Three-dimensional structure of the ion-coupled transport protein NhaA

Nature

Volumn 403, Issue 6765, 2000, Pages 112-115

  Williams, Karen A ^a  

^a MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; ION; MEMBRANE PROTEIN; TOXIN;

ARTICLE; ELECTRON MICROSCOPY; ESCHERICHIA COLI; MEMBRANE TRANSPORT; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN TRANSPORT;

CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SODIUM-HYDROGEN ANTIPORTER;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0034610788     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/47534     Document Type: Article

References (30)

1. +. Novartis Found. Symp. 221, 183-196 (1999).
2. Padan, E. & Schuldiner, S. in Handbook of Biological Physics (eds Konings, W. N., Kaback, H. R. & Lolkema, J. S.) 501-531 (Elsevier, Oxford, 1996).
3. + antiporter from Escherichia coli. J. Biol. Chem. 271, 32288-32292 (1996).
4. Williams, K. A. et al. Projection structure of NhaA, a secondary transporter from Escherichia coli, at 4.0 Å resolution. EMBO J. 18, 3558-3563 (1999).
5. Blakely, R. D., De Felice, L. J. & Hartzell, H. C. Molecular physiology of norepinephrine and serotonin transporters. J. Exp. Biol. 196, 263-281 (1994).
6. Schloss, P. & Williams, D. C. The serotonin transporter: a primary target for antidepressant drugs. J. Psychopharmacol. 12, 115-121 (1998).
7. Wright, E. M. Glucose galactose malabsorption. Am. J. Physiol. 275, 879-882 (1998).
8. Saier, M. H. Jr et al. Evolutionary origins of multidrug and drug-specific efflux pumps in bacteria. FASEB J. 12, 265-274 (1998).
9. Kaback, H. R. & Wu, J. From membrane to molecule to the third amino acid from the left with a membrane transport protein. Q. Rev. Biophys. 30, 333-364 (1997).
10. Iwata, S., Ostermeier, C., Ludwig, B. & Michel, H. Structure at 2.8 Å resolution of cytochrome c oxidase from Paracoccus denitrificans. Nature 376, 660-669 (1995).
11. +-ATPase in the open conformation. Nature 392, 840-843 (1998).
12. Zhang, P. et al. Structure of the calcium pump from sarcoplasmic reticulum at 8 Å resolution. Nature 392, 835-839 (1998).
13. Henderson, R. et al. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J. Mol. Biol. 213, 899-929 (1990).
14. Grigorieff, N., Ceska, T. A., Downing, K. H., Baldwin, J. M. & Henderson, R. Electron-crystallographic refinement of the structure of bacteriorhodopsin. J. Mol. Biol. 259, 393-421 (1996).
15. Havelka, W. A., Henderson, R. & Oesterhelt, D. Three-dimensional structure of halorhodopsin at 7 Å resolution. J. Mol. Biol. 247, 726-738 (1995).
16. + conduction and selectivity. Science 280, 69-77 (1998).
17. Chang, G., Spencer, R. H., Lee, A. T., Barclay, M. T. & Rees, D. C. Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. Science 282, 2220-2226 (1998).
18. Walz, T. et al. The three-dimensional structure of aquaporin-1. Nature 387, 624-627 (1997).
19. Cheng, A. et al. Three-dimensional organization of a human water channel. Nature 387, 627-630 (1997).
20. Li, H., Lee, S. & Jap, B. K. Molecular design of aquaporin-1 water channel as revealed by electron crystallography. Nature Struct. Biol. 4, 263-265 (1997).
21. + antiporter from Escherichia coli, with trypsin. Biochemistry 36, 14572-14576 (1997).
22. Unwin, N. Acetycholine receptor in the open state. Nature 373, 37-43 (1995).
23. Subramaniam, S. et al. Protein conformational changes in the bacteriorhodopsin photocycle. J. Mol. Biol. 287, 145-161 (1999).
24. + channel activation gating. Science 285, 73-78 (1999).
25. Wang, D. N. & Kühlbrant, W. High-resolution electron crystallography of light-harvesting chlorophyll a/b-protein complex in three different media. J. Mol. Biol. 217, 691-699 (1991).
26. Henderson, R. et al. Structure of purple membrane from Halobacterium halobium: recording, measurement and evaluation of electron micrographs at 3.5 Å resolution. Ultramicroscopy 19, 899-929 (1986).
27. Crowther, R. A., Henderson, R. & Smith, J. M. MRC image processing programs. J. Struct. Biol. 116, 9-16 (1996).
28. Shaw, P. J. & Hills, G. J. Tilted specimen in the electron microscope: a simple specimen holder and the calculation of tilt angles from crystalline specimens. Micron 12, 279-282 (1981).
29. Unger, V. M. & Schertler, G. F. X. Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy. Biophys. J. 68, 1776-1786 (1995).
30. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps. Acta Crystallogr. A 47, 110-119 (1991).