Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells

Science

Volumn 314, Issue 5802, 2006, Pages 1157-1160

  Mora, J Rodrigo ^a   Iwata, Makoto ^b   Eksteen, Bertus ^c   Song, Si Young ^b   Junt, Tobias ^a   Senman, Balimkiz ^a   Otipoby, Kevin L ^a   Yokota, Aya ^b   Takeuchi, Hajime ^b   Ricciardi Castagnoli, Paola ^d   Rajewsky, Klaus ^a   Adams, David H ^c   Von Andrian, Ulrich H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLIC ACIDS; CELL CULTURE; IMMUNOLOGY; TISSUE; VITAMINS;

DENDRITIC CELLS (DC); IMMUNOGLOBULIN A (IGA); LYMPHOID TISSUES; RETINOIC ACID;

PROTEINS;

IMMUNOGLOBULIN A; INTERLEUKIN 5; INTERLEUKIN 6; RETINOIC ACID; RETINOL;

CELLS AND CELL COMPONENTS;

ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CONTROLLED STUDY; DENDRITIC CELL; EFFECTOR CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; INTESTINE CELL; INTESTINE LYMPHATIC TISSUE; LYMPHOCYTE MIGRATION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETINOL DEFICIENCY;

ANIMALS; B-LYMPHOCYTES; CELL MOVEMENT; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; DENDRITIC CELLS; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; INTERLEUKIN-5; INTERLEUKIN-6; INTESTINAL MUCOSA; INTESTINES; LYMPHOID TISSUE; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, B-CELL; TRETINOIN; VITAMIN A; VITAMIN A DEFICIENCY; VITAMINS;

EID: 33751223544     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132742     Document Type: Article

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30. Supported by NIH grants HL62524, HL54936, HL56949, and AI-061663 to U.H.V.A J.R.M. was supported by a Career Development Award from the Crohn's and Colitis Foundation of America and a grant from the Harvard Digestive Disease Center. M.I. and S.S. were supported by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology, and from the Japan Society for the Promotion of Science, B.E. and D.H.A. were supported by grants from the Medical Research Council UK and Core Charity, UK. K.L.O. and K.R. were supported by NIH grant R37 AIOS4636. T.J. is a fellow of the Swiss National Science Foundation. We thank R. Bonasio for help with D1 cell cultures. J.R.M. is indebted to I. Ramos. The authors declare that they have no competing financial interests.