메뉴 건너뛰기




Volumn 3, Issue 4, 2003, Pages 331-341

Anatomical basis of tolerance and immunity to intestinal antigens

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

EID: 0038316325     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1057     Document Type: Review
Times cited : (1110)

References (99)
  • 2
    • 0031966706 scopus 로고    scopus 로고
    • Immune responses to dietary antigens: Oral tolerance
    • Strobel, S. & Mowat, A. Mcl. Immune responses to dietary antigens: oral tolerance. Immunol. Today 19, 173-181 (1998).
    • (1998) Immunol. Today , vol.19 , pp. 173-181
    • Strobel, S.1    Mowat, A.McI.2
  • 3
    • 0033066588 scopus 로고    scopus 로고
    • Oral tolerance: Mechanisms and therapeutic applications
    • Faria, A. M. C. & Weiner, H. L. Oral tolerance: mechanisms and therapeutic applications. Adv. Immunol. 73, 153-164 (1999).
    • (1999) Adv. Immunol. , vol.73 , pp. 153-164
    • Faria, A.M.C.1    Weiner, H.L.2
  • 4
    • 0030900764 scopus 로고    scopus 로고
    • The anatomical basis of mucosal immune responses
    • Mowat, A. Mcl. & Viney, J. L. The anatomical basis of mucosal immune responses. Immunol. Rev. 156, 145-166 (1997).
    • (1997) Immunol. Rev. , vol.156 , pp. 145-166
    • Mowat, A.McI.1    Viney, J.L.2
  • 5
    • 0036136321 scopus 로고    scopus 로고
    • Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    • Hamada, H. et al. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J. Immunol. 168, 57-64 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 57-64
    • Hamada, H.1
  • 6
    • 0037978900 scopus 로고    scopus 로고
    • Organogenesis of lymphoid tissue
    • Mebius, R. E. Organogenesis of lymphoid tissue. Nature Rev. Immunol. 3, 292-303 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 292-303
    • Mebius, R.E.1
  • 7
    • 0037147751 scopus 로고    scopus 로고
    • Requirement for the NF-κB family member RelA in the development of secondary lymphoid organs
    • Alcamo, E. et al. Requirement for the NF-κB family member RelA in the development of secondary lymphoid organs. J. Exp. Med. 195, 233-244 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 233-244
    • Alcamo, E.1
  • 8
    • 0035809317 scopus 로고    scopus 로고
    • Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis
    • Honda, K. et al. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J. Exp. Med. 193, 621-630 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 621-630
    • Honda, K.1
  • 9
    • 0037094097 scopus 로고    scopus 로고
    • Visualization of lymphotoxin-β and lymphotoxin-β receptor expression in mouse embryos
    • Browning, J. L. & French, L. E. Visualization of lymphotoxin-β and lymphotoxin-β receptor expression in mouse embryos. J. Immunol. 168, 5079-5087 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5079-5087
    • Browning, J.L.1    French, L.E.2
  • 10
    • 0036906575 scopus 로고    scopus 로고
    • Different cytokines induce surface lymphotoxin-αβ on IL7 receptor-α cells that differentially engender lymph nodes and Peyer's patches
    • Yoshida, H. et al. Different cytokines induce surface lymphotoxin-αβ on IL7 receptor-α cells that differentially engender lymph nodes and Peyer's patches. Immunity 17, 823-833 (2002).
    • (2002) Immunity , vol.17 , pp. 823-833
    • Yoshida, H.1
  • 11
    • 0037413709 scopus 로고    scopus 로고
    • RelB is required for Peyer's patch development: Differential regulation of p52-RelB by lymphotoxin and TNF
    • Yilmaz, Z. B., Weih, D. S., Sivakumar, V. & Weih, F. RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J. 22, 121-130 (2003).
    • (2003) EMBO J. , vol.22 , pp. 121-130
    • Yilmaz, Z.B.1    Weih, D.S.2    Sivakumar, V.3    Weih, F.4
  • 12
    • 0035083213 scopus 로고    scopus 로고
    • Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches
    • Debard, N., Sierro, F., Browning, J., & Kraehenbuhl, J. P. Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches. Gastroenterology 120, 1173-1182 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 1173-1182
    • Debard, N.1    Sierro, F.2    Browning, J.3    Kraehenbuhl, J.P.4
  • 13
    • 0038946003 scopus 로고    scopus 로고
    • Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria
    • Kernéis, S., Bogdanova, A., Kraehenbuhl, J.-P. & Pringault, E. Conversion by Peyer's patch lymphocytes of human enterocytes into M cells that transport bacteria. Science 277, 949-952 (1997).
