acidosis. Am. J. Physiol. 266 (Cell Physiol. 35): C480-C488, 1994.
220. RAJENDRAN, V. M., AND H. J. BINDER. Characterization of Na-H exchange in apical membrane vesicles of rat colon. J. Biol. Chem. 265: 8408-8414, 1990.
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222. + exchanger. J. Biol. Chem. 266: 2739-2745, 1991.
223. + antiporter gene expression during monocytic differentiation of HL60 cells. J. Biol. Chem. 266:13485-13488, 1991.
224. + antiporter gene expression in vascular smooth muscle cells by hypertrophic and hyperplastic stimuli. J. Biol. Chem. 265: 19393-19396, 1990.
225. + antiporter gene expression increases during retinoic acid-induced granulocytic differentiation of HL60 cells. J. Cell Physiol. 151: 361-366, 1992.
226. + antiporter is not stimulated by phorbol ester and acidification in granulocytic HL-60 cells. Am. J. Physiol. 264 (Cell Physiol. 33): C1278-C1284, 1993.
227. + pumps in intracellular pH regulation in neonatal rat osteoclasts. J. Gen. Physiol. 105: 177-208, 1995.
228. + exchange and essential hypertension: a new approach. Hypertension Dallas 25: 978-980, 1995.
229. 1 renal epithelial cells. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F1088-F1094, 1991.
230. REITHMEIER, R. A. F. Mammalian exchangers and co-transporters. Curr. Opin. Cell Biol. 6: 583-594, 1994.
231. + antiporter of Escherichia coli: cysteine (H226C) or serine (H226S) retains both normal activity and pH sensitivity, aspartate (H226D) shifts the pH profile toward basic pH, and alanine (H226A) inactivates the carrier at all pH values. J. Biol. Chem. 270: 26813-26817, 1995.
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234. 2+/calmodulin-mediated process. J. Clin. Invest. 82: 1091-1097, 1988.
235. + antiporter, a glycoprotein of 110 kD. Science Wash. DC 247: 723-726, 1990.
236. + exchanger, NHE-1, by phosphorylating a set of common sites. J. Biol. Chem. 266: 19166-19171, 1991.
237. + antiporter. Cell 56: 271-280, 1989.
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240. + exchange inhibitor and its effects in cardiac ischaemia. Br. J. Pharmacol. 109: 562-568, 1993.
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243. SCHWARTZ, M. A., C. LECHENE, AND D. E. INGBER. Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin Alpha5β1, independent of cell shape. Proc. Natl. Acad. Sci. USA 88: 7849-7853, 1991.
244. + antiporter by platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 89: 6138-6141, 1992.
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246. + exchange by altered cell volume in perfused rat mandibular salivary gland. J. Physiol. Lond. 487: 185-195, 1995.
247. + exchange in primary rat astrocytes: role of myosin light-chain kinase. Am. J. Physiol. 269 (Cell Physiol. 38): C257-C266, 1995.
248. + exchanger isoform 1 phosphorylation in normal Wistar-Kyoto and spontaneously hypertensive rats. Circ. Res. 76: 825-831, 1995.
249. + exchanger isoform 1. Hypertension Dallas 27: 859-866, 1996.
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251. + exchanger interacts with mammalian heat shock protein. Biochemistry 34: 10412-10420, 1995.
252. + exchange in pulmonary artery smooth muscle from spontaneously hypertensive and Wistar-Kyoto rats. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L673-L680, 1995.
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254. SODERLING, T. R. Protein kinases. Regulation by autoinhibitory domains. J. Biol. Chem. 265: 1823-1826, 1990.
255. + exchange in renal proximal tubule cells. J. Biol. Chem. 269: 15613-15618, 1994.
256. + exchangers in health and disease processes. J. Invest. Med. 43: 419-430, 1995.
257. + exchanger isoforms NHE-2 and NHE-1 in inner medullary collecting duct cells. Expression, functional localization, and differential regulation. J. Biol. Chem. 269: 27973-27978, 1994.
258. + exchange and protein kinase C in aortic smooth muscle cells. Circ. Res. 76: 530-535, 1995.
259. + exchanger isoform 1 of immortalized lymphoblasts in diabetic nephropathy. Diabetes 44: 1180-1185, 1995.
260. + antiporter cDNAs from human tissues. Am. J. Physiol. 262 (Cell Physiol. 31): C1069-C1076, 1992.
261. + antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system. J. Mol. Cell. Cardiol. 27: 729-742, 1995.
262. 1-Adrenergic effects on intracellular pH and calcium and on myofilaments in single rat cardiac cells. J. Physiol. Lond. 447: 275-292, 1992.
263. + exchanger isoform (NHE-3). J. Biol. Chem. 267: 9340-9346, 1992.
264. + exchanger gene family. J. Membr. Biol. 135: 93-108, 1993.
265. + exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C. Proc. Natl. Acad. Sci. USA 90: 9110-9114, 1993.
266. + exchanger-2 is an O-linked but not an N-linked sialoglycoprotein. Biochemistry 33: 12954-12961, 1994.
267. + exchanger isoform (NHE-2). J. Biol. Chem. 268: 11917-11924, 1993.
268. + exchanger. EMBO J. 10: 1957-1967, 1991.
