Inflammasomes in intestinal inflammation and cancer

Gastroenterology

Volumn 141, Issue 6, 2011, Pages 1986-1999

  Chen, Grace Y ^a   Nez, Gabriel ^b  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

CRC; IBD; Immune; Microbiota; Regulation

Indexed keywords

INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR;

CARCINOGENESIS; DIGESTIVE SYSTEM CANCER; ENTERITIS; ENZYME ACTIVATION; GASTROINTESTINAL DISEASE; HOMEOSTASIS; HOST RESISTANCE; INFLAMMATORY DISEASE; INTESTINE FLORA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TISSUE REPAIR;

EID: 81855228056     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.10.002     Document Type: Review

References (115)

1. S. Rakoff-Nahoum, J. Paglino, and F. Eslami-Varzaneh Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis Cell 118 2004 229 241 (Pubitemid 38962578)
2. G.Y. Chen, M.H. Shaw, and G. Redondo The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis Cancer Res 68 2008 10060 10067
3. D. Bouskra, C. Brezillon, and M. Berard Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis Nature 456 2008 507 510 (Pubitemid 352759006)
4. M. Fukata, A. Chen, and A.S. Vamadevan Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors Gastroenterology 133 2007 1869 1881
5. M. Saleh, and G. Trinchieri Innate immune mechanisms of colitis and colitis-associated colorectal cancer Nat Rev Immunol 11 2011 9 20
6. G.Y. Chen, and G. Nunez Sterile inflammation: sensing and reacting to damage Nat Rev Immunol 10 2010 826 837
7. G. Chen, M.H. Shaw, and Y.G. Kim NOD-like receptors: role in innate immunity and inflammatory disease Annu Rev Pathol 4 2009 365 398
8. F. Martinon, K. Burns, and J. Tschopp The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta Mol Cell 10 2002 417 426 (Pubitemid 35007355)
9. B. Faustin, L. Lartigue, and J.M. Bruey Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation Mol Cell 25 2007 713 724 (Pubitemid 46341921)
10. E. de Alba Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC) J Biol Chem 284 2009 32932 32941
11. S.B. Bratton, and G.S. Salvesen Regulation of the Apaf-1-caspase-9 apoptosome J Cell Sci 123 2010 3209 3214
12. M. Lamkanfi, T.D. Kanneganti, and P. Van Damme Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes Mol Cell Proteomics 7 2008 2350 2363
13. T. Fernandes-Alnemri, J. Wu, and J.W. Yu The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation Cell Death Differ 14 2007 1590 1604 (Pubitemid 47278845)
14. S.L. Fink, and B.T. Cookson Pyroptosis and host cell death responses during Salmonella infection Cell Microbiol 9 2007 2562 2570 (Pubitemid 47500510)
15. K.D. Mayer-Barber, D.L. Barber, and K. Shenderov Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo J Immunol 184 2010 3326 3330
16. F.L. van de Veerdonk, M.G. Netea, and C.A. Dinarello Inflammasome activation and IL-1beta and IL-18 processing during infection Trends Immunol 32 2011 110 116
17. B.J. DeYoung, and R.W. Innes Plant NBS-LRR proteins in pathogen sensing and host defense Nat Immunol 7 2006 1243 1249 (Pubitemid 46111241)
18. L. Franchi, N. Warner, and K. Viani Function of Nod-like receptors in microbial recognition and host defense Immunol Rev 227 2009 106 128
19. L. Franchi, A. Amer, and M. Body-Malapel Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages Nat Immunol 7 2006 576 582 (Pubitemid 43797338)
20. A. Amer, L. Franchi, and T.D. Kanneganti Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf J Biol Chem 281 2006 35217 35223 (Pubitemid 46043249)
21. L. Franchi, J. Stoolman, and T.D. Kanneganti Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation Eur J Immunol 37 2007 3030 3039 (Pubitemid 350131283)
22. T. Suzuki, L. Franchi, and C. Toma Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages PLoS Pathog 3 2007 e111
23. J.E. Galan, and H. Wolf-Watz Protein delivery into eukaryotic cells by type III secretion machines Nature 444 2006 567 573 (Pubitemid 44864429)
24. E.A. Miao, D.P. Mao, and N. Yudkovsky Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome Proc Natl Acad Sci U S A 107 2010 3076 3080
25. K.L. Lightfield, J. Persson, and S.W. Brubaker Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin Nat Immunol 9 2008 1171 1178
26. K.L. Lightfield, J. Persson, and N.J. Trinidad Differential requirements for NAIP5 in activation of the NLRC4 inflammasome Infect Immun 79 2011 1606 1614
27. Y. Zhao, J. Yang, and J. Shi The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus Nature 477 2011 596 600