    • (1997) Science , vol.277 , pp. 949-952
    • Kernéis, S.1    Bogdanova, A.2    Kraehenbuhl, J.-P.3    Pringault, E.4
  • 14
    • 0033521087 scopus 로고    scopus 로고
    • Organogenic role of B lymphocytes in mucosal immunity
    • Golovkina, T. V., Shlomchik, M., Hannum, L. & Chervonsky, A. Organogenic role of B lymphocytes in mucosal immunity. Science 286, 1965-1968 (1999).
    • (1999) Science , vol.286 , pp. 1965-1968
    • Golovkina, T.V.1    Shlomchik, M.2    Hannum, L.3    Chervonsky, A.4
  • 15
    • 0032792810 scopus 로고    scopus 로고
    • Development of Peyer's patches, follicle-associated epithelium and M cell: Lessons from immunodeficient and knockout mice
    • Debard, N., Sierro, F. & Kraehenbuhl, J. P. Development of Peyer's patches, follicle-associated epithelium and M cell: lessons from immunodeficient and knockout mice. Semin. Immunol. 11, 183-191 (1999).
    • (1999) Semin. Immunol. , vol.11 , pp. 183-191
    • Debard, N.1    Sierro, F.2    Kraehenbuhl, J.P.3
  • 16
    • 0033563131 scopus 로고    scopus 로고
    • Differential induction of adhesion molecule and chemokine expression by LTα3 and LTαβ in inflammation elucidates potential mechanisms of mesenteric and peripheral lymph node development
    • Cuff, C. A., Sacca, R. & Ruddle, N. H. Differential induction of adhesion molecule and chemokine expression by LTα3 and LTαβ in inflammation elucidates potential mechanisms of mesenteric and peripheral lymph node development, J. Immunol. 162, 5965-5972 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5965-5972
    • Cuff, C.A.1    Sacca, R.2    Ruddle, N.H.3
  • 17
    • 0037124334 scopus 로고    scopus 로고
    • Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin β in mesenteric lymph node genesis
    • Scheu, S. et al. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin β in mesenteric lymph node genesis. J. Exp. Med. 195, 1613-1624 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1613-1624
    • Scheu, S.1
  • 18
    • 0031597424 scopus 로고    scopus 로고
    • 7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes
    • 7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur. J. Immunol. 28, 3832-3839 (1998). This paper uses appropriate knockout and doubleknockout mice to investigate the selective requirements for different adhesion molecules in the development of the gut-associated lymphoid tissues.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 3832-3839
    • Wagner, N.1
  • 20
    • 0027237424 scopus 로고
    • 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    • 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74, 185-195 (1993).
    • (1993) Cell , vol.74 , pp. 185-195
    • Bedin, C.1
  • 22
    • 0037148514 scopus 로고    scopus 로고
    • The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells
    • Bowman, E. P. et al. The intestinal chemokine thymus-expressed chemokine (CCL25) attracts IgA antibody-secreting cells. J. Exp. Med. 195, 269-275 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 269-275
    • Bowman, E.P.1
  • 23
    • 0037033376 scopus 로고    scopus 로고
    • + T cells activated in cutaneous or mucosal lymphoid tissues
    • + T cells activated in cutaneous or mucosal lymphoid tissues. J. Exp. Med. 195, 135-141 (2002). This study provides a molecular basis for how the site of T-cell priming can determine their subsequent dissemination to peripheral or mucosal tissues.
    • (2002) J. Exp. Med. , vol.195 , pp. 135-141
    • Campbell, D.J.1    Butcher, E.C.2
  • 24
    • 9844230421 scopus 로고    scopus 로고
    • T cells of the human intestinal lamina propria are high producers of interleukin-10
    • Braunstein, J., Qiao, L., Autschbach, F., Schurmann, G. & Meuer, S. T cells of the human intestinal lamina propria are high producers of interleukin-10. Gut 41, 215-220 (1997).
    • (1997) Gut , vol.41 , pp. 215-220
    • Braunstein, J.1    Qiao, L.2    Autschbach, F.3    Schurmann, G.4    Meuer, S.5
  • 25
    • 0142159234 scopus 로고    scopus 로고
    • Spontaneous secretion of interferon y and interleukin-4 by human intraepithelial and lamina propria gut lymphocytes
    • Carol, M. et al Spontaneous secretion of interferon y and interleukin-4 by human intraepithelial and lamina propria gut lymphocytes. Gut 42, 603-604 (1998).
