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Volumn 23, Issue 4, 2007, Pages 379-383

Altered permeability in inflammatory bowel disease: Pathophysiology and clinical implications

Author keywords

Collagenous colitis; Crohn's disease; Epithelial cell apoptosis; Tight junction; Ulcerative colitis

Indexed keywords

ACTIVATED PROTEIN C; AMINO ACID; ANGIOGENIC PROTEIN; ANTICOAGULANT PROTEIN; CYTOKINE; FIBROBLAST GROWTH FACTOR; INTERLEUKIN 10; THROMBOMODULIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 34249933089     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOG.0b013e32816aa392     Document Type: Review
Times cited : (272)

References (64)
  • 1
    • 4344700784 scopus 로고    scopus 로고
    • Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment
    • Zeissig S, Bojarski C, Buergel N, et al. Downregulation of epithelial apoptosis and barrier repair in active Crohn's disease by tumour necrosis factor alpha antibody treatment. Gut 2004; 53:1295-1302.
    • (2004) Gut , vol.53 , pp. 1295-1302
    • Zeissig, S.1    Bojarski, C.2    Buergel, N.3
  • 2
    • 33845995125 scopus 로고    scopus 로고
    • Zeissig S, Burgel N, Gunzel D, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007; 56:61-72. A novel study investigating the morphology, permeability and tight junction protein expression in intestinal tissues of IBD patients.
    • Zeissig S, Burgel N, Gunzel D, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut 2007; 56:61-72. A novel study investigating the morphology, permeability and tight junction protein expression in intestinal tissues of IBD patients.
  • 3
    • 33749026654 scopus 로고    scopus 로고
    • Disrupted barrier function through epithelial cell apoptosis
    • Analysis of apoptotic leaks responsible for barrier dysfunction both in inflamed tissue and cytokine-treated intestinal epithelial cells
    • Schulzke JD, Bojarski C, Zeissig S, et al. Disrupted barrier function through epithelial cell apoptosis. Ann N Y Acad Sci 2006; 1072:288-299. Analysis of apoptotic leaks responsible for barrier dysfunction both in inflamed tissue and cytokine-treated intestinal epithelial cells.
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 288-299
    • Schulzke, J.D.1    Bojarski, C.2    Zeissig, S.3
  • 4
    • 0033818743 scopus 로고    scopus 로고
    • Gitter AH, Bendfeldt K, Schulzke JD, Fromm M. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J 2000; 14:1749-1753.
    • Gitter AH, Bendfeldt K, Schulzke JD, Fromm M. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J 2000; 14:1749-1753.
  • 5
    • 0035449868 scopus 로고    scopus 로고
    • Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis
    • Bojarski C, Gitter AH, Bendfeldt K, et al. Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis. J Physiol 2001; 535 (Pt 2):541-552.
    • (2001) J Physiol , vol.535 , Issue.PART 2 , pp. 541-552
    • Bojarski, C.1    Gitter, A.H.2    Bendfeldt, K.3
  • 6
    • 0035210487 scopus 로고    scopus 로고
    • Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging
    • Gitter AH, Wullstein F, Fromm M, Schulzke JD. Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 2001; 121:1320-1328.
    • (2001) Gastroenterology , vol.121 , pp. 1320-1328
    • Gitter, A.H.1    Wullstein, F.2    Fromm, M.3    Schulzke, J.D.4
  • 7
    • 0345104218 scopus 로고    scopus 로고
    • Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease
    • Schurmann G, Bruwer M, Klotz A, et al. Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease. Int J Colorectal Dis 1999; 14:41-46.
    • (1999) Int J Colorectal Dis , vol.14 , pp. 41-46
    • Schurmann, G.1    Bruwer, M.2    Klotz, A.3
  • 8
    • 9344264671 scopus 로고    scopus 로고
    • Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha
    • Soderholm JD, Streutker C, Yang PC, et al. Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha. Gut 2004; 53:1817-1824.
    • (2004) Gut , vol.53 , pp. 1817-1824
    • Soderholm, J.D.1    Streutker, C.2    Yang, P.C.3
  • 9
    • 3242813596 scopus 로고    scopus 로고
    • Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases
    • Kersting S, Bruewer M, Schuermann G, et al. Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases. Am J Pathol 2004; 165:425-437.
