Acute inhibition of brain-specific Na+/H+ exchanger isoform 5 by protein kinases A and C and cell shrinkage

American Journal of Physiology - Cell Physiology

Volumn 281, Issue 4 50-4, 2001, Pages

  Attaphitaya, Surat ^a   Nehrke, Keith ^a   Melvin, James E ^a,b  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Amiloride; pH regulation; Sodium proton exchange; Sodium hydrogen

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; BRAIN; BRAIN CELL; CELL VOLUME; ENZYME ACTIVATION; NONHUMAN; OSMOLALITY; PH MEASUREMENT; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; TISSUE SPECIFICITY;

EID: 0034785648     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.281.4.c1146     Document Type: Article

References (53)

1. + antiporter, and is fully reversed by amiloride
2. + exchanger (NHE5) highly expressed in brain
3. + exchanger isoform 5 (NHE5) from human brain
4. Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures
5. pH regulation in single CA1 neurons acutely isolated from the hippocampi of immature and mature rats
6. Alteration of intracellular pH and activity of CA3-pyramidal cells in guinea pig hippocampal slices by inhibition of transmembrane acid extrusion
7. + exchanger isoform NHE4 and localization in rat hippocampus
8. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity
9. -
10. Intracellular pH regulation in single cultured astrocytes from rat forebrain
11. + exchanger isoform, NHE3
12. + exchanger NHE3 isoform
13. + exchanger isoform
14. + exchangers
15. Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice
16. Ionic control of intracellular pH in rat cerebellar Purkinje cells maintained in culture
17. + exchanger (NHE-2)
18. + exchanger isoforms (NHE-1, -2, and -3) are differentially responsive to second messenger agonists of the protein kinase A and C pathways
19. + exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation
20. + exchanger (NHE5/SLC9A5) to chromosome 16q22.1
21. + exchanger NHE3 activity by cAMP-dependent protein kinase. Phosphorylation-dependent and -independent mechanisms
22. + exchange inhibitor, improves consciousness recovery and neurological outcome following transient cerebral ischaemia in gerbils
23. + exchangers stably expressed in a fibroblast cell line
24. + exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors
25. + exchange anti-porter and control of intracellular pH in hippocampal brain slices
26. + exchangers in rat central nervous system
27. + exchanger-1 deficient mice
28. + exchanger
29. Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger
30. + exchangers of mammalian cells
31. + exchanger that confer sensitivity to pharmacological antagonists
32. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins
33. + exchanger isoforms in rat parotid acinar and ductal cells
34. + exchanger
35. Intracellular pH
36. + antiporter
37. + exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion
38. + exchanger
39. + exchanger isoform 5 stably expressed in Chinese hamster ovary cells
40. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ
41. + exchange is the major mechanism of pH regulation in cultured sympathetic neurons: Measurements in single cell bodies and neurites using a fluorescent pH indicator
42. + exchanger (NHE3): Resistance to amiloride and inhibition by protein kinase C
43. +-sensing"
44. + exchangers
45. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger
46. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF)
47. Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: Role of NHE3 phosphorylation
48. + isoform 1 mutant mice
49. Functional properties of the rat Na/H exchanger NHE-2 isoform expressed in Na/H exchanger-deficient Chinese hamster ovary cells
50. + exchanger, NHE3, requires an associated regulatory protein
51. + exchangers: An epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases
52. Structure/function studies of mammalian Na-H exchangers-an update
53. Acute inhibition of Na/H exchanger NHE-3 by cAMP. Role of protein kinase A and NHE-3 phosphoserines 552 and 605