    • (1998) Gut , vol.42 , pp. 603-604
    • Carol, M.1
  • 26
    • 0033485666 scopus 로고    scopus 로고
    • + T cells results in altered cytokine production, activation threshold, and costimulatory requirements
    • + T cells results in altered cytokine production, activation threshold, and costimulatory requirements. J. Immunol. 163, 5937-5945 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 5937-5945
    • Hurst, S.D.1
  • 27
    • 0344898554 scopus 로고    scopus 로고
    • A critical role for CD40-CD 40 ligand interactions in amplification of the mucosal CD8 T cell response
    • Lefrançois, L., Olson, S. & Masopust, D. A critical role for CD40-CD40 ligand interactions in amplification of the mucosal CD8 T cell response. J. Exp. Med. 190, 1275-1283 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 1275-1283
    • Lefrançois, L.1    Olson, S.2    Masopust, D.3
  • 28
    • 0033554726 scopus 로고    scopus 로고
    • Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
    • Sallusto, F., Lenig, D., Forster, R., Lipp, M. & Lanzavecchia, A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401, 708-712 (1999).
    • (1999) Nature , vol.401 , pp. 708-712
    • Sallusto, F.1    Lenig, D.2    Forster, R.3    Lipp, M.4    Lanzavecchia, A.5
  • 29
    • 0035282433 scopus 로고    scopus 로고
    • Visualizing the generation of memory CD 4 T cells in the whole body
    • Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T. & Jenkins, M. K. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410, 101-105 (2001).
    • (2001) Nature , vol.410 , pp. 101-105
    • Reinhardt, R.L.1    Khoruts, A.2    Merica, R.3    Zell, T.4    Jenkins, M.K.5
  • 30
    • 0035937587 scopus 로고    scopus 로고
    • Preferential localization of effector memory cells in nonlymphoid tissues
    • Masopust, D., Vezys, V., Marzo, A. L. & Lefrancois, L. Preferential localization of effector memory cells in nonlymphoid tissues. Science 291, 2413-2417 (2001).
    • (2001) Science , vol.291 , pp. 2413-2417
    • Masopust, D.1    Vezys, V.2    Marzo, A.L.3    Lefrancois, L.4
  • 31
    • 0031569530 scopus 로고    scopus 로고
    • + T cell down-regulation in human intestinal mucosa: Evidence for intestinal tolerance to luminal bacterial antigens
    • + T cells in the intestinal mucosa normally recognize the local commensal bacteria, but that their responses are inhibited by local regulatory T cells in an interleukin-10 (IL-10) and/or transforming growth factor-β (TGF-β)-mediated manner.
    • (1997) J. Immunol. , vol.158 , pp. 3626-3634
    • Khoo, U.Y.1    Proctor, I.E.2    Macpherson, A.J.3
  • 33
    • 0036597371 scopus 로고    scopus 로고
    • + suppressor T cells: More questions than answers
    • + suppressor T cells: more questions than answers. Nature Rev. Immunol. 2, 389-400 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 34
    • 0033982498 scopus 로고    scopus 로고
    • Modulation of antigen trafficking to MHC class II-positive late endosomes of enterocytes
    • Zimmer, K. P., Buning, J., Weber, P., Kaiserlian, D. & Strobel, S. Modulation of antigen trafficking to MHC class II-positive late endosomes of enterocytes. Gastroenterology 118, 128-137 (2000).
    • (2000) Gastroenterology , vol.118 , pp. 128-137
    • Zimmer, K.P.1    Buning, J.2    Weber, P.3    Kaiserlian, D.4    Strobel, S.5
  • 35
    • 0032528838 scopus 로고    scopus 로고
    • Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
    • Hershberg, R. M. et al. Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J. Clin. Invest. 102, 792-803 (1998).
    • (1998) J. Clin. Invest. , vol.102 , pp. 792-803
    • Hershberg, R.M.1
  • 38
    • 0032100767 scopus 로고    scopus 로고
    • Induction of rapid T-cell activation and tolerance by systemic presentation of an orally administered antigen
    • Gütgemann, I., Fahrer, A. M., Davis, M. M. & Chien, Y.-H. Induction of rapid T-cell activation and tolerance by systemic presentation of an orally administered antigen. Immunity 8, 667-673 (1998).
    • (1998) Immunity , vol.8 , pp. 667-673
    • Gütgemann, I.1    Fahrer, A.M.2    Davis, M.M.3    Chien, Y.-H.4
  • 39
    • 0032789856 scopus 로고    scopus 로고
    • Visualizing the T-cell response elicited by oral administration of soluble protein antigen
    • Williamson, E., O'Malley J. M. & Viney, J. L. Visualizing the T-cell response elicited by oral administration of soluble protein antigen. Immunology 97, 565-572 (1999).