28. E.M. Kofoed, and R.E. Vance Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity Nature 477 2011 592 595
29. A.M. Nour, Y.G. Yeung, and L. Santambrogio Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages Infect Immun 77 2009 1262 1271
30. E.D. Boyden, and W.F. Dietrich Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin Nat Genet 38 2006 240 244 (Pubitemid 43177241)
31. T.J. Kang, S. Basu, and L. Zhang Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways Eur J Immunol 38 2008 1574 1584
32. J.K. Terra, C.K. Cote, and B. France Cutting edge: resistance to Bacillus anthracis infection mediated by a lethal toxin sensitive allele of Nalp1b/Nlrp1b J Immunol 184 2010 17 20
33. M. Moayeri, D. Crown, and Z.L. Newman Inflammasome sensor Nlrp1b-dependent resistance to anthrax is mediated by caspase-1, IL-1 signaling and neutrophil recruitment PLoS Pathog 6 2010 e1001222
34. S. Mariathasan, D.S. Weiss, and K. Newton Cryopyrin activates the inflammasome in response to toxins and ATP Nature 440 2006 228 232 (Pubitemid 43372102)
35. F.S. Sutterwala, Y. Ogura, and M. Szczepanik Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1 Immunity 24 2006 317 327
36. L. Franchi, T.D. Kanneganti, and G.R. Dubyak Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria J Biol Chem 282 2007 18810 18818 (Pubitemid 47100181)
37. F. Martinon, V. Petrilli, and A. Mayor Gout-associated uric acid crystals activate the NALP3 inflammasome Nature 440 2006 237 241 (Pubitemid 43372104)
38. V. Hornung, F. Bauernfeind, and A. Halle Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat Immunol 9 2008 847 856
39. C. Dostert, V. Petrilli, and R. Van Bruggen Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica Science 320 2008 674 677 (Pubitemid 351928351)
40. L. Franchi, T. Eigenbrod, and R. Munoz-Planillo The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis Nat Immunol 10 2009 241 247
41. F.G. Bauernfeind, G. Horvath, and A. Stutz Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression J Immunol 183 2009 787 791
42. L. Franchi, T. Eigenbrod, and G. Nunez Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation J Immunol 183 2009 792 796
43. J.M. Kahlenberg, and G.R. Dubyak Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release Am J Physiol Cell Physiol 286 2004 C1100 C1108
44. P. Pelegrin, and A. Surprenant Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor EMBO J 25 2006 5071 5082 (Pubitemid 44658525)
45. T.D. Kanneganti, M. Lamkanfi, and Y.G. Kim Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling Immunity 26 2007 433 443 (Pubitemid 46603000)
46. Y. Qu, S. Misaghi, and K. Newton Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation J Immunol 186 2011 6553 6561
47. R. Zhou, A. Tardivel, and B. Thorens Thioredoxin-interacting protein links oxidative stress to inflammasome activation Nat Immunol 11 2010 136 140
48. R. Zhou, A.S. Yazdi, and P. Menu A role for mitochondria in NLRP3 inflammasome activation Nature 469 2011 221 225
49. F. Bauernfeind, E. Bartok, and A. Rieger Cutting edge: reactive oxygen species inhibitors block priming, but not activation, of the NLRP3 inflammasome J Immunol 187 2011 613 617
50. S.L. Masters, A. Dunne, and S.L. Subramanian Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes Nat Immunol 11 2010 897 904
51. J.M. Grenier, L. Wang, and G.A. Manji Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1 FEBS Lett 530 2002 73 78 (Pubitemid 35248189)
52. E. Elinav, T. Strowig, and A.L. Kau NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis Cell 145 2011 745 757
53. G.Y. Chen, M. Liu, and F. Wang A functional role for nlrp6 in intestinal inflammation and tumorigenesis J Immunol 186 2011 7187 7194
54. M. Lech, A. Avila-Ferrufino, and V. Skuginna Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice Int Immunol 22 2010 717 728
55. S. Normand, A. Delanoye-Crespin, and A. Bressenot Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury Proc Natl Acad Sci U S A 108 2011 9601 9606
56. A. Andoh, S. Bamba, and M. Brittan Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut Pharmacol Ther 114 2007 94 106 (Pubitemid 46498158)
57. E.A. Miao, C.M. Alpuche-Aranda, and M. Dors Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf Nat Immunol 7 2006 569 575 (Pubitemid 43797337)
58. M. Lara-Tejero, F.S. Sutterwala, and Y. Ogura Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis J Exp Med 203 2006 1407 1412 (Pubitemid 43877602)