    • (2004) Am J Pathol , vol.165 , pp. 425-437
    • Kersting, S.1    Bruewer, M.2    Schuermann, G.3
  • 10
    • 33744830451 scopus 로고    scopus 로고
    • Bacterial translocation across colonic epithelial cells
    • Richter JF, Troeger H, Beutin L, et al. Bacterial translocation across colonic epithelial cells. Pflug Arch Eur J Phy 2004; 447 (Supp. 1):S41.
    • (2004) Pflug Arch Eur J Phy , vol.447 , Issue.SUPP. 1
    • Richter, J.F.1    Troeger, H.2    Beutin, L.3
  • 11
    • 33144473772 scopus 로고    scopus 로고
    • Buhner S, Buning C, Genschel J, et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut 2006; 55:342-347. Association of genetic defects in the CARD15 gene with barrier disturbance in patients with Crohn's disease.
    • Buhner S, Buning C, Genschel J, et al. Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation? Gut 2006; 55:342-347. Association of genetic defects in the CARD15 gene with barrier disturbance in patients with Crohn's disease.
  • 12
    • 33646246756 scopus 로고    scopus 로고
    • Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease
    • D'Inca R, Annese V, di Leo V, et al. Increased intestinal permeability and NOD2 variants in familial and sporadic Crohn's disease. Aliment Pharmacol Ther 2006; 23:1455-1461.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1455-1461
    • D'Inca, R.1    Annese, V.2    di Leo, V.3
  • 13
    • 0037379915 scopus 로고    scopus 로고
    • TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
    • Rosenstiel P, Fantini M, Brautigam K, et al. TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 2003; 124:1001-1009.
    • (2003) Gastroenterology , vol.124 , pp. 1001-1009
    • Rosenstiel, P.1    Fantini, M.2    Brautigam, K.3
  • 14
    • 21844465744 scopus 로고    scopus 로고
    • Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent
    • Suenaert P, Bulteel V, Vermeire S, et al. Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent. Inflamm Bowel Dis 2005; 11:667-673.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 667-673
    • Suenaert, P.1    Bulteel, V.2    Vermeire, S.3
  • 15
    • 23244455992 scopus 로고    scopus 로고
    • Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
    • Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005; 129:550-564.
    • (2005) Gastroenterology , vol.129 , pp. 550-564
    • Heller, F.1    Florian, P.2    Bojarski, C.3
  • 16
    • 0032958705 scopus 로고    scopus 로고
    • Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis
    • Schmitz H, Barmeyer C, Fromm M, et al. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology 1999; 116:301-309.
    • (1999) Gastroenterology , vol.116 , pp. 301-309
    • Schmitz, H.1    Barmeyer, C.2    Fromm, M.3
  • 17
    • 0033571047 scopus 로고    scopus 로고
    • Manner of interaction of heterogeneous claudin species within and between tight junction strands
    • Furuse M, Sasaki H, Tsukita S. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999; 147:891-903.
    • (1999) J Cell Biol , vol.147 , pp. 891-903
    • Furuse, M.1    Sasaki, H.2    Tsukita, S.3
  • 18
    • 0036320054 scopus 로고    scopus 로고
    • Mechanisms of diarrhea in collagenous colitis
    • Burgel N, Bojarski C, Mankertz J, et al. Mechanisms of diarrhea in collagenous colitis. Gastroenterology 2002; 123:433-443.
    • (2002) Gastroenterology , vol.123 , pp. 433-443
    • Burgel, N.1    Bojarski, C.2    Mankertz, J.3
  • 19
    • 0027744129 scopus 로고
    • Occludin: A novel integral membrane protein localizing at tight junctions
    • Furuse M, Hirase T, Itoh M, et al. Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993; 123 (6 Pt 2):1777-1788.
    • (1993) J Cell Biol , vol.123 , Issue.6 PART 2 , pp. 1777-1788
    • Furuse, M.1    Hirase, T.2    Itoh, M.3
  • 20
    • 2642614521 scopus 로고    scopus 로고
    • Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration
    • Martin-Padura I, Lostaglio S, Schneemann M, et al. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 1998; 142:117-127.
    • (1998) J Cell Biol , vol.142 , pp. 117-127
    • Martin-Padura, I.1    Lostaglio, S.2    Schneemann, M.3
  • 22
    • 29144533473 scopus 로고    scopus 로고
    • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    • Ikenouchi J, Furuse M, Furuse K, et al. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol 2005; 171:939-945.