    • (1999) Immunology , vol.97 , pp. 565-572
    • Williamson, E.1    O'Malley, J.M.2    Viney, J.L.3
  • 40
    • 0030586668 scopus 로고    scopus 로고
    • Direct measurement of anergy of antigen-specific T cells following oral tolerance induction
    • Van Houten, N. & Blake, S. F. Direct measurement of anergy of antigen-specific T cells following oral tolerance induction J. Immunol. 157, 1337-1341 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 1337-1341
    • Van Houten, N.1    Blake, S.F.2
  • 41
    • 0033563273 scopus 로고    scopus 로고
    • Antigen-specific T cell activation and proliferation during oral tolerance induction
    • Sun, J., Dirden-Kramer, B., Ito, K., Ernst, P. B. & Van Houten, N. Antigen-specific T cell activation and proliferation during oral tolerance induction. J. Immunol. 162, 5865-5875 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 5865-5875
    • Sun, J.1    Dirden-Kramer, B.2    Ito, K.3    Ernst, P.B.4    Van Houten, N.5
  • 42
    • 0036278333 scopus 로고    scopus 로고
    • T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division
    • Smith, K. M., Davidson, J. M. & Garside, P. T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division. Immunology 106, 144-158 (2002).
    • (2002) Immunology , vol.106 , pp. 144-158
    • Smith, K.M.1    Davidson, J.M.2    Garside, P.3
  • 43
    • 0034771968 scopus 로고    scopus 로고
    • 'Tolerosomes' are produced by intestinal epithelial cells
    • Karlsson, M. et al. 'Tolerosomes' are produced by intestinal epithelial cells. Eur. J. Immunol. 31, 2892-2900 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2892-2900
    • Karlsson, M.1
  • 44
    • 0035877018 scopus 로고    scopus 로고
    • Proteomic analysis of dendritic cell-derived exosomes: A secreted subcellular compartment distinct from apoptotic vesicles
    • Thery, C. et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 166, 7309-7318 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 7309-7318
    • Thery, C.1
  • 45
    • 0035853160 scopus 로고    scopus 로고
    • Peyer's patches are required for oral tolerance to proteins
    • Fujihashi, K. et al. Peyer's patches are required for oral tolerance to proteins. Proc. Natl Acad. Sci. USA 98, 3310-3315 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 3310-3315
    • Fujihashi, K.1
  • 46
    • 0035063241 scopus 로고    scopus 로고
    • Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches
    • Spahn, T. W. et al. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur. J. Immunol. 31, 1278-1287 (2001).
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1278-1287
    • Spahn, T.W.1
  • 47
    • 0036237353 scopus 로고    scopus 로고
    • Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches
    • Spahn, T. W. et al. Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches. Eur. J. Immunol. 32, 1109-1113 (2002). Using genetic knockouts or treatment with a soluble receptor in utero that blocks different lymphotoxin (LT)-family members and their receptors, this paper shows that mesenteric lymph nodes, but not Peyer's patches, are required for the induction of various oral-tolerance regimes.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1109-1113
    • Spahn, T.W.1
  • 48
    • 0035871627 scopus 로고    scopus 로고
    • The role of dendritic cells, B cells and M cells in gut-oriented immune responses
    • Alpan, O., Rudomen, G. & Matzinger, P. The role of dendritic cells, B cells and M cells in gut-oriented immune responses. J. Immunol. 166, 4843-4852 (2001). B-cell-deficient mice do not have normal Peyer's patches or M cells, but can be tolerized normally by feeding of protein antigen. This is associated with the presence of antigen-loaded dendritic cells in the mesenteric lymph nodes that induce T cells to produce IL-4 and IL-10.
    • (2001) J. Immunol. , vol.166 , pp. 4843-4852
    • Alpan, O.1    Rudomen, G.2    Matzinger, P.3
  • 49
    • 0022600983 scopus 로고
    • Induction of oral tolerance in rats without Peyer's patches
    • Enders, G., Gottwald, T. & Brendel, W. Induction of oral tolerance in rats without Peyer's patches. Immunology 58, 311-314 (1986).
    • (1986) Immunology , vol.58 , pp. 311-314
    • Enders, G.1    Gottwald, T.2    Brendel, W.3
  • 50
    • 0035997910 scopus 로고    scopus 로고
    • Signalling via LTβR on the lamina propria stromal cells of the gut is required for IgA production
    • Kang, H. S. et al. Signalling via LTβR on the lamina propria stromal cells of the gut is required for IgA production. Nature Immunol. 3, 576-582 (2002). This study uses bone-marrow chimeras and the transplantation of gut from Rag-deficient mice to show that the defective IgA production in LTα-deficient mice is not necessarily related to abnormalities in the Peyer's patches. Rather, non-bone-marrow-derived cells in the lamina propria can provide the appropriate microenvironment for recruitment and differentiation of IgA precursors after activation through the LTβ receptor.
