Half-lives of plasma membrane Na+/H+ exchangers NHE1-3: Plasma membrane NHE2 has a rapid rate of degradation

American Journal of Physiology - Cell Physiology

Volumn 281, Issue 6 50-6, 2001, Pages

  Cavet, Megan E ^a   Akhter, Shafinaz ^a   Murtazina, Rakhilya ^a   De Medina, Fermin Sanchez ^a   Chung Ming, T S E ^a   Donowitz, Mark ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Caco 2 cells; Lysosomes; Sodium absorption; Trafficking

Indexed keywords

BICARBONATE; BREFELDIN A; MEMBRANE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTON; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CELL STRAIN CACO 2; CONTROLLED STUDY; ENDOSOME; ENZYME INHIBITION; FIBROBLAST; HALF LIFE TIME; HUMAN; HUMAN CELL; ION TRANSPORT; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTON SODIUM EXCHANGE; SODIUM ABSORPTION; SODIUM TRANSPORT;

ANIMALIA;

EID: 0035658769     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.281.6.c2039     Document Type: Article

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9. + exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain
10. + exchanger in A6 cells
11. + exchanger 3 accumulates and is functional in recycling endosomes
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13. + exchanger gene family
14. Dual mechanisms of regulation of Na/H exchanger NHE-3 by parathyroid hormone in rat kidney
15. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin
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17. + exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase
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19. + exchanger NHE3 isoform is regulated by the phosphatidylinositol 3-kinase pathway
20. + exchanger isoforms in cultured epithelial cells from rat efferent ducts and cauda epididymis
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22. Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles
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25. Endocytosis and molecular sorting
26. Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae
27. +/Pi cotransporters
28. Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter
29. Effect of weak bases on the intralysosomal pH in mouse peritoneal macrophages
30. + exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion
31. + exchanger
32. Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin
33. + channel (ENaC) by ubiquitination
34. The ubiquitin-proteasome system and endocytosis
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36. + exchanger-2 is an O-linked but not an N-linked sialoglycoprotein
37. + exchangers
38. Degradation of CFTR by the ubiquitin-proteasome pathway
39. + exchange
40. Acid incubation causes exocytic insertion of NHE3 in OKP cells
41. + exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger