Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

Journal of Clinical Investigation

Volumn 121, Issue 7, 2011, Pages 2781-2793

  Vlantis, Katerina ^a   Wullaert, Andy ^a   Sasaki, Yoshiteru ^b,c   Schmidt Supprian, Marc ^b,d   Rajewsky, Klaus ^b   Roskams, Tania ^e   Pasparakis, Manolis ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b CENTER FOR BLOOD RESEARCH   (United States)

^c RIKEN Center for Biosystems Dynamics Research   (Japan)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; BMI1 PROTEIN; CHEMOKINE; CXCL1 CHEMOKINE; CYTOKINE; I KAPPA B ALPHA; I KAPPA B KINASE; I KAPPA B KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN; PROTEIN ASCL2; PROTEIN DLK1; PROTEIN OLFM4; STEM CELL FACTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

ADENOMA; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CANCER STEM CELL; CARCINOGENESIS; CELL INFILTRATION; CELL PROLIFERATION; CHEMICAL CARCINOGENESIS; COLITIS; COLON; CONTROLLED STUDY; CYTOKINE PRODUCTION; DYSPLASIA; ENZYME ACTIVATION; FIBROBLAST; GENE EXPRESSION; GENE MUTATION; GRANULOCYTE; HETEROZYGOTE; HYPERPLASIA; ILEUM; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; INTESTINE TUMOR; MACROPHAGE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; TUMOR PROMOTION;

ANIMALS; ENZYME ACTIVATION; EPITHELIAL CELLS; I-KAPPA B KINASE; INTESTINAL MUCOSA; INTESTINAL NEOPLASMS; ISOENZYMES; MICE; NF-KAPPA B; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 79959944892     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI45349     Document Type: Article

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