    • (2002) Nature Immunol. , vol.3 , pp. 576-582
    • Kang, H.S.1
  • 51
    • 0036686912 scopus 로고    scopus 로고
    • Lack of antigen-specific immune responses in anti-IL-7 receptor-α chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen
    • Kunisawa, J. et al. Lack of antigen-specific immune responses in anti-IL-7 receptor-α chain antibody-treated Peyer's patch-null mice following intestinal immunization with microencapsulated antigen. Eur. J. Immunol. 32, 2347-2355 (2002).
    • (2002) Eur. J. Immunol. , vol.32 , pp. 2347-2355
    • Kunisawa, J.1
  • 52
    • 0034657906 scopus 로고    scopus 로고
    • Alternate mucosal immune system: Organized Peyer's patches are not required for IgA responses in the gastrointestinal tract
    • Yamamoto, M. et al. Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J. Immunol. 164, 5184-5191 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 5184-5191
    • Yamamoto, M.1
  • 53
    • 0031586027 scopus 로고    scopus 로고
    • Inductive events in oral tolerance in the TCR transgenic adoptive-transfer model
    • Chen, Y., Inobe, J.-I. & Weiner H. L. Inductive events in oral tolerance in the TCR transgenic adoptive-transfer model. Cell. Immunol. 178, 62-68 (1997).
    • (1997) Cell. Immunol. , vol.178 , pp. 62-68
    • Chen, Y.1    Inobe, J.-I.2    Weiner, H.L.3
  • 54
    • 0035340263 scopus 로고    scopus 로고
    • Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein
    • Meyer, A. L. et al. Rapid depletion of peripheral antigen-specific T cells in TCR-transgenic mice after oral administration of myelin basic protein. J. Immunol. 166, 5773-5782 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 5773-5782
    • Meyer, A.L.1
  • 55
    • 0034544445 scopus 로고    scopus 로고
    • Enteric infection as an adjuvant for the response to a model food antigen
    • Shi, H. N., Liu, H. Y. & Nagler-Anderson, C. Enteric infection as an adjuvant for the response to a model food antigen. J. Immunol. 165, 6174-6182 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 6174-6182
    • Shi, H.N.1    Liu, H.Y.2    Nagler-Anderson, C.3
  • 57
    • 0034235362 scopus 로고    scopus 로고
    • Interferon-γ induction during oral tolerance reduces T-cell migration to sites of inflammation
    • Lee, H. O. et al. Interferon-γ induction during oral tolerance reduces T-cell migration to sites of inflammation. Gastroenterology 119, 129-138 (2000).
    • (2000) Gastroenterology , vol.119 , pp. 129-138
    • Lee, H.O.1
  • 58
    • 0343938858 scopus 로고    scopus 로고
    • Soluble antigen and CD 40 triggering are sufficient to induce primary and memory cytotoxic T cells
    • Lefrancois, L., Altman, J. D., Williams, K. & Olson, S. Soluble antigen and CD40 triggering are sufficient to induce primary and memory cytotoxic T cells. J. Immunol. 164, 725-732 (2000).
    • (2000) J. Immunol. , vol.164 , pp. 725-732
    • Lefrancois, L.1    Altman, J.D.2    Williams, K.3    Olson, S.4
  • 59
    • 0032889807 scopus 로고    scopus 로고
    • Dendritic cells and Langerhans cells in the uptake of mucosal antigens
    • MacPherson, G. G. & Uu, L. M. Dendritic cells and Langerhans cells in the uptake of mucosal antigens. Curr. Top. Microbiol. Immunol. 236, 33-53 (1999).
    • (1999) Curr. Top. Microbiol. Immunol. , vol.236 , pp. 33-53
    • MacPherson, G.G.1    Uu, L.M.2
  • 60
    • 0034614894 scopus 로고    scopus 로고
    • A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
    • Huang, F. P. et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med. 191, 435-444 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 435-444
    • Huang, F.P.1
  • 62
    • 0031008078 scopus 로고    scopus 로고
    • Maturation of Peyer's patch dendritic cells in vitro upon stimulation via cytokines or CD 40 triggering
    • Ruedl, C. & Hubele, S. Maturation of Peyer's patch dendritic cells in vitro upon stimulation via cytokines or CD40 triggering. Eur. J. Immunol. 27, 1325-1330 (1997).
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1325-1330
    • Ruedl, C.1    Hubele, S.2
  • 63
    • 0033584234 scopus 로고    scopus 로고
    • Freshly isolated Peyer's patch, but not spleen, denddtic cells produce interleukin-10 and induce the differentiation of T-helper type 2 cells
    • Iwasaki, A. & Kelsall, B. L. Freshly isolated Peyer's patch, but not spleen, denddtic cells produce interleukin-10 and induce the differentiation of T-helper type 2 cells. J. Exp. Med. 190, 229-239 (1999).