59. B. Raupach, S.K. Peuschel, and D.M. Monack Caspase-1-mediated activation of interleukin-1beta (IL-1beta) and IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection Infect Immun 74 2006 4922 4926 (Pubitemid 44157282)
60. R.C. Alaniz, L.A. Cummings, and M.A. Bergman Salmonella typhimurium coordinately regulates FliC location and reduces dendritic cell activation and antigen presentation to CD4+ T cells J Immunol 177 2006 3983 3993 (Pubitemid 44359931)
61. E.A. Miao, I.A. Leaf, and P.M. Treuting Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria Nat Immunol 11 2010 1136 1142
62. K. Hueffer, and J.E. Galan Salmonella-induced macrophage death: multiple mechanisms, different outcomes Cell Microbiol 6 2004 1019 1025 (Pubitemid 39386680)
63. P. Broz, K. Newton, and M. Lamkanfi Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella J Exp Med 207 2010 1745 1755
64. M. Lamkanfi, and V.M. Dixit Manipulation of host cell death pathways during microbial infections Cell Host Microbe 8 2010 44 54
65. P. Broz, J. von Moltke, and J.W. Jones Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing Cell Host Microbe 8 2010 471 483
66. R. Munoz-Planillo, L. Franchi, and L.S. Miller A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome J Immunol 183 2009 3942 3948
67. J. Harder, L. Franchi, and R. Munoz-Planillo Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor J Immunol 183 2009 5823 5829
68. C. Toma, N. Higa, and Y. Koizumi Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling J Immunol 184 2010 5287 5297
69. O. Gross, H. Poeck, and M. Bscheider Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence Nature 459 2009 433 436
70. T. Reimer, M.H. Shaw, and L. Franchi Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome Eur J Immunol 40 2010 764 769
71. E.V. Loftus Jr Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences Gastroenterology 126 2004 1504 1517 (Pubitemid 38649869)
72. B. Khor, A. Gardet, and R.J. Xavier Genetics and pathogenesis of inflammatory bowel disease Nature 474 2011 307 317
73. W. Strober, I.J. Fuss, and R.S. Blumberg The immunology of mucosal models of inflammation Annu Rev Immunol 20 2002 495 549 (Pubitemid 34293433)
74. W. Strober, I. Fuss, and P. Mannon The fundamental basis of inflammatory bowel disease J Clin Invest 117 2007 514 521 (Pubitemid 46348505)
75. K. Tamura, Y. Fukuda, and H. Sashio IL18 polymorphism is associated with an increased risk of Crohn's disease J Gastroenterol 37 Suppl 14 2002 111 116 (Pubitemid 35385941)
76. A. Zhernakova, E.M. Festen, and L. Franke Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP Am J Hum Genet 82 2008 1202 1210
77. A.C. Villani, M. Lemire, and G. Fortin Common variants in the NLRP3 region contribute to Crohn's disease susceptibility Nat Genet 41 2009 71 76
78. G.J. Lewis, D.C. Massey, and H. Zhang Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel Inflamm Bowel Dis 17 2011 1387 1391
79. H.S. Cooper, S.N. Murthy, and R.S. Shah Clinicopathologic study of dextran sulfate sodium experimental murine colitis Lab Invest 69 1993 238 249
80. I. Okayasu, S. Hatakeyama, and M. Yamada A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology 98 1990 694 702 (Pubitemid 20069706)
81. J. Ni, S.F. Chen, and D. Hollander Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes Gut 39 1996 234 241 (Pubitemid 26276001)
82. L.G. Axelsson, E. Landstrom, and T.J. Goldschmidt Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4(+) -cell depleted, athymic and NK-cell depleted SCID mice Inflamm Res 45 1996 181 191 (Pubitemid 26135074)
83. N. Shintani, T. Nakajima, and T. Okamoto Involvement of CD4+ T cells in the development of dextran sulfate sodium-induced experimental colitis and suppressive effect of IgG on their action Gen Pharmacol 31 1998 477 481 (Pubitemid 28398878)
84. Y. Chen, K. Chou, and E. Fuchs Protection of the intestinal mucosa by intraepithelial gamma delta T cells Proc Natl Acad Sci U S A 99 2002 14338 14343 (Pubitemid 35257673)
85. T.W. Kim, J.N. Seo, and Y.H. Suh Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis World J Gastroenterol 12 2006 302 305 (Pubitemid 43336932)
86. M.E. Street, G. de'Angelis, and C. Camacho-Hubner Relationships between serum IGF-1, IGFBP-2, interleukin-1beta and interleukin-6 in inflammatory bowel disease Horm Res 61 2004 159 164 (Pubitemid 38437684)