269. 2+ ionophore, and growth factors. Proc. Natl. Acad. Sci. USA 82: 8053-8056, 1985.
270. + antiport is activated by serum and phorbol esters in proliferating myoblasts but not in differentiated myotubes. J. Biol. Chem. 260: 8008-8013, 1985.
271. + exchange in brain capillary endothelial cells via a high affinity endothelin-3 receptor that is not coupled to phospholipase C. J. Biol. Chem. 266: 5925-5928, 1991.
272. VILELLA, S., L. GUERRA, C. HELMLE-KOLB, AND H. MÜRER. Characterization of basolateral Na/H exchange (Na/H-1) in MDCK cells. Pfluegers Arch. 420: 275-281, 1992.
273. 2+, and amiloride. J. Cell. Physiol. 107: 359-369, 1981.
274. 1A cells into an epithelial membrane. J. Biol. Chem. 263: 7099-7104, 1988.
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276. 2+ regulation-defective. J. Biol. Chem. 269: 13710-13715, 1994.
277. + exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation. J. Biol. Chem. 269: 5583-5588, 1994.
278. +-sensing." Proc. Natl. Acad. Sci. USA 89: 2424-2428, 1992.
279. 2+ responsiveness to the apical isoform NHE3. J. Biol Chem. 270: 26460-26465, 1995.
280. + exchange (NHE-1). Rev. Physiol. Biochem. Pharmacol. 119: 157-186, 1992.
281. + exchanger. Am. J. Physiol. 269 (Cell Physiol. 38): C392-C402, 1995.
282. WANG, Z., J. ORLOWSKI, AND G. E. SHULL. Primary structure and functional expression of a novel gastrointestinal isoform of the rat NaXH exchanger. J. Biol. Chem. 268: 11925-11928, 1993.
283. + exchanger from Caco-2 cells, a human intestinal cell line. Am. J. Physiol. 261 (Gastrointest. Liver Physiol. 24): G229-G238, 1991.
284. + exchange in Caco-2 cells by a mechanism which is dependent on F-actin. J. Biol. Chem. 267: 956-962, 1992.
285. i-dependence and inhibition by hyperosmolality. J. Biol. Chem. 269: 20250-20255, 1994.
286. + exchanger by calcium dependent protein kinases. J. Membr. Biol. 103: 237-244, 1988.
287. + exchanger. Annu. Rev. Physiol. 55: 289-304, 1993.
288. + exchanger requires a dissociable phosphoprotein cofactor. J. Clin. Invest. 92: 1781-1786, 1993.
289. + exchanger. J. Clin. Invest. 95: 2143-2149, 1995.
290. + antiport. Circ. Res. 64: 676-685, 1988.
291. i in intact single fibres from mouse muscle. J. Physiol. Lond. 466: 611-628, 1993.
292. + antiport activity and gene expression in cultured vascular smooth muscle cells. J. Clin. Invest. 93: 2623-2631, 1994.
293. + exchanger in hormonal activation. J. Biol. Chem. 268: 3396-3400, 1993.
294. + exchange in dog cardiac Purkinje fibres. J. Physiol. Lond. 471: 583-597, 1993.
295. + exchange in the sheep cardiac Purkinje fibre. J. Physiol. Lond. 478: 301-313, 1994.
296. WÖLL, E. M. RITTER, W. SCHOLZ, D. HÄEUSSINGER, AND F. LANG. The role of calcium in cell shrinkage and intracellular alkalinization by bradykinin in Ha-ras oncogene expressing cells. FEBS Lett. 322: 261-265, 1993.
297. YAMAJI, Y., M. AMEMIYA, A. CANO, P. A. PREISIG, R. T. MILLER, O. W. MOE, AND R. J. ALPERN. Overexpression of csk inhibits acid-induced activation of NHE-3. Proc. Natl. Acad. Sci. USA 92: 6274-6278, 1995.
298. +-antiporter partial peptide in antiport-active fractions after partial fractionation. J. Biochem. 111: 162-167, 1992.
299. +-antiporter of bovine renal cortex and its immunoaffinity purification in a reconstitutively active form. J. Biochem. 113: 136-140, 1993.
300. YANG, W. D., J. R. B. DYCK, H. Y. WANG, AND L. FLIEGEL. Regulation of NHE-1 promoter in mammalian myocardium. Am. J. Physiol. 270 (Heart Circ. Physiol 39): H259-H266, 1996.
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302. + exchanger isoform. J. Biol. Chem. 268: 206-211, 1993.
303. + exchanger isoform (NHE-2). Biochem. Biophys. Res. Commun. 193: 532-539, 1993.
304. + exchangers: an epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases. Proc. Natl. Acad. Sci. USA 92: 10723-10727, 1995.
305. + exchanger gene family: structure and function studies. Am. J. Physiol. 269 (Gastrointest. Liver Physiol. 32): G1-G11, 1995.
306. YUN, C. H. C., C. M. TSÉ, S. NATH, S. L. LEVINE, AND M. DONOWITZ. Structure/function studies of mammalian Na-H exchangers: an update. J. Physiol. Lond. 482, Suppl. P: 1S-6S, 1995.
307. + exchange inhibitors from the amiloride series. Biochemistry 23: 4481-4488, 1984.
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