    • (1999) J. Exp. Med. , vol.190 , pp. 229-239
    • Iwasaki, A.1    Kelsall, B.L.2
  • 64
    • 0034678392 scopus 로고    scopus 로고
    • Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3α, MIP-3β, and secondary lymphoid organ chemokine
    • Iwasaki, A. & Kelsall, B. L. Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3α, MIP-3β, and secondary lymphoid organ chemokine. J. Exp. Med. 191, 1381-1393 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1381-1393
    • Iwasaki, A.1    Kelsall, B.L.2
  • 65
    • 0035871705 scopus 로고    scopus 로고
    • + and double negative Peyer's patch dendritic cells
    • + and double negative Peyer's patch dendritic cells. J. Immunol. 166, 4884-4890 (2001). The description of individual and unique subsets of dendritic cells in mouse Peyer's patches, each with distinct functions, which include the preferential stimulation of IL-4- and IL-10-producing T cells.
    • (2001) J. Immunol. , vol.166 , pp. 4884-4890
    • Iwasaki, A.1    Kelsall, B.L.2
  • 66
    • 0033679107 scopus 로고    scopus 로고
    • CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
    • Cook, D. N. et al. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue. Immunity 12, 495-503 (2000).
    • (2000) Immunity , vol.12 , pp. 495-503
    • Cook, D.N.1
  • 67
    • 0036784632 scopus 로고    scopus 로고
    • Regulation of mucosal dendritic cell function by receptor activator of NF-κB(RANK)/RANK ligand interactions: Impact on tolerance induction
    • Williamson, E., Bilsborough, J. M. & Viney, J. L. Regulation of mucosal dendritic cell function by receptor activator of NF-κB(RANK)/RANK ligand interactions: impact on tolerance induction. J. Immunol. 169, 3606-3612 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 3606-3612
    • Williamson, E.1    Bilsborough, J.M.2    Viney, J.L.3
  • 68
  • 70
    • 0037100317 scopus 로고    scopus 로고
    • + dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential
    • + dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 100, 383-390 (2002).
    • (2002) Blood , vol.100 , pp. 383-390
    • Martin, P.1
  • 71
    • 0035871634 scopus 로고    scopus 로고
    • Migration and maturation of human colonic dendritic cells
    • Bell, S. J. et al. Migration and maturation of human colonic dendritic cells. J. Immunol. 166, 4958-4967 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 4958-4967
    • Bell, S.J.1
  • 72
    • 0029821698 scopus 로고    scopus 로고
    • The role of small intestinal antigen-presenting cells in the induction of T-cell reactivity to soluble protein antigens: Association between aberrant presentation in the lamina propria and oral tolerance
    • Harper, H., Cochrane, L. & Williams, N. A. The role of small intestinal antigen-presenting cells in the induction of T-cell reactivity to soluble protein antigens: association between aberrant presentation in the lamina propria and oral tolerance. Immunology 89, 449-456 (1996).
    • (1996) Immunology , vol.89 , pp. 449-456
    • Harper, H.1    Cochrane, L.2    Williams, N.A.3
  • 73
    • 0035321325 scopus 로고    scopus 로고
    • Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    • Rescigno, M. et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nature Immunol. 2, 361-367 (2001). An in vitro co-culture model showing that DCs normally do not invade monolayers of intestinal epithelial cells. However, if bacteria are placed on the apical surface of the enterocytes, DCs are stimulated to invade the epithelium and might even form tight junctions with neighbouring enterocytes to preserve the barrier. Some of the DCs can take up bacteria from the surface of the epithelium before withdrawing from the monolayer. A similar phenomenon might occur in vivo.
    • (2001) Nature Immunol. , vol.2 , pp. 361-367
    • Rescigno, M.1
  • 74
    • 0033555895 scopus 로고    scopus 로고
    • Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse
    • Anjuere, F. et al. Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. Blood 93, 590-598 (1999).
    • (1999) Blood , vol.93 , pp. 590-598
    • Anjuere, F.1
  • 75
    • 0030704726 scopus 로고    scopus 로고
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389, 737-742 (1997).
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 78
    • 0035165909 scopus 로고    scopus 로고
    • Immunology of the healthy liver: Old questions and new insights
    • Mehal, W. Z., Azzaroli, F. & Crispe, I. N. Immunology of the healthy liver: old questions and new insights. Gastroenterology 120, 250-260 (2001).
    • (2001) Gastroenterology , vol.120 , pp. 250-260
    • Mehal, W.Z.1    Azzaroli, F.2    Crispe, I.N.3
  • 79
    • 0029785825 scopus 로고    scopus 로고
    • + cells in regulation of rejection of small intestinal allografts in rats
    • + cells in regulation of rejection of small intestinal allografts in rats. Transplantation 62, 844-851 (1996).