    • (2005) J Cell Biol , vol.171 , pp. 939-945
    • Ikenouchi, J.1    Furuse, M.2    Furuse, K.3
  • 23
    • 33645963995 scopus 로고    scopus 로고
    • Claudins and epithelial paracellular transport
    • Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol 2006; 68:403-429.
    • (2006) Annu Rev Physiol , vol.68 , pp. 403-429
    • Van Itallie, C.M.1    Anderson, J.M.2
  • 24
    • 0037128938 scopus 로고    scopus 로고
    • Claudin-based tight junctions are crucial for the mammalian epidermal barrier: A lesson from claudin-1-deficient mice
    • Furuse M, Hata M, Furuse K, et al. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 2002; 156:1099-1111.
    • (2002) J Cell Biol , vol.156 , pp. 1099-1111
    • Furuse, M.1    Hata, M.2    Furuse, K.3
  • 25
    • 0037115724 scopus 로고    scopus 로고
    • Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
    • Amasheh S, Meiri N, Gitter AH, et al. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 2002; 115(Pt 24):4969-4976.
    • (2002) J Cell Sci , vol.115 , Issue.PART 24 , pp. 4969-4976
    • Amasheh, S.1    Meiri, N.2    Gitter, A.H.3
  • 26
    • 22144441209 scopus 로고    scopus 로고
    • Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells
    • Amasheh S, Schmidt T, Mahn M, et al. Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells. Cell Tissue Res 2005; 321:89-96.
    • (2005) Cell Tissue Res , vol.321 , pp. 89-96
    • Amasheh, S.1    Schmidt, T.2    Mahn, M.3
  • 27
    • 34249951006 scopus 로고    scopus 로고
    • ENaC expression by aldosterone is paralleled by upregulation of claudin-8 with increased barrier function in human colon
    • 4 S2:A50-A51
    • Amasheh S, Bergs M, Amasheh MM, et al. ENaC expression by aldosterone is paralleled by upregulation of claudin-8 with increased barrier function in human colon. Gastroenterology 2006; 130 (4 S2):A50-A51.
    • (2006) Gastroenterology , pp. 130
    • Amasheh, S.1    Bergs, M.2    Amasheh, M.M.3
  • 28
    • 0942268163 scopus 로고    scopus 로고
    • Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity
    • Mankertz J, Hillenbrand B, Tavalali S, et al. Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem Biophys Res Commun 2004; 314:1001-1007.
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 1001-1007
    • Mankertz, J.1    Hillenbrand, B.2    Tavalali, S.3
  • 29
    • 0037077248 scopus 로고    scopus 로고
    • Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha
    • Sakaguchi T, Gu X, Golden HM, et al. Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem 2002; 277:21361-21370.
    • (2002) J Biol Chem , vol.277 , pp. 21361-21370
    • Sakaguchi, T.1    Gu, X.2    Golden, H.M.3
  • 30
    • 0035129369 scopus 로고    scopus 로고
    • Rahner C, Mitic LL, Anderson JM. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology 2001; 120:411-422.
    • Rahner C, Mitic LL, Anderson JM. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. Gastroenterology 2001; 120:411-422.
  • 31
    • 14744270867 scopus 로고    scopus 로고
    • Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells
    • Escaffit F, Boudreau F, Beaulieu JF. Differential expression of claudin-2 along the human intestine: implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol 2005; 203:15-26.
    • (2005) J Cell Physiol , vol.203 , pp. 15-26
    • Escaffit, F.1    Boudreau, F.2    Beaulieu, J.F.3
  • 32
    • 0029829236 scopus 로고    scopus 로고
    • Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest
    • Shields JM, Christy RJ, Yang VW. Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem 1996; 271:20009-20017.
    • (1996) J Biol Chem , vol.271 , pp. 20009-20017
    • Shields, J.M.1    Christy, R.J.2    Yang, V.W.3
  • 33
    • 0033104158 scopus 로고    scopus 로고
    • A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells
    • Conkright MD, Wani MA, Anderson KP, Lingrel JB. A gene encoding an intestinal-enriched member of the Kruppel-like factor family expressed in intestinal epithelial cells. Nucleic Acids Res 1999; 27:1263-1270.