87. J. Li, T. Moran, E. Swanson, and C. Julian Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations Hum Mol Genet 13 2004 1715 1725 (Pubitemid 39173441)
88. B. Siegmund, H.A. Lehr, and G. Fantuzzi IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation Proc Natl Acad Sci U S A 98 2001 13249 13254 (Pubitemid 33051348)
89. T. Ishikura, T. Kanai, and K. Uraushihara Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice J Gastroenterol Hepatol 18 2003 960 969 (Pubitemid 37056177)
90. C. Bauer, F. Loher, and M. Dauer The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6 mice and suppresses IP-10 mRNA but not TNF-alpha mRNA expression Dig Dis Sci 52 2007 1642 1652 (Pubitemid 46870573)
91. B. Siegmund, G. Fantuzzi, and F. Rieder Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production Am J Physiol Regul Integr Comp Physiol 281 2001 R1264 R1273
92. J. Dupaul-Chicoine, G. Yeretssian, and K. Doiron Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases Immunity 32 2010 367 378
93. M.H. Zaki, K.L. Boyd, and P. Vogel The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis Immunity 32 2010 379 391
94. T.T. Pizarro, M.H. Michie, and M. Bentz IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells J Immunol 162 1999 6829 6835 (Pubitemid 29309411)
95. K. Nakanishi, T. Yoshimoto, and H. Tsutsui Interleukin-18 regulates both Th1 and Th2 responses Annu Rev Immunol 19 2001 423 474 (Pubitemid 32368042)
96. M. Fukata, A. Chen, and A. Klepper Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine Gastroenterology 131 2006 862 877 (Pubitemid 44316821)
97. S.L. Brown, T.E. Riehl, and M.R. Walker Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury J Clin Invest 117 2007 258 269 (Pubitemid 46048471)
98. H. Kampfer, J. Paulukat, and H. Muhl Lack of interferon-gamma production despite the presence of interleukin-18 during cutaneous wound healing Mol Med 6 2000 1016 1027
99. B. Hu, E. Elinav, and S. Huber Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4 Proc Natl Acad Sci U S A 107 2010 21635 21640
100. I.C. Allen, E.M. TeKippe, and R.M. Woodford The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer J Exp Med 207 2010 1045 1056
101. S.A. Hirota, J. Ng, and A. Lueng NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis Inflamm Bowel Dis 17 2011 1359 1372
102. C. Bauer, P. Duewell, and C. Mayer Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome Gut 59 2010 1192 1199
103. D.W. Rosenberg, C. Giardina, and T. Tanaka Mouse models for the study of colon carcinogenesis Carcinogenesis 30 2009 183 196
104. W.F. Dove, L. Clipson, and K.A. Gould Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status Cancer Res 57 1997 812 814 (Pubitemid 27097999)
105. S. Rakoff-Nahoum, and R. Medzhitov Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88 Science 317 2007 124 127 (Pubitemid 47056471)
106. S.H. Lee, L.L. Hu, and J. Gonzalez-Navajas ERK activation drives intestinal tumorigenesis in Apc(min/+) mice Nat Med 16 2010 665 670
107. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867 (Pubitemid 36019639)
108. T. Tanaka, H. Kohno, and R. Suzuki A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate Cancer Sci 94 2003 965 973 (Pubitemid 37508979)
109. R. Suzuki, H. Kohno, and S. Sugie Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate Cancer Sci 95 2004 721 727 (Pubitemid 39335091)
110. L. Tarmin, J. Yin, and N. Harpaz Adenomatous polyposis coli gene mutations in ulcerative colitis-associated dysplasias and cancers versus sporadic colon neoplasms Cancer Res 55 1995 2035 2038
111. S.H. Itzkowitz, and X. Yio Inflammation and cancer IV Colorectal cancer in inflammatory bowel disease: the role of inflammation Am J Physiol Gastrointest Liver Physiol 287 2004 G7 G17
112. R. Salcedo, A. Worschech, and M. Cardone MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18 J Exp Med 207 2010 1625 1636
113. M.H. Zaki, P. Vogel, and M. Body-Malapel IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation J Immunol 185 2010 4912 4920
114. B. Hu, E. Elinav, and R.A. Flavell Inflammasome-mediated suppression of inflammation-induced colorectal cancer progression is mediated by direct regulation of epithelial cell proliferation Cell Cycle 10 2011 1936 1939
115. D.H. Abdelaziz, M.A. Gavrilin, and A. Akhter Asc-dependent and independent mechanisms contribute to restriction of legionella pneumophila infection in murine macrophages Front Microbiol 2 2011 18