    • (1996) Transplantation , vol.62 , pp. 844-851
    • Gorczynski, R.M.1    Cohen, Z.2    Levy, G.3    Fu, X.M.4
  • 80
    • 0142252362 scopus 로고    scopus 로고
    • (ed. Crispe, I. N.) (John Wiley & Sons Inc., New York)
    • Mowat, A. Mcl. in The Immunology of the Liver (ed. Crispe, I. N.) 101-115 (John Wiley & Sons Inc., New York, 1999).
    • (1999) The Immunology of the Liver , pp. 101-115
    • Mowat, A.McI.1
  • 81
    • 0028070723 scopus 로고
    • Intestinal drainage through liver is a pre-requisite for oral tolerance induction
    • Yang, R., Liu, Q., Grosfeld, J. L. & Pescovitz, M. D. Intestinal drainage through liver is a pre-requisite for oral tolerance induction. J. Pediatr. Surg. 29, 1145-1148 (1994).
    • (1994) J. Pediatr. Surg. , vol.29 , pp. 1145-1148
    • Yang, R.1    Liu, Q.2    Grosfeld, J.L.3    Pescovitz, M.D.4
  • 82
    • 0017142996 scopus 로고
    • The immune system response in cirrhotic rats. The induction of tolerance to orally administered protein antigens
    • Thomas, H. C., Ryan, C. J., Benjamin, I. S., Blumgart, L. H. & MacSween, R. N. M. The immune system response in cirrhotic rats. The induction of tolerance to orally administered protein antigens. Gastroenterology 71, 114-117 (1976).
    • (1976) Gastroenterology , vol.71 , pp. 114-117
    • Thomas, H.C.1    Ryan, C.J.2    Benjamin, I.S.3    Blumgart, L.H.4    MacSween, R.N.M.5
  • 83
    • 0031849162 scopus 로고    scopus 로고
    • Lymphocyte surface marker and cytokine expression in peripheral and mucosal lymph nodes
    • Premier, R. R. & Meeusen, E. N. T. Lymphocyte surface marker and cytokine expression in peripheral and mucosal lymph nodes. Immunology 94, 363-367 (1998).
    • (1998) Immunology , vol.94 , pp. 363-367
    • Premier, R.R.1    Meeusen, E.N.T.2
  • 84
    • 0035879316 scopus 로고    scopus 로고
    • The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli
    • Kellermann, S. A. & McEvoy, L. M. The Peyer's patch microenvironment suppresses T cell responses to chemokines and other stimuli. J. Immunol. 167, 682-690 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 682-690
    • Kellermann, S.A.1    McEvoy, L.M.2
  • 85
    • 0037097777 scopus 로고    scopus 로고
    • Murine Peyer's patches favor development of an IL-10-secreting, regulatory T cell population
    • Jump, R. L. & Levine, A. D. Murine Peyer's patches favor development of an IL-10-secreting, regulatory T cell population. J. Immunol. 168, 6113-6119 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 6113-6119
    • Jump, R.L.1    Levine, A.D.2
  • 86
    • 0033557738 scopus 로고    scopus 로고
    • Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: Studies with OVA and human cartilage gp39
    • Wolvers, D. A. W. et al. Intranasally induced immunological tolerance is determined by characteristics of the draining lymph nodes: studies with OVA and human cartilage gp39. J. Immunol. 162, 1994-1998 (1999). An intriguing study that shows that surgical removal of the draining lymph nodes abrogates the induction of tolerance by intranasal administration of proteins and that only the appropriate lymph node can restore tolerance induction. So, lymph nodes that drain from mucosal tissues might be functionally distinct from other lymph nodes.
    • (1999) J. Immunol. , vol.162 , pp. 1994-1998
    • Wolvers, D.A.W.1
  • 87
    • 0034284803 scopus 로고    scopus 로고
    • Prokaryotic regulation of epithelial responses by inhibition of IκB-α ubiquitination
    • Neish, A. S. et al. Prokaryotic regulation of epithelial responses by inhibition of IκB-α ubiquitination. Science 289, 1560-1563 (2000). This paper shows that commensal bacteria in the gut are not merely passive spectators in the local microenvironment, as they can interact with enterocytes and actively inhibit the inflammatory signalling processes that are stimulated by pathogenic organisms. The implication is that commensal bacteria are continually involved in signalling to enterocytes and this might be important for the maintenance of normal homeostasis.
    • (2000) Science , vol.289 , pp. 1560-1563
    • Neish, A.S.1
  • 88
    • 0002647979 scopus 로고    scopus 로고
    • Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures
    • Haller, D. et al. Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 47, 79-87 (2000).