    • (1999) Nucleic Acids Res , vol.27 , pp. 1263-1270
    • Conkright, M.D.1    Wani, M.A.2    Anderson, K.P.3    Lingrel, J.B.4
  • 34
    • 0035833319 scopus 로고    scopus 로고
    • Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2
    • Dang DT, Mahatan CS, Dang LH, et al. Expression of the gut-enriched Kruppel-like factor (Kruppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2. Oncogene 2001; 20:4884-4890.
    • (2001) Oncogene , vol.20 , pp. 4884-4890
    • Dang, D.T.1    Mahatan, C.S.2    Dang, L.H.3
  • 35
    • 0036639383 scopus 로고    scopus 로고
    • Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene
    • Dang DT, Zhao W, Mahatan CS, et al. Opposing effects of Kruppel-like factor 4 (gut-enriched Kruppel-like factor) and Kruppel-like factor 5 (intestinal-enriched Kruppel-like factor) on the promoter of the Kruppel-like factor 4 gene. Nucleic Acids Res 2002; 30:2736-2741.
    • (2002) Nucleic Acids Res , vol.30 , pp. 2736-2741
    • Dang, D.T.1    Zhao, W.2    Mahatan, C.S.3
  • 36
    • 0037459050 scopus 로고    scopus 로고
    • Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation
    • Chen X, Whitney EM, Gao SY, Yang VW. Transcriptional profiling of Kruppel-like factor 4 reveals a function in cell cycle regulation and epithelial differentiation. J Mol Biol 2003; 326:665-677.
    • (2003) J Mol Biol , vol.326 , pp. 665-677
    • Chen, X.1    Whitney, E.M.2    Gao, S.Y.3    Yang, V.W.4
  • 37
    • 0034796342 scopus 로고    scopus 로고
    • Claudin-6: A novel tight junction molecule is developmentally regulated in mouse embryonic epithelium
    • Turksen K, Troy TC. Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium. Dev Dyn 2001; 222:292-300.
    • (2001) Dev Dyn , vol.222 , pp. 292-300
    • Turksen, K.1    Troy, T.C.2
  • 38
    • 0036336486 scopus 로고    scopus 로고
    • Permeability barrier dysfunction in transgenic mice overexpressing claudin 6
    • Turksen K, Troy TC. Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development 2002; 129:1775-1784.
    • (2002) Development , vol.129 , pp. 1775-1784
    • Turksen, K.1    Troy, T.C.2
  • 39
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • Saitou M, Furuse M, Sasaki H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 2000; 11:4131-4142.
    • (2000) Mol Biol Cell , vol.11 , pp. 4131-4142
    • Saitou, M.1    Furuse, M.2    Sasaki, H.3
  • 40
    • 17444392533 scopus 로고    scopus 로고
    • Epithelial transport and barrier function in occludin-deficient mice
    • Schulzke JD, Gitter AH, Mankertz J, et al. Epithelial transport and barrier function in occludin-deficient mice. Biochim Biophys Acta 2005; 1669:34-42.
    • (2005) Biochim Biophys Acta , vol.1669 , pp. 34-42
    • Schulzke, J.D.1    Gitter, A.H.2    Mankertz, J.3
  • 41
    • 2942580900 scopus 로고    scopus 로고
    • The specific fates of tight junction proteins in apoptotic epithelial cells
    • Bojarski C, Weiske J, Schoneberg T, et al. The specific fates of tight junction proteins in apoptotic epithelial cells. J Cell Sci 2004; 117 (Pt 10):2097-2107.
    • (2004) J Cell Sci , vol.117 , Issue.PART 10 , pp. 2097-2107
    • Bojarski, C.1    Weiske, J.2    Schoneberg, T.3
  • 42
    • 0033996784 scopus 로고    scopus 로고
    • Occludin 1B, a variant of the tight junction protein occludin
    • Muresan Z, Paul DL, Goodenough DA. Occludin 1B, a variant of the tight junction protein occludin. Mol Biol Cell 2000; 11:627-634.
