Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 18, 2012, Pages 7037-7042

  Mackay, Laura K ^a   Stock, Angus T ^a   Ma, Joel Z ^a   Jones, Claerwen M ^a   Kent, Stephen J ^a   Mueller, Scott N ^a   Heath, William R ^a   Carbone, Francis R ^a   Gebhardt, Thomas ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CD8+ T LYMPHOCYTE; CELL PROTECTION; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; EPITHELIUM; FEMALE; HERPES SIMPLEX VIRUS; IMMUNITY; LYMPHOCYTE SUBPOPULATION; MEMORY T LYMPHOCYTE; MOUSE; MUCOSA INFLAMMATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SKIN INFLAMMATION; UPREGULATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGEN PRESENTATION; CD8-POSITIVE T-LYMPHOCYTES; EPITHELIUM; FEMALE; HERPES GENITALIS; HERPES SIMPLEX; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SKIN; SKIN DISEASES, VIRAL; T-LYMPHOCYTE SUBSETS; TIME FACTORS;

SIMPLEXVIRUS;

EID: 84860788997     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1202288109     Document Type: Article

References (46)

1. Welsh RM, Selin LK, Szomolanyi-Tsuda E (2004) Immunological memory to viral infections. Annu Rev Immunol 22:711-743. (Pubitemid 38680439)
2. + T cell effector mechanisms in resistance to infection. Annu Rev Immunol 18:275-308.
3. Bachmann MF, Kündig TM, Hengartner H, Zinkernagel RM (1997) Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"? Proc Natl Acad Sci USA 94:640-645.
4. + T cells and antiviral protection. J Immunol 175:4677-4685.
5. +T-cell memory and prime-boost response after dendritic-cell vaccination. Nat Med 11: 748-756.
6. Wherry EJ, et al. (2003) Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol 4:225-234. (Pubitemid 36322131)
7. Kündig TM, et al. (1996) On the role of antigen in maintaining cytotoxic T-cell memory. Proc Natl Acad Sci USA 93:9716-9723. (Pubitemid 26296675)
8. Zinkernagel RM (2002) On differences between immunity and immunological memory. Curr Opin Immunol 14:523-536.
9. Hansen SG, et al. (2011) Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine. Nature 473:523-527.
10. Masopust D, Vezys V, Marzo AL, Lefrançois L (2001) Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413-2417. (Pubitemid 32231804)
11. + T cells are resident in normal skin. J Immunol 176:4431-4439.
12. Woodland DL, Kohlmeier JE (2009) Migration, maintenance and recall of memory T cells in peripheral tissues. Nat Rev Immunol 9:153-161.
13. Masopust D, Lefrançois L (2003) CD8 T-cell memory: The other half of the story. Microbes Infect 5:221-226. (Pubitemid 36385173)
14. Sallusto F, Geginat J, Lanzavecchia A (2004) Central memory and effector memory T cell subsets: Function, generation, and maintenance. Annu Rev Immunol 22:745-763. (Pubitemid 38680440)
15. Kim SK, Schluns KS, Lefrançois L (1999) Induction and visualization of mucosal memory CD8 T cells following systemic virus infection. J Immunol 163:4125-4132. (Pubitemid 29474474)
16. Klonowski KD, et al. (2004) Dynamics of blood-borne CD8 memory T cell migration in vivo. Immunity 20:551-562. (Pubitemid 38638125)
17. Masopust D, et al. (2010) Dynamic T cell migration program provides resident memory within intestinal epithelium. J Exp Med 207:553-564.
18. + T cells. Nature 477:216-219.
19. Gebhardt T, et al. (2009) Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nat Immunol 10:524-530.
20. Cerwenka A, Morgan TM, Dutton RW (1999) Naive, effector, and memory CD8 T cells in protection against pulmonary influenza virus infection: homing properties rather than initial frequencies are crucial. J Immunol 163:5535-5543.
21. Simmons A, Nash AA (1984) Zosteriform spread of herpes simplex virus as a model of recrudescence and its use to investigate the role of immune cells in prevention of recurrent disease. J Virol 52:816-821. (Pubitemid 15216305)
22. Murali-Krishna K, et al. (1998) Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177-187. (Pubitemid 28123745)
23. + T cells are more protective but slower to acquire a central-memory phenotype. J Exp Med 203:919-932.
24. + T cells. Proc Natl Acad Sci USA 98:6313-6318.
25. Hofmann M, Pircher H (2011) E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands. Proc Natl Acad Sci USA 108: 16741-16746.
26. Wakim LM, Woodward-Davis A, Bevan MJ (2010) Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence. Proc Natl Acad Sci USA 107:17872-17879.
27. E (CD103)-deficient mice. J Immunol 162:6641-6649.
28. Mackay LK, et al. (2012) Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol 188: 2173-2178.
29. Roizman B, Knipe DM, Whitley R (2007) Herpes simplex viruses. Fields Virology, eds Knipe DM, Howley PM (Lippincott, Williams and Wilkins, Philadelphia), 5th Ed, pp 2501-2601.
30. Thompson RL, Sawtell NM (2000) Replication of herpes simplex virus type 1 within trigeminal ganglia is required for high frequency but not high viral genome copy number latency. J Virol 74:965-974. (Pubitemid 30036233)
31. Lachmann RH, Efstathiou S (1997) Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system. J Virol 71:3197-3207. (Pubitemid 27119967)
32. + T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. J Immunol 172:392-397.
33. Vargas G, et al. (2009) Use of high-resolution confocal imaging of the vaginal epithelial microstructure to detect microbicide toxicity. J Infect Dis 199:1546-1552.
34. + T cells to be activated by residual antigen. J Exp Med 207: 1153-1160.
35. Zammit DJ, Turner DL, Klonowski KD, Lefrançois L, Cauley LS (2006) Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration. Immunity 24:439-449.
36. Yang L, Yu Y, Kalwani M, Tseng TW, Baltimore D (2011) Homeostatic cytokines orchestrate the segregation of CD4 and CD8 memory T-cell reservoirs in mice. Blood 118:3039-3050.
37. Mackay CR, Marston WL, Dudler L (1990) Naive and memory T cells show distinct pathways of lymphocyte recirculation. J Exp Med 171:801-817. (Pubitemid 20088983)
38. +) T cells expressing activation, adhesion and co-stimulatory molecules. Eur J Immunol 30:491-497.
39. + T cell response to respiratory virus infections. Immunity 29:101-113.
40. + T cells persist in the lungs following recovery from respiratory virus infections. J Immunol 166:1813-1822.
41. Ray SJ, et al. (2004) The collagen binding α1β1 integrin VLA-1 regulates CD8 T cell-mediated immune protection against heterologous influenza infection. Immunity 20: 167-179. (Pubitemid 38258393)
42. Lee YT, et al. (2011) Environmental and antigen receptor-derived signals support sustained surveillance of the lungs by pathogen-specific cytotoxic T lymphocytes. J Virol 85:4085-4094.
43. +) T-cell attenuation of cutaneous herpes simplex virus infection reduces the average viral copy number of the ensuing latent infection. Immunol Cell Biol 86:666-675.
44. Cohen J (2010) Immunology. Painful failure of promising genital herpes vaccine. Science 330:304.
45. Haase AT (2010) Targeting early infection to prevent HIV-1 mucosal transmission. Nature 464:217-223.
46. Blaney JE, Jr., et al. (1998) Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity. J Virol 72:9567-9574.