    • (2000) Gut , vol.47 , pp. 79-87
    • Haller, D.1
  • 89
    • 0035846113 scopus 로고    scopus 로고
    • In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
    • Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K. & Honjo, T. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria Nature 413, 639-643 (2001).
    • (2001) Nature , vol.413 , pp. 639-643
    • Fagarasan, S.1    Kinoshita, K.2    Muramatsu, M.3    Ikuta, K.4    Honjo, T.5
  • 90
    • 0032780043 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen
    • 2 by stromal cells, which then induces the differentiation of IL-10-producing DCs.
    • (1999) Nature Med. , vol.5 , pp. 900-906
    • Newberry, R.D.1    Stenson, W.P.2    Lorenz, R.G.3
  • 91
    • 0035313115 scopus 로고    scopus 로고
    • Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestinal lamina propria: Directing the tone of the intestinal immune response
    • Newberry, R. D., McDonough, J. S., Stenson, W. F. & Lorenz, R. G. Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestinal lamina propria: directing the tone of the intestinal immune response. J. Immunol. 166, 4465-4472 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 4465-4472
    • Newberry, R.D.1    McDonough, J.S.2    Stenson, W.F.3    Lorenz, R.G.4
  • 92
    • 0036498542 scopus 로고    scopus 로고
    • Cyclooxygenase-2-issued prostaglandin E2 enhances the production of endogenous IL-10, which down-regulates dendntic-cell functions
    • Harizi, H., Juzan, M., Pitard, V., Moreau, J. F. & Gualde, N. Cyclooxygenase-2-issued prostaglandin E2 enhances the production of endogenous IL-10, which down-regulates dendntic-cell functions. J. Immunol. 168, 2255-2263 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 2255-2263
    • Harizi, H.1    Juzan, M.2    Pitard, V.3    Moreau, J.F.4    Gualde, N.5
  • 93
    • 0032529846 scopus 로고    scopus 로고
    • + dendritic cells: The levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation
    • + dendritic cells: the levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J. Immunol. 161, 2804-2809 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 2804-2809
    • Kalinski, P.1    Schultemaker, J.H.2    Hilkens, C.M.3    Kapsenberg, M.L.4
  • 94
    • 0033213958 scopus 로고    scopus 로고
    • Modulating dendritic cells to optimize mucosal immunization protocols
    • Williamson, E., Westrich, G. M. & Viney, J. L. Modulating dendritic cells to optimize mucosal immunization protocols. J. Immunol. 163, 3668-3675 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 3668-3675
    • Williamson, E.1    Westrich, G.M.2    Viney, J.L.3
  • 95
    • 0028895941 scopus 로고
    • Endotoxin-mediated dendritic cell release from the intestine Characterization of released dendritic cells and TNF dependence
    • MacPherson, G. G., Jenkins, C. D., Stein, M. J. & Edwards, C. Endotoxin-mediated dendritic cell release from the intestine Characterization of released dendritic cells and TNF dependence. J. Immunol. 154, 1317-1322 (1995).
    • (1995) J. Immunol. , vol.154 , pp. 1317-1322
    • MacPherson, G.G.1    Jenkins, C.D.2    Stein, M.J.3    Edwards, C.4
  • 96
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factorβ after antigen-specific triggering
    • Miller, A., Lider, O., Roberts, A. B., Sporn, M. B. & Weiner, H. L. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factorβ after antigen-specific triggering. Proc. Natl Acad. Sci. USA 89, 421-425 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3    Sporn, M.B.4    Weiner, H.L.5
  • 97
    • 0035399985 scopus 로고    scopus 로고
    • + T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen
    • + T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J. Immunol. 167, 188-195 (2001).
    • (2001) J. Immunol. , vol.167 , pp. 188-195
    • Thorstenson, K.M.1    Khoruts, A.2
  • 98
    • 0023146356 scopus 로고
    • The regulation of immune responses to dietary protein antigens
    • Mowat, A. Mcl. The regulation of immune responses to dietary protein antigens. Immunol. Today 8, 93-95 (1987).
    • (1987) Immunol. Today , vol.8 , pp. 93-95
    • Mowat, A.McI.1
  • 99
    • 0031569452 scopus 로고    scopus 로고
    • γδ T lymphocytes regulate the induction of oral tolerance
    • Ke, Y., Pearce, K., Lake, J. P., Ziegler, H. K. & Kapp, J. A. γδ T lymphocytes regulate the induction of oral tolerance. J. Immunol. 58, 3610-3618 (1997).
    • (1997) J. Immunol. , vol.58 , pp. 3610-3618
    • Ke, Y.1    Pearce, K.2    Lake, J.P.3    Ziegler, H.K.4    Kapp, J.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.