    • (2000) Mol Biol Cell , vol.11 , pp. 627-634
    • Muresan, Z.1    Paul, D.L.2    Goodenough, D.A.3
  • 43
    • 0036435718 scopus 로고    scopus 로고
    • Gene expression of the tight junction protein occludin includes differential splicing and alternative promoter usage
    • Mankertz J, Waller JS, Hillenbrand B, et al. Gene expression of the tight junction protein occludin includes differential splicing and alternative promoter usage. Biochem Biophys Res Commun 2002; 298:657-666.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 657-666
    • Mankertz, J.1    Waller, J.S.2    Hillenbrand, B.3
  • 44
    • 0036675385 scopus 로고    scopus 로고
    • Occludin TM4(-): An isoform of the tight junction protein present in primates lacking the fourth transmembrane domain
    • Ghassemifar MR, Sheth B, Papenbrock T, et al. Occludin TM4(-): an isoform of the tight junction protein present in primates lacking the fourth transmembrane domain. J Cell Sci 2002; 115 (Pt 15):3171-3180.
    • (2002) J Cell Sci , vol.115 , Issue.PART 15 , pp. 3171-3180
    • Ghassemifar, M.R.1    Sheth, B.2    Papenbrock, T.3
  • 45
    • 33749007683 scopus 로고    scopus 로고
    • Inflammatory bowel disease and the apical junctional complex
    • Bruewer M, Samarin S, Nusrat A. Inflammatory bowel disease and the apical junctional complex. Ann N Y Acad Sci 2006; 1072:242-252.
    • (2006) Ann N Y Acad Sci , vol.1072 , pp. 242-252
    • Bruewer, M.1    Samarin, S.2    Nusrat, A.3
  • 46
    • 33645233839 scopus 로고    scopus 로고
    • Chiba H, Kojima T, Osanai M, Sawada N. The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease. Sci STKE 2006; 2006(316):pe1.
    • Chiba H, Kojima T, Osanai M, Sawada N. The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease. Sci STKE 2006; 2006(316):pe1.
  • 47
    • 2142813761 scopus 로고    scopus 로고
    • A porous defense: The leaky epithelial barrier in intestinal disease
    • Clayburgh DR, Shen L, Turner JR. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 2004; 84:282-291.
    • (2004) Lab Invest , vol.84 , pp. 282-291
    • Clayburgh, D.R.1    Shen, L.2    Turner, J.R.3
  • 48
    • 33745797135 scopus 로고    scopus 로고
    • Regulation of the intestinal epithelial barrier by the apical junctional complex
    • Laukoetter MG, Bruewer M, Nusrat A. Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr Opin Gastroenterol 2006; 22:85-89.
    • (2006) Curr Opin Gastroenterol , vol.22 , pp. 85-89
    • Laukoetter, M.G.1    Bruewer, M.2    Nusrat, A.3
  • 49
    • 9344257937 scopus 로고    scopus 로고
    • Increased gut permeability in Crohn's disease: Is TNF the link?
    • Gibson PR. Increased gut permeability in Crohn's disease: is TNF the link? Gut 2004; 53:1724-1725.
    • (2004) Gut , vol.53 , pp. 1724-1725
    • Gibson, P.R.1
  • 50
    • 0036677473 scopus 로고    scopus 로고
    • Crohn's disease, TNF-alpha, and the leaky gut: The chicken or the egg?
    • Hollander D. Crohn's disease, TNF-alpha, and the leaky gut: the chicken or the egg? Am J Gastroenterol 2002; 97:1867-1868.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1867-1868
    • Hollander, D.1
  • 51
    • 3042721899 scopus 로고    scopus 로고
    • Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease
    • Stallmach A, Giese T, Schmidt C, et al. Cytokine/chemokine transcript profiles reflect mucosal inflammation in Crohn's disease. Int J Colorectal Dis 2004; 19:308-315.
    • (2004) Int J Colorectal Dis , vol.19 , pp. 308-315
    • Stallmach, A.1    Giese, T.2    Schmidt, C.3
  • 52
    • 17844396691 scopus 로고    scopus 로고
    • Quantitative measurement of cytokine mRNA in inflammatory bowel disease: Relation to clinical and endoscopic activity and outcome
    • Raddatz D, Bockemuhl M, Ramadori G. Quantitative measurement of cytokine mRNA in inflammatory bowel disease: relation to clinical and endoscopic activity and outcome. Eur J Gastroenterol Hepatol 2005; 17:547-557.
    • (2005) Eur J Gastroenterol Hepatol , vol.17 , pp. 547-557
    • Raddatz, D.1    Bockemuhl, M.2    Ramadori, G.3
  • 53
    • 0025333699 scopus 로고
    • Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
    • MacDonald TT, Hutchings P, Choy MY, et al. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 1990; 81:301-305.
    • (1990) Clin Exp Immunol , vol.81 , pp. 301-305
    • MacDonald, T.T.1    Hutchings, P.2    Choy, M.Y.3
  • 54
    • 0000418018 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6
    • Schmitz H, Fromm M, Bentzel CJ, et al. Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci 1999; 112 (Pt 1):137-146.
    • (1999) J Cell Sci , vol.112 , Issue.PART 1 , pp. 137-146
    • Schmitz, H.1    Fromm, M.2    Bentzel, C.J.3
  • 55
    • 0345447585 scopus 로고    scopus 로고
    • Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms
    • Bruewer M, Luegering A, Kucharzik T, et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 2003; 171:6164-6172.
    • (2003) J Immunol , vol.171 , pp. 6164-6172
    • Bruewer, M.1    Luegering, A.2    Kucharzik, T.3
  • 56
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis- like process
    • Bruewer M, Utech M, Ivanov AI, et al. Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis- like process. FASEB J 2005; 19:923-933.
    • (2005) FASEB J , vol.19 , pp. 923-933
    • Bruewer, M.1    Utech, M.2    Ivanov, A.I.3
  • 57
    • 0347360336 scopus 로고    scopus 로고
    • Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment
    • Ivanov AI, Nusrat A, Parkos CA. Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell 2004; 15:176-188.
    • (2004) Mol Biol Cell , vol.15 , pp. 176-188
    • Ivanov, A.I.1    Nusrat, A.2    Parkos, C.A.3
  • 58
    • 26244442836 scopus 로고    scopus 로고
    • Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: Myosin II-dependent vacuolarization of the apical plasma membrane
    • Utech M, Ivanov AI, Samarin SN, et al. Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell 2005; 16:5040-5052.
    • (2005) Mol Biol Cell , vol.16 , pp. 5040-5052
    • Utech, M.1    Ivanov, A.I.2    Samarin, S.N.3
  • 59
    • 0037960269 scopus 로고    scopus 로고
    • Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: Evidence in Crohn's disease and experimental colitis
    • Segain JP, Raingeard de la Bletiere D, Sauzeau V, et al. Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. Gastroenterology 2003; 124:1180-1187.
    • (2003) Gastroenterology , vol.124 , pp. 1180-1187
    • Segain, J.P.1    Raingeard de la Bletiere, D.2    Sauzeau, V.3
  • 60
    • 13844308129 scopus 로고    scopus 로고
    • Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression
    • Ma TY, Boivin MA, Ye D, et al. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 2005; 288:G422-G430.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Ma, T.Y.1    Boivin, M.A.2    Ye, D.3
  • 61
    • 33644981348 scopus 로고    scopus 로고
    • Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier
    • Gastrointest Liver Physiol, Mediation of intestinal barrier function and MLCK-promoter activation by TNF-alpha
    • Ye D, Ma I, Ma TY. Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 2006; 290:G496-G504. Mediation of intestinal barrier function and MLCK-promoter activation by TNF-alpha.
    • (2006) Am J Physiol , vol.290
    • Ye, D.1    Ma, I.2    Ma, T.Y.3
  • 62
    • 0034122209 scopus 로고    scopus 로고
    • Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma
    • Mankertz J, Tavalali S, Schmitz H, et al. Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 2000; 113 (Pt 11):2085-2090.
    • (2000) J Cell Sci , vol.113 , Issue.PART 11 , pp. 2085-2090
    • Mankertz, J.1    Tavalali, S.2    Schmitz, H.3
  • 63
    • 27744551342 scopus 로고    scopus 로고
    • Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
    • Prasad S, Mingrino R, Kaukinen K, et al. Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells. Lab Invest 2005; 85:1139-1162.
    • (2005) Lab Invest , vol.85 , pp. 1139-1162
    • Prasad, S.1    Mingrino, R.2    Kaukinen, K.3
  • 64
    • 27644477373 scopus 로고    scopus 로고
    • Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition
    • Willemsen LE, Hoetjes JP, van Deventer SJ, van Tol EA. Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition. Clin Exp Immunol 2005; 142:275-284.
    • (2005) Clin Exp Immunol , vol.142 , pp. 275-284
    • Willemsen, L.E.1    Hoetjes, J.P.2    van Deventer, S.J.3    van Tol, E.A.4


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